Alejandro González Candia Profesor Asistente

    Grado Académico

    Doctorado en Farmacología Universidad de Chile

    Título(s) Profesional

    Bioquimico Universidad Andrés Bello

    Descripción

    Mi investigación se centra en la función vascular en condiciones fisiológicas y patológicas, principalmente en los mecanismos adaptativos relacionados con la hipoxia y el estrés oxidativo en el período prenatal y sus efectos a corto y mediano plazo en el sistema cardiovascular y cerebral (DOHaD hypothesis).

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    Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases

    • Adolfo A. Paz • Alejandro González •

    DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

    Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy

    • Alejandro Candia Henríquez • Tamara Jiménez • Alvaro Navarrete • Felipe Beñaldo • Pablo Silva

    DOI: http://dx.doi.org/10.3390/vetsci10020144

    Chronic intermittent hypobaric hypoxia induces cardiovascular dysfunction in a high-altitude working shift model

    • Alejandro González • Alejandro A. Candia • Pamela V. Arias • Adolfo A. Paz • Emilio A. Herrera

    DOI: http://dx.doi.org/10.1016/j.lfs.2023.121800

    Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function

    • Alejandro A. Candia • Pamela V. Arias • Cristopher Gonzalez-Candia • Alvaro Navarrete • German Ebensperger

    DOI: http://dx.doi.org/10.1016/j.vph.2022.106971

    Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model

    • Andrés Utrera • Alvaro Navarrete • Alejandro González • Claudio García-Herrera • Emilio A. Herrera

    DOI: http://dx.doi.org/10.1038/s41598-022-07616-3

    Editorial: Mechanisms of Ischemia-Reperfusion Injury in Animal Models and Clinical Conditions: Current Concepts of Pharmacological Strategies

    • Rodrigo L. Castillo • Alejandro González • Rodrigo Carrasco •

    DOI: http://dx.doi.org/10.3389/fphys.2022.880543

    miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hypoxia

    • Esteban G. Figueroa • Aitor Caballero-Román • Josep R. Ticó • Montserrat Miñarro • Anna Nardi-Ricart

    DOI: http://dx.doi.org/10.1016/j.crphar.2022.100129

    Potential Pharmacological Target of Tight Junctions to improve the BBB Permeability in Neonatal Hypoxic-Ischemic Encephalopathy Diseases

    • Adolfo A. Paz • Alejandro González •

    DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

    Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia

    • Alejandro González • Alejandro Candia Henríquez • Adolfo Paz • Fuad Mobarec • Rodrigo Urbina-Varela

    DOI: http://dx.doi.org/10.3390/antiox11061043

    Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates

    • Esteban Figueroa Becerra • Alejandro González • Cristian A. Villanueva • German Ebensperger • Roberto V. Reyes

    DOI: http://dx.doi.org/10.1016/j.vph.2021.106853

    Blood-brain barrier dysfunction in hemorrhagic transformation: a therapeutic opportunity for nanoparticles and melatonin.

    • Esteban Figueroa Becerra • Alejandro González • Aitor Caballero-Román • Cristina Fornaguera • Elvira Escribano-Ferrer

    DOI: http://dx.doi.org/10.1152/jn.00638.2020

    Caracterización del daño mecánico de la aorta en condición de hipoxia

    • Alejandro Bezmalinovic • Eugenio Rivera • Claudio García-Herrera • Diego Celentano • Alejandro González

    DOI: http://dx.doi.org/10.1590/s1517-707620210001.1240

    Gestational Hypoxia and Blood-Brain Barrier Permeability: Early Origins of Cerebrovascular Dysfunction Induced by Epigenetic Mechanisms

    • Emilio A. Herrera • Alejandro González •

    DOI: http://dx.doi.org/10.3389/fphys.2021.717550

    High Altitude Pregnancies and Vascular Dysfunction: Observations From Latin American Studies

    • Alejandro González • Emilio A. Herrera •

    DOI: http://dx.doi.org/10.3389/fphys.2021.786038

    Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia

    • Alejandro González • Pamela V. Arias • Simón A. Aguilar • Esteban Figueroa Becerra • Roberto V. Reyes

    DOI: http://dx.doi.org/10.3390/antiox10111658

    Blood-Brain Barrier Dysfunction in the Detrimental Brain Function

    • Alejandro González • Nicole K. Rogers • Rodrigo L. Castillo •

    DOI: http://dx.doi.org/10.5772/intechopen.94572

    Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs

    • Eugenio Rivera • Claudio García-Herrera • Alejandro González • Diego J. Celentano • Emilio A. Herrera

    DOI: http://dx.doi.org/10.1016/j.jmbbm.2020.104013

    Comment on Melatonin as a potential adjuvant treatment for COVID-19

    • Emilio A. Herrera • Alejandro González •

    DOI: http://dx.doi.org/10.1016/j.lfs.2020.117739

    The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

    • Alejandro González • Alejandro Candia Henríquez • German Ebensperger • Roberto V. Reyes • Anibal J. Llanos

    DOI: http://dx.doi.org/10.1017/s2040174420000616

    Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

    • Alvaro Navarrete • Zhuoming Chen • Pedro Aranda • Daniel Poblete • Andrés Utrera

    DOI: http://dx.doi.org/10.3389/fbioe.2020.590488

    Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep

    • Alejandro González • Marcelino Veliz • Catalina Carrasco-Pozo • Rodrigo L. Castillo • J. Cesar Cárdenas

    DOI: http://dx.doi.org/10.1016/j.redox.2019.101128

    Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates

    • Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Elisenda Feixes • Cristopher Gonzalez-Candia

    DOI: http://dx.doi.org/10.1111/jpi.12613

    Biomolecular markers and pulmonary structure in rats exposed to acute intermittent hypobaria

    • Jorge Rodriguez Borges • Miguel Aguilar • Alejandro González • Rodrigo Castillo • Emilio Herrera

    DOI: http://dx.doi.org/10.1183/13993003.congress-2019.pa4068

    Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs

    • Felipe A. Beñaldo • Anibal J. Llanos • Claudio Araya-Quijada • Auristela Rojas • Alejandro González

    DOI: http://dx.doi.org/10.3389/fendo.2019.00433

    El tratamiento postnatal con melatonina modula la expresión de agentes prostanoides en pulmón de neonatos de oveja con hipertensión pulmonar

    • Simón A. Aguilar • Pamela V. Arias • Ignacio Canquil • German Ebensperger • Anibal J. Llanos

    DOI: http://dx.doi.org/10.4067/s0034-98872019000300281

    Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

    • Rodrigo L. Castillo • Emilio A. Herrera • Alejandro González • Marjorie Reyes-Farias • Nicole de la Jara

    DOI: http://dx.doi.org/10.1155/2018/7239123

    Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

    • Cristian R. Astorga • Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Daniel Cañas

    DOI: http://dx.doi.org/10.3389/fphys.2018.00185

    Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress

    • Miguel Aguilar • Alejandro González • Jorge Rodríguez • Catalina Carrasco-Pozo • Daniel Cañas

    DOI: http://dx.doi.org/10.3390/ijms19020366

    Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep

    • Alejandro González • Marcelino Veliz • Claudio Araya • Sebastian Quezada • German Ebensperger

    DOI: http://dx.doi.org/10.1016/j.ajog.2016.02.040

    Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep

    • Flavio Torres • Alejandro González • Camilo Montt • German Ebensperger • Magdalena Chubretovic

    DOI: http://dx.doi.org/10.1111/jpi.12222

    ?3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats

    • Emilio Herrera • Jorge Farías • Alejandro González • Stefania Short • Catalina Carrasco-Pozo

    DOI: http://dx.doi.org/10.3390/md13020838

    • ● Enero 2023

    Riesgo cardiovascular en una cohorte de sobrevivientes de cáncer infantil en Chile: estudio piloto que evalúa el impacto del entrenamiento físico en marcadores de capacidad cardiorrespiratoria y ocurrencia de cardiotoxicidad

    Responsable Alterno
    • ● Abril 2022

    Fondecyt Regular 2022

    Responsable Alterno
    • ● Noviembre 2021

    Creación de imágenes de superresolución ultrasónicas en placentas humanas ex vivo

    Co-Investigador/a
    • ● Septiembre 2021

    Crea y Valida I+D+i Colaborativo

    Co-Investigador/a
    • ● Diciembre 2020

    Blood-Brain Barrier Programming Dysfunction in Intrauterine Hypoxia: Epigenetics, Permeability and Integrity Assessment for Cerebrovascular Protection

    Co-Investigador/aCo-Investigador/a

    Campus Rancagua – Avenida Libertador Bernardo O’Higgins #611, Rancagua