Natural Hydrogen in Chile: Unlocking the Geological Sources for a Green Energy Transition

As the world explores alternatives to fossil fuels, hydrogen (H₂) has emerged as a critical element in accelerating the transition to clean and renewable energy sources (Gaucher et al., 2023; Le et al., 2023; Blay-Roger et al., 2024). Unlike gasoline, which emits CO2 when burned, H₂ combustion produces only water vapor, making it a high-quality and environmentally friendly fuel alternative. Hydrogen is primarily produced for industry processes, including “green hydrogen”, “blue hydrogen”, and “gray hydrogen” (IEA, 2019). On the other hand, the so-called “natural” or “white hydrogen” is potentially a more cost-effective and environmentally friendly alternative because it is ready to be used for energy production, without the need for polluting processes to obtain it (Smith et al., 2005; Lapi et al., 2022; Gaucher et al., 2023; Blay-Roger et al., 2024). However, H₂ accumulation in the subsurface has been largely overlooked due to assumptions of its rarity or nonexistence, attributed to the hydrogen’s inheritance characteristics (small and reactive molecule). The first fortuitous discoveries in the USA or Mali (West Africa) proved that it was a mistake (Zgonnik, 2020).

Currently, the geological processes that generate natural hydrogen have started to be better understood, but the conditions for its accumulation remain poorly constrained (Lévy et al., 2023). The potential for global extraction of natural hydrogen is significant, so it is critical that we understand how it is generated, transported, and ultimately trapped. Recent discoveries of natural hydrogen in various geological settings, including mid-ocean ridges, ophiolitic nappes, transform faults, convergent subduction margins, and intraplate settings (Zgonnik et al., 2020; Jackson et al., 2024) highlight the increasing interest in this resource. As a result, exploration projects are currently active in several countries such as Australia, the USA, France, Spain, and South America (e.g., Zgonnik et al., 2020, Jackson et al., 2024). Experience in managing H₂ reservoirs is obviously still missing, but the analogies should perhaps rather be sought in the field of geothermal energy (Moretti et al., 2023).

In terms of geotectonic settings of natural hydrogen formation, subduction zones represent the primary geological environment for the large-scale interaction between water and mantle peridotite, i.e., serpentinization processes (Zgonnik et al., 2020). Serpentinization is the most effective and hence important subsurface process for producing and focusing natural hydrogen in potentially commercial volumes (Jackson et al., 2024). Particularly, in the Central Andean Volcanic Zone (CAVZ; 18-28°S; Fig. 1a) only a limited number of investigations have focused on natural hydrogen data. Moretti et al. (2023) confirmed the presence of natural hydrogen in the Bolivian Altiplano (e.g., Pampa Lirima and Sol de Mañana; Fig. 1a) by using geochemical measurements of gasses from hot springs and in-situ analysis of soil gas. Moreover, the 3He/4He ratios in the Altiplano-Puna plateau indicate that the amount of He uprising from the mantle (i.e., 3He content) is very large (Fig. 1b). This indicates that deep gasses are migrating toward the overriding plate surface above subduction (Fig. 1c). Based on the findings of Moretti et al. (2023), it is highly probable to find natural hydrogen in the Chilean portion of the Altiplano. In this context, the proposed research plans to unlock the geological origin and assess the potential of natural hydrogen in northern Chile. Moreover, this project goes one step further than the study of Moretti et al. (2023) and proposes to investigate the potential occurrences of natural hydrogen associated with specific structural arrangements related to volcanic and geothermal systems (Veloso et al., 2019). For that reason, the acquisition of new geological, structural, geochemical, seismological, and geophysical data is crucial to better understand natural hydrogen systems and to determine the prospectivity of new areas in Chile.

Spatiotemporal dynamics of lithium in Andean salars: Insights for Sustainable Exploration and Exploitation

We propose to undertake a 3-year long project, devoted to achieving a detailed comprehension of the Li dynamics and impacts, from source to sink, in the Andean salars (including Preandean and high Andean salars) of the Antofagasta Region of Chile (Fig. 1). The methodological approach is multidisciplinary and includes geological, hydrological, mineralogical, geochemical, microbiological and social techniques. The specific study cases are given by the Salar de Atacama (SDA), recognized as the most important Li brine reservoir in Chile (Cabello, 2022), and 3 salt flats domains located eastwards; these latter domains are, from south to north:
Northern domain. Pujsa, Tara, and Quisquiro salt lakes.
Southern domain. Capur, Talar, and Tuyajto salt lakes.
Central domain. Aguas Calientes Sur and Laguna Lejia salt lakes.

Water energy food nexus for urban areas of central chile(wef-chile)

Ensuring a secure and sustainable water supply is a major challenge for the 21th century. The population growth,
urbanization, and industrial/agriculture expansion need an increasing water provision, delivered at a constant rate.
Furthermore, under the current climate change and droughts scenarios, with the depletion of surface water storage
and quality, groundwater resources are fulfilling the growing water requirement for food and energy production.
Estimated data indicate that in the 2010 ́s, groundwater supplies 36% of potable water, 43% of irrigated agriculture
(considering the baseflow feeding rivers, this percentage is higher), and 24% of direct industrial water supply. The
groundwater use is growing at a rate of 5% per year, and by 2050, the food and water demand will increase by 50%.
However, the misconceiving and oversimplification of conceptual models about groundwater recharge points out
that around 25% of its use is unsustainable. These considerations highlight how identifying innovative and
integrated solutions to tackle the intertwined challenges of water and climate change as well as the complex
interlink between water, energy, and food supply systems under current climate variability is an increasingly major
imperative for the near future.
The study of the water–energy–food nexus has received increasing attention from the global scientific community,
focusing on how these three elements can interact sustainably. The interdependence of water resources, energy
generation, and food production depends on reliable data and information on these resources. In this context,
groundwater can serve to supply water and energy demand, strengthening food security and reducing fossil fuel
energy dependence. Aquifers can provide water and geothermal energy, a clean baseload resource independent
from weather conditions, which could significantly contribute to energy needs, improved air quality and food
production as well as to reach the decarbonization targets. This combined aquifer’s use improvement could be
especially relevant in urban areas where more than 50% of the world’s population lives and which is forecast to
increase to 68% by 2050 with associated greenhouse gas emissions growth up to 80%.
Aquifers are important heat reservoirs because groundwater flow is a powerful heat carrier, which can help achieve
a more sustainable water-energy-food management, representing a major challenge to improving water, energy,
and food security. In fact, by 2050, the demand for water and food is expected to increase by 60%, and the energy
demand will be practically doubled.
In this proposal, the WEF nexus will be specially addressed from the point of view of resources to generate the
necessary knowledge to understand its complexity in Central Chile, and that will provide a timely transfer of the
existing connections to decision makers and society. The aim of this study will be to comprehend the recharge and
connection of surface and ground water in Central Chile and unravel their relationship with energy and food
production. In this sense, the focus is on evaluating the hydrological cycle from mountain areas to the lowlands and
evaluating the possibility that water resources can generate enough heat for direct geothermal projects. These
results, calculated based on real and current water data, will provide valuable information for the energy transition
in Central Chile and will be an instrument to evaluate the real possibility of greenhouse gas reduction. Food
production not only needs water but also to increase its resilience to extreme events (frost, heavy rains, etc.), so
the relationship between water availability, production per hectare, and geothermal energy (direct use) to stabilize
crop conditions will be explored.

Structural control on residence times and metal sources in geothermal waters from Southern Andes: implications for geothermal systems and epithermal deposits formation

Ensure a secure and sustainable energy and mineral supply is a major challenge for the 21th century. Understanding the nature and evolution of hydrothermal systems can contribute to that aim by improving the effectiveness of exploration strategies for geothermal energy and precious metal epithermal deposits. Studies bridging together geochemistry and structural geology have shown that fault activity plays a critical role on fluid circulation and fluid chemical composition in hydrothermal systems. Despite the relevance of processes affecting the chemical and physical dimensions in such dynamic systems, little is known about the residence times of fluids and its metal budget in different structural contexts.
Into this framework, fundamental questions arise regarding the optimal conditions leading to the development of high enthalpy geothermal resources and the formation of epithermal deposits: What is the structural control on the sources and concentration of base metals in hydrothermal fluids? How does the structural context affect the water residence times in hydrothermal systems? How does the meteoric recharge affect the geothermal systems in different structural domains?
An ideal natural laboratory to address these questions is the Andean Cordillera of Central-Southern Chile, where hydrothermal systems occur in close spatial relationship with active volcanism as well as major seismically-active fault systems. Recent studies based on fluid geochemistry and noble gases isotopic composition have shown that the intersection of structural features promotes both the accumulation formation of magmatic/hydrothermal reservoir in the upper crust exerting a first-order control on hydrothermal fluid composition by conditioning residence times of magmas, promoting magma differentiation and separation of magmatic vapors. However, how similar processes are involved on residence times and metal budget of hydrothermal fluids remains unconstrained.
We propose a geochemical and multi-isotopic study that integrates state-of-the-art analytical techniques to unravel the circulation times and base metals contribution from magma degassing and water- rock interaction in two volcano-tectonic settings in Southern Andes, i) the arc parallel strike-slip Liquiñe- Ofqui Fault System (LOFS) and ii) the intersection between the LOFS structures and the Andean Transverse Fault (ATF). I will integrate major and trace elements (e.g., Cu, Pb, Zn, among others) geochemistry of hot springs with water dating systems (3H-3He, 14C, U-Th/4He), noble gas (3He/4He; 40Ar/36Ar, 4He/20Ne), strontium (87Sr/86Sr) and water stable (𝛿!”𝑂, 𝛿 #𝐻) isotopes to identify the circulation times, recharge condition and metal budget of hydrothermal systems.
This study will be the first to directly measure the residence times and metals contents of hydrothermal fluids in the Southern Andes of Chile. The results from the study will contribute to a better understanding of the fundamental geological and environmental controls on the evolution of hydrothermal systems. The data will directly impact the community exploring for geothermal energy in the Andes because it will help them to better constrain the formation and recharge times of geothermal reservoirs. In addition, this will be an original contribution that will impact the general geochemical science community, as no data exists on the links between residence times of hydrothermal fluids and the structural context.

Breaking the current recharge paradigm in Central Chile: a deep borehole for Andean groundwater flows estimation

The main aim of the present proposal is to assess, in the Western Andean Front, the magnitude and the spatiotemporal variability of deep groundwater flows and derived mountain block recharge using an original and direct collection of hydrogeological, lithological, and geophysical data. Specific objectives are:
– Obj. 1: Assess the spatial variation at depth of the Abanico Formation hydraulic properties to improve the understanding of Western Andean Front fault systems and their impacts on the water transference to alluvial aquifers.
– Obj. 2: Unravel the aquifer capacity of fractured rocks (i.e. Abanico Formation) and the critical zone extinction depth for groundwater flows and mountain block recharge mechanisms in the Western Andean Front of Central Chile.
– Obj. 3: Estimate the mountain block recharge mechanisms regarding their quantitative (flow) and qualitative (hydrogeochemistry) aspects and assess the vulnerability of deep groundwater flows to shallow water-store variations caused by current and future hydroclimatic changes in the Western Andean Front.
The study of borehole core lithological and hydraulic properties, groundwater geochemical composition, flow rates, together with spring hydraulic and hydrogeochemistry behaviors will help to fill a gap of knowledge about deep groundwater flows originating from the Principal Cordillera. This deep borehole and derived original information will therefore be used as an “eye” inside the deep Chilean Andes groundwater resources. Finally, it will be a useful observation point for multidisciplinary research due to the interest of national and international researchers to collect samples at depth and therefore will expand shared knowledge and national frontier research

Energías renovables para producción de Sal de Cáhuil

Implementación de una microrred de energías renovables (solar, eólica y geotérmica) en el distrito salinero artesanal Barranca-La Villa de Cáhuil. Implementación de una planta piloto geotérmica de producción de sal y electrificación de bombas y planta de yodación comunitaria mediante energías renovables no convencionales.

Centro UOH de BioIngeniería (CUBI)

Proyecto interno de la UOH de carácter multidisciplinario que busca crear mapas moleculares multiómicos de los cánceres prevalentes en la región, utilizando tecnologías de vanguardia y algoritmos avanzados.

Análisis multiómico de redes reguladoras post-transcripcionales microARN- ARNm en el músculo esquelético humano envejecido.

Durante las últimas décadas, la expectativa de vida promedio ha aumentado dramáticamente, mientras
que la salud no ha aumentado proporcionalmente. Para Chile se espera que para el 2050 el número de
adultos mayores superará el 30% de la población con un incremento del 109% respecto al 2015,
superando el 75% proyectado para la población mundial. Entender el proceso de envejecimeinto y
encontrar marcadores biológicos con capacidad diagnóstica y pronóstica, permitirá promover estrategias
para aumentar el número de años de vida saludable, disminuyendo los gastos en salud asociado al
envejecimiento.
Varios estudios han permitido avanzar y entender los mecanismos moleculares de pérdidad de función
muscular durante el evenjecimiento, más conocida como sarcopenia. Sin embargo, la complejidad del
proceso y el insuficiente conocimiento de los mecanismos subjacentes dificultan el diseño de estrategias
terapéuticas eficaces. Hasta el momento, la actividad física y el ejercicio siguen siendo la estrategia más
eficaz para previnir y tratar la sarcopenia. Por lo cual, identificar nuevos biomarcadores musculares en
combinación con marcadores clínicos bien establecidos de parámetros físicos y funcionales, fortalecería
la actual evaluación geriátrica, al utilizar un enfoque interdiciplinario.
Los microRNA (miRNA, 18–25 nt de largo) han ganado interés debido a que son moléculas altamente
conservadas en todas las especies, y actúan como reguladores positivos y/o negativos de la expresión
génica. Entender la relación reguladora directa entre los miARN y el ARN mensajero (mRNA) desempeña
en el músculo esquelética es fundamentaltanto para el proceso de transcripción del ARNm y traducción
de proteínas como para entender el deterioro de la función muscular. Sin embargo, la regulación de la
red post-transcripcional miARN-ARNm y los mecanismos genéticos involucrados en el proceso de
envejecimiento del músculo esquelético humano están lejos de ser elucidados.
En el presente estudio, nuestro objetivo es explorar e integrar coperfiles emparejados de miARN y ARNm
durante la pérdida de función muscular producidad durante el envejecimeinto en personas mayores. Este
análisis integral permitirá la identificación de nuevos blancos de miARN y estrategias reguladoras que
controlan la expresión génica en la pérdidad de función del músculo esquelético y cómo éstas son
modificadas por el entrenamiento de fuerza.
Se hipotetiza que existen redes de regulación post-transcripcional miRNA/mRNA que se expresan de
manera diferencial en el músculo esquelético de personas jóvenes y personas mayores, que estarían
asociadas con cambios en la función muscular durante el envejecimiento. Además, el entrenamiento de
fuerza modifica estas redes de regulación, lo que podría contribuir a la mejora de la función muscular y la
prevención o atenuación de la sarcopenia.
Objetivos generales
– Identificar las redes de regulación post-transcripcional miRNA/mRNA involucradas en la
pérdida de función musclular en personas mayores que son moduladas por un entrenamiento
de fuerza, para proponer nuevos biomarcadores de función muscular durante el
envejecimeinto que se correlacionan con parámetros clínicos/funcionales.
Objetivos específicos
1. Determinar las redes de regulación post-transcripcional miRNA/mRNA que se expresan
diferencialmente en el músculo esquelético de personas jóvenes y personas mayores.
2. Identificar las redes de regulación post-transcripcional miRNA/mRNA que se modifican
después de 12 semanas de entrenamiento de fuerza en personas mayores
3. Correlacionar las redes miRNA/mRNA identificadas con parámetros bioquímicos, físicos y
funcionales de función muscular, antes y después de 12 semanas de entrenamiento de
fuerza en personas mayores
Este proyecto busca Identificar nuevos biomarcadores de función muscular durante el envejecimiento,
podrían ser utilizados en futuros estudios y en la práctica clínica para evaluar la salud muscular en
personas mayores. Además, de contribuir a una mejor comprensión de los mecanismos moleculares que
subyacen a la pérdida de masa muscular en el envejecimiento y cómo la intervención del entrenamiento
de fuerza puede modificar esos mecanismos. Finalmente, el uso de tecnologías avanzadas de
secuenciación (mARN y miARN) y bioinformática permitirá impulsar el desarrollo y la mejora de técnicas
de secuenciación y análisis de datos en el campo de la genómica y la transcriptómica en el área del
envejecimiento, como también, promover la colaboración a nivel nacional e internacional a través de las
bases de datos y recursos bioinformáticos generados que estarán a disposición de investigadores del área.

Realidad de las mujeres en las Ciencias de la Ingeniería en la región de O’Higgins

El presente trabajo, financiado por la Dirección de Equidad de Género y Diversidades
de la Universidad de O’Higgins (Convocatoria 2022), busca evaluar las principales
motivaciones y dificultades de las mujeres para ingresar a carreras de las Ciencias de
la Ingeniería, titularse y continuar una carrera académica en la Región de O’Higgins.
La Universidad Estatal de O’Higgins es una institución de 7 años que desde sus inicios
ha promovido políticas para la equidad de género, sin embargo estas medidas
pareciera ser aún insuficientes o no se le ha dado un seguimiento para ver su
verdadero impacto en esta materia.
La diferencia en el número de matrículas de mujeres vs hombres en carreras de
Ciencias de la Ingeniería de Universidades chilenas es abismante, a pesar de la no
existencia de diferencias inherentes/innatas entre hombres y mujeres que expliquen
las brechas en los aprendizajes o trayectorias académicas en las matemáticas (
Bakker et al., 2021; Kersey et al., 2019; Lachance & Mazzocco, 2006; Spelke, 2005).
Según Ing2030 (2018), el aumento de mujeres en carreras de ingeniería en Chile no

ha sido significativo en un lapso de 10 años: 20% el año 2004 y 24% el año 2014.
Tanto así que en el año 2019, el 7% de las mujeres que se titularon de pregrado en
Chile, lo hicieron en las áreas de ciencia, tecnología, ingeniería y matemáticas (STEM),
siendo el país con el porcentaje más bajo de los miembros de la OCDE (Ministerio de
Ciencia, Tecnología, Conocimiento e Innovación, 2022).
Para llevar a cabo este estudio se han usado metodologías cuantitativas y
cualitativas. El estudio cuantitativo se realiza mediante encuestas online mientras que
el estudio cualitativo es a través del desarrollo de Focus group. Se analizaron 468
encuestas online a estudiantes de enseñanza media de la Región de O’Higgins, 94
encuestas a estudiantes de las carreras de Ingeniería de la Universidad de O’Higgins y
25 encuestas a académicos(as) e investigadores del Instituto de Ciencias de la
Ingeniería de la Universidad de O’Higgins. Adicionalmente, se analizaron los
resultados de 3 focus groups a alumnas de enseñanza media de la comuna de
Rancagua y 3 focus groups a alumnas de las carreras de Ingeniería de la Universidad
de O’Higgins.
Dentro de los resultados se observa que un 83% de los y las estudiantes de
enseñanza media de la Región de O’Higgins considera que tanto hombres como
mujeres avanzan con igual rapidez en sus carreras, un 84% de las y los estudiantes
de carreras de Ingeniería de la Universidad de O’Higgins considera que mujeres y
hombres tienen igualdad de avance en sus carreras, mientras que un 76% de
académicos(as) e investigadores(as) estima que los hombres avanzan más rápido en
su carrera. Se constató que estudiantes de enseñanza media, estudiantes de las
carreras de ingeniería y académicas e investigadoras de la Región de O’Higgins
experimentan brechas y barreras, sumado a la falta de confianza en sus capacidades
y logros (Síndrome de la Impostora; Paterson & Vincent-Akpu, 2021). Adicionalmente,
a pesar de considerar que en la Región de O’Higgins y en la Universidad de O’Higgins
se promueve una cultura para la igualdad de género, el grupo en estudio tiene la
creencia que las estudiantes y académicas de las Geociencias y Ciencias de la
Ingeniería son más propensas a sufrir acoso. Asimismo, las estudiantes y científicas
enfrentan importantes dificultades para compatibilizar la vida familiar y laboral.
A través de este estudio buscamos visibilizar las principales dificultades que enfrentan
estudiantes e investigadoras de esta área durante el desarrollo de su carrera. Tomar
conciencia de la realidad de las mujeres en áreas STEM en la Región de O’Higgins
permitirá tomar medidas más eficientes y eficaces tanto para la atracción como para
evitar la fuga y/o estancamiento de estudiantes y científicas con alto potencial,
permitiendo un acceso más igualitario en carreras STEM y un desarrollo en un espacio
seguro y de respeto.

A Biopsychosocial Approach for Frailty Intervention: Uncovering a Circulating microRNA Biomarker Panel Using an Omics-Based Machine Learning Approach

Frailty is increasingly becoming an important public health challenge worldwide because it is associated with older age, and with adverse outcomes such as reduced quality of life, increased mortality rates, hospitalizations, falls, depression, and dementia. Frailty is defined as dynamic state affecting an individual who experiences losses in one or more domains of human functioning (physical, psychological, social) that are caused by the influence of a range of variables, and which increases the risk of adverse outcomes. This more integral conceptual definition promotes the collaboration of scientists, social and behavioral professionals as well as clinicians from diverse specialties. In this proposal an interdisciplinary group (Biochemistry, Geriatric, Occupational Therapist, Kinesiologist, social worker, bioengineer, statistician among others) aims to evaluate frailty in Chile with a biopsychosocial approach with the final purpose to identify and manage frailty while taking into consideration all the dimensions. Additionally, we aim to design a multidomain personalized person-base intervention for a healthy aging that can uncover a circulating microRNA biomarker panel that can allow an early-detection of frailty, leading to a new multidimensional geriatric assessment. We propose the following hypothesis: A personalized multidimensional training program reduces the frailty prevalence, increasing adherence and participation in the program among community-living older adults. This intervention will be paralleled by a distinctive miRNA profile reflecting the multiple domains of frailty, as well as improvements in diverse psychosocial traits.