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  4. Nicolás Santander Grez

Nicolás Santander Grez ● Profesor Asistente

Grado Académico

Doctor en Ciencias Médicas, Pontificia Universidad Católica de Chile

Título(s) Profesional

Bioquímico, Pontificia Universidad Católica de Chile

Descripción

Mi investigación se centra en la función vascular en condiciones fisiológicas y patológicas, principalmente en los mecanismos adaptativos relacionados con la hipoxia y el estrés oxidativo en el período prenatal y sus efectos a corto y mediano plazo en el sistema cardiovascular y cerebral (DOHaD hypothesis).

Publicaciones

17

Publicaciones

A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational Diabetes Mellitus

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1002/mnfr.202300047

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1038/s41590-023-01627-6

Transcriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed

• German A. Arenas • Nicolás Santander Grez • Bernardo Krause •

DOI: http://dx.doi.org/10.3390/ijms231911873

Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility

• Andreina Arias • Alonso Quiroz • Nicolás Santander Grez • Eugenia Morselli • Dolores Busso

DOI: http://dx.doi.org/10.3389/fcell.2022.941539

Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1007/s12975-021-00955-9

Lipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in mice

• Francisca Salas • Aline Xavier • Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1016/j.bbalip.2021.158909

Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis

• Nicolás Santander Grez • Thomas Arnold •

DOI: http://dx.doi.org/10.21769/bioprotoc.4058

A new genetic strategy for targeting microglia in development and disease

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.7554/eLife.54590.sa2

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier

• Nicolás Santander Grez • Carlos O. Lizama • Eman Meky • Gabriel L. McKinsey • Bongnam Jung

DOI: http://dx.doi.org/10.1172/jci136578

Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1084/jem.20181290

Ovarian cholesterol efflux: ATP-binding cassette transporters and follicular fluid HDL regulate cholesterol content in mouse oocytes+

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1093/biolre/ioz159

Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure

• Nicolás Santander Grez • Francisca Salas •

DOI: http://dx.doi.org/10.1186/s12864-018-5110-2

High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1186/s12967-018-1683-4

Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo-2 cells by upregulating SR-BI via a PI3K, AKT, and mTOR-dependent pathway

• Marcela Fuentes • Nicolás Santander Grez • Víctor Cortés •

DOI: http://dx.doi.org/10.1002/jcb.27410

Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1038/s41598-017-05422-w

Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1155/2014/280497

Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI

• Nicolás Santander Grez •

DOI: http://dx.doi.org/10.1093/hmg/dds510