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  4. Alejandro González Candia

Alejandro González Candia ● Profesor Asistente

Grado Académico

Doctorado en Farmacología Universidad de Chile

Título(s) Profesional

Bioquimico Universidad Andrés Bello

Descripción

Mi investigación se centra en la función vascular en condiciones fisiológicas y patológicas, principalmente en los mecanismos adaptativos relacionados con la hipoxia y el estrés oxidativo en el período prenatal y sus efectos a corto y mediano plazo en el sistema cardiovascular y cerebral (DOHaD hypothesis).

Publicaciones

30

Proyectos

5

Publicaciones

Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases

• Adolfo A. Paz • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy

• Alejandro Candia Henríquez • Alejandro A. Candia • Tamara Jiménez • Alvaro Navarrete • Felipe Beñaldo

DOI: http://dx.doi.org/10.3390/vetsci10020144

Chronic intermittent hypobaric hypoxia induces cardiovascular dysfunction in a high-altitude working shift model

• Alejandro González • Alejandro A. Candia • Pamela V. Arias • Adolfo A. Paz • Emilio A. Herrera

DOI: http://dx.doi.org/10.1016/j.lfs.2023.121800

Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function

• Alejandro Candia Henríquez • Pamela V. Arias • Cristopher Gonzalez-Candia • Alvaro Navarrete • German Ebensperger

DOI: http://dx.doi.org/10.1016/j.vph.2022.106971

Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model

• Andrés Utrera • Alvaro Navarrete • Alejandro González • Claudio García-Herrera • Emilio A. Herrera

DOI: http://dx.doi.org/10.1038/s41598-022-07616-3

Editorial: Mechanisms of Ischemia-Reperfusion Injury in Animal Models and Clinical Conditions: Current Concepts of Pharmacological Strategies

• Rodrigo L. Castillo • Alejandro González • Rodrigo Carrasco •

DOI: http://dx.doi.org/10.3389/fphys.2022.880543

miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hypoxia

• Esteban Figueroa Becerra • Aitor Caballero-Román • Josep R. Ticó • Montserrat Miñarro • Anna Nardi-Ricart

DOI: http://dx.doi.org/10.1016/j.crphar.2022.100129

Potential Pharmacological Target of Tight Junctions to improve the BBB Permeability in Neonatal Hypoxic-Ischemic Encephalopathy Diseases

• Adolfo A. Paz • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia

• Alejandro González • Alejandro Candia Henríquez • Adolfo Paz • Fuad Mobarec • Rodrigo Urbina-Varela

DOI: http://dx.doi.org/10.3390/antiox11061043

Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates

• Esteban Figueroa Becerra • Alejandro González • Cristian A. Villanueva • German Ebensperger • Roberto V. Reyes

DOI: http://dx.doi.org/10.1016/j.vph.2021.106853

Blood-brain barrier dysfunction in hemorrhagic transformation: a therapeutic opportunity for nanoparticles and melatonin.

• Esteban Figueroa Becerra • Alejandro González • Aitor Caballero-Román • Cristina Fornaguera • Elvira Escribano-Ferrer

DOI: http://dx.doi.org/10.1152/jn.00638.2020

Caracterización del daño mecánico de la aorta en condición de hipoxia

• Alejandro Bezmalinovic • Eugenio Rivera • Claudio García-Herrera • Diego Celentano • Alejandro González

DOI: http://dx.doi.org/10.1590/s1517-707620210001.1240

Gestational Hypoxia and Blood-Brain Barrier Permeability: Early Origins of Cerebrovascular Dysfunction Induced by Epigenetic Mechanisms

• Emilio A. Herrera • Alejandro González •

DOI: http://dx.doi.org/10.3389/fphys.2021.717550

High Altitude Pregnancies and Vascular Dysfunction: Observations From Latin American Studies

• Alejandro González • Emilio A. Herrera •

DOI: http://dx.doi.org/10.3389/fphys.2021.786038

Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia

• Alejandro González • Pamela V. Arias • Simón A. Aguilar • Esteban Figueroa Becerra • Roberto V. Reyes

DOI: http://dx.doi.org/10.3390/antiox10111658

Blood-Brain Barrier Dysfunction in the Detrimental Brain Function

• Alejandro González • Nicole K. Rogers • Rodrigo L. Castillo •

DOI: http://dx.doi.org/10.5772/intechopen.94572

Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs

• Eugenio Rivera • Claudio García-Herrera • Alejandro González • Diego J. Celentano • Emilio A. Herrera

DOI: http://dx.doi.org/10.1016/j.jmbbm.2020.104013

Comment on Melatonin as a potential adjuvant treatment for COVID-19

• Emilio A. Herrera • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.lfs.2020.117739

The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

• Alejandro González • Alejandro Candia Henríquez • German Ebensperger • Roberto V. Reyes • Anibal J. Llanos

DOI: http://dx.doi.org/10.1017/s2040174420000616

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

• Alvaro Navarrete • Zhuoming Chen • Pedro Aranda • Daniel Poblete • Andrés Utrera

DOI: http://dx.doi.org/10.3389/fbioe.2020.590488

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep

• Alejandro González • Marcelino Veliz • Catalina Carrasco-Pozo • Rodrigo L. Castillo • J. Cesar Cárdenas

DOI: http://dx.doi.org/10.1016/j.redox.2019.101128

Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates

• Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Elisenda Feixes • Cristopher Gonzalez-Candia

DOI: http://dx.doi.org/10.1111/jpi.12613

Biomolecular markers and pulmonary structure in rats exposed to acute intermittent hypobaria

• Jorge Rodriguez Borges • Miguel Aguilar • Alejandro González • Rodrigo Castillo • Emilio Herrera

DOI: http://dx.doi.org/10.1183/13993003.congress-2019.pa4068

Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs

• Felipe A. Beñaldo • Anibal J. Llanos • Claudio Araya-Quijada • Auristela Rojas • Alejandro González

DOI: http://dx.doi.org/10.3389/fendo.2019.00433

El tratamiento postnatal con melatonina modula la expresión de agentes prostanoides en pulmón de neonatos de oveja con hipertensión pulmonar

• Simón A. Aguilar • Pamela V. Arias • Ignacio Canquil • German Ebensperger • Anibal J. Llanos

DOI: http://dx.doi.org/10.4067/s0034-98872019000300281

Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

• Rodrigo L. Castillo • Emilio A. Herrera • Alejandro González • Marjorie Reyes-Farias • Nicole de la Jara

DOI: http://dx.doi.org/10.1155/2018/7239123

Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

• Cristian R. Astorga • Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Daniel Cañas

DOI: http://dx.doi.org/10.3389/fphys.2018.00185

Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress

• Miguel Aguilar • Alejandro González • Jorge Rodríguez • Catalina Carrasco-Pozo • Daniel Cañas

DOI: http://dx.doi.org/10.3390/ijms19020366

Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep

• Alejandro González • Marcelino Veliz • Claudio Araya • Sebastian Quezada • German Ebensperger

DOI: http://dx.doi.org/10.1016/j.ajog.2016.02.040

Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep

• Flavio Torres • Alejandro González • Camilo Montt • German Ebensperger • Magdalena Chubretovic

DOI: http://dx.doi.org/10.1111/jpi.12222

?3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats

• Emilio Herrera • Jorge Farías • Alejandro González • Stefania Short • Catalina Carrasco-Pozo

DOI: http://dx.doi.org/10.3390/md13020838

Proyectos

  • ● Enero 2023

Riesgo cardiovascular en una cohorte de sobrevivientes de cáncer infantil en Chile: estudio piloto que evalúa el impacto del entrenamiento físico en marcadores de capacidad cardiorrespiratoria y ocurrencia de cardiotoxicidad

Responsable Alterno
  • ● Abril 2022
  • ● Marzo 2026

Fondecyt Regular 2022

Responsable Alterno
  • ● Noviembre 2021

Creación de imágenes de superresolución ultrasónicas en placentas humanas ex vivo

Co-Investigador/a
  • ● Septiembre 2021

Crea y Valida I+D+i Colaborativo

Co-Investigador/a
  • ● Diciembre 2020
  • ● Diciembre 2023

Blood-Brain Barrier Programming Dysfunction in Intrauterine Hypoxia: Epigenetics, Permeability and Integrity Assessment for Cerebrovascular Protection

Co-Investigador/aCo-Investigador/a

Contacto

alejandro.gonzalez@uoh.cl

Campus Rancagua – Avenida Libertador Bernardo O’Higgins #611, Rancagua