Alejandro González Candia Profesor Asistente

Grado Académico

Doctorado en Farmacología Universidad de Chile

Título(s) Profesional

Bioquimico Universidad Andrés Bello

Descripción

Mi investigación se centra en la función vascular en condiciones fisiológicas y patológicas, principalmente en los mecanismos adaptativos relacionados con la hipoxia y el estrés oxidativo en el período prenatal y sus efectos a corto y mediano plazo en el sistema cardiovascular y cerebral (DOHaD hypothesis).

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Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases

• Adolfo A. Paz • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy

• Alejandro Candia Henríquez • Alejandro A. Candia • Tamara Jiménez • Alvaro Navarrete • Felipe Beñaldo

DOI: http://dx.doi.org/10.3390/vetsci10020144

Chronic intermittent hypobaric hypoxia induces cardiovascular dysfunction in a high-altitude working shift model

• Alejandro González • Alejandro A. Candia • Pamela V. Arias • Adolfo A. Paz • Emilio A. Herrera

DOI: http://dx.doi.org/10.1016/j.lfs.2023.121800

Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function

• Alejandro Candia Henríquez • Pamela V. Arias • Cristopher Gonzalez-Candia • Alvaro Navarrete • German Ebensperger

DOI: http://dx.doi.org/10.1016/j.vph.2022.106971

Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model

• Andrés Utrera • Alvaro Navarrete • Alejandro González • Claudio García-Herrera • Emilio A. Herrera

DOI: http://dx.doi.org/10.1038/s41598-022-07616-3

Editorial: Mechanisms of Ischemia-Reperfusion Injury in Animal Models and Clinical Conditions: Current Concepts of Pharmacological Strategies

• Rodrigo L. Castillo • Alejandro González • Rodrigo Carrasco •

DOI: http://dx.doi.org/10.3389/fphys.2022.880543

miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hypoxia

• Esteban Figueroa Becerra • Aitor Caballero-Román • Josep R. Ticó • Montserrat Miñarro • Anna Nardi-Ricart

DOI: http://dx.doi.org/10.1016/j.crphar.2022.100129

Potential Pharmacological Target of Tight Junctions to improve the BBB Permeability in Neonatal Hypoxic-Ischemic Encephalopathy Diseases

• Adolfo A. Paz • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.bcp.2022.115356

Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia

• Alejandro González • Alejandro Candia Henríquez • Adolfo Paz • Fuad Mobarec • Rodrigo Urbina-Varela

DOI: http://dx.doi.org/10.3390/antiox11061043

Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates

• Esteban Figueroa Becerra • Alejandro González • Cristian A. Villanueva • German Ebensperger • Roberto V. Reyes

DOI: http://dx.doi.org/10.1016/j.vph.2021.106853

Blood-brain barrier dysfunction in hemorrhagic transformation: a therapeutic opportunity for nanoparticles and melatonin.

• Esteban Figueroa Becerra • Alejandro González • Aitor Caballero-Román • Cristina Fornaguera • Elvira Escribano-Ferrer

DOI: http://dx.doi.org/10.1152/jn.00638.2020

Caracterización del daño mecánico de la aorta en condición de hipoxia

• Alejandro Bezmalinovic • Eugenio Rivera • Claudio García-Herrera • Diego Celentano • Alejandro González

DOI: http://dx.doi.org/10.1590/s1517-707620210001.1240

Gestational Hypoxia and Blood-Brain Barrier Permeability: Early Origins of Cerebrovascular Dysfunction Induced by Epigenetic Mechanisms

• Emilio A. Herrera • Alejandro González •

DOI: http://dx.doi.org/10.3389/fphys.2021.717550

High Altitude Pregnancies and Vascular Dysfunction: Observations From Latin American Studies

• Alejandro González • Emilio A. Herrera •

DOI: http://dx.doi.org/10.3389/fphys.2021.786038

Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia

• Alejandro González • Pamela V. Arias • Simón A. Aguilar • Esteban Figueroa Becerra • Roberto V. Reyes

DOI: http://dx.doi.org/10.3390/antiox10111658

Blood-Brain Barrier Dysfunction in the Detrimental Brain Function

• Alejandro González • Nicole K. Rogers • Rodrigo L. Castillo •

DOI: http://dx.doi.org/10.5772/intechopen.94572

Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs

• Eugenio Rivera • Claudio García-Herrera • Alejandro González • Diego J. Celentano • Emilio A. Herrera

DOI: http://dx.doi.org/10.1016/j.jmbbm.2020.104013

Comment on Melatonin as a potential adjuvant treatment for COVID-19

• Emilio A. Herrera • Alejandro González •

DOI: http://dx.doi.org/10.1016/j.lfs.2020.117739

The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

• Alejandro González • Alejandro Candia Henríquez • German Ebensperger • Roberto V. Reyes • Anibal J. Llanos

DOI: http://dx.doi.org/10.1017/s2040174420000616

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

• Alvaro Navarrete • Zhuoming Chen • Pedro Aranda • Daniel Poblete • Andrés Utrera

DOI: http://dx.doi.org/10.3389/fbioe.2020.590488

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep

• Alejandro González • Marcelino Veliz • Catalina Carrasco-Pozo • Rodrigo L. Castillo • J. Cesar Cárdenas

DOI: http://dx.doi.org/10.1016/j.redox.2019.101128

Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates

• Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Elisenda Feixes • Cristopher Gonzalez-Candia

DOI: http://dx.doi.org/10.1111/jpi.12613

Biomolecular markers and pulmonary structure in rats exposed to acute intermittent hypobaria

• Jorge Rodriguez Borges • Miguel Aguilar • Alejandro González • Rodrigo Castillo • Emilio Herrera

DOI: http://dx.doi.org/10.1183/13993003.congress-2019.pa4068

Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs

• Felipe A. Beñaldo • Anibal J. Llanos • Claudio Araya-Quijada • Auristela Rojas • Alejandro González

DOI: http://dx.doi.org/10.3389/fendo.2019.00433

El tratamiento postnatal con melatonina modula la expresión de agentes prostanoides en pulmón de neonatos de oveja con hipertensión pulmonar

• Simón A. Aguilar • Pamela V. Arias • Ignacio Canquil • German Ebensperger • Anibal J. Llanos

DOI: http://dx.doi.org/10.4067/s0034-98872019000300281

Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

• Rodrigo L. Castillo • Emilio A. Herrera • Alejandro González • Marjorie Reyes-Farias • Nicole de la Jara

DOI: http://dx.doi.org/10.1155/2018/7239123

Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

• Cristian R. Astorga • Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Daniel Cañas

DOI: http://dx.doi.org/10.3389/fphys.2018.00185

Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress

• Miguel Aguilar • Alejandro González • Jorge Rodríguez • Catalina Carrasco-Pozo • Daniel Cañas

DOI: http://dx.doi.org/10.3390/ijms19020366

Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep

• Alejandro González • Marcelino Veliz • Claudio Araya • Sebastian Quezada • German Ebensperger

DOI: http://dx.doi.org/10.1016/j.ajog.2016.02.040

Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep

• Flavio Torres • Alejandro González • Camilo Montt • German Ebensperger • Magdalena Chubretovic

DOI: http://dx.doi.org/10.1111/jpi.12222

?3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats

• Emilio Herrera • Jorge Farías • Alejandro González • Stefania Short • Catalina Carrasco-Pozo

DOI: http://dx.doi.org/10.3390/md13020838

  • ● Enero 2023

Riesgo cardiovascular en una cohorte de sobrevivientes de cáncer infantil en Chile: estudio piloto que evalúa el impacto del entrenamiento físico en marcadores de capacidad cardiorrespiratoria y ocurrencia de cardiotoxicidad

Responsable Alterno
  • ● Abril 2022
  • ● Marzo 2026

Fondecyt Regular 2022

Responsable Alterno
  • ● Noviembre 2021

Creación de imágenes de superresolución ultrasónicas en placentas humanas ex vivo

Co-Investigador/a
  • ● Septiembre 2021

Crea y Valida I+D+i Colaborativo

Co-Investigador/a
  • ● Diciembre 2020
  • ● Diciembre 2023

Blood-Brain Barrier Programming Dysfunction in Intrauterine Hypoxia: Epigenetics, Permeability and Integrity Assessment for Cerebrovascular Protection

Co-Investigador/aCo-Investigador/a

Campus Rancagua – Avenida Libertador Bernardo O’Higgins #611, Rancagua