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Alejandro González Candia ● Profesor Asistente

Grado Académico
Doctorado en Farmacología Universidad de Chile
Título(s) Profesional
Bioquimico Universidad Andrés Bello
Descripción
Mi investigación se centra en la función vascular en condiciones fisiológicas y patológicas, principalmente en los mecanismos adaptativos relacionados con la hipoxia y el estrés oxidativo en el período prenatal y sus efectos a corto y mediano plazo en el sistema cardiovascular y cerebral (DOHaD hypothesis).
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Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases
• Adolfo A. Paz • Alejandro González •Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy
• Alejandro Candia Henríquez • Alejandro A. Candia • Tamara Jiménez • Alvaro Navarrete • Felipe Beñaldo- REVISTA Life Sciences
- ● 2023
Chronic intermittent hypobaric hypoxia induces cardiovascular dysfunction in a high-altitude working shift model
• Alejandro González • Alejandro A. Candia • Pamela V. Arias • Adolfo A. Paz • Emilio A. HerreraMelatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function
• Alejandro Candia Henríquez • Pamela V. Arias • Cristopher Gonzalez-Candia • Alvaro Navarrete • German EbenspergerBiomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model
• Andrés Utrera • Alvaro Navarrete • Alejandro González • Claudio García-Herrera • Emilio A. HerreraEditorial: Mechanisms of Ischemia-Reperfusion Injury in Animal Models and Clinical Conditions: Current Concepts of Pharmacological Strategies
• Rodrigo L. Castillo • Alejandro González • Rodrigo Carrasco •miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hypoxia
• Esteban Figueroa Becerra • Aitor Caballero-Román • Josep R. Ticó • Montserrat Miñarro • Anna Nardi-RicartPotential Pharmacological Target of Tight Junctions to improve the BBB Permeability in Neonatal Hypoxic-Ischemic Encephalopathy Diseases
• Adolfo A. Paz • Alejandro González •- REVISTA Antioxidants
- ● 2022
Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia
• Alejandro González • Alejandro Candia Henríquez • Adolfo Paz • Fuad Mobarec • Rodrigo Urbina-VarelaBeneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates
• Esteban Figueroa Becerra • Alejandro González • Cristian A. Villanueva • German Ebensperger • Roberto V. ReyesBlood-brain barrier dysfunction in hemorrhagic transformation: a therapeutic opportunity for nanoparticles and melatonin.
• Esteban Figueroa Becerra • Alejandro González • Aitor Caballero-Román • Cristina Fornaguera • Elvira Escribano-FerrerCaracterización del daño mecánico de la aorta en condición de hipoxia
• Alejandro Bezmalinovic • Eugenio Rivera • Claudio García-Herrera • Diego Celentano • Alejandro GonzálezGestational Hypoxia and Blood-Brain Barrier Permeability: Early Origins of Cerebrovascular Dysfunction Induced by Epigenetic Mechanisms
• Emilio A. Herrera • Alejandro González •High Altitude Pregnancies and Vascular Dysfunction: Observations From Latin American Studies
• Alejandro González • Emilio A. Herrera •- REVISTA Antioxidants
- ● 2021
Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia
• Alejandro González • Pamela V. Arias • Simón A. Aguilar • Esteban Figueroa Becerra • Roberto V. ReyesBlood-Brain Barrier Dysfunction in the Detrimental Brain Function
• Alejandro González • Nicole K. Rogers • Rodrigo L. Castillo •Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs
• Eugenio Rivera • Claudio García-Herrera • Alejandro González • Diego J. Celentano • Emilio A. Herrera- REVISTA Life Sciences
- ● 2020
Comment on Melatonin as a potential adjuvant treatment for COVID-19
• Emilio A. Herrera • Alejandro González •The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude
• Alejandro González • Alejandro Candia Henríquez • German Ebensperger • Roberto V. Reyes • Anibal J. LlanosStudy of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries
• Alvaro Navarrete • Zhuoming Chen • Pedro Aranda • Daniel Poblete • Andrés Utrera- REVISTA Redox Biology
- ● 2019
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep
• Alejandro González • Marcelino Veliz • Catalina Carrasco-Pozo • Rodrigo L. Castillo • J. Cesar CárdenasMelatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates
• Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Elisenda Feixes • Cristopher Gonzalez-CandiaBiomolecular markers and pulmonary structure in rats exposed to acute intermittent hypobaria
• Jorge Rodriguez Borges • Miguel Aguilar • Alejandro González • Rodrigo Castillo • Emilio HerreraDOI: http://dx.doi.org/10.1183/13993003.congress-2019.pa4068
Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs
• Felipe A. Beñaldo • Anibal J. Llanos • Claudio Araya-Quijada • Auristela Rojas • Alejandro GonzálezEl tratamiento postnatal con melatonina modula la expresión de agentes prostanoides en pulmón de neonatos de oveja con hipertensión pulmonar
• Simón A. Aguilar • Pamela V. Arias • Ignacio Canquil • German Ebensperger • Anibal J. LlanosQuercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats
• Rodrigo L. Castillo • Emilio A. Herrera • Alejandro González • Marjorie Reyes-Farias • Nicole de la JaraMelatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs
• Cristian R. Astorga • Alejandro González • Alejandro Candia Henríquez • Esteban Figueroa Becerra • Daniel CañasMechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress
• Miguel Aguilar • Alejandro González • Jorge Rodríguez • Catalina Carrasco-Pozo • Daniel CañasPotential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep
• Alejandro González • Marcelino Veliz • Claudio Araya • Sebastian Quezada • German EbenspergerMelatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
• Flavio Torres • Alejandro González • Camilo Montt • German Ebensperger • Magdalena Chubretovic- REVISTA Marine Drugs
- ● 2015
?3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats
• Emilio Herrera • Jorge Farías • Alejandro González • Stefania Short • Catalina Carrasco-Pozo- ● Enero 2023
Riesgo cardiovascular en una cohorte de sobrevivientes de cáncer infantil en Chile: estudio piloto que evalúa el impacto del entrenamiento físico en marcadores de capacidad cardiorrespiratoria y ocurrencia de cardiotoxicidad
Responsable Alterno- ● Abril 2022
- ● Marzo 2026
Fondecyt Regular 2022
Responsable Alterno- ● Noviembre 2021
Creación de imágenes de superresolución ultrasónicas en placentas humanas ex vivo
Co-Investigador/a- ● Septiembre 2021
Crea y Valida I+D+i Colaborativo
Co-Investigador/a- ● Diciembre 2020
- ● Diciembre 2023
Blood-Brain Barrier Programming Dysfunction in Intrauterine Hypoxia: Epigenetics, Permeability and Integrity Assessment for Cerebrovascular Protection
Co-Investigador/aCo-Investigador/aCampus Rancagua – Avenida Libertador Bernardo O’Higgins #611, Rancagua