{"id":665,"date":"2022-04-28T20:37:25","date_gmt":"2022-04-28T23:37:25","guid":{"rendered":"https:\/\/www.uoh.cl\/investigacion\/academico\/carlos-puebla-2\/"},"modified":"2026-09-29T03:44:58","modified_gmt":"2026-09-29T06:44:58","slug":"denisse-valladares-ide","status":"publish","type":"academics","link":"https:\/\/www.uoh.cl\/investigacion\/academico\/denisse-valladares-ide\/","title":{"rendered":"Denisse Valladares Ide"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_section el_class=&#8221;container mx-auto align-items-center circle&#8211;pattern&#8221; css=&#8221;.vc_custom_1650056176159{padding-top: 3rem !important;}&#8221;][vc_row][vc_column][vc_wp_custommenu nav_menu=&#8221;5&#8243;]<div class=\"breadcrumb\"><ol itemscope itemtype=\"https:\/\/schema.org\/BreadcrumbList\"><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"http:\/\/www.uoh.cl\"><span itemprop=\"name\">Inicio<\/span><\/a><meta itemprop=\"position\" content=\"1\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/investigacion\"><span itemprop=\"name\">Investigaci\u00f3n<\/span><\/a><meta itemprop=\"position\" content=\"2\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/investigacion\"><span itemprop=\"name\">Investigaci\u00f3n<\/span><\/a><meta itemprop=\"position\" content=\"3\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/investigacion\/academicos\"><span itemprop=\"name\">Acad\u00e9micos<\/span><\/a><meta itemprop=\"position\" content=\"4\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><span itemprop=\"name\">Denisse Valladares Ide <\/span><meta itemprop=\"position\" content=\"5\" \/><\/ol><\/div><ul class=\"p-0 list-style-none d-inline-block\"><li class=\"p-0\"><a href=\"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\" class=\"px-1 py-2\">\n                            Instituto de Ciencias de la Salud \n                        <\/a><\/li><\/ul><div class=\"uoh_title_component-container\"><h1 class=\"title title--ms d-inline-block big\">Denisse Valladares Ide<em class=\"position__title\"> <span>\u25cf<\/span> Profesora Asociada<\/em><\/h1><\/div>[vc_row_inner el_class=&#8221;border-separator m-0 mt-4&#8243;][vc_column_inner width=&#8221;1\/6&#8243;]<div class=\"vc_single_image-wrapper vc_box_rounded  vc_box_border_grey\"><img decoding=\"async\" width=\"1000\" height=\"1000\" data-src=\"https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide.png\" class=\"attachment-large size-large wp-post-image lazyload\" alt=\"Denisse Valladares Ide\" data-srcset=\"https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide.png 1000w, https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide-300x300.png 300w, https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide-150x150.png 150w, https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide-768x768.png 768w, https:\/\/www.uoh.cl\/investigacion\/wp-content\/uploads\/sites\/12\/2022\/04\/Denisse-Valladares-Ide-600x600.png 600w\" data-sizes=\"(max-width: 1000px) 100vw, 1000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1000px; --smush-placeholder-aspect-ratio: 1000\/1000;\" \/><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;]<div class=\"block--info\">\n                                <div class=\"sub_title__grade\">Grado Acad\u00e9mico<\/div>\n                                <h3>Doctora en Ciencias Biom\u00e9dicas, Universidad de Chile \/ Mag\u00edster en Formaci\u00f3n Docente para la Ense\u00f1anza Universitaria, Universidad Finis Terrae<\/h3> <\/div><div class=\"block--info\">\n                                <div class=\"sub_title__grade\">T\u00edtulo(s) Profesional<\/div>\n                                <h3>Bioqu\u00edmica, Universidad Austral de Chile<\/h3> <\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div class=\"uoh_social_network_component uoh_row col-12 justify-content-end m-0 p-0\"> <div class=\"icon__facebook-share-button\">\n                       <a href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https:\/\/www.uoh.cl\/investigacion\/academico\/denisse-valladares-ide\/\" target=\"_blank\"> <div class=\"icon__facebook-svg\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" width=\"22.4px\" height=\"48.3px\" viewBox=\"0 0 22.4 48.3\" style=\"overflow:visible;enable-background:new 0 0 22.4 48.3;\" xml:space=\"preserve\">\n                <defs>\n                <\/defs>\n                <path class=\"st0\" d=\"M22.4,15.6h-7.6v-5c0-1.9,1.2-2.3,2.1-2.3c0.9,0,5.4,0,5.4,0V0l-7.4,0C6.6,0,4.8,6.2,4.8,10.1v5.5H0v8.5h4.8\n                    c0,10.9,0,24.1,0,24.1h10c0,0,0-13.3,0-24.1h6.8L22.4,15.6z\"><\/path>\n                <\/svg><\/a><\/div>\n                    <\/div><div class=\"icon__twitter-share-button\">\n                        <div class=\"icon__twitter-svg\"><a target=\"_blank\" href=\"http:\/\/twitter.com\/share?url=https:\/\/www.uoh.cl\/investigacion\/academico\/denisse-valladares-ide\/\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"1em\" viewBox=\"0 0 512 512\"><!--! Font Awesome Free 6.4.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license (Commercial License) Copyright 2023 Fonticons, Inc. --><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"\/><\/svg><\/a><\/div>\n                        <\/div><div class=\"icon__linkedin-share-button\">\n                        <div class=\"icon__linkedin-svg\">\n                        <a target=\"__blank\" href=\"https:\/\/www.linkedin.com\/sharing\/share-offsite\/?url=https:\/\/www.uoh.cl\/investigacion\/academico\/denisse-valladares-ide\/\"><svg enable-background=\"new 0 0 100 100\" height=\"100px\" id=\"Layer_1\" version=\"1.1\" viewBox=\"0 0 100 100\" width=\"100px\" xml:space=\"preserve\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"><g><circle cx=\"50\" cy=\"50\" fill=\"#ccc\" r=\"45\"\/><g id=\"LinkedIn_1_\"><rect fill=\"#FFFFFF\" height=\"24.361\" width=\"7.69\" x=\"31.271\" y=\"43.569\"\/><path d=\"M59.968,43.334c-4.406,0-7.165,2.387-7.677,4.058v-3.823h-8.636c0.109,2.03,0,24.361,0,24.361h8.636    V54.748c0-0.733-0.034-1.465,0.19-1.991c0.594-1.464,1.869-2.985,4.162-2.985c2.998,0,4.361,2.253,4.361,5.552V67.93h8.721V54.384    C69.726,46.839,65.432,43.334,59.968,43.334z\" fill=\"#FFFFFF\"\/><path d=\"M34.973,32.069c-2.839,0-4.696,1.823-4.696,4.229c0,2.361,1.804,4.224,4.589,4.224h0.054    c2.891,0,4.69-1.869,4.69-4.229C39.555,33.888,37.81,32.069,34.973,32.069z\" fill=\"#FFFFFF\"\/><\/g><\/g><\/svg><\/a><\/div>\n\n            <\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][\/vc_section][vc_section css=&#8221;.vc_custom_1650239278498{background-color: #ffffff !important;}&#8221; el_class=&#8221;p-md-0 pt-md-5&#8243;][vc_row el_class=&#8221;container mx-auto align-items-center&#8221;][vc_column][vc_row_inner][vc_column_inner width=&#8221;5\/6&#8243;]<div class=\"uoh_title_component-container\"><h4 class=\"title title--ms d-inline-block title--decorator  small\">Descripci\u00f3n<\/h4><\/div><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\">Graduada en Bioqu\u00edmica por la Universidad Austral de Chile, donde se enfoc\u00f3 en investigar el efecto de los receptores de adenosina sobre el factor de crecimiento vascular en un modelo de nefropat\u00eda diab\u00e9tica. Durante su doctorado plante\u00f3 la modulaci\u00f3n de la autofagia en el m\u00fasculo esquel\u00e9tico como una nueva estrategia para el tratamiento de la distrofia muscular de Duchenne.<\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\">Actualmente, ocupa el cargo de Investigadora Principal en el Laboratorio \"Long Active Life\", donde se dedica al estudio de los mecanismos moleculares vinculados con la funci\u00f3n muscular durante el proceso de envejecimiento, con el prop\u00f3sito de promover la actividad f\u00edsica y la nutrici\u00f3n como pilares fundamentales para un envejecimiento saludable. Espec\u00edficamente, su investigaci\u00f3n se centra en la activaci\u00f3n de la autofagia como un mecanismo para mejorar la funci\u00f3n muscular durante la sarcopenia, utilizando la actividad f\u00edsica como su principal modulador. <\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\">En su proyecto m\u00e1s reciente se propone explorar la fragilidad desde una perspectiva integral, abordando no s\u00f3lo la capacidad f\u00edsica, sino tambi\u00e9n el impacto de las capacidades cognitivas y sociales, con el objetivo de fomentar una comprensi\u00f3n biopsicosocial del proceso de envejecimiento en nuestro pa\u00eds.<\/p>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][\/vc_section][vc_section css=&#8221;.vc_custom_1650056119592{background-color: #ffffff !important;}&#8221; el_class=&#8221;p-md-0 pt-md-5 pb-md-5&#8243;][vc_row el_class=&#8221;container mx-auto align-items-start&#8221;][vc_column width=&#8221;1\/6&#8243; el_class=&#8221;p-0&#8243;]<div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-newspaper\" style=\"color: #42a0f8\"><\/i><span>Publicaciones<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>24<\/p><\/div><\/div><div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-project-diagram\" style=\"color: #42a0f8\"><\/i><span>Proyectos<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>14<\/p><\/div><\/div><div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-book-bookmark\" style=\"color: #42a0f8\"><\/i><span>Cap\u00edtulos de Libros<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>1<\/p><\/div><\/div>[\/vc_column][vc_column width=&#8221;5\/6&#8243;][vc_tta_tabs active_section=&#8221;1&#8243; el_class=&#8221;tabs-inner-academic&#8221;][vc_tta_section title=&#8221;Publicaciones&#8221; tab_id=&#8221;publicaciones&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Proyectos&#8221; tab_id=&#8221;proyectos&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Cap\u00edtulos de Libros&#8221; tab_id=&#8221;cap-libros&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Contacto&#8221; tab_id=&#8221;contacto&#8221;]\n            <div class=\"block--info\">\n                <div class=\"sub_title__grade\">Mail de contacto<\/div>\n                <a href=\"mailto:denisse.valladares@uoh.cl\"> <h3>denisse.valladares@uoh.cl<\/h3><\/a>\n            <\/div>[\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row][\/vc_section]<\/p>\n<\/div>","protected":false},"featured_media":24875,"parent":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"institute_academics":[10],"profile_academics":[14],"class_list":["post-665","academics","type-academics","status-publish","has-post-thumbnail","hentry","institute_academics-instituto-de-ciencias-de-la-salud","profile_academics-academico"],"rut_academico":"9704677-8","mail_academico":"denisse.valladares@uoh.cl","n_proyectos":"14","n_publicaciones":"24","n_libros":"0","n_cap_libros":"1","n_otros_libros":"0","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - 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