{"id":75,"date":"2022-04-29T11:50:07","date_gmt":"2022-04-29T14:50:07","guid":{"rendered":"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/?page_id=75"},"modified":"2025-07-03T10:51:07","modified_gmt":"2025-07-03T13:51:07","slug":"proyectos","status":"publish","type":"page","link":"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/proyectos\/","title":{"rendered":"Proyectos"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_section el_class=&#8221;container mx-auto align-items-center text-right circle&#8211;pattern&#8221; css=&#8221;.vc_custom_1648956589196{padding-top: 3rem !important;}&#8221;][vc_row][vc_column][vc_wp_custommenu nav_menu=&#8221;9&#8243;]<div class=\"breadcrumb\"><ol itemscope itemtype=\"https:\/\/schema.org\/BreadcrumbList\"><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"http:\/\/www.uoh.cl\"><span itemprop=\"name\">Inicio<\/span><\/a><meta itemprop=\"position\" content=\"1\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\"><span itemprop=\"name\">Instituto de Ciencias de la Ingenier\u00eda <\/span><\/a><meta itemprop=\"position\" content=\"2\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><span itemprop=\"name\">Proyectos <\/span><meta itemprop=\"position\" content=\"3\" \/><\/ol><\/div><div class=\"uoh_title_component-container\"><h1 class=\"title title--ms d-inline-block title--decorator  big\">Proyectos<\/h1><\/div><div class=\"row filter__row m-0 horizontal\"> <form class=\"filter__form p-0 row m-0\" action=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-admin\/admin-ajax.php\" method=\"post\" id=\"filter\"><div class=\"col-12 col-md-6 filter__container-input p-0\"><div class=\"filter__icon-search\"><svg enable-background=\"new 0 0 32 32\" id=\"Editable-line\" version=\"1.1\" viewBox=\"0 0 32 32\" xml:space=\"preserve\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\"><circle cx=\"14\" cy=\"14\" fill=\"none\" id=\"XMLID_42_\" r=\"9\" stroke=\"#000000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-miterlimit=\"10\" stroke-width=\"2\"><\/circle><line fill=\"none\" id=\"XMLID_44_\" stroke=\"#000000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-miterlimit=\"10\" stroke-width=\"2\" x1=\"27\" x2=\"20.366\" y1=\"27\" y2=\"20.366\"><\/line><\/svg><\/div><input type=\"text\" class=\"filter__input\" placeholder=\"Buscar Proyectos\" name=\"filter__form-text\" autocomplete=\"off\"\/><\/div><div class=\"col-12 col-md-6 row m-0 justify-content-end p-0\"><input type=\"hidden\" name=\"action\" value=\"uoh_filter\" \/><input type=\"hidden\" name=\"posttype\" value=\"projects\" \/><div class=\"loading\"><svg version=\"1.1\" id=\"L5\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 100 100\" enable-background=\"new 0 0 0 0\" xml:space=\"preserve\">\n                  <circle fill=\"#42a0f8\" stroke=\"none\" cx=\"6\" cy=\"50\" r=\"6\">\n                    <animateTransform attributeName=\"transform\" dur=\"1s\" type=\"translate\" values=\"0 15 ; 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el_class=&#8221;p-md-0&#8243;][vc_row el_class=&#8221;container mx-auto p-md-0&#8243;][vc_column width=&#8221;1\/4&#8243;]<div class=\"row filter__row margin-box-vertical box-vertical\"> <form  p-0 row m-0\" action=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-admin\/admin-ajax.php\" method=\"post\" id=\"filter__vertical\"><div class=\"select__for-authors\">\n                                <span> Ordenar Resultados<\/span>\n\n                                <div class=\"select__for-authors-input\">\n                                    <select name=\"order\" id=\"order\" class=\"select__author mb-4\">\n                                        <option value=\"desc\">M\u00e1s Nuevos<\/option>\n                                        <option value=\"asc\">M\u00e1s Antiguos<\/option>\n                                    <\/select>\n                                <\/div>\n                            <\/div><div class=\"select__for-authors mb-2\"><span> Filtrar por autor<\/span><input type=\"text\" id=\"autocomplete__authors\" name=\"author\" placeholder=\"Buscar autor\" autocomplete=\"off\"><div class=\"loading loading-author\"><svg version=\"1.1\" id=\"L5\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 100 100\" enable-background=\"new 0 0 0 0\" xml:space=\"preserve\">\n                  <circle fill=\"#42a0f8\" stroke=\"none\" cx=\"6\" cy=\"50\" r=\"6\">\n                    <animateTransform attributeName=\"transform\" dur=\"1s\" type=\"translate\" values=\"0 15 ; 0 -15; 0 15\" repeatCount=\"indefinite\" begin=\"0.1\"><\/animateTransform>\n                  <\/circle>\n                  <circle fill=\"#42a0f8\" stroke=\"none\" cx=\"30\" cy=\"50\" r=\"6\">\n                    <animateTransform attributeName=\"transform\" dur=\"1s\" type=\"translate\" values=\"0 10 ; 0 -10; 0 10\" repeatCount=\"indefinite\" begin=\"0.2\"><\/animateTransform>\n                  <\/circle>\n                  <circle fill=\"#42a0f8\" stroke=\"none\" cx=\"54\" cy=\"50\" r=\"6\">\n                    <animateTransform attributeName=\"transform\" dur=\"1s\" type=\"translate\" values=\"0 5 ; 0 -5; 0 5\" repeatCount=\"indefinite\" begin=\"0.3\"><\/animateTransform>\n                  <\/circle>\n                <\/svg><\/div><div id=\"user__option\">\n                        <li class=\"academic-list pe-4 py-2 inline\"><a target=\"__blank\" href=\"\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" ><\/a><h5 class=\"name-user-option\"><em class=\"d-block font-style-normal name-user-option-em\"> <\/em><\/h5><\/li>\n                        <div class=\"btn-close\"><\/div>\n                        <\/div><div id=\"someElem\"><\/div><\/div><div class=\"tax_select mt-4\">\n                    <span class=\"col-12 p-0  d-block\"> Filtrar por Categor\u00eda<\/span><div class=\"select__for-authors-input\"><select name=\"tax\" class=\"select__author mb-4\"><option value=\"-1\" class=\"filter__option-title\">Seleccionar <\/option><\/select><\/div><\/div><div class=\"tags-cloud mt-2 d-block mb-4\">\n                    <span class=\"col-12 p-0 mb-3 d-block\"> Filtrar por tema de int\u00e9res<\/span><\/div><\/div><input type=\"hidden\" name=\"action\" value=\"uoh_filter\" \/><input type=\"hidden\" name=\"posttype\" value=\"projects\" \/>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div><div class=\"content-holder row m-0 p-0 aling-items-center pt-5 pb-5 \"><div class=\"row  large--swipper-content p-0 \"><div class=\"\"><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8832\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Charting Colon Cancer\u0092s Molecular Axes via an Integrated Multi-Omic Atlas and AI-Driven Histopathology\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8832\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8832\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Chile is facing one of the steepest increases in Colorectal cancer (CRC) incidence and mortality in the Southern Cone, with\r\nthe greatest surge occurring in adults &#8804; 50 years. Incidence is lowest in the far north and increases toward the\r\nsouth-central regions, mirroring a gradient in Aymara-Mapuche Native-American ancestry, an axis largely absent from the\r\nEuropean reference cohorts that guide modern precision oncology. To fill this gap, we propose a four-year project to create\r\nthe first Chile-specific, multi-omic and histopathological atlas of CRC and to explore ancestry-aware, AI-assisted\r\ndiagnostics.\r\nRationale and Hypothesis.\r\nWe hypothesise that Chilean CRC shows (i) unique, ancestry-driven molecular patterns that differ from European tumors;\r\n(ii) AI models can detect these patterns directly on routine whole-slide images, and (iii) they shape distinct evolutionary\r\npaths in early- versus late-onset disease.\r\nSpecific objectives.\r\nMolecular landscape & heterogeneity: Produce single-gland long-read WGS, methylome, and transcriptome profiles for\r\n100 tumors (30 early-onset, 70 late-onset; &#8805;30\u00d7 coverage, &#8805;50 % purity).\r\nAncestry impact: Phase somatic alterations by local ancestry and contrast their frequencies with European CRC\r\ngenomes (TCGA, PCAWG).\r\nAI-enhanced histopathology: Train and externally validate multi-instance-learning (MIL) models that predict microsatellite\r\ninstability, driver mutations, and whole-genome doubling from matched WSIs, targeting AUC &#8805; 0.80 (pilot: AUC &#8805; 0.85 for\r\nwhole-genome doubling on TCGA WSIs).\r\nEvolutionary trajectories: Multi-region sequence early-onset and late-onset tumors, reconstruct their clonal phylogenies,\r\nand contrast the resulting evolutionary patterns between the two age groups.\r\nTeam capacity & resources. Computational biologist Alex Di Genova (genomics & AI), pathologist Juan Carlos Araya\r\n(digital pathology), and gastro-immunologist Tamara P\u00e9rez-Jeldres (clinical phenotyping) have prospective access to >220\r\nnew CRC resections and >1,800 registry entries each year. A biobank already houses 100 well-annotated tumour\r\nspecimens from hospitals in Santiago and the O\u0092Higgins Region, ready for immediate sequencing and imaging.\r\nAs a team we are delivering important results as (i) the generation of the first telomere-to-telomere Chilean genome,\r\nestablishing a population-specific reference; (ii) sequenced >270 high-coverage whole genomes of chileans individuals (70\r\nhealthy donors, 120 hereditary-breast-cancer cases, 80 primary gallbladder tumors); iii) built the first multi-omic atlas of\r\ngallbladder cancer by integrating our data with Korean (n = 94) and Indian (n = 64) cohorts, uncovering a Chile-enriched\r\nproliferative phenotype; and (iv) developed CRAB-MIL, a weakly supervised deep-learning framework that predicts\r\nwhole-genome doubling from routine H&E slides with an AUC > 0.85 and provides attention maps for interpretability. These\r\naccomplishments demonstrate our ability to generate, integrate, and clinically interpret large-scale genomic and AI\r\ndatasets\u0097capabilities directly transferable to Chilean CRC. International collaborators Ana\u00efs Baudot (Marseille) and Luis\r\nZapata (Institute of Cancer Research, London) further contribute multi-omic network analysis and evolutionary-genomics\r\nexpertise, respectively.\r\nInterdisciplinary workflow. Clinical phenotyping, computational histopathology, PromethION sequencing, and Nextflow\r\nharmonisation feed ancestry-aware genomic analyses; attention-based models are fine-tuned on TCGA and Chilean WSIs;\r\ncomputational, pathology, and gastroenterology teams jointly review outputs to prioritise clinically relevant signals. All\r\nvariant calls, methylomes, expression matrices, AI prediction, and metadata will be released through an open and intuitive\r\nTumorMap portal.\r\nExpected Outcomes and Impact.\r\nThe project will (i) reveal population-specific drivers and mutational processes, (ii) quantify the frequency of clinically\r\nactionable biomarkers originally identified in Europeans, (iii) deliver image-based tools that offer low-cost, molecular\r\nstratification and heterogeneity scoring, and (iv) provide a high-resolution evolutionary framework for EO versus LO CRC.\r\nCollectively, these data will offer the first high-resolution portrait of the Chilean CRC and lay the groundwork for\r\nancestry-aware screening, diagnostic, and treatment strategies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8833\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Charting Colon Cancer\u0092s Molecular Axes via an Integrated Multi-Omic Atlas and AI-Driven Histopathology\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8833\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8833\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Chile is facing one of the steepest increases in Colorectal cancer (CRC) incidence and mortality in the Southern Cone, with\r\nthe greatest surge occurring in adults &#8804; 50 years. Incidence is lowest in the far north and increases toward the\r\nsouth-central regions, mirroring a gradient in Aymara-Mapuche Native-American ancestry, an axis largely absent from the\r\nEuropean reference cohorts that guide modern precision oncology. To fill this gap, we propose a four-year project to create\r\nthe first Chile-specific, multi-omic and histopathological atlas of CRC and to explore ancestry-aware, AI-assisted\r\ndiagnostics.\r\nRationale and Hypothesis.\r\nWe hypothesise that Chilean CRC shows (i) unique, ancestry-driven molecular patterns that differ from European tumors;\r\n(ii) AI models can detect these patterns directly on routine whole-slide images, and (iii) they shape distinct evolutionary\r\npaths in early- versus late-onset disease.\r\nSpecific objectives.\r\nMolecular landscape & heterogeneity: Produce single-gland long-read WGS, methylome, and transcriptome profiles for\r\n100 tumors (30 early-onset, 70 late-onset; &#8805;30\u00d7 coverage, &#8805;50 % purity).\r\nAncestry impact: Phase somatic alterations by local ancestry and contrast their frequencies with European CRC\r\ngenomes (TCGA, PCAWG).\r\nAI-enhanced histopathology: Train and externally validate multi-instance-learning (MIL) models that predict microsatellite\r\ninstability, driver mutations, and whole-genome doubling from matched WSIs, targeting AUC &#8805; 0.80 (pilot: AUC &#8805; 0.85 for\r\nwhole-genome doubling on TCGA WSIs).\r\nEvolutionary trajectories: Multi-region sequence early-onset and late-onset tumors, reconstruct their clonal phylogenies,\r\nand contrast the resulting evolutionary patterns between the two age groups.\r\nTeam capacity & resources. Computational biologist Alex Di Genova (genomics & AI), pathologist Juan Carlos Araya\r\n(digital pathology), and gastro-immunologist Tamara P\u00e9rez-Jeldres (clinical phenotyping) have prospective access to >220\r\nnew CRC resections and >1,800 registry entries each year. A biobank already houses 100 well-annotated tumour\r\nspecimens from hospitals in Santiago and the O\u0092Higgins Region, ready for immediate sequencing and imaging.\r\nAs a team we are delivering important results as (i) the generation of the first telomere-to-telomere Chilean genome,\r\nestablishing a population-specific reference; (ii) sequenced >270 high-coverage whole genomes of chileans individuals (70\r\nhealthy donors, 120 hereditary-breast-cancer cases, 80 primary gallbladder tumors); iii) built the first multi-omic atlas of\r\ngallbladder cancer by integrating our data with Korean (n = 94) and Indian (n = 64) cohorts, uncovering a Chile-enriched\r\nproliferative phenotype; and (iv) developed CRAB-MIL, a weakly supervised deep-learning framework that predicts\r\nwhole-genome doubling from routine H&E slides with an AUC > 0.85 and provides attention maps for interpretability. These\r\naccomplishments demonstrate our ability to generate, integrate, and clinically interpret large-scale genomic and AI\r\ndatasets\u0097capabilities directly transferable to Chilean CRC. International collaborators Ana\u00efs Baudot (Marseille) and Luis\r\nZapata (Institute of Cancer Research, London) further contribute multi-omic network analysis and evolutionary-genomics\r\nexpertise, respectively.\r\nInterdisciplinary workflow. Clinical phenotyping, computational histopathology, PromethION sequencing, and Nextflow\r\nharmonisation feed ancestry-aware genomic analyses; attention-based models are fine-tuned on TCGA and Chilean WSIs;\r\ncomputational, pathology, and gastroenterology teams jointly review outputs to prioritise clinically relevant signals. All\r\nvariant calls, methylomes, expression matrices, AI prediction, and metadata will be released through an open and intuitive\r\nTumorMap portal.\r\nExpected Outcomes and Impact.\r\nThe project will (i) reveal population-specific drivers and mutational processes, (ii) quantify the frequency of clinically\r\nactionable biomarkers originally identified in Europeans, (iii) deliver image-based tools that offer low-cost, molecular\r\nstratification and heterogeneity scoring, and (iv) provide a high-resolution evolutionary framework for EO versus LO CRC.\r\nCollectively, these data will offer the first high-resolution portrait of the Chilean CRC and lay the groundwork for\r\nancestry-aware screening, diagnostic, and treatment strategies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> PYT-2026-186<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026 - Marzo 2029<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Fundaci\u00f3n para la Innovaci\u00f3n Agraria - FIA<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"7970\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Obtenci\u00f3n de ingredientes funcionales desde pulpa de sand\u00eda residual post cosecha para su uso en la industria de alimentos funcionales y en la agricultura\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-7970\" class=\"accordion-collapse collapse\" data-bs-parent=\"#7970\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La producci\u00f3n de semillas de sand\u00eda en Chile es una de las que genera mayores vol\u00famenes (12,5%) y mejores precios (26 MM U$FOB) de\r\nexportaci\u00f3n respecto del total de semillas exportadas. En los \u00faltimos 5 a\u00f1os su exportaci\u00f3n ha aumentado considerablemente ocupando el\r\nsegundo lugar en este mercado. Derivado del procesamiento de los frutos se genera un alto porcentaje de pulpa y c\u00e1scara; residuos no\r\naprovechables como subproducto para otras industrias como cuarta gama y\/o farmac\u00e9utica. El elevado contenido antioxidantes de la sand\u00eda\r\nrepresenta una oportunidad para su extracci\u00f3n y uso en otras industrias. La soluci\u00f3n innovadora permitir\u00e1 reutilizar grandes vol\u00famenes de la\r\npulpa y c\u00e1scara, mitigando su disposici\u00f3n inadecuada y mejorando pr\u00e1cticas agr\u00edcolas y biotecnol\u00f3gicas. El objetivo de la propuesta es\r\ndesarrollar un paquete tecnol\u00f3gico consistente en tres aplicaciones que permiten valorizar los residuos de c\u00e1scara y pulpa de sand\u00eda para la\r\nproducci\u00f3n de nutrac\u00e9uticos, bioenmienda de suelos provenientes de relaves mineros, y sustrato para el crecimiento de microorganismos. El\r\nproyecto busca generar innovaciones que promuevan la transformaci\u00f3n de los residuos agr\u00edcolas, proyectando as\u00ed nuevos negocios para los\r\nproductores hort\u00edcolas en la industria de los alimentos dando valor agregado a los residuos derivados del procesamiento de semillas. Los\r\nresultados esperados de esta iniciativa son: Portafolio de al menos 2 ingredientes funcionales (Licopeno y Citrulina) desarrollados y\r\ncaracterizados; validaci\u00f3n t\u00e9cnica del ingrediente principal (Licopeno o citrulina) con actividad antioxidante; bioenmienda validada en un\r\nentorno operacional (campo), alcanzando el nivel de madurez tecnol\u00f3gica TRL7; an\u00e1lisis de mercado robusto que incluye un plan de\r\nescalamiento t\u00e9cnico de la bioenmienda; medio de cultivo validado en un entorno operacional (empresas), alcanzando el nivel de madurez\r\ntecnol\u00f3gica TRL7; y an\u00e1lisis de mercado robusto que incluye un plan de escalamiento t\u00e9cnico.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 11261116<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026 - Marzo 2029<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8797\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Cooperative control of intelligent agents using reinforcement learning to support the implementation of AC\/DC multi-microgrids in the energy industry, from regions in Chile to the rest of the world.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8797\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8797\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]This project will address the implementation of distributed controllers in intelligent agents within AC\/DC electrical microgrids. Specifically, this project will address open issues in the distributed control literature for microgrids; these include optimal \r\nparameter tuning and resilience to communications disturbances such as transport delays, packet loss, and communication failures due to cyberattacks. All of these are important components that prevent the proliferation of microgrid projects throughout the country and the world. Microgrids have the potential to improve the energy management of renewable resources and the resilience of current and future electrical systems. Furthermore, they aid in decarbonization and benefit the energization of isolated communities and national industries. Based on the above, the main objective of this research is to formulate, implement, and validate distributed intelligent controllers, using reinforcement learning, in agents that comprise interconnected AC\/DC microgrids, in order to achieve optimal operation concerning available energy resources despite disturbances and failures in communication channels. To achieve this objective, the following specific objectives are specified: (i) investigate the state of the art in the use of reinforcement learning algorithms in cooperative multi-agent system control and their application to microgrids; (ii) design a deep reinforcement learning algorithm to auxiliary control an ILC of a hybrid AC\/DC microgrid with communication loss and variable time delays; (iii) design a distributed controller with parameter and structure adjustment capability through deep reinforcement learning algorithms for the agents of an AC\/DC multi-microgrid with communication losses and variable time delay; (iv) design a robust distributed controller through deep reinforcement learning algorithms that allows agents in an AC\/DC multi-microgrid to be resilient to heterogeneous and variable transport delays, loss of data packets, and DoS cyber-attacks; (v) build a prototyping platform for multi-agent-based intelligent agent control schemes with digital twin co-simulation; (vi) implement and validate the proposed reinforcement learning controllers in an AC\/DC multi-microgrid experimental setup.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8858\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Pressure and shear shock waves on porous matrices: The erosion mechanism underneath water-dripping-on-stone craters\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8858\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8858\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The phenomenon of a soft liquid drop eroding a hard stone surface over time, immortalized in the ancient proverb \u00abdripping water wears away the stone,\u00bb presents a profound mechanical puzzle. While craters are common imprints of high-energy events, those formed by persistent, low-energy water dripping are exceptional. The impact energy of a single drop is far below the threshold required to plastically deform or fracture the material, yet erosion occurs. This project seeks to answer the fundamental question: How can water erode stone through dripping and create distinctive craters?\r\nWhile recent advancements in drop-impact dynamics have revealed that an impacting drop generates propagating fronts of intense, singular pressure and shear, these theories were developed for ideal, non-porous surfaces and are insufficient to explain the erosion. Our preliminary experimental work\u0097which has successfully reproduced water-dripping craters on gypsum targets while failing to erode non-porous materials\u0097points to a crucial, previously overlooked element: the porous nature of the target material. We discovered that erosion and the formation of a distinct surface microstructure of pores commence only after the substrate becomes fully saturated with water. This key finding suggests that the complex interaction between the impact-induced flow and the internal, liquid-filled pore structure is the primary driver of the erosion mechanism.\r\nThis project will establish the first comprehensive experimental and theoretical framework for slow erosion in porous ma- terials by water dripping. We will investigate three potential and non-exclusive micro-mechanisms. The first is low-Reynolds accumulative erosion, where the impact pressure pumps liquid into the matrix, generating high shear stress along pore walls that slowly abrades material, a process whose rate is expected to be proportional to the wall shear stress. The second is the inter-pore propagation of pressure shocks; because the surface pressure front arrives at adjacent pore openings at slightly different times, large pressure gradients are generated within the saturated matrix, inducing mechanical fatigue and failure of inter-pore walls. The third is cavitation bursts, where the negative-pressure front trailing the initial impact shock\u0097 akin to an explosion\u0092s blast wave\u0097causes the formation and violent collapse of vapor bubbles. These collapses generate localized but highly destructive shock waves, a process potentially detectable via acoustic emissions.\r\nOur methodology integrates a novel, multi-scale experimental approach with robust theoretical modeling. An automated, custom-built setup, featuring a syringe pump for precise drop control and a photo-gate for impact counting and synchroniza- tion, tracks crater evolution over tens of thousands of reproducible impacts. An automated translation stage will move the sample between the impact zone and a characterization chamber for on-the-run 3D shape reconstruction via high-resolution laser profilometry and for mass measurement via an integrated load cell. This will be complemented by a suite of characteriza- tion techniques, including high-speed imaging to capture rare ejecta events, microscopic surface imaging, and advanced bulk imaging (X-ray Micro-Tomography, Scanning Electron Microscopy or Nuclear Magnetic Resonance) to visualize the internal 3D pore network and wear propagation. Experiments will mainly utilize natural materials like gypsum and selenite, as well as custom-fabricated synthetic porous samples (e.g., PDMS). These transparent, engineered samples will allow for direct flow visualization via Particle Image Velocimetry (PIV) to isolate and study specific mechanisms in a controlled environment.\r\nThe theoretical work will couple established models for drop-impact pressure distributions with frameworks for flow in porous media, wall-shear erosion, and wave propagation. The goal is to develop predictive formulae for crater growth rates and their scaling with fluid and material properties, which can be validated against our extensive experimental data. By leveraging the research team\u0092s expertise in drop-impact forces and tackling this 2,500-year-old question, this project will provide novel insights into fluid-solid interactions, wear on porous materials, and landscape evolution. It moves beyond prior studies, which used simplified substrates, to address the central role of porosity in this long-unsolved problem in continuum physics.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8859\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Pressure and shear shock waves on porous matrices: The erosion mechanism underneath water-dripping-on-stone craters\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8859\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8859\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The phenomenon of a soft liquid drop eroding a hard stone surface over time, immortalized in the ancient proverb \u00abdripping water wears away the stone,\u00bb presents a profound mechanical puzzle. While craters are common imprints of high-energy events, those formed by persistent, low-energy water dripping are exceptional. The impact energy of a single drop is far below the threshold required to plastically deform or fracture the material, yet erosion occurs. This project seeks to answer the fundamental question: How can water erode stone through dripping and create distinctive craters?\r\nWhile recent advancements in drop-impact dynamics have revealed that an impacting drop generates propagating fronts of intense, singular pressure and shear, these theories were developed for ideal, non-porous surfaces and are insufficient to explain the erosion. Our preliminary experimental work\u0097which has successfully reproduced water-dripping craters on gypsum targets while failing to erode non-porous materials\u0097points to a crucial, previously overlooked element: the porous nature of the target material. We discovered that erosion and the formation of a distinct surface microstructure of pores commence only after the substrate becomes fully saturated with water. This key finding suggests that the complex interaction between the impact-induced flow and the internal, liquid-filled pore structure is the primary driver of the erosion mechanism.\r\nThis project will establish the first comprehensive experimental and theoretical framework for slow erosion in porous ma- terials by water dripping. We will investigate three potential and non-exclusive micro-mechanisms. The first is low-Reynolds accumulative erosion, where the impact pressure pumps liquid into the matrix, generating high shear stress along pore walls that slowly abrades material, a process whose rate is expected to be proportional to the wall shear stress. The second is the inter-pore propagation of pressure shocks; because the surface pressure front arrives at adjacent pore openings at slightly different times, large pressure gradients are generated within the saturated matrix, inducing mechanical fatigue and failure of inter-pore walls. The third is cavitation bursts, where the negative-pressure front trailing the initial impact shock\u0097 akin to an explosion\u0092s blast wave\u0097causes the formation and violent collapse of vapor bubbles. These collapses generate localized but highly destructive shock waves, a process potentially detectable via acoustic emissions.\r\nOur methodology integrates a novel, multi-scale experimental approach with robust theoretical modeling. An automated, custom-built setup, featuring a syringe pump for precise drop control and a photo-gate for impact counting and synchroniza- tion, tracks crater evolution over tens of thousands of reproducible impacts. An automated translation stage will move the sample between the impact zone and a characterization chamber for on-the-run 3D shape reconstruction via high-resolution laser profilometry and for mass measurement via an integrated load cell. This will be complemented by a suite of characteriza- tion techniques, including high-speed imaging to capture rare ejecta events, microscopic surface imaging, and advanced bulk imaging (X-ray Micro-Tomography, Scanning Electron Microscopy or Nuclear Magnetic Resonance) to visualize the internal 3D pore network and wear propagation. Experiments will mainly utilize natural materials like gypsum and selenite, as well as custom-fabricated synthetic porous samples (e.g., PDMS). These transparent, engineered samples will allow for direct flow visualization via Particle Image Velocimetry (PIV) to isolate and study specific mechanisms in a controlled environment.\r\nThe theoretical work will couple established models for drop-impact pressure distributions with frameworks for flow in porous media, wall-shear erosion, and wave propagation. The goal is to develop predictive formulae for crater growth rates and their scaling with fluid and material properties, which can be validated against our extensive experimental data. By leveraging the research team\u0092s expertise in drop-impact forces and tackling this 2,500-year-old question, this project will provide novel insights into fluid-solid interactions, wear on porous materials, and landscape evolution. It moves beyond prior studies, which used simplified substrates, to address the central role of porosity in this long-unsolved problem in continuum physics.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026 - Marzo 2030<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8860\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Mixed-integer quadratic bilevel optimization algorithms for security and decision-focused learning\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8860\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8860\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Postulaci\u00f3n a Fondecyt Regular[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026 - Marzo 2030<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8861\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Mixed-integer quadratic bilevel optimization algorithms for security and decision-focused learning\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8861\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8861\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Postulaci\u00f3n a Fondecyt Regular[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>INRIA associative teams<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8872\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Reliable Artificial Intelligence via Stochastic Game Techniques\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8872\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8872\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Game theory and artificial intelligence are deeply connected fields, particularly when model-\r\ning adversarial learning problems as Stackelberg games under uncertainty. In such settings,\r\n\r\ndefenders allocate resources randomly to prevent attackers from anticipating their moves. As\r\ntime evolves, the environment changes, and new strategies or actions may emerge. A suitable\r\nsubfield of game theory to model these dynamics is stochastic games, where the state captures\r\n\r\nthe set of available actions in a time-dependent process. Moreover, the attacker\u0096defender inter-\r\naction naturally exhibits a hierarchical bilevel structure: the defender must design randomized\r\n\r\nstrategies to protect targets, while the attacker responds by executing an action that maxi-\r\nmizes its reward. This makes stochastic dynamic Stackelberg games a model of choice for such\r\n\r\napplications [15], the Chilean party being very active in the domain [9, 10, 11].\r\nIn a previous collaboration [1], we have shown that defining an appropriate solution concept\r\nfor these games is far from trivial, and in some cases remains an open research question. Even\r\nwhen a proper solution concept can be established, computing it becomes prohibitively expensive\r\nfor games with massive state and action spaces.\r\nThese challenges are not only of theoretical interest but also of high practical relevance.\r\nThis associate team will focus on two among the many possible applications.\r\nChallenge 1: The first one is wildfire prevention. This theme has been widely examined in\r\nthe literature, particularly through models that optimize the design of firebreaks [16], [12] and\r\nthe the placement of surveillance cameras to limit fire spread. In contrast, the operational\r\n\r\ndimension of prevention and firefighting\u0097where resources must be dynamically allocated un-\r\nder uncertainty\u0097has received far less attention. Emerging distributed AI technologies with\r\n\r\nautonomous agents, both centralized (e.g., coordinated command-and-control systems) and de-\r\ncentralized (e.g., drones and sensor swarms), could play a key role in addressing this challenge.\r\n\r\nChallenge 2: Similarly, in the domain of distributed AI learning systems (e.g. Federated\r\nLearning), a central authority is in charge of agregating the updates of distributed clients in the\r\nprocess of minimizing a global metric. The presence of Byzantine (or faulty) agents can derail\r\nconvergence or induce a biais in this process. To mitigate this, robust agregation techniques\r\nhave been proposed in the literature based on identifying and discarding suspect contributions\r\n[17, 18, 19]. But concrete attacks like ALIE [20] or FoE [21] tend to exhibit patterns. This lead\r\nresearchers to propose the first history-aware defenses [22, 23, 24]. Purely deterministic rules,\r\nthough, are likely to be defeated by powerful and well-informed agents. The attacker\u0096defender\r\nframework is crucial to design secure training environments against adversarial manipulations,\r\nthe principal issue being to decide if and when to exclude a suspected malicious agent.\r\nBoth these applications can be tackeled with tools of Game Theory. More applications\r\ncould be cited, like environmental conservation problems, such as poaching prevention [25],\r\nenvironmental tax evasion [26] or border patrol security [9].[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>INRIA associative teams<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"8873\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Reliable Artificial Intelligence via Stochastic Game Techniques\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-8873\" class=\"accordion-collapse collapse\" data-bs-parent=\"#8873\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Game theory and artificial intelligence are deeply connected fields, particularly when model-\r\ning adversarial learning problems as Stackelberg games under uncertainty. In such settings,\r\n\r\ndefenders allocate resources randomly to prevent attackers from anticipating their moves. As\r\ntime evolves, the environment changes, and new strategies or actions may emerge. A suitable\r\nsubfield of game theory to model these dynamics is stochastic games, where the state captures\r\n\r\nthe set of available actions in a time-dependent process. Moreover, the attacker\u0096defender inter-\r\naction naturally exhibits a hierarchical bilevel structure: the defender must design randomized\r\n\r\nstrategies to protect targets, while the attacker responds by executing an action that maxi-\r\nmizes its reward. This makes stochastic dynamic Stackelberg games a model of choice for such\r\n\r\napplications [15], the Chilean party being very active in the domain [9, 10, 11].\r\nIn a previous collaboration [1], we have shown that defining an appropriate solution concept\r\nfor these games is far from trivial, and in some cases remains an open research question. Even\r\nwhen a proper solution concept can be established, computing it becomes prohibitively expensive\r\nfor games with massive state and action spaces.\r\nThese challenges are not only of theoretical interest but also of high practical relevance.\r\nThis associate team will focus on two among the many possible applications.\r\nChallenge 1: The first one is wildfire prevention. This theme has been widely examined in\r\nthe literature, particularly through models that optimize the design of firebreaks [16], [12] and\r\nthe the placement of surveillance cameras to limit fire spread. In contrast, the operational\r\n\r\ndimension of prevention and firefighting\u0097where resources must be dynamically allocated un-\r\nder uncertainty\u0097has received far less attention. Emerging distributed AI technologies with\r\n\r\nautonomous agents, both centralized (e.g., coordinated command-and-control systems) and de-\r\ncentralized (e.g., drones and sensor swarms), could play a key role in addressing this challenge.\r\n\r\nChallenge 2: Similarly, in the domain of distributed AI learning systems (e.g. Federated\r\nLearning), a central authority is in charge of agregating the updates of distributed clients in the\r\nprocess of minimizing a global metric. The presence of Byzantine (or faulty) agents can derail\r\nconvergence or induce a biais in this process. To mitigate this, robust agregation techniques\r\nhave been proposed in the literature based on identifying and discarding suspect contributions\r\n[17, 18, 19]. But concrete attacks like ALIE [20] or FoE [21] tend to exhibit patterns. This lead\r\nresearchers to propose the first history-aware defenses [22, 23, 24]. Purely deterministic rules,\r\nthough, are likely to be defeated by powerful and well-informed agents. The attacker\u0096defender\r\nframework is crucial to design secure training environments against adversarial manipulations,\r\nthe principal issue being to decide if and when to exclude a suspected malicious agent.\r\nBoth these applications can be tackeled with tools of Game Theory. More applications\r\ncould be cited, like environmental conservation problems, such as poaching prevention [25],\r\nenvironmental tax evasion [26] or border patrol security [9].[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"pagination justify-content-center my-5\"><span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-json\/wp\/v2\/pages\/75\/\/page\/2\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-json\/wp\/v2\/pages\/75\/\/page\/3\">3<\/a>\n<span class=\"page-numbers dots\">&hellip;<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-json\/wp\/v2\/pages\/75\/\/page\/35\">35<\/a>\n<a class=\"next page-numbers\" href=\"https:\/\/www.uoh.cl\/instituto-de-ciencias-de-la-ingenieria\/wp-json\/wp\/v2\/pages\/75\/\/page\/2\"><div class=\"icon-pagination-next\"> <?xml version=\"1.0\" ?><svg viewBox=\"0 0 96 96\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><title\/><path d=\"M39.3756,48.0022l30.47-25.39a6.0035,6.0035,0,0,0-7.6878-9.223L26.1563,43.3906a6.0092,6.0092,0,0,0,0,9.2231L62.1578,82.615a6.0035,6.0035,0,0,0,7.6878-9.2231Z\"\/><\/svg> <\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][\/vc_section][vc_section css=&#8221;.vc_custom_1649210787516{background-color: #f6faff !important;}&#8221; 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