{"id":1281,"date":"2022-07-17T10:17:43","date_gmt":"2022-07-17T13:17:43","guid":{"rendered":"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/academico\/juan-pino-moran\/"},"modified":"2026-04-07T07:16:48","modified_gmt":"2026-04-07T10:16:48","slug":"juan-pino-moran","status":"publish","type":"academics","link":"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/academico\/juan-pino-moran\/","title":{"rendered":"Juan Pino Mor\u00e1n"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_section el_class=&#8221;container mx-auto align-items-center circle&#8211;pattern&#8221; css=&#8221;.vc_custom_1650056176159{padding-top: 3rem !important;}&#8221;][vc_row][vc_column][vc_wp_custommenu nav_menu=&#8221;5&#8243;]<div class=\"breadcrumb\"><ol itemscope itemtype=\"https:\/\/schema.org\/BreadcrumbList\"><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"http:\/\/www.uoh.cl\"><span itemprop=\"name\">Inicio<\/span><\/a><meta itemprop=\"position\" content=\"1\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\"><span itemprop=\"name\">Instituto de Ciencias de la Salud <\/span><\/a><meta itemprop=\"position\" content=\"2\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/investigacion\"><span itemprop=\"name\">Investigaci\u00f3n<\/span><\/a><meta itemprop=\"position\" content=\"3\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><a itemprop=\"item\" href=\"https:\/\/www.uoh.cl\/investigacion\/academicos\"><span itemprop=\"name\">Acad\u00e9micos<\/span><\/a><meta itemprop=\"position\" content=\"4\" \/><li itemprop=\"itemListElement\" itemscope itemtype=\"https:\/\/schema.org\/ListItem\"><span itemprop=\"name\">Juan Pino Mor\u00e1n <\/span><meta itemprop=\"position\" content=\"5\" \/><\/ol><\/div><ul class=\"p-0 list-style-none d-inline-block\"><\/ul><div class=\"uoh_title_component-container\"><h1 class=\"title title--ms d-inline-block big\">Juan Pino Mor\u00e1n<em class=\"position__title\"> <span>\u25cf<\/span> Profesor Asociado<\/em><\/h1><\/div>[vc_row_inner el_class=&#8221;border-separator m-0 mt-4&#8243;][vc_column_inner width=&#8221;1\/6&#8243;]<div class=\"vc_single_image-wrapper vc_box_rounded  vc_box_border_grey\"><img decoding=\"async\" width=\"1000\" height=\"1000\" data-src=\"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino.jpg\" class=\"attachment-large size-large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino.jpg 1000w, https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino-300x300.jpg 300w, https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino-150x150.jpg 150w, https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino-768x768.jpg 768w, https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/wp-content\/uploads\/sites\/26\/2022\/10\/Foto-perfil-Juan-Pino-600x600.jpg 600w\" data-sizes=\"(max-width: 1000px) 100vw, 1000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1000px; --smush-placeholder-aspect-ratio: 1000\/1000;\" \/><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;]<div class=\"block--info\">\n                                <div class=\"sub_title__grade\">Grado Acad\u00e9mico<\/div>\n                                <h3>Doctor en Sociolog\u00eda, Universidad Aut\u00f3noma de Barcelona - Magister en Psicolog\u00eda Comunitaria, Universidad de Chile<\/h3> <\/div><div class=\"block--info\">\n                                <div class=\"sub_title__grade\">T\u00edtulo(s) Profesional<\/div>\n                                <h3>Terapeuta Ocupacional, Universidad de Playa Ancha<\/h3> <\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;]<div class=\"uoh_social_network_component uoh_row col-12 justify-content-end m-0 p-0\"> <div class=\"icon__facebook-share-button\">\n                       <a href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/academico\/juan-pino-moran\/\" target=\"_blank\"> <div class=\"icon__facebook-svg\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" width=\"22.4px\" height=\"48.3px\" viewBox=\"0 0 22.4 48.3\" style=\"overflow:visible;enable-background:new 0 0 22.4 48.3;\" xml:space=\"preserve\">\n                <defs>\n                <\/defs>\n                <path class=\"st0\" d=\"M22.4,15.6h-7.6v-5c0-1.9,1.2-2.3,2.1-2.3c0.9,0,5.4,0,5.4,0V0l-7.4,0C6.6,0,4.8,6.2,4.8,10.1v5.5H0v8.5h4.8\n                    c0,10.9,0,24.1,0,24.1h10c0,0,0-13.3,0-24.1h6.8L22.4,15.6z\"><\/path>\n                <\/svg><\/a><\/div>\n                    <\/div><div class=\"icon__twitter-share-button\">\n                        <div class=\"icon__twitter-svg\"><a target=\"_blank\" href=\"http:\/\/twitter.com\/share?url=https:\/\/www.uoh.cl\/instituto-ciencias-de-la-salud\/academico\/juan-pino-moran\/\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"1em\" viewBox=\"0 0 512 512\"><!--! 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Desde su formaci\u00f3n inicial como Terapeuta Ocupacional, comenz\u00f3 con un especial inter\u00e9s en la intervenci\u00f3n sociosanitaria con comunidades, colectivos y grupos que se encuentran en situaci\u00f3n de vulnerabilidad y exclusi\u00f3n social. A ra\u00edz de eso, realiz\u00f3 el Magister en Psicolog\u00eda Comunitaria, donde abordo la inclusi\u00f3n social de personas desde el enfoque comunitario en la estrategia de rehabilitaci\u00f3n basada en la comunidad.<\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\"><\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\">Posteriormente realiz\u00f3 su formaci\u00f3n doctoral en Sociolog\u00eda, donde investig\u00f3 sobre cuerpos y activismos de personas disidentes de la discapacidad en Chile.<\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\"><\/p><p class=\"info-headings mb-2 text-left mt-4 mt-md-2\">Actualmente realiza una investigaci\u00f3n FONDECYT Postdoctoral 2022-2024 (ANID) en el Instituto de Ciencias de la Salud de la Universidad de O\u2019Higgins sobre cuidados sociocomunitarios de personas con discapacidad y colabora con el grupo de estudios cr\u00edticos de la discapacidad de CLACSO y con el grupo de Estudios sociales y de g\u00e9nero sobre la corporalidad, la subjetividad y el sufrimiento evitable de la Universidad Aut\u00f3noma de Barcelona. Sus l\u00edneas de investigaci\u00f3n son: estudios cr\u00edticos de la discapacidad; estudios latinoamericanos de Terapia Ocupacional; Epistemolog\u00edas feministas, \u00c9tica del cuidado y discapacidad.<\/p>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][\/vc_section][vc_section css=&#8221;.vc_custom_1650056119592{background-color: #ffffff !important;}&#8221; el_class=&#8221;p-md-0 pt-md-5 pb-md-5&#8243;][vc_row el_class=&#8221;container mx-auto align-items-start&#8221;][vc_column width=&#8221;1\/6&#8243; el_class=&#8221;p-0&#8243;]<div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-newspaper\" style=\"color: #42a0f8\"><\/i><span>Publicaciones<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>24<\/p><\/div><\/div><div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-project-diagram\" style=\"color: #42a0f8\"><\/i><span>Proyectos<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>8<\/p><\/div><\/div><div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-book-bookmark\" style=\"color: #42a0f8\"><\/i><span>Cap\u00edtulos de Libros<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>6<\/p><\/div><\/div><div class=\"uoh_link_component pe-4 d-inline-block py-1 button_icon inline\"><i class=\"me-2 fas fa-feather-pointed\" style=\"color: #42a0f8\"><\/i><span>Otros Escritos<\/span><\/div><div class=\"wpb_text_column wpb_content_element  citas mb-3 pb-3\"><div class=\"wpb_wrapper\"><p>1<\/p><\/div><\/div>[\/vc_column][vc_column width=&#8221;5\/6&#8243;][vc_tta_tabs active_section=&#8221;1&#8243; el_class=&#8221;tabs-inner-academic&#8221;][vc_tta_section title=&#8221;Publicaciones&#8221; tab_id=&#8221;publicaciones&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div><div class=\"content-holder row m-0 p-0 aling-items-center pt-5 pb-5 \"><div class=\"row  large--swipper-content p-0 \"><div class=\"\"><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cadernos Brasileiros de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Teatro y artivismo anticapacitista<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/2526-8910.cto416441023\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/2526-8910.cto416441023<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Salud Colectiva<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">\u0093Vivir el paso a paso\u0094: Itinerarios de rehabilitaci\u00f3n de la ni\u00f1ez con discapacidad en narrativas de mujeres cuidadoras en la zona poniente de Santiago de Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.18294\/sc.2025.5792\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.18294\/sc.2025.5792<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA International Journal of Environmental Research and Public Health<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Politico-Epistemic Tensions Regarding Personal Assistance and Care for People with Disabilities: An Integrative Literature Review<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n \u2022  P\u00eda Valeria Rodr\u00edguez Garrido \u2022  Mar\u00eda Soledad Burrone Colombino <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.3390\/ijerph20021366\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.3390\/ijerph20021366<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Estudios Sociales del Estado<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Neoliberalismo y campa\u00f1as Telet\u00f3n en Chile: discursos pol\u00edticos contra la  dictadura de la caridad<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.35305\/ese.v9i17.324\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.35305\/ese.v9i17.324<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cadernos Brasileiros de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Reivindicative occupational practices of activist with disabilities living in Chile.<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoAO269135102\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoAO269135102<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Saude e Sociedade<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Wild, Indigenous, Lame, Invalid: Anti-Capacitist Epistemologies of the South<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/s0104-12902023211010es\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/s0104-12902023211010es<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Temas Sociol\u00f3gicos<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">\u0093\u00a1No m\u00e1s caridad, queremos derechos, justicia y dignidad!\u0094. Las marchas anti-telet\u00f3n en Chile (2011-2021)<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.29344\/07196458.32.3278\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.29344\/07196458.32.3278<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Gender & Development<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Motherhood, disability, and rurality: descolonising practices and knowledge via the Las Quiscas case in Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 P\u00eda Valeria Rodr\u00edguez Garrido \u2022  Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1080\/13552074.2023.2254570\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1080\/13552074.2023.2254570<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cadernos Brasileiros de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Reivindicative occupational practices of activist with disabilities<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n \u2022  P\u00eda Valeria Rodr\u00edguez Garrido <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoAO269135102\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoAO269135102<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista de Estudios Sociales<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Discursos pol\u00edticos de activistas disidentes de la discapacidad en Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.7440\/res81.2022.01\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.7440\/res81.2022.01<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cadernos Brasileiros de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Perspectivas feministas sobre (in)justicias ocupacionales de maternidades adolescentes<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Paula Mesa Molina \u2022  P\u00eda Valeria Rodr\u00edguez Garrido \u2022  Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoao2169\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoao2169<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cadernos Brasileiros de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Juventudes migrantes institucionalizadas: una mirada desde la Terapia Ocupacional del Sur<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Laia Ruiz \u2022  Cristina Robles \u2022  Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoao2228\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1590\/2526-8910.ctoao2228<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Salud Colectiva<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Subvertir la vulneraci\u00f3n m\u00e9dica: itinerarios corporales disidentes de la discapacidad en Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n \u2022  P\u00eda Rodr\u00edguez-Garrrido \u2022  Inmaculada Zango-Mart\u00edn \u2022  Enrico Mora-Malo <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.18294\/sc.2021.3021\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.18294\/sc.2021.3021<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Gallega de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Tullidos: austeridad y demonizaci\u00f3n de las personas discapacitadas. Recensi\u00f3n.<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/S1885-527X2021000100009\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/S1885-527X2021000100009<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Public Health Nursing<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Exploring social and health care representations about home birth: An Integrative Literature Review<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.1111\/phn.12724\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.1111\/phn.12724<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Estudios de Pol\u00edticas P\u00fablicas<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">De-Generadas: La Violencia Institucional Capacitista hacia Mujeres con Discapacidad en Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.5354\/0719-6296.2019.50904\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.5354\/0719-6296.2019.50904<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Colombiana de Ciencias Sociales<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Encuentros entre la perspectiva decolonial y los estudios de la discapacidad<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.21501\/22161201.2893\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.21501\/22161201.2893<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista chilena de salud p\u00fablica<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">C\u00e1ncer de mama: an\u00e1lisis desde perspectivas transdisciplinar, psicosocial y de g\u00e9nero en Chile y Catalu\u00f1a.<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.5354\/0719-5281.2018.53239\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.5354\/0719-5281.2018.53239<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista chilena de salud p\u00fablica<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2017<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">C\u00e1ncer de mama y sexualidad: \u00bfuna discapacidad emergente?<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.5354\/0719-5281.2017.44946\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.5354\/0719-5281.2017.44946<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Intersticios. Revista Sociol\u00f3gica de Pensamiento Cr\u00edtico<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2017<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">\u00bfVivir para Trabajar?: Mujeres, Activismo y Discapacidad en Chile<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/https:\/\/intersticios.es\/article\/view\/17704\/11489\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/https:\/\/intersticios.es\/article\/view\/17704\/11489<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Cuadernos Brasile\u00f1os de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Perspectiva cr\u00edtica desde Latinoam\u00e9rica: hacia una desobediencia epistemol\u00f3gica de Terapia Ocupacional Contempor\u00e1nea.<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.4322\/0104-4931.ctoARF0726\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.4322\/0104-4931.ctoARF0726<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Gallega de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2015<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Terapia Ocupacional Comunitaria Cr\u00edtica. Di\u00e1logos y Reflexiones para iniciar una propuesta Colectiva<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/https:\/\/www.revistatog.com\/num22\/pdfs\/colab3.pdf\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/https:\/\/www.revistatog.com\/num22\/pdfs\/colab3.pdf<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista chilena de salud p\u00fablica<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2015<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">An\u00e1lisis desde el enfoque de derechos a la pol\u00edtica chilena en discapacidad mental<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.5354\/0719-5281.2015.37644\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.5354\/0719-5281.2015.37644<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #B8B8B8\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 me-2\"><i class=\"fas fa-solid fa-newspaper fa-fw\"><\/i> REVISTA Revista Chilena de Terapia Ocupacional<\/li><li class=\"p-0\"><i class=\"fa fa-regular fa-calendar fa-fw\"><\/i> 2015<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><h3 class=\"small-space title-ss text-decoration-none m-0\">Terapia Ocupacional Comunitaria y RBC: hacia una inclusi\u00f3n sociocomunitaria<\/h3><br><i class=\"fas fa-solid fa-users fa-fw me-2\"><\/i><small class=\"text-muted\"> \u2022 Juan Andr\u00e9s Pino Mor\u00e1n <\/small><br><p class=\"text-muted pt-3 position-relative\" style=\"z-index:2;\"><a href=\"http:\/\/dx.doi.org\/10.5354\/0719-5346.2015.38167\" target=\"_blank\"><i class=\"fas fa-solid fa-link fa-fw\"><\/i> http:\/\/dx.doi.org\/10.5354\/0719-5346.2015.38167<\/a><\/small><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Proyectos&#8221; tab_id=&#8221;proyectos&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div><div class=\"content-holder row m-0 p-0 aling-items-center pt-5 pb-5 \"><div class=\"row  large--swipper-content p-0 \"><div class=\"\"><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2026 - Noviembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6980\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto de Innovaci\u00f3n para el Manejo de Huertos Productivos Agroecol\u00f3gicos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6980\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6980\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El proyecto busca implementar un plan de innovaci\u00f3n social y t\u00e9cnica que permita rehabilitar los suelos y fortalecer la autogesti\u00f3n de los peque\u00f1os agricultores agroecol\u00f3gicos en la comuna de Marchig\u00fce.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2026 - Noviembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6981\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto de Innovaci\u00f3n para el Manejo de Huertos Productivos Agroecol\u00f3gicos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6981\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6981\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El proyecto busca implementar un plan de innovaci\u00f3n social y t\u00e9cnica que permita rehabilitar los suelos y fortalecer la autogesti\u00f3n de los peque\u00f1os agricultores agroecol\u00f3gicos en la comuna de Marchig\u00fce.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2026 - Noviembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6982\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto de Innovaci\u00f3n para el Manejo de Huertos Productivos Agroecol\u00f3gicos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6982\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6982\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El proyecto busca implementar un plan de innovaci\u00f3n social y t\u00e9cnica que permita rehabilitar los suelos y fortalecer la autogesti\u00f3n de los peque\u00f1os agricultores agroecol\u00f3gicos en la comuna de Marchig\u00fce.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2026 - Noviembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6983\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto de Innovaci\u00f3n para el Manejo de Huertos Productivos Agroecol\u00f3gicos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6983\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6983\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El proyecto busca implementar un plan de innovaci\u00f3n social y t\u00e9cnica que permita rehabilitar los suelos y fortalecer la autogesti\u00f3n de los peque\u00f1os agricultores agroecol\u00f3gicos en la comuna de Marchig\u00fce.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> NCS2025_37<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2026 - Diciembre 2028<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6566\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Nucleo Milenio Discapacidad y Ciudadania\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6566\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6566\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]DISCA (Discapacidad y Ciudadan\u00eda) es un n\u00facleo que desde 2022 est\u00e1 dedicado al estudio inter y transdisciplinario de los procesos y mecanismos a trav\u00e9s de los cuales las personas con discapacidad (PcD) se transforman en ciudadanas. Su objetivo general es examinar cr\u00edticamente c\u00f3mo las PcD construyen y negocian su ciudadan\u00eda en los \u00e1mbitos de: L1. la participaci\u00f3n pol\u00edtica, L2. el acceso a la justicia y L3. el acceso a la salud mental. Cada uno de estos \u00e1mbitos ser\u00e1 una l\u00ednea de trabajo de DISCA en los tres a\u00f1os del proyecto. Una cuarta l\u00ednea se centrar\u00e1 en el uso de metodolog\u00edas inclusivas y participativas en investigaci\u00f3n en discapacidad.\r\nNuestro enfoque se basa en dos pilares. Primero, la ciudadan\u00eda como forma de integraci\u00f3n social mediante la igual consideraci\u00f3n de todos. Consideramos aspectos institucionales (derechos civiles, pol\u00edticos y sociales) y relacionales (demandas de reconocimiento). Segundo, el modelo social de la discapacidad, que busca superar el enfoque biom\u00e9dico y entiende la discapacidad como resultado de la interacci\u00f3n entre condiciones de salud o d\u00e9ficits individuales y barreras sociales que impiden la plena participaci\u00f3n de las PcD.\r\nEl modelo social no es la mirada predominante. Siguen vigentes visiones asistencialistas que restringen la inclusi\u00f3n y el ejercicio de la ciudadan\u00eda de las PcD. Es urgente que la academia cree sinergias, tanto con organizaciones de PcD como con las instituciones del Estado, para examinar las barreras que afectan a las PcD y las v\u00edas para su superaci\u00f3n. La escasez de investigaci\u00f3n en discapacidad en Chile, y la necesidad de incorporar a PcD en la generaci\u00f3n de conocimiento, hace nuestro proyecto muy relevante. La incorporaci\u00f3n de PcD en el mundo acad\u00e9mico a trav\u00e9s de DISCA es una valiosa oportunidad para realizar cambios que preparen el camino para una mayor participaci\u00f3n de otras PcD. Esperamos que sus resultados generen pol\u00edticas inclusivas y participativas en discapacidad.\r\nDISCA est\u00e1 dirigido por una PcD, cuenta con un consejo de Expertos por Experiencia (con 7 PcD) y observa los principios de la investigaci\u00f3n inclusiva y participativa. Sus investigadores principales, pioneros en la investigaci\u00f3n en discapacidad en Chile, utilizan metodolog\u00edas mixtas, cuantitativas y cualitativas, integrando conocimientos de sociolog\u00eda, derecho, salud, econom\u00eda, sociolog\u00eda y psicolog\u00eda en conjunto con el campo transdisciplinario de los estudios de la discapacidad.\r\nLos logros a corto plazo se dirigen a: i) producir investigaci\u00f3n inter y transdisciplinaria en discapacidad, ii) consolidar redes de colaboraci\u00f3n con otros centros de investigaci\u00f3n en el mundo, iii) formar capital humano en varios niveles, incluyendo PcD en todo el quehacer de DISCA y iv) informar la pol\u00edtica p\u00fablica. La meta a mediano plazo es consolidar a DISCA como el primer centro de excelencia en investigaci\u00f3n en discapacidad de Latinoam\u00e9rica, contribuyendo al fortalecimiento de los estudios de la discapacidad en el mundo.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2026 - Enero 2031<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6935\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6935\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6935\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Es un centro de excelencia en salud mental[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2026 - Enero 2031<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6936\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6936\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6936\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Es un centro de excelencia en salud mental[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN 250068<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025 - Diciembre 2030<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6956\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n e Innovaci\u00f3n en Ni\u00f1ez, Adolescencia, Resiliencia y Adversidad (Centro IINARA)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6956\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6956\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The proposed IINARA Research Center (Investigaci\u00f3n e Innovaci\u00f3n en Ni\u00f1ez, Adolescencia, Resiliencia y Adversidad) seeks to address the pressing challenge of adversity during childhood and their profound effects on children\u0092s and adolescents\u0092 development in Chile. By combining cutting-edge research with a strong focus on public policy, capacity building, and community collaboration, the Center aims to generate actionable evidence that fosters resilience and promotes well-being among vulnerable populations that could inform public policy making. The initiative aligns with national priorities, including equitable access to developmental resources, and seeks to build a foundation for sustainable social and economic progress. \r\nAdverse Childhood Experiences\u0097ranging from abuse and neglect to socioeconomic adversity\u0097have been linked to long-term mental health issues, behavioral difficulties, and chronic illnesses. In Chile, adverse experiences are particularly prevalent in communities affected by poverty, migration, natural disasters, and systemic inequalities. Children and adolescents from indigenous and migrant populations face unique challenges, including cultural marginalization and reduced access to essential resources. Despite advancements in legal frameworks and public policies aimed at protecting children\u0092s rights, such as the \u0093Chile Crece M\u00e1s\u0094 (former Chile Crece Contigo) program, significant gaps remain in understanding the local contexts of adversity and developing targeted, evidence-based solutions.\r\nThe IINARA Center addresses these gaps through a multidisciplinary approach, integrating fields such as neuroscience, psychology, public health, and social sciences. Its mission is to understand the mechanisms underlying resilience in children and adolescents, using this knowledge to design interventions that protect vulnerable groups from the negative effects of adversity. The Center\u0092s objectives include identifying neurobiological, socioemotional, and contextual indicators of vulnerability and resilience; implementing culturally adapted interventions to promote positive developmental trajectories; and informing public policy through evidence-based recommendations. \r\nThe research will employ both qualitative methodologies, such as ethnographic studies and semi-structured interviews, and quantitative methodologies, such as the application of instruments that measure cognitive, emotional and social functioning and neuroscientific measures to understand the underlying neural mechanisms of this functioning. It will also include a randomized controlled trial (RCT) to test an intervention developed synergistically in IINARA. A significant focus will be placed on studying diverse cultural contexts that are particular to Chile, such as indigenous and migrant communities, to ensure interventions are inclusive and culturally relevant. All this will allow us to construct a model of cognitive and socioemotional functioning of children exposed to adversity across the territory, helping to guide the identification of biomarkers and predictors of resilience.\r\nThe expected impact of the IINARA Center extends across multiple dimensions. In the realm of public policy, the Center will provide robust, evidence-based recommendations for designing and implementing strategies that address childhood adversity. This includes fostering intersectoral collaboration among government agencies, educational institutions, and healthcare providers to create a comprehensive support system for children and adolescents. The Center will also strengthen capacity building by training human resources, including researchers, educators, and policymakers, in interdisciplinary approaches to childhood resilience. \r\nThrough its collaborative framework, the Center will promote associativity among academia, public institutions, and civil society organizations. By partnering with international research networks and leveraging global expertise, it will position Chile as a leader in addressing childhood adversity in Latin \r\nAmerica. The dissemination of findings will include outreach to both public and private sectors, ensuring the transfer of knowledge and technologies that benefit diverse stakeholders. By engaging communities directly in the design and implementation of interventions, the Center will foster a participatory approach that enhances the cultural relevance and sustainability of its initiatives. \r\nUltimately, the IINARA Center aspires to contribute to the development of a more resilient and equitable society by improving developmental outcomes for children and adolescents across Chile. Its work will not only reduce the long-term impact of adversity but also strengthen the country\u0092s social and economic fabric, creating opportunities for future generations to thrive.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6957\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Centro CIADES)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6957\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6957\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Mental health conditions and inequities in Chile have risen significantly over recent decades, fueled\r\nby factors such as social exclusion, precarious employment, and environmental challenges. In line with recent\r\nnational legislation and policy reforms, including the recently proposed Mental Health Law (2024,) there is\r\ngrowing recognition that these issues require not only expanded clinical services but also a deeper focus on the\r\nsocio-structural determinants of mental health (Breilh, 2023; Lund et al., 2018). The Centro de Investigaci\u00f3n y\r\nAcci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Center for Research and Action in Social Determination and\r\nMental Health) or CIADES responds to this urgency by adopting a Latin American\u0096rooted Social Determination\r\nof Health (SDnH) framework, thereby situating mental health vulnerabilities and risks within broader historical,\r\neconomic, and political contexts.\r\nCIADES will work in close collaboration with the Ministry of Social Development and Family (MIDESO)\r\nand the Ministry of Health (MINSAL), to generate robust evidence and policy guidance to address the social\r\nfactors that affect and produce mental health problems beyond the individual. This collaboration ensures that\r\nthe Center\u0092s research advances academic knowledge and informs public-sector strategies and interventions. In\r\ndoing so, CIADES seeks to address crucial social factors, including growing economic inequalities, stigma, and\r\nsocial disintegration, which have direct implications for mental well-being across the lifespan.\r\nMethodologically, CIADES employs a three-by-three matrix that interlinks three social determinants\u0097\r\nSocial Exclusion and Discrimination, Environmental Factors, and Employment\u0097with three priority populations:\r\nmigrants, older adults, and people with SMI (SMI). This matrix underpins interdisciplinary research lines,\r\nintegrating quantitative (e.g., epidemiological surveys, geospatial risk mapping), qualitative (e.g., multimodal\r\nand sensory ethnography, focus groups), and participatory methods. AI-driven analyses, such as natural\r\nlanguage processing for tracking stigma on social media, and economic evaluations that assess intervention\r\nfeasibility also feature prominently within the Center\u0092s approach.\r\nThe significance of this research lies in its focus on macro-structural drivers\u0097housing insecurity,\r\nworkplace discrimination, socio-environmental conflicts\u0097and how they contribute to mental health inequities.\r\nBy examining these intersecting challenges, CIADES will move beyond an exclusively clinical perspective to\r\npropose and evaluate, in close collaboration with MIDESO and MINSAL, evidence-based strategies that can be\r\nimplemented at multiple levels: local (community-based initiatives), regional (intersectoral policies), and\r\nnational (legislative reforms). This holistic orientation positions CIADES as a transformative force in Chile\u0092s\r\npublic policy on mental health. Once established, the Center expects to identify and integrate other social\r\ndeterminants and priority groups.\r\nThe Center\u0092s work will be guided by four Specific Objectives. First, Generate Evidence for Strategic\r\nInterventions and Policy Reforms involves collaborating with MIDESO and MINSAL to systematically examine\r\nsocio-structural determinants\u0097such as discrimination, environmental stressors, and employment\r\nvulnerabilities\u0097and generate robust evidence to inform and guide future interventions and policy actions.\r\nSecond, Methodological Development uses participatory and mixed-methods approaches, emphasizing\r\ncommunity involvement and local knowledge. Third, Capacity Building trains emerging researchers,\r\npolicymakers, and practitioners to apply the SDnH framework. Finally, Knowledge Dissemination and Policy\r\nAdvocacy entails translating findings into policy briefs, stakeholder workshops, and legislative\r\nrecommendations that foreground structural change and equitable access to the exercise of rights, and to\r\npolicies, programs and services.\r\nCIADES benefits from a multidisciplinary team involving principal and associate investigators with\r\nextensive track records in mental health, social sciences, environmental studies, and policy work. Their\r\ncollective experience includes leading large-scale epidemiological surveys, designing culturally relevant\r\ninterventions, and influencing legislative reforms. This breadth enables the Center to integrate cutting-edge\r\nmethods\u0097such as AI-driven stigma detection and geospatial modeling\u0097within a robust theoretical framework.\r\nBy drawing on a wide range of expertise, CIADES is uniquely positioned to undertake a comprehensive agenda\r\nthat links empirical research to transformative actions in policy and practice.\r\nCIADES anticipates having a significant impact at the national level by influencing discussions on the\r\ndesign, implementation, and evaluation of policies related to labor laws, anti-discrimination statutes,\r\ncommunity-oriented service models, environmental regulations, urban transformations, and other public\r\npolicies with an impact on mental health. In the short term, the center aims to increase recognition of the\r\nstructural factors that affect the mental health of different populations, factors that are often overlooked or\r\nignored due to the current emphasis on individual-focused approaches. Collaborating with communities,\r\nCIADES will co-design initiatives and pilot projects that serve as scalable case studies. These efforts will lead to\r\nthe production of policy briefs and guidelines, offering new frameworks to understand mental health challenges\r\nand proposing context-sensitive interventions. Over the medium to long term, CIADES aims to enhance\r\nintersectoral collaboration to drive structural-level interventions able to reduce mental health disparities\u0097\r\npositioning Chile as a regional leader in addressing mental health through a justice-based perspective.\r\nThe Center places a strong emphasis on capacity building and human capital formation as integral\r\ncomponents of its mission. Students from undergraduate to postgraduate levels will benefit from\r\ninterdisciplinary training in mental health, social epidemiology, qualitative methods, participatory methods and\r\ninclusive research, and implementation and dissemination science. This approach aims to nurture a new\r\ngeneration of scholars, practitioners, and other stakeholders equipped with the skills and knowledge necessary\r\nto advance the SDnH perspective. Furthermore, partnerships with leading international institutions, such as\r\nKing\u0092s College London and Columbia University, will facilitate knowledge exchange, foster global networks, and\r\nenhance CIADES\u0092 reach and credibility on an international scale.\r\nThrough proactive dissemination, outreach, and knowledge transfer, CIADES will engage with both\r\npublic and private sectors to drive actionable change. Dissemination channels include academic publications,\r\nopen-access materials, community forums, policy dialogues, and strategic communication through social media\r\nto ensure broader public penetration of the center's work.\r\nRegarding academic publications, CIADES is committed to publishing in high-impact international journals while\r\nalso recognizing the strategic importance of positioning itself within Latin American and national contexts by\r\ncontributing to academic journals in Spanish. Open-access materials will include the development of\r\nconceptual, methodological, and practical tools and guides, which will be freely available for public use.\r\nCommunity forums will serve both to share research findings and to identify emerging issues among the general\r\npopulation, while policy dialogues will aim to directly support and influence decision-making processes at the\r\npolicy level based on the center\u0092s research findings and experiences.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Patrocinante<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN 250068<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025 - Diciembre 2030<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6958\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n e Innovaci\u00f3n en Ni\u00f1ez, Adolescencia, Resiliencia y Adversidad (Centro IINARA)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6958\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6958\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The proposed IINARA Research Center (Investigaci\u00f3n e Innovaci\u00f3n en Ni\u00f1ez, Adolescencia, Resiliencia y Adversidad) seeks to address the pressing challenge of adversity during childhood and their profound effects on children\u0092s and adolescents\u0092 development in Chile. By combining cutting-edge research with a strong focus on public policy, capacity building, and community collaboration, the Center aims to generate actionable evidence that fosters resilience and promotes well-being among vulnerable populations that could inform public policy making. The initiative aligns with national priorities, including equitable access to developmental resources, and seeks to build a foundation for sustainable social and economic progress. \r\nAdverse Childhood Experiences\u0097ranging from abuse and neglect to socioeconomic adversity\u0097have been linked to long-term mental health issues, behavioral difficulties, and chronic illnesses. In Chile, adverse experiences are particularly prevalent in communities affected by poverty, migration, natural disasters, and systemic inequalities. Children and adolescents from indigenous and migrant populations face unique challenges, including cultural marginalization and reduced access to essential resources. Despite advancements in legal frameworks and public policies aimed at protecting children\u0092s rights, such as the \u0093Chile Crece M\u00e1s\u0094 (former Chile Crece Contigo) program, significant gaps remain in understanding the local contexts of adversity and developing targeted, evidence-based solutions.\r\nThe IINARA Center addresses these gaps through a multidisciplinary approach, integrating fields such as neuroscience, psychology, public health, and social sciences. Its mission is to understand the mechanisms underlying resilience in children and adolescents, using this knowledge to design interventions that protect vulnerable groups from the negative effects of adversity. The Center\u0092s objectives include identifying neurobiological, socioemotional, and contextual indicators of vulnerability and resilience; implementing culturally adapted interventions to promote positive developmental trajectories; and informing public policy through evidence-based recommendations. \r\nThe research will employ both qualitative methodologies, such as ethnographic studies and semi-structured interviews, and quantitative methodologies, such as the application of instruments that measure cognitive, emotional and social functioning and neuroscientific measures to understand the underlying neural mechanisms of this functioning. It will also include a randomized controlled trial (RCT) to test an intervention developed synergistically in IINARA. A significant focus will be placed on studying diverse cultural contexts that are particular to Chile, such as indigenous and migrant communities, to ensure interventions are inclusive and culturally relevant. All this will allow us to construct a model of cognitive and socioemotional functioning of children exposed to adversity across the territory, helping to guide the identification of biomarkers and predictors of resilience.\r\nThe expected impact of the IINARA Center extends across multiple dimensions. In the realm of public policy, the Center will provide robust, evidence-based recommendations for designing and implementing strategies that address childhood adversity. This includes fostering intersectoral collaboration among government agencies, educational institutions, and healthcare providers to create a comprehensive support system for children and adolescents. The Center will also strengthen capacity building by training human resources, including researchers, educators, and policymakers, in interdisciplinary approaches to childhood resilience. \r\nThrough its collaborative framework, the Center will promote associativity among academia, public institutions, and civil society organizations. By partnering with international research networks and leveraging global expertise, it will position Chile as a leader in addressing childhood adversity in Latin \r\nAmerica. The dissemination of findings will include outreach to both public and private sectors, ensuring the transfer of knowledge and technologies that benefit diverse stakeholders. By engaging communities directly in the design and implementation of interventions, the Center will foster a participatory approach that enhances the cultural relevance and sustainability of its initiatives. \r\nUltimately, the IINARA Center aspires to contribute to the development of a more resilient and equitable society by improving developmental outcomes for children and adolescents across Chile. Its work will not only reduce the long-term impact of adversity but also strengthen the country\u0092s social and economic fabric, creating opportunities for future generations to thrive.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6959\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Centro CIADES)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6959\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6959\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Mental health conditions and inequities in Chile have risen significantly over recent decades, fueled\r\nby factors such as social exclusion, precarious employment, and environmental challenges. In line with recent\r\nnational legislation and policy reforms, including the recently proposed Mental Health Law (2024,) there is\r\ngrowing recognition that these issues require not only expanded clinical services but also a deeper focus on the\r\nsocio-structural determinants of mental health (Breilh, 2023; Lund et al., 2018). The Centro de Investigaci\u00f3n y\r\nAcci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Center for Research and Action in Social Determination and\r\nMental Health) or CIADES responds to this urgency by adopting a Latin American\u0096rooted Social Determination\r\nof Health (SDnH) framework, thereby situating mental health vulnerabilities and risks within broader historical,\r\neconomic, and political contexts.\r\nCIADES will work in close collaboration with the Ministry of Social Development and Family (MIDESO)\r\nand the Ministry of Health (MINSAL), to generate robust evidence and policy guidance to address the social\r\nfactors that affect and produce mental health problems beyond the individual. This collaboration ensures that\r\nthe Center\u0092s research advances academic knowledge and informs public-sector strategies and interventions. In\r\ndoing so, CIADES seeks to address crucial social factors, including growing economic inequalities, stigma, and\r\nsocial disintegration, which have direct implications for mental well-being across the lifespan.\r\nMethodologically, CIADES employs a three-by-three matrix that interlinks three social determinants\u0097\r\nSocial Exclusion and Discrimination, Environmental Factors, and Employment\u0097with three priority populations:\r\nmigrants, older adults, and people with SMI (SMI). This matrix underpins interdisciplinary research lines,\r\nintegrating quantitative (e.g., epidemiological surveys, geospatial risk mapping), qualitative (e.g., multimodal\r\nand sensory ethnography, focus groups), and participatory methods. AI-driven analyses, such as natural\r\nlanguage processing for tracking stigma on social media, and economic evaluations that assess intervention\r\nfeasibility also feature prominently within the Center\u0092s approach.\r\nThe significance of this research lies in its focus on macro-structural drivers\u0097housing insecurity,\r\nworkplace discrimination, socio-environmental conflicts\u0097and how they contribute to mental health inequities.\r\nBy examining these intersecting challenges, CIADES will move beyond an exclusively clinical perspective to\r\npropose and evaluate, in close collaboration with MIDESO and MINSAL, evidence-based strategies that can be\r\nimplemented at multiple levels: local (community-based initiatives), regional (intersectoral policies), and\r\nnational (legislative reforms). This holistic orientation positions CIADES as a transformative force in Chile\u0092s\r\npublic policy on mental health. Once established, the Center expects to identify and integrate other social\r\ndeterminants and priority groups.\r\nThe Center\u0092s work will be guided by four Specific Objectives. First, Generate Evidence for Strategic\r\nInterventions and Policy Reforms involves collaborating with MIDESO and MINSAL to systematically examine\r\nsocio-structural determinants\u0097such as discrimination, environmental stressors, and employment\r\nvulnerabilities\u0097and generate robust evidence to inform and guide future interventions and policy actions.\r\nSecond, Methodological Development uses participatory and mixed-methods approaches, emphasizing\r\ncommunity involvement and local knowledge. Third, Capacity Building trains emerging researchers,\r\npolicymakers, and practitioners to apply the SDnH framework. Finally, Knowledge Dissemination and Policy\r\nAdvocacy entails translating findings into policy briefs, stakeholder workshops, and legislative\r\nrecommendations that foreground structural change and equitable access to the exercise of rights, and to\r\npolicies, programs and services.\r\nCIADES benefits from a multidisciplinary team involving principal and associate investigators with\r\nextensive track records in mental health, social sciences, environmental studies, and policy work. Their\r\ncollective experience includes leading large-scale epidemiological surveys, designing culturally relevant\r\ninterventions, and influencing legislative reforms. This breadth enables the Center to integrate cutting-edge\r\nmethods\u0097such as AI-driven stigma detection and geospatial modeling\u0097within a robust theoretical framework.\r\nBy drawing on a wide range of expertise, CIADES is uniquely positioned to undertake a comprehensive agenda\r\nthat links empirical research to transformative actions in policy and practice.\r\nCIADES anticipates having a significant impact at the national level by influencing discussions on the\r\ndesign, implementation, and evaluation of policies related to labor laws, anti-discrimination statutes,\r\ncommunity-oriented service models, environmental regulations, urban transformations, and other public\r\npolicies with an impact on mental health. In the short term, the center aims to increase recognition of the\r\nstructural factors that affect the mental health of different populations, factors that are often overlooked or\r\nignored due to the current emphasis on individual-focused approaches. Collaborating with communities,\r\nCIADES will co-design initiatives and pilot projects that serve as scalable case studies. These efforts will lead to\r\nthe production of policy briefs and guidelines, offering new frameworks to understand mental health challenges\r\nand proposing context-sensitive interventions. Over the medium to long term, CIADES aims to enhance\r\nintersectoral collaboration to drive structural-level interventions able to reduce mental health disparities\u0097\r\npositioning Chile as a regional leader in addressing mental health through a justice-based perspective.\r\nThe Center places a strong emphasis on capacity building and human capital formation as integral\r\ncomponents of its mission. Students from undergraduate to postgraduate levels will benefit from\r\ninterdisciplinary training in mental health, social epidemiology, qualitative methods, participatory methods and\r\ninclusive research, and implementation and dissemination science. This approach aims to nurture a new\r\ngeneration of scholars, practitioners, and other stakeholders equipped with the skills and knowledge necessary\r\nto advance the SDnH perspective. Furthermore, partnerships with leading international institutions, such as\r\nKing\u0092s College London and Columbia University, will facilitate knowledge exchange, foster global networks, and\r\nenhance CIADES\u0092 reach and credibility on an international scale.\r\nThrough proactive dissemination, outreach, and knowledge transfer, CIADES will engage with both\r\npublic and private sectors to drive actionable change. Dissemination channels include academic publications,\r\nopen-access materials, community forums, policy dialogues, and strategic communication through social media\r\nto ensure broader public penetration of the center's work.\r\nRegarding academic publications, CIADES is committed to publishing in high-impact international journals while\r\nalso recognizing the strategic importance of positioning itself within Latin American and national contexts by\r\ncontributing to academic journals in Spanish. Open-access materials will include the development of\r\nconceptual, methodological, and practical tools and guides, which will be freely available for public use.\r\nCommunity forums will serve both to share research findings and to identify emerging issues among the general\r\npopulation, while policy dialogues will aim to directly support and influence decision-making processes at the\r\npolicy level based on the center\u0092s research findings and experiences.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Patrocinante<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6960\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Centro CIADES)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6960\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6960\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Mental health conditions and inequities in Chile have risen significantly over recent decades, fueled\r\nby factors such as social exclusion, precarious employment, and environmental challenges. In line with recent\r\nnational legislation and policy reforms, including the recently proposed Mental Health Law (2024,) there is\r\ngrowing recognition that these issues require not only expanded clinical services but also a deeper focus on the\r\nsocio-structural determinants of mental health (Breilh, 2023; Lund et al., 2018). The Centro de Investigaci\u00f3n y\r\nAcci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Center for Research and Action in Social Determination and\r\nMental Health) or CIADES responds to this urgency by adopting a Latin American\u0096rooted Social Determination\r\nof Health (SDnH) framework, thereby situating mental health vulnerabilities and risks within broader historical,\r\neconomic, and political contexts.\r\nCIADES will work in close collaboration with the Ministry of Social Development and Family (MIDESO)\r\nand the Ministry of Health (MINSAL), to generate robust evidence and policy guidance to address the social\r\nfactors that affect and produce mental health problems beyond the individual. This collaboration ensures that\r\nthe Center\u0092s research advances academic knowledge and informs public-sector strategies and interventions. In\r\ndoing so, CIADES seeks to address crucial social factors, including growing economic inequalities, stigma, and\r\nsocial disintegration, which have direct implications for mental well-being across the lifespan.\r\nMethodologically, CIADES employs a three-by-three matrix that interlinks three social determinants\u0097\r\nSocial Exclusion and Discrimination, Environmental Factors, and Employment\u0097with three priority populations:\r\nmigrants, older adults, and people with SMI (SMI). This matrix underpins interdisciplinary research lines,\r\nintegrating quantitative (e.g., epidemiological surveys, geospatial risk mapping), qualitative (e.g., multimodal\r\nand sensory ethnography, focus groups), and participatory methods. AI-driven analyses, such as natural\r\nlanguage processing for tracking stigma on social media, and economic evaluations that assess intervention\r\nfeasibility also feature prominently within the Center\u0092s approach.\r\nThe significance of this research lies in its focus on macro-structural drivers\u0097housing insecurity,\r\nworkplace discrimination, socio-environmental conflicts\u0097and how they contribute to mental health inequities.\r\nBy examining these intersecting challenges, CIADES will move beyond an exclusively clinical perspective to\r\npropose and evaluate, in close collaboration with MIDESO and MINSAL, evidence-based strategies that can be\r\nimplemented at multiple levels: local (community-based initiatives), regional (intersectoral policies), and\r\nnational (legislative reforms). This holistic orientation positions CIADES as a transformative force in Chile\u0092s\r\npublic policy on mental health. Once established, the Center expects to identify and integrate other social\r\ndeterminants and priority groups.\r\nThe Center\u0092s work will be guided by four Specific Objectives. First, Generate Evidence for Strategic\r\nInterventions and Policy Reforms involves collaborating with MIDESO and MINSAL to systematically examine\r\nsocio-structural determinants\u0097such as discrimination, environmental stressors, and employment\r\nvulnerabilities\u0097and generate robust evidence to inform and guide future interventions and policy actions.\r\nSecond, Methodological Development uses participatory and mixed-methods approaches, emphasizing\r\ncommunity involvement and local knowledge. Third, Capacity Building trains emerging researchers,\r\npolicymakers, and practitioners to apply the SDnH framework. Finally, Knowledge Dissemination and Policy\r\nAdvocacy entails translating findings into policy briefs, stakeholder workshops, and legislative\r\nrecommendations that foreground structural change and equitable access to the exercise of rights, and to\r\npolicies, programs and services.\r\nCIADES benefits from a multidisciplinary team involving principal and associate investigators with\r\nextensive track records in mental health, social sciences, environmental studies, and policy work. Their\r\ncollective experience includes leading large-scale epidemiological surveys, designing culturally relevant\r\ninterventions, and influencing legislative reforms. This breadth enables the Center to integrate cutting-edge\r\nmethods\u0097such as AI-driven stigma detection and geospatial modeling\u0097within a robust theoretical framework.\r\nBy drawing on a wide range of expertise, CIADES is uniquely positioned to undertake a comprehensive agenda\r\nthat links empirical research to transformative actions in policy and practice.\r\nCIADES anticipates having a significant impact at the national level by influencing discussions on the\r\ndesign, implementation, and evaluation of policies related to labor laws, anti-discrimination statutes,\r\ncommunity-oriented service models, environmental regulations, urban transformations, and other public\r\npolicies with an impact on mental health. In the short term, the center aims to increase recognition of the\r\nstructural factors that affect the mental health of different populations, factors that are often overlooked or\r\nignored due to the current emphasis on individual-focused approaches. Collaborating with communities,\r\nCIADES will co-design initiatives and pilot projects that serve as scalable case studies. These efforts will lead to\r\nthe production of policy briefs and guidelines, offering new frameworks to understand mental health challenges\r\nand proposing context-sensitive interventions. Over the medium to long term, CIADES aims to enhance\r\nintersectoral collaboration to drive structural-level interventions able to reduce mental health disparities\u0097\r\npositioning Chile as a regional leader in addressing mental health through a justice-based perspective.\r\nThe Center places a strong emphasis on capacity building and human capital formation as integral\r\ncomponents of its mission. Students from undergraduate to postgraduate levels will benefit from\r\ninterdisciplinary training in mental health, social epidemiology, qualitative methods, participatory methods and\r\ninclusive research, and implementation and dissemination science. This approach aims to nurture a new\r\ngeneration of scholars, practitioners, and other stakeholders equipped with the skills and knowledge necessary\r\nto advance the SDnH perspective. Furthermore, partnerships with leading international institutions, such as\r\nKing\u0092s College London and Columbia University, will facilitate knowledge exchange, foster global networks, and\r\nenhance CIADES\u0092 reach and credibility on an international scale.\r\nThrough proactive dissemination, outreach, and knowledge transfer, CIADES will engage with both\r\npublic and private sectors to drive actionable change. Dissemination channels include academic publications,\r\nopen-access materials, community forums, policy dialogues, and strategic communication through social media\r\nto ensure broader public penetration of the center's work.\r\nRegarding academic publications, CIADES is committed to publishing in high-impact international journals while\r\nalso recognizing the strategic importance of positioning itself within Latin American and national contexts by\r\ncontributing to academic journals in Spanish. Open-access materials will include the development of\r\nconceptual, methodological, and practical tools and guides, which will be freely available for public use.\r\nCommunity forums will serve both to share research findings and to identify emerging issues among the general\r\npopulation, while policy dialogues will aim to directly support and influence decision-making processes at the\r\npolicy level based on the center\u0092s research findings and experiences.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIN250054<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6961\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro de Investigaci\u00f3n y Acci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Centro CIADES)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6961\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6961\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Mental health conditions and inequities in Chile have risen significantly over recent decades, fueled\r\nby factors such as social exclusion, precarious employment, and environmental challenges. In line with recent\r\nnational legislation and policy reforms, including the recently proposed Mental Health Law (2024,) there is\r\ngrowing recognition that these issues require not only expanded clinical services but also a deeper focus on the\r\nsocio-structural determinants of mental health (Breilh, 2023; Lund et al., 2018). The Centro de Investigaci\u00f3n y\r\nAcci\u00f3n en Determinaci\u00f3n Social y Salud Mental (Center for Research and Action in Social Determination and\r\nMental Health) or CIADES responds to this urgency by adopting a Latin American\u0096rooted Social Determination\r\nof Health (SDnH) framework, thereby situating mental health vulnerabilities and risks within broader historical,\r\neconomic, and political contexts.\r\nCIADES will work in close collaboration with the Ministry of Social Development and Family (MIDESO)\r\nand the Ministry of Health (MINSAL), to generate robust evidence and policy guidance to address the social\r\nfactors that affect and produce mental health problems beyond the individual. This collaboration ensures that\r\nthe Center\u0092s research advances academic knowledge and informs public-sector strategies and interventions. In\r\ndoing so, CIADES seeks to address crucial social factors, including growing economic inequalities, stigma, and\r\nsocial disintegration, which have direct implications for mental well-being across the lifespan.\r\nMethodologically, CIADES employs a three-by-three matrix that interlinks three social determinants\u0097\r\nSocial Exclusion and Discrimination, Environmental Factors, and Employment\u0097with three priority populations:\r\nmigrants, older adults, and people with SMI (SMI). This matrix underpins interdisciplinary research lines,\r\nintegrating quantitative (e.g., epidemiological surveys, geospatial risk mapping), qualitative (e.g., multimodal\r\nand sensory ethnography, focus groups), and participatory methods. AI-driven analyses, such as natural\r\nlanguage processing for tracking stigma on social media, and economic evaluations that assess intervention\r\nfeasibility also feature prominently within the Center\u0092s approach.\r\nThe significance of this research lies in its focus on macro-structural drivers\u0097housing insecurity,\r\nworkplace discrimination, socio-environmental conflicts\u0097and how they contribute to mental health inequities.\r\nBy examining these intersecting challenges, CIADES will move beyond an exclusively clinical perspective to\r\npropose and evaluate, in close collaboration with MIDESO and MINSAL, evidence-based strategies that can be\r\nimplemented at multiple levels: local (community-based initiatives), regional (intersectoral policies), and\r\nnational (legislative reforms). This holistic orientation positions CIADES as a transformative force in Chile\u0092s\r\npublic policy on mental health. Once established, the Center expects to identify and integrate other social\r\ndeterminants and priority groups.\r\nThe Center\u0092s work will be guided by four Specific Objectives. First, Generate Evidence for Strategic\r\nInterventions and Policy Reforms involves collaborating with MIDESO and MINSAL to systematically examine\r\nsocio-structural determinants\u0097such as discrimination, environmental stressors, and employment\r\nvulnerabilities\u0097and generate robust evidence to inform and guide future interventions and policy actions.\r\nSecond, Methodological Development uses participatory and mixed-methods approaches, emphasizing\r\ncommunity involvement and local knowledge. Third, Capacity Building trains emerging researchers,\r\npolicymakers, and practitioners to apply the SDnH framework. Finally, Knowledge Dissemination and Policy\r\nAdvocacy entails translating findings into policy briefs, stakeholder workshops, and legislative\r\nrecommendations that foreground structural change and equitable access to the exercise of rights, and to\r\npolicies, programs and services.\r\nCIADES benefits from a multidisciplinary team involving principal and associate investigators with\r\nextensive track records in mental health, social sciences, environmental studies, and policy work. Their\r\ncollective experience includes leading large-scale epidemiological surveys, designing culturally relevant\r\ninterventions, and influencing legislative reforms. This breadth enables the Center to integrate cutting-edge\r\nmethods\u0097such as AI-driven stigma detection and geospatial modeling\u0097within a robust theoretical framework.\r\nBy drawing on a wide range of expertise, CIADES is uniquely positioned to undertake a comprehensive agenda\r\nthat links empirical research to transformative actions in policy and practice.\r\nCIADES anticipates having a significant impact at the national level by influencing discussions on the\r\ndesign, implementation, and evaluation of policies related to labor laws, anti-discrimination statutes,\r\ncommunity-oriented service models, environmental regulations, urban transformations, and other public\r\npolicies with an impact on mental health. In the short term, the center aims to increase recognition of the\r\nstructural factors that affect the mental health of different populations, factors that are often overlooked or\r\nignored due to the current emphasis on individual-focused approaches. Collaborating with communities,\r\nCIADES will co-design initiatives and pilot projects that serve as scalable case studies. These efforts will lead to\r\nthe production of policy briefs and guidelines, offering new frameworks to understand mental health challenges\r\nand proposing context-sensitive interventions. Over the medium to long term, CIADES aims to enhance\r\nintersectoral collaboration to drive structural-level interventions able to reduce mental health disparities\u0097\r\npositioning Chile as a regional leader in addressing mental health through a justice-based perspective.\r\nThe Center places a strong emphasis on capacity building and human capital formation as integral\r\ncomponents of its mission. Students from undergraduate to postgraduate levels will benefit from\r\ninterdisciplinary training in mental health, social epidemiology, qualitative methods, participatory methods and\r\ninclusive research, and implementation and dissemination science. This approach aims to nurture a new\r\ngeneration of scholars, practitioners, and other stakeholders equipped with the skills and knowledge necessary\r\nto advance the SDnH perspective. Furthermore, partnerships with leading international institutions, such as\r\nKing\u0092s College London and Columbia University, will facilitate knowledge exchange, foster global networks, and\r\nenhance CIADES\u0092 reach and credibility on an international scale.\r\nThrough proactive dissemination, outreach, and knowledge transfer, CIADES will engage with both\r\npublic and private sectors to drive actionable change. Dissemination channels include academic publications,\r\nopen-access materials, community forums, policy dialogues, and strategic communication through social media\r\nto ensure broader public penetration of the center's work.\r\nRegarding academic publications, CIADES is committed to publishing in high-impact international journals while\r\nalso recognizing the strategic importance of positioning itself within Latin American and national contexts by\r\ncontributing to academic journals in Spanish. Open-access materials will include the development of\r\nconceptual, methodological, and practical tools and guides, which will be freely available for public use.\r\nCommunity forums will serve both to share research findings and to identify emerging issues among the general\r\npopulation, while policy dialogues will aim to directly support and influence decision-making processes at the\r\npolicy level based on the center\u0092s research findings and experiences.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2025 - Diciembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>University of Applied Sciences Emden\/Leer, Germany and Universidad de Valpara\u00edso, Chile<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6560\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Memorias y consecuencias transgeneracionales de violencia pol\u00edtica para la salud mental y social (Argentina, Chile, Grecia y Polonia)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6560\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6560\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La violencia sistem\u00e1tica desde el Estado ocurri\u00f3 en muchos pa\u00edses, incluyendo a Chile,\r\nArgentina, Polonia y Grecia. Las dictaduras militares en Chile (1973\u00961990), Argentina (1976-\r\n1983) y Grecia (1967-1974) produjeron violaciones sistem\u00e1ticas a los derechos humanos,\r\nincluyendo: desapariciones, torturas, ejecuciones y exilio. Aunque existen m\u00faltiples estudios\r\nsobre las v\u00edctimas directas, a\u00fan hay menos conocimiento sobre c\u00f3mo el impacto de estas\r\nexperiencias transforma la salud mental y social de las v\u00edctimas directas, sus hijos y nietos. Este\r\nestudio internacional busca contribuir a comprender mejor esta situaci\u00f3n, con el objetivo de explorar los mecanismos de transmisi\u00f3n intergeneracional de las memorias de la dictadura y sus efectos en la salud mental y social de los descendientes de v\u00edctimas directas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> N\u00ba 2025-03<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2025 - Noviembre 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Sociedad Chilena de Endocrinolog\u00eda y Diabetes<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6479\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Disfunci\u00f3n Pancre\u00e1tica y Muscular Asociada a la hepatoquina Fetuina-A en un Modelo Murino de Esteatohepatitis\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6479\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6479\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Disfunci\u00f3n Pancre\u00e1tica y Muscular Asociada a la hepatoquina Fetuina-A en un Modelo Murino de Esteatohepatitis[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 19591<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2025 - Octubre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6521\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Explorando la coocurrencia entre autismo y diversidad de g\u00e9nero: intersecciones, identidades y transiciones en la adolescencia y la adultez joven.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6521\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6521\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Si bien, hay algunos estudios que sugieren un v\u00ednculo entre la diversidad de G\u00e9nero (DiG) y las personas autistas, esta relaci\u00f3n est\u00e1 poco explorada, especialmente en Latinoam\u00e9rica, existiendo muchas limitaciones en las instrumentos y metodolog\u00edas utilizados en los diferentes estudios. En ese sentido, el proyecto busca explorar la relaci\u00f3n entre los rasgos autistas y diversidad de g\u00e9nero en adolescentes j\u00f3venes entre 13 a 21 a\u00f1os, que consultan en centros de salud p\u00fablica y privada en Chile en diversas regiones de Chile de la zona Norte (ejemplo Iquique), Centro (ejemplo Metropolitana y de O\u0092Higgins) y Sur (Los Lagos). Para esto, se implementar\u00e1 un estudio transversal, descriptivo y exploratorio con enfoque mixto (cuantitativo y cualitativo).[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 19591<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2025 - Octubre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6559\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Explorando la coocurrencia entre autismo y diversidad de g\u00e9nero: intersecciones, identidades y transiciones en la adolescencia y la adultez joven.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6559\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6559\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Si bien, hay algunos estudios que sugieren un v\u00ednculo entre la diversidad de G\u00e9nero (DiG) y las personas autistas, esta relaci\u00f3n est\u00e1 poco explorada, especialmente en Latinoam\u00e9rica, existiendo muchas limitaciones en las instrumentos y metodolog\u00edas utilizados en los diferentes estudios. En ese sentido, el proyecto busca explorar la relaci\u00f3n entre los rasgos autistas y diversidad de g\u00e9nero en adolescentes j\u00f3venes entre 13 a 21 a\u00f1os, que consultan en centros de salud p\u00fablica y privada en Chile en diversas regiones de Chile de la zona Norte (ejemplo Iquique), Centro (ejemplo Metropolitana y de O\u0092Higgins) y Sur (Los Lagos). Para esto, se implementar\u00e1 un estudio transversal, descriptivo y exploratorio con enfoque mixto (cuantitativo y cualitativo).[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 11250237<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2025 - Abril 2028<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6478\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Implications for an adipose tissue-ear axis in obesity-induced hearing loss: role of cochlear Nrf2\/ARE and NF-kB pathways\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6478\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6478\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Implications for an adipose tissue-ear axis in obesity-induced hearing loss: role of cochlear Nrf2\/ARE and NF-kB pathways[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1251945<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2025 - Abril 2029<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6558\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Social, technological, and health explorations of the uses of wearable technologies in Chile\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6558\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6558\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]This research aims to explore the everyday interactions and relationships among individuals who use wearable technologies in Chile, focusing on health self-tracking and its implications.\r\nWearable technologies, which integrate advanced computing and electronics into clothing and accessories, have seen significant global adoption since the early 21st century due to the miniaturization of computational devices. These technologies offer continuous, fluid, and hands-free operations, transforming them into an extension of the body and mind. Their applications span various domains, including health and fitness, medical applications, consumer electronics, military uses, and fashion. Despite their benefits, wearable technologies present technical and ethical challenges, particularly concerning privacy, data analysis, and surveillance.\r\nIn Chile, wearable devices are increasingly used to monitor health variables, although detailed data on their adoption rates among the general population is limited. Studies indicate a growing interest in integrating these technologies into healthcare practices, suggesting potential widespread use in the near future.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Proyecto N\u00ba 3250704<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2025 - Diciembre 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6568\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt de Postdoctorado 2025\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6568\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6568\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Fondecyt de Postdoctorado 2025 Proyecto N\u00ba 3250704, Universidad de Chile y Universidad de O'Higgins - Implementaci\u00f3n de la investigaci\u00f3n 'Exploraci\u00f3n de las bases neuroanat\u00f3micas de la alteraci\u00f3n del insight en la enfermedad de Alzheimer' como Investigador Postdoctoral[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2025 - Diciembre 2029<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD (Alemania) Program \"Excellence in Higher Education for Development Cooperation - exceed\" for the period 2025-2029.<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6520\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            One Health \u0096 Training and Research Global Network (OH-TARGET) &#8211; 2nd. phase\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6520\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6520\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The One Health \u0096 Training and Research Global Network (OH-TARGET) aims to improve global health\r\nconditions through an integrated One Health approach, which recognizes the interconnectedness of human,\r\nanimal, and environmental health. This approach is crucial for addressing complex health challenges, as it\r\nfosters a comprehensive understanding and systemic collaborative effort across various sectors. Aligned with\r\nthe priorities of German development cooperation, OH-TARGET specifically addresses global pandemic\r\nresponse, climate protection, health and education, gender equality, and digitalization. Building on the\r\ninsights gained from the 2020-2024 Exceed funding period, OH-TARGET will focus on the consolidation and\r\nlong-term sustainability of its activities. The project will employ a holistic and participatory approach to\r\ndevelop context-specific solutions in education, training, and research. By fostering interdisciplinary\r\ncollaboration, OH-TARGET enhances research competence, promotes sustainable development, and\r\noptimizes the health of people, animals, and ecosystems. The One Health approach not only provides a\r\nframework for addressing immediate health challenges but also contributes to long-term resilience and\r\nsustainability in global health, ultimately aiming to create healthier communities worldwide.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Proyecto URO 21991<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2025 - Marzo 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6567\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Concurso de antecedentes de Agosto 2024 para optar a posiciones de Investigador\/a Postdoctoral en la Universidad de O&#8217;Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6567\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6567\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Implementaci\u00f3n de la investigaci\u00f3n 'Uso de inteligencia artificial para la exploraci\u00f3n de las bases neuroanat\u00f3micas del deterioro del insight en la enfermedad de Alzheimer' desde el cargo de Investigador Postdoctoral del Instituto de Ciencias de la Ingenier\u00eda de la Universidad de O\u0092Higgins.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2024 - Julio 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6469\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Estr\u00e9s y condiciones laborales en profesores de educaci\u00f3n media: Un enfoque multidisciplinario para el dise\u00f1o de pol\u00edticas p\u00fablicas en la Comuna de Rancagua\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6469\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6469\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El estr\u00e9s docente es un problema creciente en el sistema educativo chileno, con implicaciones significativas para la calidad de la ense\u00f1anza y el bienestar de los educadores. Este proyecto interdisciplinario aborda esta problem\u00e1tica en la educaci\u00f3n secundaria de la Comuna de Rancagua, utilizando un enfoque innovador desde un planteamiento de estudio mixto cuanti-cualitativo. El estudio se centra en la comprensi\u00f3n integral del estr\u00e9s docente, considerando que las transformaciones recientes en el sistema educativo chileno han aumentado las exigencias sobre los profesores. Factores como la mercantilizaci\u00f3n de la educaci\u00f3n, la presi\u00f3n por resultados en pruebas estandarizadas, las condiciones laborales precarias contribuyen a niveles elevados de estr\u00e9s, afectando la calidad educativa y el bienestar docente. A ello se suman presiones administrativas y exigencias que generan agobio laboral (burnout), estr\u00e9s y que se han relacionado con un aumento de la tasa de abandono laboral en el sistema educacional chileno.   \r\n\r\nEl objetivo general del proyecto es analizar la relaci\u00f3n entre marcadores biol\u00f3gicos, psicol\u00f3gicos y las percepciones subjetivas que explican el origen del estr\u00e9s asociado al trabajo docente de profesores de educaci\u00f3n media de la Comuna de Rancagua, con el fin de desarrollar un modelo comprensivo que permita el dise\u00f1o de pol\u00edticas p\u00fablicas orientadas a mejorar las condiciones laborales y el bienestar en este sector educativo. Los objetivos espec\u00edficos incluyen: 1) determinar la prevalencia y severidad del estr\u00e9s en profesores mediante medidas fisiol\u00f3gicas y psicol\u00f3gicas; 2) analizar las principales fuentes de estr\u00e9s percibido por los profesores; 3) correlacionar variables fisiol\u00f3gicas, psicol\u00f3gicas y sociales para desarrollar un modelo te\u00f3rico integrado; y 4) generar recomendaciones basadas en evidencia para el dise\u00f1o de intervenciones y pol\u00edticas p\u00fablicas. \r\n\r\nLa metodolog\u00eda del estudio emplea un dise\u00f1o mixto de corte transversal, con una muestra de 100 profesores de educaci\u00f3n media de Rancagua. Se utilizar\u00e1 un muestreo estratificado proporcional considerando caracter\u00edsticas socioecon\u00f3micas del colegio, tipo de financiamiento, proyecto educativo, y otros factores relevantes. La innovaci\u00f3n metodol\u00f3gica clave es la medici\u00f3n de cortisol en u\u00f1as como biomarcador de estr\u00e9s cr\u00f3nico, ofreciendo ventajas significativas sobre m\u00e9todos tradicionales como el an\u00e1lisis de pelo. Esta t\u00e9cnica proporciona una medida menos invasiva, m\u00e1s accesible y potencialmente m\u00e1s estable del estr\u00e9s a largo plazo. Adem\u00e1s de la medici\u00f3n de cortisol, el estudio incluir\u00e1 evaluaciones psicol\u00f3gicas utilizando instrumentos validados como la Escala de Estr\u00e9s Percibido (PSS-14), DAAS-21 para depresi\u00f3n y ansiedad, y el Inventario de Burnout de Maslach (MBI-ES). Se realizar\u00e1n entrevistas en profundidad con 40 profesores para comprender las fuentes de estr\u00e9s y el contexto laboral. El an\u00e1lisis de datos incluir\u00e1 modelos de regresi\u00f3n multilineal y an\u00e1lisis de componentes principales para correlacionar las variables fisiol\u00f3gicas, psicol\u00f3gicas y sociales. \r\n\r\nEl proyecto se destaca por su enfoque interdisciplinario, integrando experticias en neurociencias, psicolog\u00eda, pol\u00edticas educativas y metodolog\u00eda cualitativa. El equipo de investigaci\u00f3n incluye al Dr. Gonzalo Terreros, la Dra. Camila Oda, la Dra. Ngaire Honey, el Dr. Felipe Mu\u00f1oz y la Dra(c). Cecilia Cort\u00e9s Rojas. Esta colaboraci\u00f3n permite un an\u00e1lisis hol\u00edstico del fen\u00f3meno del estr\u00e9s docente, desde su manifestaci\u00f3n biol\u00f3gica hasta sus implicaciones en las pol\u00edticas educativas.Se espera que los resultados de este estudio proporcionen hallazgos valiosos para el dise\u00f1o de intervenciones y pol\u00edticas que aborden efectivamente el estr\u00e9s docente.  \r\n\r\nEl proyecto tiene el potencial de influir significativamente en la formulaci\u00f3n de pol\u00edticas educativas, mejorando las condiciones laborales de los docentes y fortaleciendo el sistema educativo chileno en su conjunto. La implementaci\u00f3n pionera de la medici\u00f3n de cortisol en u\u00f1as posiciona este estudio a la vanguardia de la investigaci\u00f3n sobre estr\u00e9s docente, ofreciendo una nueva perspectiva sobre este importante problema educativo. \r\n\r\nAdem\u00e1s de su contribuci\u00f3n al conocimiento cient\u00edfico, este estudio tiene implicaciones pr\u00e1cticas directas para la mejora de la calidad educativa en Chile. Los resultados podr\u00edan informar el dise\u00f1o de programas de prevenci\u00f3n y manejo del estr\u00e9s para docentes, as\u00ed como reformas en las pol\u00edticas educativas que aborden las causas estructurales del estr\u00e9s en el sistema escolar. El proyecto tambi\u00e9n contribuye a la formaci\u00f3n de nuevos investigadores, incluyendo estudiantes de pregrado que participar\u00e1n en diversas etapas de la investigaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6486\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Determinaci\u00f3n de micotoxinas estrog\u00e9nicas en mujeres con s\u00edndrome de ovario poliqu\u00edstico y su impacto a nivel hep\u00e1tico en un modelo celular\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6486\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6486\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Las micotoxinas son metabolitos producidos por algunos hongos del tipo Aspergillus, Penicillum o Fusarium, contaminantes habituales de alimentos que necesitan secado como granos, frutos secos y condimentos. Las micotoxinas son extremadamente t\u00f3xicas y afectan tanto a animales como humanos; las de mayor significancia son la ocratoxina A, aflatoxina, fumonisina, tricotecenos y zearalenona. En t\u00e9rminos generales, las micotoxinas al ser ingeridas son absorbidas en el tracto gastrointestinal, metabolizadas en el h\u00edgado a trav\u00e9s de reacciones de Fase I (oxidaci\u00f3n) y Fase II (conjugaci\u00f3n), y finalmente excretadas por orina y heces. El principal \u00f3rgano afectado por la exposici\u00f3n a micotoxinas es el h\u00edgado, \u00f3rgano central del metabolismo, incrementando el tama\u00f1o hep\u00e1tico, el estr\u00e9s oxidativo y modificando los niveles de lisofosfatidilcolina, que puede aumentar la apoptosis a trav\u00e9s de la producci\u00f3n de especies reactivas de ox\u00edgeno.  Adem\u00e1s, se ha descrito que algunas de las micotoxinas pueden tener efectos endocrinos, principalmente de tipo estrog\u00e9nico. La zearalenona (ZEN) es una de las micotoxinas m\u00e1s importantes producidas por Fusarium spp. Los hongos del tipo Fusarium son uno de los m\u00e1s frecuentes encontrados en Chile, y se ve aumentada en condiciones de estr\u00e9s h\u00eddrico. La ZEN es termoestable y no se degrada por el procesamiento. La ZEN es una fusariotoxina estrog\u00e9nica, es decir se clasifica como un fitoestr\u00f3geno o como un micoestr\u00f3geno, ya que su estructura qu\u00edmica es an\u00e1loga a la de los estr\u00f3genos naturales. Esto permite su uni\u00f3n con los sitios receptores estrog\u00e9nicos, lo que conduce a una estrogenicidad amplificada. Como resultado, la intoxicaci\u00f3n por ZEN conduce con mayor frecuencia a disrupci\u00f3n endocrina y trastornos del sistema reproductivo. Los metabolitos hep\u00e1ticos pueden tener aun mayor afinidad con los receptores estrog\u00e9nicos; por ejemplo, el alfa-zearalenol (&#945;-ZEL) es 60 veces m\u00e1s estrog\u00e9nico que ZEN. Si bien en Chile se han realizado estudios de biomonitoreo de micotoxinas, no existe en la actualidad informaci\u00f3n sobre la exposici\u00f3n a ZEN y sus metabolitos especialmente en mujeres y sus posibles efectos como disruptores hormonales.\r\n\r\nEn este contexto, existe una condici\u00f3n endocrinometab\u00f3lica muy prevalente en la poblaci\u00f3n chilena denominada \u0093S\u00edndrome de ovario poliqu\u00edstico\u0094 (SOP), la cual se caracteriza por la presencia de un exceso de hormonas andr\u00f3genicas, irregularidad menstrual y morfolog\u00eda de ovarios poliqu\u00edsticos. Adem\u00e1s, las mujeres con SOP poseen un mayor riesgo de desarrollar alteraciones metab\u00f3licas como resistencia a la insulina, diabetes tipo 2, s\u00edndrome metab\u00f3lico y enfermedad cardiovascular, impactando su calidad de vida. El estudio de la fisiopatolog\u00eda del SOP es desafiante ya que es una condici\u00f3n muy heterog\u00e9nea, sin embargo, se ha descrito que el hiperandrogenismo, la disfunci\u00f3n ovulatoria, alteraciones en la pulsatilidad de la hormona liberadora de gonadotrofinas (GnRH) y la resistencia a la insulina, tienen un rol clave en el desarrollo de esta condici\u00f3n. Por otra parte, el exceso de andr\u00f3genos incrementa los niveles de insulina y reduce la producci\u00f3n de la globulina transportadora de hormonas sexuales (SHBG) en el h\u00edgado, lo que aumenta la circulaci\u00f3n de testosterona bioactiva libre. Adem\u00e1s, la hiperinsulinemia estimula la s\u00edntesis de andr\u00f3genos activando la v\u00eda de la esteroidog\u00e9nesis e incrementa estados de inflamaci\u00f3n y estr\u00e9s oxidativo, debido a la disfunci\u00f3n mitocondrial, promoviendo el desarrollo de un c\u00edrculo vicioso.  Sin embargo, la contribuci\u00f3n individual de estos factores puede variar entre las pacientes, dando cuenta de la heterogeneidad cl\u00ednica que se observa en la cl\u00ednica. Aunque en su etiolog\u00eda se han implicado factores gen\u00e9ticos y de estilo de vida, cada vez hay m\u00e1s pruebas de que la exposici\u00f3n a contaminantes ambientales, incluyendo los disruptores endocrinos, tambi\u00e9n pueden contribuir significativamente al desarrollo y la fisiopatolog\u00eda del SOP. En este contexto, el rol de las micotoxinas como disruptores endocrinos no ha sido estudiado extensamente en el contexto del SOP, y debido a posibles efectos acumulativos e interacciones sin\u00e9rgicas entre estos contaminantes, se requiere evaluar su potencial impacto en la fisiopatolog\u00eda del SOP. En particular, se ha considerado que las micotoxinas con actividad estrog\u00e9nica, como la zearalenona, podr\u00edan influir en el equilibrio hormonal de las mujeres y potencialmente contribuir al desarrollo o exacerbaci\u00f3n del SOP. De esta manera, el objetivo general de esta propuesta es evaluar los niveles circulantes de ZEN y sus metabolitos como posibles factores de riesgo dietarios, y determinar su posible asociaci\u00f3n con alteraciones endocrinometab\u00f3licas en mujeres chilenas con SOP. Este objetivo ser\u00e1 abordado mediante un estudio cl\u00ednico en mujeres chilenas y un estudio in vitro. \r\n\r\nLa investigaci\u00f3n propuesta aportar\u00e1 informaci\u00f3n valiosa y novedosa sobre c\u00f3mo factores dietarios contribuyen al desarrollo y severidad del SOP, abriendo nuevas v\u00edas para la comprensi\u00f3n y manejo de esta condici\u00f3n. Finalmente, esta propuesta se enmarca dentro del objetivo de vincular el ICA3 y el Instituto de Ciencias de la Salud, contribuyendo al objetivo estrat\u00e9gico de la Universidad de consolidar los Institutos de Investigaci\u00f3n mediante la colaboraci\u00f3n estrecha e interdisciplinaria. M\u00e1s a\u00fan, el estudio aportar\u00e1 con formaci\u00f3n de estudiantes de ambos institutos, la divulgaci\u00f3n y difusi\u00f3n de los resultados del proyecto.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6375\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            A Biopsychosocial Approach for Frailty Intervention: Uncovering a Circulating microRNA Biomarker Panel Using an Omics-Based Machine Learning Approach\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6375\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6375\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Frailty is increasingly becoming an important public health challenge worldwide because it is associated with older age, and with adverse outcomes such as reduced quality of life, increased mortality rates, hospitalizations, falls, depression, and dementia. Frailty is defined as dynamic state affecting an individual who experiences losses in one or more domains of human functioning (physical, psychological, social) that are caused by the influence of a range of variables, and which increases the risk of adverse outcomes. This more integral conceptual definition promotes the collaboration of scientists, social and behavioral professionals as well as clinicians from diverse specialties. In this proposal an interdisciplinary group (Biochemistry, Geriatric, Occupational Therapist, Kinesiologist, social worker, bioengineer, statistician among others) aims to evaluate frailty in Chile with a biopsychosocial approach with the final purpose to identify and manage frailty while taking into consideration all the dimensions. Additionally, we aim to design a multidomain personalized person-base intervention for a healthy aging that can uncover a circulating microRNA biomarker panel that can allow an early-detection of frailty, leading to a new multidimensional geriatric assessment. We propose the following hypothesis:  A personalized multidimensional training program reduces the frailty prevalence, increasing adherence and participation in the program among community-living older adults. This intervention will be paralleled by a distinctive miRNA profile reflecting the multiple domains of frailty, as well as improvements in diverse psychosocial traits.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6401\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            A Biopsychosocial Approach for Frailty Intervention: Uncovering a Circulating microRNA Biomarker Panel Using an Omics-Based Machine Learning Approach\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6401\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6401\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Frailty is increasingly becoming an important public health challenge worldwide because it is associated with older age, and with adverse outcomes such as reduced quality of life, increased mortality rates, hospitalizations, falls, depression, and dementia. Frailty is defined as dynamic state affecting an individual who experiences losses in one or more domains of human functioning (physical, psychological, social) that are caused by the influence of a range of variables, and which increases the risk of adverse outcomes. This more integral conceptual definition promotes the collaboration of scientists, social and behavioral professionals as well as clinicians from diverse specialties. In this proposal an interdisciplinary group (Biochemistry, Geriatric, Occupational Therapist, Kinesiologist, social worker, bioengineer, statistician among others) aims to evaluate frailty in Chile with a biopsychosocial approach with the final purpose to identify and manage frailty while taking into consideration all the dimensions. Additionally, we aim to design a multidomain personalized person-base intervention for a healthy aging that can uncover a circulating microRNA biomarker panel that can allow an early-detection of frailty, leading to a new multidimensional geriatric assessment. We propose the following hypothesis:  A personalized multidimensional training program reduces the frailty prevalence, increasing adherence and participation in the program among community-living older adults. This intervention will be paralleled by a distinctive miRNA profile reflecting the multiple domains of frailty, as well as improvements in diverse psychosocial traits.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6432\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            A Biopsychosocial Approach for Frailty Intervention: Uncovering a Circulating microRNA Biomarker Panel Using an Omics-Based Machine Learning Approach\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6432\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6432\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Frailty is increasingly becoming an important public health challenge worldwide because it is associated with older age, and with adverse outcomes such as reduced quality of life, increased mortality rates, hospitalizations, falls, depression, and dementia. Frailty is defined as dynamic state affecting an individual who experiences losses in one or more domains of human functioning (physical, psychological, social) that are caused by the influence of a range of variables, and which increases the risk of adverse outcomes. This more integral conceptual definition promotes the collaboration of scientists, social and behavioral professionals as well as clinicians from diverse specialties. In this proposal an interdisciplinary group (Biochemistry, Geriatric, Occupational Therapist, Kinesiologist, social worker, bioengineer, statistician among others) aims to evaluate frailty in Chile with a biopsychosocial approach with the final purpose to identify and manage frailty while taking into consideration all the dimensions. Additionally, we aim to design a multidomain personalized person-base intervention for a healthy aging that can uncover a circulating microRNA biomarker panel that can allow an early-detection of frailty, leading to a new multidimensional geriatric assessment. We propose the following hypothesis:  A personalized multidimensional training program reduces the frailty prevalence, increasing adherence and participation in the program among community-living older adults. This intervention will be paralleled by a distinctive miRNA profile reflecting the multiple domains of frailty, as well as improvements in diverse psychosocial traits.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1241626<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6451\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            EPIGENOMIC PROGRAMMING IN THE EARLY FETAL BLOOD-BRAIN BARRIER BY GESTATIONAL  HYPOXIA: CONSEQUENCES FOR THE NEURO-ENDOTHELIAL LIFESPAN.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6451\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6451\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]EPIGENOMIC PROGRAMMING IN THE EARLY FETAL BLOOD-BRAIN BARRIER BY GESTATIONAL \r\nHYPOXIA: CONSEQUENCES FOR THE NEURO-ENDOTHELIAL LIFESPAN.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1241626<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6474\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            EPIGENOMIC PROGRAMMING IN THE EARLY FETAL BLOOD-BRAIN BARRIER BY GESTATIONAL HYPOXIA: CONSEQUENCES FOR THE NEURO-ENDOTHELIAL LIFESPAN\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6474\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6474\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The proposal focuses on understanding the neuro-vascular aging mechanisms associated with alterations in fetal growth by intrauterine hypoxia using molecular biology and physiology as an area. \r\nThe aim of the study is to demonstrate that impaired fetal growth conditions are associated with epigenetic programming of aging-related DNA methylation, chromatin remodeling, and miRNA-omic profile of junctional complex genes in the neuroendothelium, which can alter BBB integrity and permeability, increasing cerebral damage which impacts the juvenile and adulthood neurocognitive function.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Diciembre 2028<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>SeCyT<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6519\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Los procesos de ense\u00f1anza, integraci\u00f3n curricular, evaluaci\u00f3n y acreditaci\u00f3n en salud en grado y posgrado y su vinculaci\u00f3n con la trayectoria acad\u00e9mica y actividad docente\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6519\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6519\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Analizar los procesos de ense\u00f1anza, integraci\u00f3n curricular, evaluaci\u00f3n y acreditaci\u00f3n en carreras del \u00e1rea de salud en grado y posgrado y su relaci\u00f3n con la trayectoria acad\u00e9mica de los estudiantes y la actividad docente en Argentina y Chile.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Patrocinante<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2024 - Diciembre 2028<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>SeCyT<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6557\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Los procesos de ense\u00f1anza, integraci\u00f3n curricular, evaluaci\u00f3n y acreditaci\u00f3n en salud en grado y posgrado y su vinculaci\u00f3n con la trayectoria acad\u00e9mica y actividad docente\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6557\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6557\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Analizar los procesos de ense\u00f1anza, integraci\u00f3n curricular, evaluaci\u00f3n y acreditaci\u00f3n en carreras del \u00e1rea de salud en grado y posgrado y su relaci\u00f3n con la trayectoria acad\u00e9mica de los estudiantes y la actividad docente en Argentina y Chile.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 11240017<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6472\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Role of cholesterol in brain vascular development of mouse embryos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6472\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6472\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The brain is an energy intensive organ that requires a robust supply of nutrients and oxygen. The vasculature irrigating the brain is a huge and complex network of blood vessels fulfilling this requirement, while also protecting the neural tissue from blood-borne toxic substances. This regulated nutrient supply is accomplished by the formation of a highly selective molecular barrier, termed the blood-brain barrier (BBB). Dysfunction of the BBB or malformations of the vascular network are associated with pathological conditions that impair brain function, and can lead to death. Thus, appropriate morphogenesis and establishment of the brain vasculature is necessary for a healthy life. \r\nThe brain vasculature forms during intrauterine development, matching brain growth in this same period. Anatomically, blood vessels grow first surrounding the brain primordium and then penetrate the parenchyma until they vascularize the periventricular zone. The molecular regulation of this patterned growth is not completely understood. Several signaling pathways are known to be involved in brain angiogenesis, including WNT, TGF-&#946;, Hh, and NOTCH, which differentially regulate vascular growth. Recently, cholesterol has been shown to modulate angiogenic growth in other vascular beds by regulating the activity of the NOTCH pathway, suggesting that cholesterol levels could influence developmental angiogenesis in the brain. Interestingly, cholesterol is also required for signal transduction of the Hh pathway. In preliminary in vitro experiments, we have observed that brain endothelial cells activate an angiogenic program after cholesterol depletion. Here, we will extend those studies to in vivo models to determine the role of cholesterol in developmental brain angiogenesis. We propose that an increase in vascular cell cholesterol activates NOTCH and attenuates Hh signaling pathways, restricting sprouting angiogenesis and blood-brain barrier formation in mouse embryo brain vasculature. \r\nTo test this hypothesis, we will study mouse embryos with altered cholesterol levels by dietary, pharmacological, and genetic manipulations. We expect these manipulations to induce a reduction or an increase in cholesterol levels in the brain vasculature during embryonic development, which we will evaluate by measuring cholesterol content in isolated vascular fragments. \r\nIn all these models, we will (Specific aim 1) study vascularization in the brain during intrauterine development using immunofluorescence with specific antibodies against endothelium proteins. In addition, we will measure the levels of transcript and proteins of general key regulators of angiogenesis in isolated vascular fragments, using qPCR and Western blot. We will (Specific aim 2) also evaluate the state of the BBB in the brain vasculature of these models at a fetal stage when the barrier is already formed and functional. For this, we will use immunofluorescence to detect the presence of marker proteins of the BBB in vascular fragments, and we will measure their levels by Western blot. Further, we will test the functionality of the barrier by injecting a fluorescent tracer and evaluating its extravasation in the brain. Finally, we will (Specific aim 3) determine the activation of the NOTCH and Hh pathways in the brain vasculature of the models at the stage of maximal angiogenesis. We will use qPCR and Western blot to measure the levels of marker genes and proteins for these two pathways in vascular fragments, and Proximity Ligation In Situ Hybridization in tissue sections to evaluate the transcript levels of those markers in situ. \r\nWe expect that the different models of dietary, pharmacological, and genetic interventions will increase or reduce cholesterol levels in the brain vasculature. These changes are expected to correlate with opposing effects on angiogenesis in the brain during development (i.e. low cholesterol will increase angiogenesis, while high cholesterol will inhibit it). In the same way, we expect that distinct cholesterol levels will have opposing effects on the integrity of the BBB. These changes in angiogenesis and BBB function are expected to be associated with concomitant disruption of the NOTCH and Hh pathways.\r\nIn summary, in this proposal we aim to cover a knowledge gap regarding the role of cholesterol in the regulation of developmental angiogenesis in the brain. These experiments may uncover new mechanisms driving vascular growth and barrier establishment in the brain, which could lead to new strategies for the prevention and treatment of pathologies involving the brain vasculature.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FONDECYT REGULAR 1241502<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6402\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fetal Programming of cardiovascular accelerated dysfunction and aging by intrauterine hypoxia\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6402\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6402\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Non-communicable diseases (NCDs) are responsible for 74% of worldwide human deaths, with cardiovascular\r\ncauses in the first place (1). NCDs are determined by a combination of environmental, genetic and epigenetic\r\nfactors. In fact, adverse intrauterine conditions, such as reduced oxygen availability (hypoxia) and oxidative\r\nstress, can increase the risk of developing diseases during life, a phenomenon known as Fetal Programming\r\nor Developmental Origins of Health and Disease (DOHaD). Intrauterine hypoxia (IUH) affects most of the\r\npregnancies in high altitudes populations (> 2500m) (2-4) and 3-4% in lowlands, with uteroplacental and\r\ndevelopmental complications (4,5). We, and a couple of others, have recently shown that IUH determines\r\ncardiovascular oxidative stress during lifespan affecting endothelial function and vasodilator capacity, similar\r\nto what is seen with aging. The hypoxia-induced responses during development are responsible for\r\nfetal survival, but also determine mechanisms that program postnatal cardiovascular function\r\nthat may increase cardiovascular health risks and accelerate aging (6). This proposal aims to\r\ndetermine the mechanisms and trace the origins and outcomes of cardiovascular dysfunction resulting from\r\nintrauterine hypoxia and oxidative stress, and further identify the interrelated senescence mechanisms in\r\nthe heart and blood vessels. To assess the aforementioned, we will study the effects of IUH on cardiovascular\r\naging along lifespan, as important regulators of the function, structure and biomechanical properties of the\r\ncardiovascular system.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FONDECYT REGULAR 1241502<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6433\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fetal Programming of cardiovascular accelerated dysfunction and aging by intrauterine hypoxia\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6433\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6433\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Non-communicable diseases (NCDs) are responsible for 74% of worldwide human deaths, with cardiovascular\r\ncauses in the first place (1). NCDs are determined by a combination of environmental, genetic and epigenetic\r\nfactors. In fact, adverse intrauterine conditions, such as reduced oxygen availability (hypoxia) and oxidative\r\nstress, can increase the risk of developing diseases during life, a phenomenon known as Fetal Programming\r\nor Developmental Origins of Health and Disease (DOHaD). Intrauterine hypoxia (IUH) affects most of the\r\npregnancies in high altitudes populations (> 2500m) (2-4) and 3-4% in lowlands, with uteroplacental and\r\ndevelopmental complications (4,5). We, and a couple of others, have recently shown that IUH determines\r\ncardiovascular oxidative stress during lifespan affecting endothelial function and vasodilator capacity, similar\r\nto what is seen with aging. The hypoxia-induced responses during development are responsible for\r\nfetal survival, but also determine mechanisms that program postnatal cardiovascular function\r\nthat may increase cardiovascular health risks and accelerate aging (6). This proposal aims to\r\ndetermine the mechanisms and trace the origins and outcomes of cardiovascular dysfunction resulting from\r\nintrauterine hypoxia and oxidative stress, and further identify the interrelated senescence mechanisms in\r\nthe heart and blood vessels. To assess the aforementioned, we will study the effects of IUH on cardiovascular\r\naging along lifespan, as important regulators of the function, structure and biomechanical properties of the\r\ncardiovascular system.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FONDECYT REGULAR 1241502<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2024 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6450\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fetal Programming of cardiovascular accelerated dysfunction and aging by intrauterine hypoxia\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6450\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6450\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Non-communicable diseases (NCDs) are responsible for 74% of worldwide human deaths, with cardiovascular\r\ncauses in the first place (1). NCDs are determined by a combination of environmental, genetic and epigenetic\r\nfactors. In fact, adverse intrauterine conditions, such as reduced oxygen availability (hypoxia) and oxidative\r\nstress, can increase the risk of developing diseases during life, a phenomenon known as Fetal Programming\r\nor Developmental Origins of Health and Disease (DOHaD). Intrauterine hypoxia (IUH) affects most of the\r\npregnancies in high altitudes populations (> 2500m) (2-4) and 3-4% in lowlands, with uteroplacental and\r\ndevelopmental complications (4,5). We, and a couple of others, have recently shown that IUH determines\r\ncardiovascular oxidative stress during lifespan affecting endothelial function and vasodilator capacity, similar\r\nto what is seen with aging. The hypoxia-induced responses during development are responsible for\r\nfetal survival, but also determine mechanisms that program postnatal cardiovascular function\r\nthat may increase cardiovascular health risks and accelerate aging (6). This proposal aims to\r\ndetermine the mechanisms and trace the origins and outcomes of cardiovascular dysfunction resulting from\r\nintrauterine hypoxia and oxidative stress, and further identify the interrelated senescence mechanisms in\r\nthe heart and blood vessels. To assess the aforementioned, we will study the effects of IUH on cardiovascular\r\naging along lifespan, as important regulators of the function, structure and biomechanical properties of the\r\ncardiovascular system.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6448\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Epigenomic programming in the early fetal blood-brain barrier by gestational hypoxia: consequences for the neuro-endothelial lifespan.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6448\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6448\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The quality of fetal and early post-natal environment influences lifelong health and predicts the risk for a range of non-communicable chronic diseases (NCDs). These observations form the basis of the \"Developmental Origins of Health and Disease\" (DOHaD hypothesis), which indicates that the intrauterine signals that compromise fetal growth also act to \"program\" tissue differentiation in a manner that predisposes later illnesses. Interestingly, the DOHaD hypothesis asserts that some aging-associated diseases that occur in adults are closely related to the development and conditions in the intrauterine environment. Thus, aging and aging-associated diseases can be viewed, at least in part, as the result of a developmental program activated early in embryogenesis and persists throughout the organism's lifespan. On the other hand, one of the main consequences of this programming is Fetal Growth Restriction (FGR) and which remains a leading\r\ncause of perinatal morbidity and mortality, affecting about 10% of pregnancies, but the incidence is reportedly sixfold greater in low-income countries depending on the region surveyed's nutrition and health access availability. FGR is clinically defined as a fetal weight below the 10th percentile of normal for gestational age, associated with some loss of fetal-placental blood flow diagnosed by ultrasound, and it is a condition in which the potential growth of the fetus is negatively influenced by environmental and maternal factor; the short-term consequences of FGR are low birth weight (LBW) and the corresponding phenotype, which is associated with increased perinatal morbidity and mortality. Besides, the long-term effects include\r\na 2 to 3-fold increase in the risk of developing cerebrovascular disease in adulthood. Indeed, many neurodevelopmental dysfunctions originated in the antenatal period, but few studies have focused on how growth restriction interferes with normal brain development of the blood-brain barrier (BBB) in the FGR neonate. The BBB is a cellular network formed by a monolayer of neuro-endothelial and mural cells. The BBB regulates the transport of molecules into and out of the central nervous system (CNS) (selective permeability and integrity of the BBB). In cerebrovascular aging, BBB breakdown and dysfunction lead to leakages of components into the central nervous system (CNS), contributing to neurological deficits; growing evidence from genomic data shows that FGR vascular dysfunction is mediated by aging, with a series of prominent\r\nhallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling, and non-coding RNA (ncRNA) regulation; however, how this mechanism regulates the aging process and contributes to aging-related BBB dysfunction remains elusive. We hypothesize that the impaired fetal growth conditions associated with epigenetic programming of aging-related DNA methylation, chromatin remodeling, and miRNA-omic profile of complex junctional genes in the neuro-endothelium, which can alter BBB integrity and permeability, increasing cerebral damage which impacts the perinatal and adulthood neurocognitive function.\r\nThis hypothesis will be addressed by the study of the effects of gestational chronic hypoxia on the aging epigenetic programming of gene expression of junctional complexes: Tight junction, adherens junction, and Gap junction family\u0092s molecules, as important regulators of the permeability para and transcellular of the BBB. For this, we will use a well-established Guinea pig model of cerebrovascular programming (DOHaD model) to demonstrate DNA methylation shift, chromatin remodeling, miRNA-omic profile, and transcriptomic analyses in neuro-endothelial cells isolated from cortex and hippocampus from animals gestated under hypobaric hypoxia at two stages of life (juvenile period and adulthood). The methodology for this project is an in vivo assess locomotor, exploratory activity, and memory acquisition evaluation, and in vitro determinations of epigenetic regulation of aging in BBB from the cortex, hypothalamus, and neuro- endothelial cell culture primary at different stages of life in animals gestated under hypoxia. Our expected outcome is to improve the knowledge about neuro-endothelial epigenetic programming by aging induced by the FGR and enhance the characterization of those epigenomic patterns and mechanisms associated with BBB breakdown by intrauterine hypoxia. This project aims to demonstrate that the effect of gestational hypoxia can accelerate the permeability of the BBB by epigenetic mechanisms not yet studied and that these changes continue throughout life, producing further deterioration of brain function[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2024 - Diciembre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6379\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            An\u00e1lisis multi\u00f3mico de redes reguladoras post-transcripcionales microARN- ARNm en el m\u00fasculo esquel\u00e9tico humano envejecido.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6379\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6379\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Durante las \u00faltimas d\u00e9cadas, la expectativa de vida promedio ha aumentado dram\u00e1ticamente, mientras\r\nque la salud no ha aumentado proporcionalmente. Para Chile se espera que para el 2050 el n\u00famero de\r\nadultos mayores superar\u00e1 el 30% de la poblaci\u00f3n con un incremento del 109% respecto al 2015,\r\nsuperando el 75% proyectado para la poblaci\u00f3n mundial. Entender el proceso de envejecimeinto y\r\nencontrar marcadores biol\u00f3gicos con capacidad diagn\u00f3stica y pron\u00f3stica, permitir\u00e1 promover estrategias\r\npara aumentar el n\u00famero de a\u00f1os de vida saludable, disminuyendo los gastos en salud asociado al\r\nenvejecimiento.\r\nVarios estudios han permitido avanzar y entender los mecanismos moleculares de p\u00e9rdidad de funci\u00f3n\r\nmuscular durante el evenjecimiento, m\u00e1s conocida como sarcopenia. Sin embargo, la complejidad del\r\nproceso y el insuficiente conocimiento de los mecanismos subjacentes dificultan el dise\u00f1o de estrategias\r\nterap\u00e9uticas eficaces. Hasta el momento, la actividad f\u00edsica y el ejercicio siguen siendo la estrategia m\u00e1s\r\neficaz para previnir y tratar la sarcopenia. Por lo cual, identificar nuevos biomarcadores musculares en\r\ncombinaci\u00f3n con marcadores cl\u00ednicos bien establecidos de par\u00e1metros f\u00edsicos y funcionales, fortalecer\u00eda\r\nla actual evaluaci\u00f3n geri\u00e1trica, al utilizar un enfoque interdiciplinario.\r\nLos microRNA (miRNA, 18\u009625 nt de largo) han ganado inter\u00e9s debido a que son mol\u00e9culas altamente\r\nconservadas en todas las especies, y act\u00faan como reguladores positivos y\/o negativos de la expresi\u00f3n\r\ng\u00e9nica. Entender la relaci\u00f3n reguladora directa entre los miARN y el ARN mensajero (mRNA) desempe\u00f1a\r\nen el m\u00fasculo esquel\u00e9tica es fundamentaltanto para el proceso de transcripci\u00f3n del ARNm y traducci\u00f3n\r\nde prote\u00ednas como para entender el deterioro de la funci\u00f3n muscular. Sin embargo, la regulaci\u00f3n de la\r\nred post-transcripcional miARN-ARNm y los mecanismos gen\u00e9ticos involucrados en el proceso de\r\nenvejecimiento del m\u00fasculo esquel\u00e9tico humano est\u00e1n lejos de ser elucidados.\r\nEn el presente estudio, nuestro objetivo es explorar e integrar coperfiles emparejados de miARN y ARNm\r\ndurante la p\u00e9rdida de funci\u00f3n muscular producidad durante el envejecimeinto en personas mayores. Este\r\nan\u00e1lisis integral permitir\u00e1 la identificaci\u00f3n de nuevos blancos de miARN y estrategias reguladoras que\r\ncontrolan la expresi\u00f3n g\u00e9nica en la p\u00e9rdidad de funci\u00f3n del m\u00fasculo esquel\u00e9tico y c\u00f3mo \u00e9stas son\r\nmodificadas por el entrenamiento de fuerza.\r\nSe hipotetiza que existen redes de regulaci\u00f3n post-transcripcional miRNA\/mRNA que se expresan de\r\nmanera diferencial en el m\u00fasculo esquel\u00e9tico de personas j\u00f3venes y personas mayores, que estar\u00edan\r\nasociadas con cambios en la funci\u00f3n muscular durante el envejecimiento. Adem\u00e1s, el entrenamiento de\r\nfuerza modifica estas redes de regulaci\u00f3n, lo que podr\u00eda contribuir a la mejora de la funci\u00f3n muscular y la\r\nprevenci\u00f3n o atenuaci\u00f3n de la sarcopenia.\r\nObjetivos generales\r\n- Identificar las redes de regulaci\u00f3n post-transcripcional miRNA\/mRNA involucradas en la\r\np\u00e9rdida de funci\u00f3n musclular en personas mayores que son moduladas por un entrenamiento\r\nde fuerza, para proponer nuevos biomarcadores de funci\u00f3n muscular durante el\r\nenvejecimeinto que se correlacionan con par\u00e1metros cl\u00ednicos\/funcionales.\r\nObjetivos espec\u00edficos\r\n1. Determinar las redes de regulaci\u00f3n post-transcripcional miRNA\/mRNA que se expresan\r\ndiferencialmente en el m\u00fasculo esquel\u00e9tico de personas j\u00f3venes y personas mayores.\r\n2. Identificar las redes de regulaci\u00f3n post-transcripcional miRNA\/mRNA que se modifican\r\ndespu\u00e9s de 12 semanas de entrenamiento de fuerza en personas mayores\r\n3. Correlacionar las redes miRNA\/mRNA identificadas con par\u00e1metros bioqu\u00edmicos, f\u00edsicos y\r\nfuncionales de funci\u00f3n muscular, antes y despu\u00e9s de 12 semanas de entrenamiento de\r\nfuerza en personas mayores\r\nEste proyecto busca Identificar nuevos biomarcadores de funci\u00f3n muscular durante el envejecimiento,\r\npodr\u00edan ser utilizados en futuros estudios y en la pr\u00e1ctica cl\u00ednica para evaluar la salud muscular en\r\npersonas mayores. Adem\u00e1s, de contribuir a una mejor comprensi\u00f3n de los mecanismos moleculares que\r\nsubyacen a la p\u00e9rdida de masa muscular en el envejecimiento y c\u00f3mo la intervenci\u00f3n del entrenamiento\r\nde fuerza puede modificar esos mecanismos. Finalmente, el uso de tecnolog\u00edas avanzadas de\r\nsecuenciaci\u00f3n (mARN y miARN) y bioinform\u00e1tica permitir\u00e1 impulsar el desarrollo y la mejora de t\u00e9cnicas\r\nde secuenciaci\u00f3n y an\u00e1lisis de datos en el campo de la gen\u00f3mica y la transcript\u00f3mica en el \u00e1rea del\r\nenvejecimiento, como tambi\u00e9n, promover la colaboraci\u00f3n a nivel nacional e internacional a trav\u00e9s de las\r\nbases de datos y recursos bioinform\u00e1ticos generados que estar\u00e1n a disposici\u00f3n de investigadores del \u00e1rea.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 955576 - Resoluci\u00f3n: 5461-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6517\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6517\" aria-expanded=\"false\" aria-controls=\"collapse-6517\">\n                                            Programa de Participaci\u00f3n Inclusiva Territorial 2023 en la Macrozona Austral. Desarrollo de herramientas para la implementaci\u00f3n.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6517\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6517\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de transferencia Programa Participaci\u00f3n Inclusiva Territorial, a\u00f1o 2023, entre Servicio Nacional de la Discapacidad y Universidad de O\u0092Higgins. \"Programa de participaci\u00f3n inclusiva en la Macrozona Austral: desarrollo de herramientas para la implementaci\u00f3n\". El presente proyecto tiene el objetivo de fortalecer el proceso de inclusi\u00f3n y participaci\u00f3n de las organizaciones de y para personas con discapacidad, cuidadoras\/es y sus familiares, mediante la entrega de herramientas pr\u00e1cticas a las organizaciones, la promoci\u00f3n de la asociatividad y el posicionamiento de la tem\u00e1tica con los actores relevantes en el territorio de la Macrozona Austral. Para esto propone alcanzar su objetivo general y sus objetivos espec\u00edficos a trav\u00e9s  de aplicaci\u00f3n de m\u00e9todos mixtos multic\u00e9ntricos e intervenciones de base comunitaria, estructurados en cuatro l\u00edneas de trabajo principales, 1) fortalecimiento de las organizaciones en el territorio a partir de la realizaci\u00f3n de un catastro regional y de diagn\u00f3sticos participativos, 2) escuela de gesti\u00f3n social y territorial, 3) actividades de difusi\u00f3n y 4) sistematizaci\u00f3n y evaluaci\u00f3n desde un enfoque de ciencias de la implementaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 955576 - Resoluci\u00f3n: 5461-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6555\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6555\" aria-expanded=\"false\" aria-controls=\"collapse-6555\">\n                                            Programa de Participaci\u00f3n Inclusiva Territorial 2023 en la Macrozona Austral. Desarrollo de herramientas para la implementaci\u00f3n.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6555\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6555\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de transferencia Programa Participaci\u00f3n Inclusiva Territorial, a\u00f1o 2023, entre Servicio Nacional de la Discapacidad y Universidad de O\u0092Higgins. \"Programa de participaci\u00f3n inclusiva en la Macrozona Austral: desarrollo de herramientas para la implementaci\u00f3n\". El presente proyecto tiene el objetivo de fortalecer el proceso de inclusi\u00f3n y participaci\u00f3n de las organizaciones de y para personas con discapacidad, cuidadoras\/es y sus familiares, mediante la entrega de herramientas pr\u00e1cticas a las organizaciones, la promoci\u00f3n de la asociatividad y el posicionamiento de la tem\u00e1tica con los actores relevantes en el territorio de la Macrozona Austral. Para esto propone alcanzar su objetivo general y sus objetivos espec\u00edficos a trav\u00e9s  de aplicaci\u00f3n de m\u00e9todos mixtos multic\u00e9ntricos e intervenciones de base comunitaria, estructurados en cuatro l\u00edneas de trabajo principales, 1) fortalecimiento de las organizaciones en el territorio a partir de la realizaci\u00f3n de un catastro regional y de diagn\u00f3sticos participativos, 2) escuela de gesti\u00f3n social y territorial, 3) actividades de difusi\u00f3n y 4) sistematizaci\u00f3n y evaluaci\u00f3n desde un enfoque de ciencias de la implementaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 950106 Resoluci\u00f3n: 5457-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6518\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6518\" aria-expanded=\"false\" aria-controls=\"collapse-6518\">\n                                            Proyecto de fortalecimiento en capacitaci\u00f3n para el Programa Tr\u00e1nsito a la vida independiente.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6518\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6518\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Capacitar en vida independiente, autonom\u00eda y perspectivas de derechos a equipos profesionales, personas con discapacidad, cuidadoras\/es y servicios de apoyo relacionados al programa Tr\u00e1nsito a la Vida Independiente. La capacitaci\u00f3n se realizar\u00e1 desde un enfoque de derechos, autonom\u00eda, autodeterminaci\u00f3n e independencia, participaci\u00f3n social y vida independiente.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 950106 Resoluci\u00f3n: 5457-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6556\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6556\" aria-expanded=\"false\" aria-controls=\"collapse-6556\">\n                                            Proyecto de fortalecimiento en capacitaci\u00f3n para el Programa Tr\u00e1nsito a la vida independiente.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6556\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6556\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Capacitar en vida independiente, autonom\u00eda y perspectivas de derechos a equipos profesionales, personas con discapacidad, cuidadoras\/es y servicios de apoyo relacionados al programa Tr\u00e1nsito a la Vida Independiente. La capacitaci\u00f3n se realizar\u00e1 desde un enfoque de derechos, autonom\u00eda, autodeterminaci\u00f3n e independencia, participaci\u00f3n social y vida independiente.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 948796 - Resoluci\u00f3n: 5395-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6516\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6516\" aria-expanded=\"false\" aria-controls=\"collapse-6516\">\n                                            Transferencia de Innovaci\u00f3n Social para el proceso de Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas.  \u0093Fortalecimiento de la Red de Incubadoras de Cooperativas Inclusivas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6516\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6516\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de transferencia para el servicios de asesor\u00eda y acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo en las regiones de Atacama, de los R\u00edos, de Magallanes y de la Ant\u00e1rtica Chilena; Valpara\u00edso; Biob\u00edo, Maule y Metropolitana de Santiago. \r\nEl presente proyecto de transferencia de innovaci\u00f3n social, permite entregar soporte t\u00e9cnico y acompa\u00f1ar los procesos de instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas para promover el ejercicio del derecho al trabajo de las personas con discapacidad a trav\u00e9s del desarrollo de un programa de asesor\u00eda, capacitaci\u00f3n y acompa\u00f1amiento que les permita su inserci\u00f3n en el mercado laboral de manera aut\u00f3noma y sustentable. Lo anterior se realiza a trav\u00e9s de un modelo de trabajo integral y transversal, que desarrolle  estrategias flexibles de formaci\u00f3n, asesor\u00eda y acompa\u00f1amiento para promover pertinencia local en la promoci\u00f3n del reconocimiento por parte de actores locales, de espacios de \r\ndesarrollo productivo en el marco de la econom\u00eda social e inclusi\u00f3n de las personas con discapacidad.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID: 948796 - Resoluci\u00f3n: 5395-2023<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2023 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6554\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6554\" aria-expanded=\"false\" aria-controls=\"collapse-6554\">\n                                            Transferencia de Innovaci\u00f3n Social para el proceso de Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas.  \u0093Fortalecimiento de la Red de Incubadoras de Cooperativas Inclusivas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6554\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6554\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de transferencia para el servicios de asesor\u00eda y acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo en las regiones de Atacama, de los R\u00edos, de Magallanes y de la Ant\u00e1rtica Chilena; Valpara\u00edso; Biob\u00edo, Maule y Metropolitana de Santiago. \r\nEl presente proyecto de transferencia de innovaci\u00f3n social, permite entregar soporte t\u00e9cnico y acompa\u00f1ar los procesos de instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas para promover el ejercicio del derecho al trabajo de las personas con discapacidad a trav\u00e9s del desarrollo de un programa de asesor\u00eda, capacitaci\u00f3n y acompa\u00f1amiento que les permita su inserci\u00f3n en el mercado laboral de manera aut\u00f3noma y sustentable. Lo anterior se realiza a trav\u00e9s de un modelo de trabajo integral y transversal, que desarrolle  estrategias flexibles de formaci\u00f3n, asesor\u00eda y acompa\u00f1amiento para promover pertinencia local en la promoci\u00f3n del reconocimiento por parte de actores locales, de espacios de \r\ndesarrollo productivo en el marco de la econom\u00eda social e inclusi\u00f3n de las personas con discapacidad.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ensayo clinico<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6449\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Riesgo cardiovascular en una cohorte de sobrevivientes de c\u00e1ncer infantil en Chile: estudio piloto que eval\u00faa el impacto del entrenamiento f\u00edsico en marcadores de capacidad cardiorrespiratoria y ocurrencia de cardiotoxicidad\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6449\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6449\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Antecedentes: los sobrevivientes de c\u00e1ncer son una poblaci\u00f3n en r\u00e1pido crecimiento con necesidades de salud espec\u00edficas. En los EE. UU., aproximadamente 17 millones de adultos son sobrevivientes de c\u00e1ncer, lo que representa el 5 % de la poblaci\u00f3n adulta, y las proyecciones indican que este n\u00famero aumentar\u00e1 a 20 millones para 2026, seg\u00fan el  Instituto Nacional del C\u00e1ncer de Estados Unidos. Los eventos cardiovasculares son la principal causa (no maligna) de muerte entre los sobrevivientes de c\u00e1ncer, con un riesgo de muerte aproximadamente siete veces mayor en relaci\u00f3n con sus contrapartes de la misma edad. Por tanto, el estudio de los factores de riesgo CV en pacientes oncol\u00f3gicos pedi\u00e1tricos supervivientes es un tema en auge, con ensayos cl\u00ednicos prospectivos en marcha y que actualmente carecen de una base mecan\u00edstica. Cada a\u00f1o en Chile se presentan aproximadamente 400 casos nuevos de c\u00e1ncer infantil, y sabiendo que la sobrevida global es cercana al 60%, llegamos a un n\u00famero apreciable de ni\u00f1os (alrededor de 240) que logran superar su enfermedad a\u00f1o tras a\u00f1o. Sin embargo, desde el inicio del programa, la monitorizaci\u00f3n del riesgo CV ha sido insuficiente, a pesar de que el 60-70% de los protocolos del PINDA (Programa Infantil para Drogas Antineopl\u00e1sicas) incluyen antraciclinas, que son agentes quimioter\u00e1picos relacionados con alto riesgo de cardiotoxicidad. En relaci\u00f3n a las medidas de intervenci\u00f3n disiponibles, es bien sabido que el entrenamiento aer\u00f3bico conduce a una mayor capacidad\/aptitud cardiorrespiratoria, CCR (ingl\u00e9s CRF; cardiorrespiratoty fitness). Por otro lado, el tipo de entrenamiento, en el caso de resistencia aumenta significativamente la fuerza muscular y mejora la forma f\u00edsica, asoci\u00e1ndose a mejor\u00eda de los outcomes cardiovasculares en adultos sobreviviente de c\u00e1ncer. En esta poblaci\u00f3n se ha visto que un CCR m\u00e1s baja se asocia con una mayor carga de s\u00edntomas y un mayor riesgo de morbilidad y mortalidad CV por afecciones no cancerosas; sin embargo, la relaci\u00f3n entre la aptitud f\u00edsica expresada por la CCR y la ocurrencia de cardiotoxicidad no ha sido bien caracterizadas en la poblaci\u00f3n infantil, o en la transici\u00f3n infantil-adulto, ya que cuentan con un vac\u00edo de seguimiento CV. Con base en estos antecedentes, planteamos la hip\u00f3tesis de que mejorar la condici\u00f3n\/aptitud f\u00edsica en una cohorte de sobrevivientes de c\u00e1ncer infantil a trav\u00e9s de la intervenci\u00f3n con ejercicios se asocia con una disminuci\u00f3n de los factores de riesgo cardiovascular y los marcadores ocurrencia de cardiotoxicidad.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 23CVC-245806<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2023 - Diciembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6377\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Strong-Bee: Gel multi-ingredientes formulado en base a compuestos naturales, especialmente desarrollado para favorecer la recuperaci\u00f3n muscular y el rendimiento de deportistas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6377\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6377\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Desarrollar y validar mediante ensayos in vivo un gel energ\u00e9tico para deportistas de alto rendimiento, formulado en\r\nbase a miel y extractos naturales, para ser utilizado como potenciador del rendimiento deportivo y la recuperaci\u00f3n\r\nmuscular post ejercicio. Los principales objetivos son: 1) Formular el gel energ\u00e9tico en base a los requerimientos\r\nnutricionales espec\u00ed&#1048789;cos de deportistas de alto rendimiento, caracteriz\u00e1ndolo en t\u00e9rminos nutricionales, capacidad\r\nantioxidante y ausencia de sustancias no deseadas. 2)Evaluar la tolerabilidad in vivo del producto en t\u00e9rminos de\r\npalatabilidad y efectos gastrointestinales. 3)Dise\u00f1ar e implementar el proceso mezclamiento y envasado para escalar\r\nla producci\u00f3n. 4)Cuanti&#1048789;car los efectos del producto desarrollado respecto del aporte sobre el rendimiento deportivo,\r\nla recuperaci\u00f3n muscular post ejercicio y s\u00edntomas de malestar gastrointestinal. y 5) Fortalecer el modelo de negocios.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 23CVC-245806<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2023 - Diciembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6409\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Strong-Bee: Gel multi-ingredientes formulado en base a compuestos naturales, especialmente desarrollado para favorecer la recuperaci\u00f3n muscular y el rendimiento de deportistas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6409\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6409\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Desarrollar y validar mediante ensayos in vivo un gel energ\u00e9tico para deportistas de alto rendimiento, formulado en\r\nbase a miel y extractos naturales, para ser utilizado como potenciador del rendimiento deportivo y la recuperaci\u00f3n\r\nmuscular post ejercicio. Los principales objetivos son: 1) Formular el gel energ\u00e9tico en base a los requerimientos\r\nnutricionales espec\u00ed&#1048789;cos de deportistas de alto rendimiento, caracteriz\u00e1ndolo en t\u00e9rminos nutricionales, capacidad\r\nantioxidante y ausencia de sustancias no deseadas. 2)Evaluar la tolerabilidad in vivo del producto en t\u00e9rminos de\r\npalatabilidad y efectos gastrointestinales. 3)Dise\u00f1ar e implementar el proceso mezclamiento y envasado para escalar\r\nla producci\u00f3n. 4)Cuanti&#1048789;car los efectos del producto desarrollado respecto del aporte sobre el rendimiento deportivo,\r\nla recuperaci\u00f3n muscular post ejercicio y s\u00edntomas de malestar gastrointestinal. y 5) Fortalecer el modelo de negocios.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 23CVC-245806<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2023 - Diciembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6440\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Strong-Bee: Gel multi-ingredientes formulado en base a compuestos naturales, especialmente desarrollado para favorecer la recuperaci\u00f3n muscular y el rendimiento de deportistas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6440\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6440\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Desarrollar y validar mediante ensayos in vivo un gel energ\u00e9tico para deportistas de alto rendimiento, formulado en\r\nbase a miel y extractos naturales, para ser utilizado como potenciador del rendimiento deportivo y la recuperaci\u00f3n\r\nmuscular post ejercicio. Los principales objetivos son: 1) Formular el gel energ\u00e9tico en base a los requerimientos\r\nnutricionales espec\u00ed&#1048789;cos de deportistas de alto rendimiento, caracteriz\u00e1ndolo en t\u00e9rminos nutricionales, capacidad\r\nantioxidante y ausencia de sustancias no deseadas. 2)Evaluar la tolerabilidad in vivo del producto en t\u00e9rminos de\r\npalatabilidad y efectos gastrointestinales. 3)Dise\u00f1ar e implementar el proceso mezclamiento y envasado para escalar\r\nla producci\u00f3n. 4)Cuanti&#1048789;car los efectos del producto desarrollado respecto del aporte sobre el rendimiento deportivo,\r\nla recuperaci\u00f3n muscular post ejercicio y s\u00edntomas de malestar gastrointestinal. y 5) Fortalecer el modelo de negocios.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2023 - Junio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Consejo Latinoamericano de Ciencias Sociales (CLACSO)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6565\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6565\" aria-expanded=\"false\" aria-controls=\"collapse-6565\">\n                                            Experiencias del Movimiento Social de la Discapacidad en Am\u00e9rica Latina: Itinerarios de lucha por los derechos del Colectivo Nacional por la Discapacidad de Chile y la Asociaci\u00f3n de Discapacidad del Guayas de Ecuador\u0094.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6565\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6565\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Experiencias del Movimiento Social de la Discapacidad en Am\u00e9rica Latina: Itinerarios de lucha por los derechos del Colectivo Nacional por la Discapacidad de Chile y la Asociaci\u00f3n de Discapacidad del Guayas de Ecuador.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2023 - Septiembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6410\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro UOH de BioIngenier\u00eda (CUBI)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6410\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6410\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto interno de la UOH de car\u00e1cter multidisciplinario que busca crear mapas moleculares multi\u00f3micos de los c\u00e1nceres prevalentes en la regi\u00f3n, utilizando tecnolog\u00edas de vanguardia y algoritmos avanzados.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2023 - Septiembre 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6441\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro UOH de BioIngenier\u00eda (CUBI)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6441\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6441\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto interno de la UOH de car\u00e1cter multidisciplinario que busca crear mapas moleculares multi\u00f3micos de los c\u00e1nceres prevalentes en la regi\u00f3n, utilizando tecnolog\u00edas de vanguardia y algoritmos avanzados.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2023 - Julio 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6400\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro UOH de Bioingenier\u00eda (CUBI)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6400\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6400\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El c\u00e1ncer es una enfermedad gen\u00e9tica compleja y mortal que afecta a un gran n\u00famero de personas en Chile, con una alta tasa de mortalidad y un aumento constante en el n\u00famero de casos. Ante esta realidad, es crucial implementar la Medicina de Precisi\u00f3n en el pa\u00eds para brindar un tratamiento personalizado y mejorar los resultados para los pacientes. El Centro UOH de BioIngenier\u00eda (CUBI) se propone liderar este avance, enfoc\u00e1ndose en la regi\u00f3n de O'Higgins, Chile.\r\nEl CUBI busca crear mapas moleculares multi\u00f3micos de los c\u00e1nceres prevalentes en la regi\u00f3n, utilizando tecnolog\u00edas de vanguardia y algoritmos avanzados. Esto permitir\u00e1 comprender los perfiles gen\u00e9ticos y moleculares del c\u00e1ncer, as\u00ed como la heterogeneidad y evoluci\u00f3n som\u00e1tica de los tumores chilenos. El equipo propuesto por CUBI, con su destacada capacidad de secuenciaci\u00f3n gen\u00f3mica, procesamiento masivo de datos y experiencia en biolog\u00eda molecular y computacional, desempe\u00f1ar\u00e1 un papel protag\u00f3nico en el logro de estos objetivos.\r\nEl CUBI se organiza en tres l\u00edneas de investigaci\u00f3n principales. La primera l\u00ednea se centra en las tecnolog\u00edas gen\u00f3micas para el mapeo de genotipos, fenotipos y evoluci\u00f3n tumoral, dirigida por el Dr. Di Genova. Su objetivo es comprender los factores gen\u00e9ticos que contribuyen al c\u00e1ncer, as\u00ed como la variabilidad molecular y la evoluci\u00f3n som\u00e1tica de los tumores chilenos. La segunda l\u00ednea, liderada por el doctor Henao, se enfoca en las tecnolog\u00edas de imagen para el mapeo y evaluaci\u00f3n de fenotipos tumorales. Mediante el uso de im\u00e1genes histol\u00f3gicas y de ultrasonido, combinadas con la inteligencia artificial y modelos f\u00edsico\/matem\u00e1ticos, se busca identificar patrones morfol\u00f3gicos y topol\u00f3gicos asociados a biomarcadores o procesos mutacionales espec\u00edficos de los tumores. La tercera l\u00ednea de investigaci\u00f3n, liderada por el Dr. Krause, se centra en la utilizaci\u00f3n de modelos precl\u00ednicos para validar las relaciones fenotipo-genotipo desCUBIertas en las l\u00edneas de investigaci\u00f3n anteriores y la creaci\u00f3n de un biobanco regional. Esto permitir\u00e1 realizar estudios moleculares, cl\u00ednicos y epidemiol\u00f3gicos en la regi\u00f3n de O'Higgins, fortaleciendo la base de conocimientos y facilitando la aplicaci\u00f3n de los hallazgos en la pr\u00e1ctica cl\u00ednica.\r\nEl CUBI cuenta con un equipo interdisciplinario de investigadores j\u00f3venes, intermedios y senior, con l\u00edneas de investigaci\u00f3n claras y bien definidas. Adem\u00e1s, se ha establecido una s\u00f3lida red nacional e internacional de colaboraci\u00f3n con instituciones l\u00edderes en investigaci\u00f3n del c\u00e1ncer, como el IARC de Lyon, Francia, el ICR de Londres, UK y hospitales e instituciones en Chile.\r\nEl CUBI busca posicionarse como un centro pionero en la investigaci\u00f3n en medicina de precisi\u00f3n oncol\u00f3gica en Chile. Su objetivo principal es comprender y mapear la biolog\u00eda \u00fanica de los pacientes chilenos\/as con c\u00e1ncer, con el fin de brindar tratamientos m\u00e1s efectivos y mejorar las oportunidades para la regi\u00f3n. Con su infraestructura, equipo, red de colaboraci\u00f3n y enfoque multidisciplinario, el CUBI tiene el potencial de generar un impacto significativo en la sociedad chilena al avanzar en la comprensi\u00f3n del c\u00e1ncer y la implementaci\u00f3n de estrategias de tratamiento personalizado. Proyectamos que la operaci\u00f3n del CUBI tendr\u00e1 un impacto positivo en la regi\u00f3n y pa\u00eds en varios aspectos:\r\n1. Mejorar la atenci\u00f3n del c\u00e1ncer: El CUBI permitir\u00e1 una mejor comprensi\u00f3n de las caracter\u00edsticas gen\u00e9ticas y moleculares de los tumores en la poblaci\u00f3n regional y nacional. Esto conducir\u00e1 a un diagn\u00f3stico m\u00e1s preciso, una estratificaci\u00f3n m\u00e1s efectiva de los pacientes y una selecci\u00f3n m\u00e1s precisa de los tratamientos. Como resultado, los pacientes recibir\u00e1n terapias m\u00e1s efectivas, lo que mejorar\u00e1 sus resultados cl\u00ednicos y su calidad de vida. 2. Avances cient\u00edficos y tecnol\u00f3gicos: El centro promover\u00e1 el desarrollo y la aplicaci\u00f3n de tecnolog\u00edas de vanguardia y m\u00e9todos de an\u00e1lisis de datos avanzados. Esto fomentar\u00e1 la investigaci\u00f3n cient\u00edfica del c\u00e1ncer y permitir\u00e1 descubrir nuevas asociaciones gen\u00e9ticas y moleculares, as\u00ed como identificar posibles blancos terap\u00e9uticos. Estos avances no solo beneficiar\u00e1n a los pacientes de c\u00e1ncer en Chile, sino que tambi\u00e9n contribuir\u00e1n al conocimiento global en la lucha contra esta enfermedad. 3. Formaci\u00f3n y educaci\u00f3n: El centro brindar\u00e1 oportunidades de formaci\u00f3n y capacitaci\u00f3n para estudiantes, investigadores y profesionales de la salud interesados en la medicina de precisi\u00f3n en oncolog\u00eda. Esto fortalecer\u00e1 la capacidad cient\u00edfica y cl\u00ednica de la regi\u00f3n, permitiendo la formaci\u00f3n de especialistas altamente calificados en el diagn\u00f3stico y tratamiento del c\u00e1ncer. 4. Impacto socioecon\u00f3mico: La detecci\u00f3n temprana, el tratamiento personalizado y la reducci\u00f3n de los efectos secundarios innecesarios pueden mejorar la eficiencia de los sistemas de salud y disminuir los costos asociados con el c\u00e1ncer. Adem\u00e1s, la generaci\u00f3n de conocimiento cient\u00edfico y tecnol\u00f3gico puede impulsar la innovaci\u00f3n y el desarrollo de la industria biotecnol\u00f3gica en la regi\u00f3n, creando oportunidades econ\u00f3micas y empleo especializado.\r\nEn resumen, el CUBI tiene el potencial de generar un impacto significativo en la sociedad regional al mejorar la atenci\u00f3n m\u00e9dica, impulsar la investigaci\u00f3n cient\u00edfica, fortalecer la capacitaci\u00f3n y la colaboraci\u00f3n, y tener repercusiones socioecon\u00f3micas positivas. Al comprender y abordar la complejidad biol\u00f3gica del c\u00e1ncer en la poblaci\u00f3n chilena, se allana el camino para una atenci\u00f3n m\u00e1s efectiva y personalizada, y se brinda esperanza a los pacientes y sus familias en la lucha contra el c\u00e1ncer.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2023 - Julio 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6431\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Centro UOH de Bioingenier\u00eda (CUBI)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6431\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6431\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El c\u00e1ncer es una enfermedad gen\u00e9tica compleja y mortal que afecta a un gran n\u00famero de personas en Chile, con una alta tasa de mortalidad y un aumento constante en el n\u00famero de casos. Ante esta realidad, es crucial implementar la Medicina de Precisi\u00f3n en el pa\u00eds para brindar un tratamiento personalizado y mejorar los resultados para los pacientes. El Centro UOH de BioIngenier\u00eda (CUBI) se propone liderar este avance, enfoc\u00e1ndose en la regi\u00f3n de O'Higgins, Chile.\r\nEl CUBI busca crear mapas moleculares multi\u00f3micos de los c\u00e1nceres prevalentes en la regi\u00f3n, utilizando tecnolog\u00edas de vanguardia y algoritmos avanzados. Esto permitir\u00e1 comprender los perfiles gen\u00e9ticos y moleculares del c\u00e1ncer, as\u00ed como la heterogeneidad y evoluci\u00f3n som\u00e1tica de los tumores chilenos. El equipo propuesto por CUBI, con su destacada capacidad de secuenciaci\u00f3n gen\u00f3mica, procesamiento masivo de datos y experiencia en biolog\u00eda molecular y computacional, desempe\u00f1ar\u00e1 un papel protag\u00f3nico en el logro de estos objetivos.\r\nEl CUBI se organiza en tres l\u00edneas de investigaci\u00f3n principales. La primera l\u00ednea se centra en las tecnolog\u00edas gen\u00f3micas para el mapeo de genotipos, fenotipos y evoluci\u00f3n tumoral, dirigida por el Dr. Di Genova. Su objetivo es comprender los factores gen\u00e9ticos que contribuyen al c\u00e1ncer, as\u00ed como la variabilidad molecular y la evoluci\u00f3n som\u00e1tica de los tumores chilenos. La segunda l\u00ednea, liderada por el doctor Henao, se enfoca en las tecnolog\u00edas de imagen para el mapeo y evaluaci\u00f3n de fenotipos tumorales. Mediante el uso de im\u00e1genes histol\u00f3gicas y de ultrasonido, combinadas con la inteligencia artificial y modelos f\u00edsico\/matem\u00e1ticos, se busca identificar patrones morfol\u00f3gicos y topol\u00f3gicos asociados a biomarcadores o procesos mutacionales espec\u00edficos de los tumores. La tercera l\u00ednea de investigaci\u00f3n, liderada por el Dr. Krause, se centra en la utilizaci\u00f3n de modelos precl\u00ednicos para validar las relaciones fenotipo-genotipo desCUBIertas en las l\u00edneas de investigaci\u00f3n anteriores y la creaci\u00f3n de un biobanco regional. Esto permitir\u00e1 realizar estudios moleculares, cl\u00ednicos y epidemiol\u00f3gicos en la regi\u00f3n de O'Higgins, fortaleciendo la base de conocimientos y facilitando la aplicaci\u00f3n de los hallazgos en la pr\u00e1ctica cl\u00ednica.\r\nEl CUBI cuenta con un equipo interdisciplinario de investigadores j\u00f3venes, intermedios y senior, con l\u00edneas de investigaci\u00f3n claras y bien definidas. Adem\u00e1s, se ha establecido una s\u00f3lida red nacional e internacional de colaboraci\u00f3n con instituciones l\u00edderes en investigaci\u00f3n del c\u00e1ncer, como el IARC de Lyon, Francia, el ICR de Londres, UK y hospitales e instituciones en Chile.\r\nEl CUBI busca posicionarse como un centro pionero en la investigaci\u00f3n en medicina de precisi\u00f3n oncol\u00f3gica en Chile. Su objetivo principal es comprender y mapear la biolog\u00eda \u00fanica de los pacientes chilenos\/as con c\u00e1ncer, con el fin de brindar tratamientos m\u00e1s efectivos y mejorar las oportunidades para la regi\u00f3n. Con su infraestructura, equipo, red de colaboraci\u00f3n y enfoque multidisciplinario, el CUBI tiene el potencial de generar un impacto significativo en la sociedad chilena al avanzar en la comprensi\u00f3n del c\u00e1ncer y la implementaci\u00f3n de estrategias de tratamiento personalizado. Proyectamos que la operaci\u00f3n del CUBI tendr\u00e1 un impacto positivo en la regi\u00f3n y pa\u00eds en varios aspectos:\r\n1. Mejorar la atenci\u00f3n del c\u00e1ncer: El CUBI permitir\u00e1 una mejor comprensi\u00f3n de las caracter\u00edsticas gen\u00e9ticas y moleculares de los tumores en la poblaci\u00f3n regional y nacional. Esto conducir\u00e1 a un diagn\u00f3stico m\u00e1s preciso, una estratificaci\u00f3n m\u00e1s efectiva de los pacientes y una selecci\u00f3n m\u00e1s precisa de los tratamientos. Como resultado, los pacientes recibir\u00e1n terapias m\u00e1s efectivas, lo que mejorar\u00e1 sus resultados cl\u00ednicos y su calidad de vida. 2. Avances cient\u00edficos y tecnol\u00f3gicos: El centro promover\u00e1 el desarrollo y la aplicaci\u00f3n de tecnolog\u00edas de vanguardia y m\u00e9todos de an\u00e1lisis de datos avanzados. Esto fomentar\u00e1 la investigaci\u00f3n cient\u00edfica del c\u00e1ncer y permitir\u00e1 descubrir nuevas asociaciones gen\u00e9ticas y moleculares, as\u00ed como identificar posibles blancos terap\u00e9uticos. Estos avances no solo beneficiar\u00e1n a los pacientes de c\u00e1ncer en Chile, sino que tambi\u00e9n contribuir\u00e1n al conocimiento global en la lucha contra esta enfermedad. 3. Formaci\u00f3n y educaci\u00f3n: El centro brindar\u00e1 oportunidades de formaci\u00f3n y capacitaci\u00f3n para estudiantes, investigadores y profesionales de la salud interesados en la medicina de precisi\u00f3n en oncolog\u00eda. Esto fortalecer\u00e1 la capacidad cient\u00edfica y cl\u00ednica de la regi\u00f3n, permitiendo la formaci\u00f3n de especialistas altamente calificados en el diagn\u00f3stico y tratamiento del c\u00e1ncer. 4. Impacto socioecon\u00f3mico: La detecci\u00f3n temprana, el tratamiento personalizado y la reducci\u00f3n de los efectos secundarios innecesarios pueden mejorar la eficiencia de los sistemas de salud y disminuir los costos asociados con el c\u00e1ncer. Adem\u00e1s, la generaci\u00f3n de conocimiento cient\u00edfico y tecnol\u00f3gico puede impulsar la innovaci\u00f3n y el desarrollo de la industria biotecnol\u00f3gica en la regi\u00f3n, creando oportunidades econ\u00f3micas y empleo especializado.\r\nEn resumen, el CUBI tiene el potencial de generar un impacto significativo en la sociedad regional al mejorar la atenci\u00f3n m\u00e9dica, impulsar la investigaci\u00f3n cient\u00edfica, fortalecer la capacitaci\u00f3n y la colaboraci\u00f3n, y tener repercusiones socioecon\u00f3micas positivas. Al comprender y abordar la complejidad biol\u00f3gica del c\u00e1ncer en la poblaci\u00f3n chilena, se allana el camino para una atenci\u00f3n m\u00e1s efectiva y personalizada, y se brinda esperanza a los pacientes y sus familias en la lucha contra el c\u00e1ncer.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FIC IDI 40048442-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2023 - Mayo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6466\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de innovaci\u00f3n social: inclusi\u00f3n y turismo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6466\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6466\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Consolidar y fortalecer una nueva red de nodos de innovaci\u00f3n social que promueva la inclusi\u00f3n socio laboral en personas con alguna discapacidad, personas mayores, mujeres y personas en situaci\u00f3n de vulnerabilidad enfocada en los sectores econ\u00f3micos priorizados en la Estrategia de Desarrollo Regional 2011-2020 (EDRE) y de innovaci\u00f3n, priorizando el sector tur\u00edstico, y agroalimentario y la puesta en valor de la identidad cultural.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FIC IDI 40048442-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2023 - Mayo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6508\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de innovaci\u00f3n social: inclusi\u00f3n y turismo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6508\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6508\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Consolidar y fortalecer una nueva red de nodos de innovaci\u00f3n social que promueva la inclusi\u00f3n socio laboral en personas con alguna discapacidad, personas mayores, mujeres y personas en situaci\u00f3n de vulnerabilidad enfocada en los sectores econ\u00f3micos priorizados en la Estrategia de Desarrollo Regional 2011-2020 (EDRE) y de innovaci\u00f3n, priorizando el sector tur\u00edstico, y agroalimentario y la puesta en valor de la identidad cultural.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FIC IDI 40048442-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2023 - Mayo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6550\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de innovaci\u00f3n social: inclusi\u00f3n y turismo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6550\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6550\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Consolidar y fortalecer una nueva red de nodos de innovaci\u00f3n social que promueva la inclusi\u00f3n socio laboral en personas con alguna discapacidad, personas mayores, mujeres y personas en situaci\u00f3n de vulnerabilidad enfocada en los sectores econ\u00f3micos priorizados en la Estrategia de Desarrollo Regional 2011-2020 (EDRE) y de innovaci\u00f3n, priorizando el sector tur\u00edstico, y agroalimentario y la puesta en valor de la identidad cultural.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> FIC IDI 40048442-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2023 - Mayo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6561\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de innovaci\u00f3n social: inclusi\u00f3n y turismo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6561\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6561\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Consolidar y fortalecer una nueva red de nodos de innovaci\u00f3n social que promueva la inclusi\u00f3n socio laboral en personas con alguna discapacidad, personas mayores, mujeres y personas en situaci\u00f3n de vulnerabilidad enfocada en los sectores econ\u00f3micos priorizados en la Estrategia de Desarrollo Regional 2011-2020 (EDRE) y de innovaci\u00f3n, priorizando el sector tur\u00edstico, y agroalimentario y la puesta en valor de la identidad cultural.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2023 - Abril 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>SOCHINUT<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6571\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            No Whey: L\u00e1cteos altos en prote\u00edna y ejercicio de resistencia para la mejora de la composici\u00f3n corporal y funci\u00f3n muscular de personas mayores\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6571\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6571\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"].[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1231401<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2023 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6399\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Capillary networks, gel debonding in prostheses, and fracture in rock mining from the viewpoint of the mathematical analysis of free-discontinuity problems\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6399\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6399\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]One goal is to enhance the methods being currently developed by Esp&#305;&#769;ndola (Physics), Krause (Physiology), and Xavier (Biomedical Engineering) for reconstructing capillary networks with ultrasound. The super-resolution is needed for early detection diseases such as cognitive decline, cancer, or liver fibrosis. They perfuse lipid-encapsulated microbubbles as contrast agents and then localize the bubbles in the ultrasound images with the singular value filter. However, that method leaves a non-negligible percentage of bubbles undetected. Here we propose to complement the singular value filter for the detection and tracking of microbubbles with the sophisticated and mathematically sound Mumford-Shah method for image contour detection, which stems from the conceptually-insightful and numerically-robust perspective of the minimization of energies. In the reconstruction of the capillary network from ultrasound, it is impossible to directly distinguish the microbubbles, or even the blood vessels, in each frame separately, due to the attentuation and degradation in this imaging technique. It is essential to take into account the dynamic nature of the problem, distinguishing the slowly-varying signals emitted by the tissue from those emitted by the microbubbles, which flow rapidly, behave nonlinearly, and have a much shorter coherence length. We therefore propose to regard the collection of two-dimensional frames as a single three-dimensional image, where a moving bubble becomes a tubular neighbourhood of a filament, which the Mumford-Shah model is expected to recover. From these filaments, bubbles can be detected and tracked, and the vertical inclinations of theses filaments will yield the microbubbles velocities. From the velocity profiles it is possible to estimate the shear wall stresses (their \u0091tangential elastic rigidities\u0092) of the blood vessels, and anomalies in these stresses are commonly good indicators of the presence of specific diseases. \r\n A fortunate encounter between mathematics and mechanics led to the observation that the problem of\r\nfinding the path that the propagation of a crack will follow inside a structure upon loading could be solved with the mathematical theory (the analysis of free-discontinuity problems) developed for the apparently unrelated image segmentation Mumford-Shah model. The variational fracture theory initiated by Francfort and Marigo is by now (20 years after) very well established. The second goal of this proposal is to further develop the ongoing collaboration between Song (Pharmaceutics), Siegel (Pharmaceutics), S\u00e1nchez (Numerical analysis), Calderer (Applied mathematics), and the PI on the study of the debonding of polymer gels from rigid substrates (relevant in the design of the synthetic polymers coating the metallic parts of pacemakers and other medical prostheses) from this variational fracture theory perspective.\r\n The third main goal is to apply the mathematical analysis of free-discontinuity problems to the modelling of the evolution of the cavity in the block caving technique in underground rock mining. This has been pursued by Ortega, Lecaros, and coworkers from the side of applied mathematics in academia, in collaboration with Gaete from the Geomechanics Research Department at El Teniente, research group to which Guti\u00e9rrez and the PI have joined in the last months. We propose to study the seismic activity induced by the fracture of the rock mass due to gravity, following the works in the last decade within the variational fracture theory that incorporate the inertia e&#64256;ects. The final aim is to optimize the injection of water jets for the aminoration of the seismic events near the operation sites.\r\n The three research lines are applications of the phase-field regularization by Ambrosio and Tortorelli of the Mumford-Shah free-discontinuity model, a di&#64256;erent variant being required in each of the three contexts. The first stage of the implementation is of mathematical modelling and high-level numerical simulation abilities, in which the intuition and first-hand knowledge from the members of the research team that are experts in vascular function, ultrasound imaging, polymer chemistry, and mining geomechanics is translated into particular mathematical concepts and concrete computational methods. This is followed by a stage of calibration and validation, where the full interplay with experiments is required. The product of a robust and validated computational method will constitute then an advancement in the capabilities, available resources, and understanding in each of the applied disciplines.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1231401<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2023 - Marzo 2027<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6430\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Capillary networks, gel debonding in prostheses, and fracture in rock mining from the viewpoint of the mathematical analysis of free-discontinuity problems\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6430\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6430\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]One goal is to enhance the methods being currently developed by Esp&#305;&#769;ndola (Physics), Krause (Physiology), and Xavier (Biomedical Engineering) for reconstructing capillary networks with ultrasound. The super-resolution is needed for early detection diseases such as cognitive decline, cancer, or liver fibrosis. They perfuse lipid-encapsulated microbubbles as contrast agents and then localize the bubbles in the ultrasound images with the singular value filter. However, that method leaves a non-negligible percentage of bubbles undetected. Here we propose to complement the singular value filter for the detection and tracking of microbubbles with the sophisticated and mathematically sound Mumford-Shah method for image contour detection, which stems from the conceptually-insightful and numerically-robust perspective of the minimization of energies. In the reconstruction of the capillary network from ultrasound, it is impossible to directly distinguish the microbubbles, or even the blood vessels, in each frame separately, due to the attentuation and degradation in this imaging technique. It is essential to take into account the dynamic nature of the problem, distinguishing the slowly-varying signals emitted by the tissue from those emitted by the microbubbles, which flow rapidly, behave nonlinearly, and have a much shorter coherence length. We therefore propose to regard the collection of two-dimensional frames as a single three-dimensional image, where a moving bubble becomes a tubular neighbourhood of a filament, which the Mumford-Shah model is expected to recover. From these filaments, bubbles can be detected and tracked, and the vertical inclinations of theses filaments will yield the microbubbles velocities. From the velocity profiles it is possible to estimate the shear wall stresses (their \u0091tangential elastic rigidities\u0092) of the blood vessels, and anomalies in these stresses are commonly good indicators of the presence of specific diseases. \r\n A fortunate encounter between mathematics and mechanics led to the observation that the problem of\r\nfinding the path that the propagation of a crack will follow inside a structure upon loading could be solved with the mathematical theory (the analysis of free-discontinuity problems) developed for the apparently unrelated image segmentation Mumford-Shah model. The variational fracture theory initiated by Francfort and Marigo is by now (20 years after) very well established. The second goal of this proposal is to further develop the ongoing collaboration between Song (Pharmaceutics), Siegel (Pharmaceutics), S\u00e1nchez (Numerical analysis), Calderer (Applied mathematics), and the PI on the study of the debonding of polymer gels from rigid substrates (relevant in the design of the synthetic polymers coating the metallic parts of pacemakers and other medical prostheses) from this variational fracture theory perspective.\r\n The third main goal is to apply the mathematical analysis of free-discontinuity problems to the modelling of the evolution of the cavity in the block caving technique in underground rock mining. This has been pursued by Ortega, Lecaros, and coworkers from the side of applied mathematics in academia, in collaboration with Gaete from the Geomechanics Research Department at El Teniente, research group to which Guti\u00e9rrez and the PI have joined in the last months. We propose to study the seismic activity induced by the fracture of the rock mass due to gravity, following the works in the last decade within the variational fracture theory that incorporate the inertia e&#64256;ects. The final aim is to optimize the injection of water jets for the aminoration of the seismic events near the operation sites.\r\n The three research lines are applications of the phase-field regularization by Ambrosio and Tortorelli of the Mumford-Shah free-discontinuity model, a di&#64256;erent variant being required in each of the three contexts. The first stage of the implementation is of mathematical modelling and high-level numerical simulation abilities, in which the intuition and first-hand knowledge from the members of the research team that are experts in vascular function, ultrasound imaging, polymer chemistry, and mining geomechanics is translated into particular mathematical concepts and concrete computational methods. This is followed by a stage of calibration and validation, where the full interplay with experiments is required. The product of a robust and validated computational method will constitute then an advancement in the capabilities, available resources, and understanding in each of the applied disciplines.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> R01EY034615<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>NIH National Eye Insitute<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6473\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            The role of heme in retinal vascular development and disease\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6473\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6473\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Retinal vascular diseases are major causes of vision loss in the United States and around the world. To better treat these disorders, we need to understand the signaling pathways that control the growth and integrity of retinal blood vessels. Our recent publications and preliminary data detail a novel angiogenic signaling system centered around heme, a co-factor critical for oxygen transport, metabolism, and gene transcription. We found that heme promotes angiogenic growth in the retina by regulating tip\/stalk selection, and that reduced heme production or import leads to reduced retinal vascularization and tissue hypoxia, similar to other retinal vasculopathies including retinopathy of prematurity, choroidal neovascularization, and the rare but important exudative vitreoretinopathies. Furthermore, we found that VEGF suppresses, while Norrin-bCatenin promotes, the expression of the obligate endothelial heme importer, Flvcr2.  Based on these data, we hypothesize that heme, is involved in retinal angiogenesis and retinal vasculopathies. The Specific Aims of this proposal are to (1) determine how heme intersects with Notch signaling to control angiogenic tip\/stalk selection, (2) characterize the role for Flvcr2\/heme in VEGF-induced angiogenic proliferation and neo-vascularization, and (3) determine whether induction of Flvcr2\/heme signaling is sufficient and necessary to reverse the vascular defects and downstream vision changes observed in mouse models of exudative vitreoretinopathy. To accomplish these aims, we developed new tools to directly manipulate heme in cultured retinal endothelial cells and assess heme transport and intracellular trafficking in vitro. We also generated new conditional knock-in and knock-out alleles to manipulate endothelial heme transport in vivo. Our studies will fundamentally impact our understanding of how endothelial heme levels are controlled, and the role of heme in retinal angiogenesis and vascular disease.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2023 - Marzo 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>SOCHINUT-NESTLE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6570\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            La suplementaci\u00f3n diaria con cuerpos cet\u00f3nicos durante la recuperaci\u00f3n de una lesi\u00f3n aguda previene la infiltraci\u00f3n grasa y acelera la reparaci\u00f3n muscular\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6570\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6570\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La respuesta inflamatoria al da\u00f1o muscular puede comprometer la fuerza\/masa al inducir la formaci\u00f3n de\r\ntejido adiposo intermuscular (IMAT). IMAT se origina de la diferenciaci\u00f3n adipog\u00e9nica de c\u00e9lulas\r\nmesenquimales progenitoras fibro-adipog\u00e9nicas (FAPs). Este proceso podr\u00eda revertirse modulando la\r\nrespuesta inflamatoria aguda. Sin embargo, el uso de antiinflamatorios inhibe la s\u00edntesis proteica y reduce\r\nla capacidad regenerativa muscular. Alternativamente, medidas f\u00edsicas como el reposo funcional o la\r\nreincorporaci\u00f3n temprana a la actividad han reportado efectos contradictorios sobre el proceso\r\ninflamatorio, lo que dificulta establecer indicaciones en el manejo de la lesi\u00f3n muscular. Por otro lado, se\r\nha descrito un potente papel antinflamatorio local o sist\u00e9mico del cuerpo cet\u00f3nico &#946;-hydroxybutirato\r\n(&#946;HB); efecto mediado por la inhibici\u00f3n del inflamasoma NLRP3 y la secreci\u00f3n de citoquinas\r\nproinflamatorias. Importantemente, la activaci\u00f3n del inflamasoma NLRP3 favorecer\u00eda la adipog\u00e9nesis de\r\nc\u00e9lulas mesenquimales, lo que sugiere un rol en la formaci\u00f3n de IMAT. Se hipotetiza que la suplementaci\u00f3n\r\ncon &#946;HB durante la recuperaci\u00f3n de una lesi\u00f3n muscular aguda inhibe la diferenciaci\u00f3n adipog\u00e9nica de\r\nFAPs reduciendo la formaci\u00f3n de IMAT lo que acelera la reparaci\u00f3n y recuperaci\u00f3n funcional del tejido\r\nmuscular. Este efecto estar\u00eda mediado por la inhibici\u00f3n del inflamasoma NLRP3. Se inyectar\u00e1 una soluci\u00f3n\r\nhiperosm\u00f3tica al 25% de glicerol o salino en el m\u00fasculo tibial anterior en ratones con o sin suplementaci\u00f3n\r\nde 3 mg\/g &#946;HB durante 2 semanas post injuria. Se recolectar\u00e1 tejido muscular al 14dpi para an\u00e1lisis\r\nhistol\u00f3gico de IMAT. Paralelamente, se aislar\u00e1n FAPs del estroma vascular muscular al 3dpi. En FAPs\r\naisladas se evaluar\u00e1n prote\u00ednas de la v\u00eda NLPR3 inflamasoma y su capacidad adipog\u00e9nica en respuesta al\r\ntratamiento in-vitro con 3mM &#946;HB. Los resultados de esta propuesta nos permitir\u00e1n mostrar los efectos\r\nterap\u00e9uticos de la suplementaci\u00f3n dietar\u00eda con cuerpos cet\u00f3nicos en la funci\u00f3n y recuperaci\u00f3n muscular\r\npost da\u00f1o.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2023 - Febrero 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Sociedad Chilena de Nutrici\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6373\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            No Whey: L\u00e1cteos altos en prote\u00edna y ejercicio de resistencia para la mejora de la composici\u00f3n corporal y funci\u00f3n muscular de personas mayores.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6373\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6373\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La suplementaci\u00f3n con prote\u00ednas es una de las principales recomendaciones ante la practica regular de ejercicio f\u00edsico de resistencia (RT). En personas mayores, la necesidad de prote\u00edna se incrementa particularmente ante cambios fisiol\u00f3gicos y fisiopatol\u00f3gicos los que se asocian con la p\u00e9rdida de la funci\u00f3n y tejido muscular, por lo que su ingesta se hace de mayor relevancia en esta poblaci\u00f3n. Los l\u00e1cteos fermentados como el yogur, y en especial los con un contenido extra de prote\u00edna, han aumentado su popularidad y consumo en el mercado nacional. Su composici\u00f3n nutricional resulta de particular inter\u00e9s, dado su perfil de amino\u00e1cidos y en particular su alto contenido de Leucina, el que podr\u00eda compararse con los cl\u00e1sico suplementos de prote\u00edna recomendados para la ganancia y recuperaci\u00f3n muscular. Objetivo: Analizar el efecto en la composici\u00f3n corporal, perfil lip\u00eddico, condici\u00f3n fisica y funcionalidad muscular inducidas por ingesta de yogures altos en prote\u00edna versus prote\u00edna Whey junto un programa de resistencia muscular en personas mayores Hip\u00f3tesis: La ingesta de yogures altos en prote\u00edna conllevar\u00e1 a iguales o mayores ganancias de masa muscular, condici\u00f3n fisica y funcionalidad que las obtenidas con la ingesta de prote\u00ednas Whey en conjunto a un entrenamiento de resistencia en personas mayores. Metodolog\u00eda: Se reclutar\u00e1n 16 personas mayores (60-75 a\u00f1os), sanas y sin intolerancia a la lactosa para llevar a cabo 8 semanas de entrenamiento de resistencia (RT) muscular 3 veces por semana, los que de forma aleatoria ser\u00e1n suplementados con yogurt alto en prote\u00ednas (YPRT) o prote\u00edna Whey (WPRT). Al inicio y al t\u00e9rmino de la intervenci\u00f3n se evaluar\u00e1 la composici\u00f3n corporal mediante DEXA, fuerza muscular, consumo m\u00e1ximo de ox\u00edgeno y perfil lip\u00eddico. Resultados Esperados: Se espera que el grupo YPRT logre incrementos similares o superiores en la fuerza muscular, masa libre de grasa, perfil lip\u00eddico y disminuci\u00f3n de la masa grasa y que el grupo WPRT.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2023 - Julio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD - Alemania<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6509\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6509\" aria-expanded=\"false\" aria-controls=\"collapse-6509\">\n                                            ANTIBIOtic RESidues in Food: a comparative analysis in Bolivia, Italy, Ghana, and Nepal\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6509\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6509\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Antimicrobial resistance is a global phenomenon aggravated in recent decades by the inappropriate use of antimicrobials in human and veterinary medicine, the lack of prevention and control measures for infections associated with health care, and the limited development of new antimicrobials. It causes an increase in mortality, morbidity, and health spending. In this sense, the irrational use of antimicrobials in food-producing animals can reduce the effectiveness of those antibiotics in treating animal and human diseases. It also represents an additional risk for antimicrobial resistance by transferring antibiotics to food for human consumption and generating a new source of exposure. The residual antibiotics in food have been related to some adverse effects on human health, including allergic reactions, disruption of digestive system function, and chronic toxic effects from prolonged low-level exposure. It also represents a risk for the animals by jeopardizing the effectiveness of the necessary treatments.\r\n\r\nConsidering that, the project seeks to generate evidence regarding progress at the local level in regulatory issues and regarding the presence of antibiotics in food to raise awareness about the proper use of antibiotics in animals and humans and promote good practices[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2023 - Julio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD - Alemania<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6510\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6510\" aria-expanded=\"false\" aria-controls=\"collapse-6510\">\n                                            ECOH: Environment Care with a One Health approach &#8211; Water\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6510\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6510\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Water is an irreplaceable resource for developing socioeconomic activities and maintaining life on the planet. According to projections, water scarcity will increase, especially in those countries vulnerable to the effects of climate change and accelerated population growth. The negative impacts of the water deficit are already visible in some regions of the planet.\r\n\r\nThrough the ECOH-WATER project, we will develop capacities for the access and use of rainwater in educational centers in Guatemala and Bolivia for sustainable consumption, adapting to the impacts generated by climate change through strategies based on local needs. To do this, we will first diagnose the areas at risk of drought using Geographic Information Systems (GIS) to prioritize interventions. In the selected areas, we will develop an Action Research study with a strong participatory component to involve communities in implementing a rainwater harvesting system. Additionally, we will implement educational strategies for developing skills in seeking rational and sustainable water use. The project will establish alliances with local actors for the project's sustainability.\r\nThe search for strategies to access quality water for human, animal, and environmental consumption is a worldwide priority. It must involve the communities, raise awareness about natural resources and risk behaviors, and work collaboratively with decision-makers. On the other hand, the transdisciplinary work proposed in this project will allow the search for solutions with an integral vision. On the other hand, this project highlights the south-south collaboration to generate learning, enhance local resources, and move toward our region's sustainable development.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2022 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Centro Interuniversitario de Envejecimiento Saludable<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6378\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Caracterizaci\u00f3n de la capacidad funcional y condici\u00f3n f\u00edsica de personas mayores de siete comunas de la zona centro-sur de Chile\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6378\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6378\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que involucra a 7 universidades p\u00fablicas chilenas donde evaluaremos la condici\u00f3n f\u00edsica y capacidad funcional de personas mayores en siete diferentes comunas de la zona centro-sur de Chile y su asociaci\u00f3n con antecedentes bio-demogr\u00e1ficos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Resoluci\u00f3n exenta N\u00b0 2848-2022<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2022 - Diciembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6515\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Servicios de Asesor\u00eda y Acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6515\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6515\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de Transferencia Directa de recursos para la Ejecuci\u00f3n de Servicios de Asesor\u00eda y Acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo.\r\n\r\nCoordinaci\u00f3n de la Red de Cooperativas Inclusivas de Chile, REFICOOP.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Resoluci\u00f3n exenta N\u00b0 2848-2022<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2022 - Diciembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Servicio Nacional de la Discapacidad (SENADIS)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6553\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Servicios de Asesor\u00eda y Acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6553\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6553\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Convenio de Transferencia Directa de recursos para la Ejecuci\u00f3n de Servicios de Asesor\u00eda y Acompa\u00f1amiento en la Instalaci\u00f3n de Incubadoras de Cooperativas Inclusivas a Municipalidades adjudicatarias de la Modalidad Continuidad de la Estrategia de Desarrollo Local Inclusivo.\r\n\r\nCoordinaci\u00f3n de la Red de Cooperativas Inclusivas de Chile, REFICOOP.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIES005<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2022 - Julio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6376\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Caracterizaci\u00f3n de la capacidad funcional  y condici\u00f3n f\u00edsica de personas mayores de siete comunas de la zona centro-sur de Chile\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6376\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6376\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]mayores (PM) de 65 a\u00f1os superan el n\u00famero de menores de 5 a\u00f1os y se espera que para el a\u00f1o 2030 \u00e9sta cifra aumente en un 34%. Frente a esto, Chile tiene importantes desaf\u00edos orientados al desarrollo de estrategias que promuevan el envejecimiento activo y saludable. Se acepta que una buena condici\u00f3n f\u00edsica se relaciona con una mejor capacidad funcional y reducci\u00f3n de la mortalidad en PM. Si bien existen estudios de cohortes de PM en Chile como ALEXANDROS, n= 2311 y la encuesta nacional de calidad de vida en la vejez  (n=2.132), estas no est\u00e1n espec\u00edficamente orientadas a la evaluaci\u00f3n de la condici\u00f3n f\u00edsica y su relaci\u00f3n con la capacidad funcional de las personas y, adem\u00e1s, son cohortes pertenecientes principalmente a la Regi\u00f3n Metropolitana. \r\nEl prop\u00f3sito de este proyecto es caracterizar la condici\u00f3n f\u00edsica y capacidad funcional de personas mayores de siete diferentes comunas de la zona centro-sur de Chile y su relaci\u00f3n con caracter\u00edsticas bio-demogr\u00e1ficas, de manera que permita orientar pol\u00edticas y acciones necesarias e integrales para la mejora de estos par\u00e1metros considerados determinantes del envejecimiento activo y saludable. Adicionalmente, se espera iniciar una cohorte multi-regional para estudios longitudinales, como tambi\u00e9n, el inicio de un biobanco para futuros an\u00e1lisis de biomarcadores relacionados a sarcopenia, condici\u00f3n f\u00edsica y capacidad funcional.\r\nSe propone un dise\u00f1o transversal, en donde se incluir\u00e1n PM de 60 a\u00f1os y m\u00e1s,  capaces de caminar sin ayuda de otra persona al menos una distancia de 10 metros, pertenecientes a centros de Atenci\u00f3n Primaria o centros comunitarios de 7 comunas: Valpara\u00edso, Santiago, Rancagua, Talca, Chill\u00e1n, Temuco y Puerto Montt. Se excluir\u00e1n personas que presenten deterioro cognitivo, patolog\u00edas card\u00edacas, respiratorias, m\u00fasculo esquel\u00e9ticas o neurol\u00f3gicas que le impidan o tengan contraindicaci\u00f3n para realizar las evaluaciones o pruebas de rendimiento f\u00edsico, incapacidad para comunicarse o dependencia en las actividades b\u00e1sicas de la vida diaria seg\u00fan \u00cdndice de Barthel. \r\nEl tama\u00f1o muestral se ha estimado a partir de la poblaci\u00f3n total compuesta por el total de sujetos de las 7 comunas (279.991), utilizando los siguientes par\u00e1metros: N=total poblacional, Z2=3,84 (nivel de confianza 95%), p=prevalencia de sarcopenia (19,1%), p=1-p y d2=3% precisi\u00f3n o error de muestreo. La muestra calculada se ajust\u00f3 a un 30% de p\u00e9rdidas por lo que tama\u00f1o de muestra fue de 936 en total. La muestra ser\u00e1 seleccionada mediante muestreo aleatorio simple. \r\nSe  caracterizar\u00e1n antecedentes biodemogr\u00e1ficos, de salud,  capacidad funcional y condici\u00f3n f\u00edsica de las PM, a trav\u00e9s de la aplicaci\u00f3n de cuestionarios,  pruebas de condici\u00f3n f\u00edsica y test funcionales, todos validados y estandarizados en cada lugar de evaluaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIES005<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2022 - Julio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6408\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Caracterizaci\u00f3n de la capacidad funcional  y condici\u00f3n f\u00edsica de personas mayores de siete comunas de la zona centro-sur de Chile\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6408\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6408\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]mayores (PM) de 65 a\u00f1os superan el n\u00famero de menores de 5 a\u00f1os y se espera que para el a\u00f1o 2030 \u00e9sta cifra aumente en un 34%. Frente a esto, Chile tiene importantes desaf\u00edos orientados al desarrollo de estrategias que promuevan el envejecimiento activo y saludable. Se acepta que una buena condici\u00f3n f\u00edsica se relaciona con una mejor capacidad funcional y reducci\u00f3n de la mortalidad en PM. Si bien existen estudios de cohortes de PM en Chile como ALEXANDROS, n= 2311 y la encuesta nacional de calidad de vida en la vejez  (n=2.132), estas no est\u00e1n espec\u00edficamente orientadas a la evaluaci\u00f3n de la condici\u00f3n f\u00edsica y su relaci\u00f3n con la capacidad funcional de las personas y, adem\u00e1s, son cohortes pertenecientes principalmente a la Regi\u00f3n Metropolitana. \r\nEl prop\u00f3sito de este proyecto es caracterizar la condici\u00f3n f\u00edsica y capacidad funcional de personas mayores de siete diferentes comunas de la zona centro-sur de Chile y su relaci\u00f3n con caracter\u00edsticas bio-demogr\u00e1ficas, de manera que permita orientar pol\u00edticas y acciones necesarias e integrales para la mejora de estos par\u00e1metros considerados determinantes del envejecimiento activo y saludable. Adicionalmente, se espera iniciar una cohorte multi-regional para estudios longitudinales, como tambi\u00e9n, el inicio de un biobanco para futuros an\u00e1lisis de biomarcadores relacionados a sarcopenia, condici\u00f3n f\u00edsica y capacidad funcional.\r\nSe propone un dise\u00f1o transversal, en donde se incluir\u00e1n PM de 60 a\u00f1os y m\u00e1s,  capaces de caminar sin ayuda de otra persona al menos una distancia de 10 metros, pertenecientes a centros de Atenci\u00f3n Primaria o centros comunitarios de 7 comunas: Valpara\u00edso, Santiago, Rancagua, Talca, Chill\u00e1n, Temuco y Puerto Montt. Se excluir\u00e1n personas que presenten deterioro cognitivo, patolog\u00edas card\u00edacas, respiratorias, m\u00fasculo esquel\u00e9ticas o neurol\u00f3gicas que le impidan o tengan contraindicaci\u00f3n para realizar las evaluaciones o pruebas de rendimiento f\u00edsico, incapacidad para comunicarse o dependencia en las actividades b\u00e1sicas de la vida diaria seg\u00fan \u00cdndice de Barthel. \r\nEl tama\u00f1o muestral se ha estimado a partir de la poblaci\u00f3n total compuesta por el total de sujetos de las 7 comunas (279.991), utilizando los siguientes par\u00e1metros: N=total poblacional, Z2=3,84 (nivel de confianza 95%), p=prevalencia de sarcopenia (19,1%), p=1-p y d2=3% precisi\u00f3n o error de muestreo. La muestra calculada se ajust\u00f3 a un 30% de p\u00e9rdidas por lo que tama\u00f1o de muestra fue de 936 en total. La muestra ser\u00e1 seleccionada mediante muestreo aleatorio simple. \r\nSe  caracterizar\u00e1n antecedentes biodemogr\u00e1ficos, de salud,  capacidad funcional y condici\u00f3n f\u00edsica de las PM, a trav\u00e9s de la aplicaci\u00f3n de cuestionarios,  pruebas de condici\u00f3n f\u00edsica y test funcionales, todos validados y estandarizados en cada lugar de evaluaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> CIES005<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2022 - Julio 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6439\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Caracterizaci\u00f3n de la capacidad funcional  y condici\u00f3n f\u00edsica de personas mayores de siete comunas de la zona centro-sur de Chile\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6439\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6439\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]mayores (PM) de 65 a\u00f1os superan el n\u00famero de menores de 5 a\u00f1os y se espera que para el a\u00f1o 2030 \u00e9sta cifra aumente en un 34%. Frente a esto, Chile tiene importantes desaf\u00edos orientados al desarrollo de estrategias que promuevan el envejecimiento activo y saludable. Se acepta que una buena condici\u00f3n f\u00edsica se relaciona con una mejor capacidad funcional y reducci\u00f3n de la mortalidad en PM. Si bien existen estudios de cohortes de PM en Chile como ALEXANDROS, n= 2311 y la encuesta nacional de calidad de vida en la vejez  (n=2.132), estas no est\u00e1n espec\u00edficamente orientadas a la evaluaci\u00f3n de la condici\u00f3n f\u00edsica y su relaci\u00f3n con la capacidad funcional de las personas y, adem\u00e1s, son cohortes pertenecientes principalmente a la Regi\u00f3n Metropolitana. \r\nEl prop\u00f3sito de este proyecto es caracterizar la condici\u00f3n f\u00edsica y capacidad funcional de personas mayores de siete diferentes comunas de la zona centro-sur de Chile y su relaci\u00f3n con caracter\u00edsticas bio-demogr\u00e1ficas, de manera que permita orientar pol\u00edticas y acciones necesarias e integrales para la mejora de estos par\u00e1metros considerados determinantes del envejecimiento activo y saludable. Adicionalmente, se espera iniciar una cohorte multi-regional para estudios longitudinales, como tambi\u00e9n, el inicio de un biobanco para futuros an\u00e1lisis de biomarcadores relacionados a sarcopenia, condici\u00f3n f\u00edsica y capacidad funcional.\r\nSe propone un dise\u00f1o transversal, en donde se incluir\u00e1n PM de 60 a\u00f1os y m\u00e1s,  capaces de caminar sin ayuda de otra persona al menos una distancia de 10 metros, pertenecientes a centros de Atenci\u00f3n Primaria o centros comunitarios de 7 comunas: Valpara\u00edso, Santiago, Rancagua, Talca, Chill\u00e1n, Temuco y Puerto Montt. Se excluir\u00e1n personas que presenten deterioro cognitivo, patolog\u00edas card\u00edacas, respiratorias, m\u00fasculo esquel\u00e9ticas o neurol\u00f3gicas que le impidan o tengan contraindicaci\u00f3n para realizar las evaluaciones o pruebas de rendimiento f\u00edsico, incapacidad para comunicarse o dependencia en las actividades b\u00e1sicas de la vida diaria seg\u00fan \u00cdndice de Barthel. \r\nEl tama\u00f1o muestral se ha estimado a partir de la poblaci\u00f3n total compuesta por el total de sujetos de las 7 comunas (279.991), utilizando los siguientes par\u00e1metros: N=total poblacional, Z2=3,84 (nivel de confianza 95%), p=prevalencia de sarcopenia (19,1%), p=1-p y d2=3% precisi\u00f3n o error de muestreo. La muestra calculada se ajust\u00f3 a un 30% de p\u00e9rdidas por lo que tama\u00f1o de muestra fue de 936 en total. La muestra ser\u00e1 seleccionada mediante muestreo aleatorio simple. \r\nSe  caracterizar\u00e1n antecedentes biodemogr\u00e1ficos, de salud,  capacidad funcional y condici\u00f3n f\u00edsica de las PM, a trav\u00e9s de la aplicaci\u00f3n de cuestionarios,  pruebas de condici\u00f3n f\u00edsica y test funcionales, todos validados y estandarizados en cada lugar de evaluaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> NCS2022_039<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2022 - Octubre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6563\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            N\u00facleo Milenio de estudios de discapacidad y ciudadania\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6563\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6563\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]l N\u00facleo Milenio Discapacidad y Ciudadan\u00eda (DISCA) es un centro de investigaci\u00f3n interdisciplinario financiado por la Agencia Nacional de Investigaci\u00f3n y Desarrollo (2023 a 2025).\r\n\r\nCon un abordaje multi y transdisciplinario, la agenda de DISCA se centra en el estudio de los procesos y mecanismos a trav\u00e9s de los cuales las personas con discapacidad se transforman en ciudadanas.\r\n\r\nDISCA est\u00e1 dirigido por una persona con discapacidad, cuenta con un consejo de expertas y expertos por experiencia y esta alineado con los principios de la investigaci\u00f3n inclusiva y participativa. Sus investigadores, pioneros en la investigaci\u00f3n en discapacidad en el pa\u00eds, utilizan metodolog\u00edas mixtas, cuantitativas y cualitativas, integrando conocimientos de la antropolog\u00eda social, el derecho, la salud, la econom\u00eda, la sociolog\u00eda y la psicolog\u00eda, en conjunto con el campo transdisciplinario de los estudios de la discapacidad.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2022 - Septiembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6507\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Dise\u00f1o \u00f3ptimo de red de monitoreo de calidad de aire para medici\u00f3n de impacto en salud respiratoria\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6507\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6507\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La contaminaci\u00f3n ambiental extradomiciliaria es un importante problema de salud ambiental ya que es responsable del 7,6% de la mortalidad anual total y de la p\u00e9rdida de 103,1 millones de a\u00f1os de vida saludable. Entre algunos de los efectos adversos que se han reportado para el Material Particulado, uno de los principales contaminantes, se encuentran aumento en la mortalidad, morbilidad, muerte prematura, enfermedades cardiovasculares y respiratorias, c\u00e1ncer de pulm\u00f3n, impacto adverso en la actividad del sistema nervioso central que resulta en deterioro cognitivo, y efectos nocivos sobre el desarrollo fetal y el embarazo, afectando mayormente a grupos m\u00e1s vulnerables. Si bien, a nivel global, se cuentan con estrategias y criterios de monitoreo de calidad del aire para identificar la concentraci\u00f3n de los contaminantes relacionados con la salud, es posible que estos no permitan analizar con mayor profundidad las diferencias en la distribuci\u00f3n geogr\u00e1fica de los contaminantes y su impacto en poblaciones espec\u00edficas. \r\nEn ese sentido, el presente proyecto tiene el objetivo de establecer una metodolog\u00eda para la generaci\u00f3n de un mapa confiable de la contaminaci\u00f3n del aire a partir de una red de monitoreo, el cual permita correlacionar de manera m\u00e1s precisa a trav\u00e9s de modelos de interpolaci\u00f3n, la contaminaci\u00f3n del aire con los problemas de salud respiratorio de las personas del sector considerado, hacer una validaci\u00f3n de la metodolog\u00eda propuesta con un programa piloto en un \u00e1rea a determinar de la comuna de Rancagua y realizar divulgaci\u00f3n de resultados en colegios y jardines de la regi\u00f3n con la finalidad de generar un debate m\u00e1s amplio y democr\u00e1tico sobre tanto de pr\u00e1cticas personales as\u00ed como de las nuevas pol\u00edticas relacionadas con la contaminaci\u00f3n del aire.\r\nPara esto se propone emplear diversos m\u00e9todos propios de cada disciplina. Primeramente, se estimar\u00e1 un radio m\u00e1ximo de cobertura de un sensor dentro del cual se garantice cierto grado de confianza (Variograma emp\u00edrico) respecto de los valores entregados por el sensor como promedios representativos, para as\u00ed determinar el tama\u00f1o\/forma del \u00e1rea geogr\u00e1fica total donde instalar la red de sensores (Obj 1). Con esta informaci\u00f3n se determinar\u00e1 una configuraci\u00f3n inicial de los sensores en un \u00e1rea geogr\u00e1fica determinada considerando la capacidad de la red, usando como ubicaci\u00f3n potencial establecimientos educativos. Luego se har\u00e1 un an\u00e1lisis estad\u00edstico con los datos proporcionados por la red y por sensores m\u00f3viles para determinar una nueva configuraci\u00f3n que maximice la confianza de la nueva interpolaci\u00f3n. Una vez instalados los sensores y a partir de los datos entregados por ellos se escoger\u00e1 una nueva configuraci\u00f3n a trav\u00e9s de un an\u00e1lisis estad\u00edstico de covarianzas (Obj 2). Adem\u00e1s, se realizar\u00e1 un estudio ecol\u00f3gico para correlacionar las mediciones de contaminaci\u00f3n de aire y algunos indicadores de salud respiratoria y atenci\u00f3n de salud considerando distintos puntos geogr\u00e1ficos de la sexta regi\u00f3n (Obj 3). Finalmente, el proyecto desarrollar\u00e1 un plan de educaci\u00f3n ambiental para concientizar sobre el tema y favorecer el cambio de comportamientos a nivel individual y comunitario (Obj 4).\r\nCon este proyecto se espera abordar con una visi\u00f3n interdisciplinaria un tema que es de especial preocupaci\u00f3n en la regi\u00f3n, como es la contaminaci\u00f3n ambiental, fortaleciendo esta l\u00ednea de investigaci\u00f3n tanto en el instituto de ingenier\u00eda como en el de Salud, involucrando de forma activa tambi\u00e9n a estudiantes de pregrado.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2022 - Diciembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Fundaci\u00f3n para la Innovaci\u00f3n Agraria - FIA<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6523\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Salud mental, g\u00e9nero y cuidados, en las personas trabajadoras de salud durante la pandemia COVID-19\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6523\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6523\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto financiaci\u00f3n PICTO-2022- GENERO00045. \r\nEl equipo de investigaci\u00f3n integra las disciplinas en aspectos jur\u00eddicos y de derechos humanos, salud mental, medicina,\r\nsociolog\u00eda, estad\u00edsticas y especialistas en desarrollo local; ciencias pol\u00edticas, justicia de g\u00e9nero y planificaci\u00f3n estrat\u00e9gica con enfoque de g\u00e9nero. Es un equipo interdisciplinar y contribuye al campo de los cuidados, en la incorporaci\u00f3n del enfoque de g\u00e9nero; desarrollo territorial y derechos.\r\nhttps:\/\/www.argentina.gob.ar\/noticias\/se-presentaron-los-proyectos-seleccionados-de-la-convocatoria-picto-genero[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6366\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6366\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6366\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6403\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6403\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6403\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6434\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6434\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6434\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6480\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6480\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6480\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6487\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6487\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6487\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> URO2295<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2022 - Enero 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6522\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles con foco en actividad f\u00edsica y nutrici\u00f3n saludable\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6522\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6522\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]URO 2295. El Ministerio de Educaci\u00f3n a trav\u00e9s del Departamento de Fortalecimiento Institucional de la Subsecretaria de Educaci\u00f3n Superior financia proyectos que permitan contribuir al desarrollo social y territorial, a nivel local y\/o regional, a trav\u00e9s de la generaci\u00f3n compartida de conocimientos, oportunidades de desarrollo y\/o beneficios entre las instituciones de educaci\u00f3n superior y los actores sociales, tanto p\u00fablicos como privados. En este contexto, este proyecto busca generar estrategias eficaces \u0096 con la comunidad y distintos actores sociales de la regi\u00f3n \u0096 y basadas en la evidencia que aborden el aumento de la prevalencia de enfermedades cr\u00f3nicas no transmisibles a trav\u00e9s de la mejora de los patrones de actividad f\u00edsica y alimentarios de la poblaci\u00f3n regional. \r\nObjetivo general: Fortalecer las estrategias comunitarias de promoci\u00f3n de la salud, prevenci\u00f3n y tratamiento temprano y oportuno de enfermedades cr\u00f3nicas no transmisibles en la Regi\u00f3n de O\u0092Higgins con foco en actividad f\u00edsica y nutrici\u00f3n saludable[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2022 - Abril 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6467\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto de la obesidad inducida por el consumo de una dieta alta en grasas sobre la activaci\u00f3n del inflamamos NLRP3 en la c\u00f3clea y la funci\u00f3n del sistema auditivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6467\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6467\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]EFECTO DE LA OBESIDAD INDUCIDA POR EL CONSUMO DE UNA DIETA ALTA EN GRASAS SOBRE LA ACTIVACI\u00d3N DEL INFLAMASOMA NLRP3 EN LA C\u00d3CLEA Y LA FUNCI\u00d3N DEL SISTEMA AUDITIVO[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Patrocinante<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2022 - Abril 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6477\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto de la obesidad inducida por el consumo de una dieta alta en grasas sobre la activaci\u00f3n del inflamamos NLRP3 en la c\u00f3clea y la funci\u00f3n del sistema auditivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6477\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6477\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]EFECTO DE LA OBESIDAD INDUCIDA POR EL CONSUMO DE UNA DIETA ALTA EN GRASAS SOBRE LA ACTIVACI\u00d3N DEL INFLAMASOMA NLRP3 EN LA C\u00d3CLEA Y LA FUNCI\u00d3N DEL SISTEMA AUDITIVO[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2022 - Marzo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6380\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 2022\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6380\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6380\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, compelling evidence shows how the context in which early life takes place impinges risk or protection for later development of non-communicable chronic diseases. In this regard, impaired fetal growth, as occur in the fetal growth restriction (FGR), leads to a higher risk for later cardiovascular diseases, an effect that would be mediated by accelerated aging at molecular, structural, and functional levels. FGR remains a leading cause of perinatal morbidity and mortality, affecting ~10% of pregnancies, but ranging from 5 to 25% depending on the population surveyed, with a higher prevalence among pregnant women of low socioeconomic status. In the clinic, FGR is normally defined by a fetal weight below the 10th percentile, however, new evidence shows that impaired intrauterine growth may affect several neonates born over the 10th percentile, especially late in pregnancy, which may be missed from the perinatal survey for preventing adverse outcomes. This points out the need for further studies to improve the understanding and identification of altered fetal growth trajectories and their consequences on vascular function. \r\nStudies in the placenta show that FGR vascular dysfunction is also found at birth in chorionic and umbilical arteries. We have demonstrated the presence of functional and molecular markers (e.g. vasodilator mediators and epigenetic changes) of endothelial dysfunction in human FGR umbilical and chorionic vessels, findings that have been further confirmed by comparing systemic and umbilical arteries in guinea pigs and chicken FGR models. These traits suggest that umbilical artery endothelial cells (HUAEC), in complement with approaches in animal models, can be used as a surrogate to explore the vascular programming within the fetus, however, their translation to clinical preventive applications for promoting healthy aging deserves further studies. It worth noting that fetal reduced oxygen supply (fetal hypoxia) and altered blood flow patterns (e.g. shear stress) are key clinical markers in the FGR, independently of the constraints leading to impaired growth, and both factors exert a tight control of vascular development and function across life. However, how these key stimuli interact and impose an epigenetic program on the endothelial function remains elusive. This proposal will focus on the crosstalk between hypoxia and shear stress that results in the endothelial programming related to impaired fetal growth, and the molecular mechanisms that mediate the vascular responses to these stimuli. Furthermore, we will address if these molecular markers may allow detecting early vascular aging in FGR subjects beyond the 10th centile cutoff. We hypothesize that \u0093Impaired fetal growth conditions are associated with epigenetic programming of aging- and mechanosensing-related miRNAs and transcripts in the endothelium, which can be triggered by the confluence of altered flow patterns and hypoxia resulting in molecular and structural pro-hypertensive biomechanical vascular properties\u0094. \r\nThis hypothesis will be addressed by three General Objectives (GO) involving ex vivo, in vitro, and in vivo observational and mechanistic approaches: GO1 To demonstrate, in HUAEC, whether late FGR results in epigenetic changes related to the regulation of vascular aging and the expression of mechanosensing mechanisms involved in the endothelial-dependent relaxation, and their relationship with general prenatal parameters of vascular health. GO1 will be performed by recruiting HUAEC samples from late FGR and control pregnancies, to assess transcriptomic and DNA methylation analyses that will be crossed with prenatal clinical data. GO2 To study, in vivo, whether hypoxia and shear stress differentially regulate mechanosensing pathways involved in the endothelial-dependent relaxation and their relationship with the in vivo and ex vivo vascular properties (e.g. functional and biomechanical). GO2 will be performed in chicken embryos exposed to hypoxia and treated with agents targeting mechanosensing pathways, in which wall shear stress will be determined by Ultrasound Localization Microscopy, with complementary functional, structural, and molecular analyses. GO 3. To study, in cultured HUAEC, whether stimuli related to impaired fetal growth converge in the regulation of mechanosensing- and aging-related transcripts and miRNA, contributing to the cellular programming of endothelial dysfunction. GO3 will be performed in HUAEC exposed, in vitro, to sustained hypoxia and diverse flow patterns (shear stress), in which target DNA methylation, miRNA, transcripts, and proteins will be assessed. Our expected outcome is to improve the knowledge about the endothelial epigenetic programming after FGR in humans and enhance the characterization of the shear stress patterns and mechanisms associated with chronic fetal hypoxia. These effects will be isolated by studying, in vivo, hypoxic chicken embryos and, in vitro, cultured HUAEC exposed to FGR-like flow patterns. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction but also to open potential approaches for preventing, diagnosing, and treating FGR-pregnancies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2022 - Marzo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6411\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 2022\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6411\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6411\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, compelling evidence shows how the context in which early life takes place impinges risk or protection for later development of non-communicable chronic diseases. In this regard, impaired fetal growth, as occur in the fetal growth restriction (FGR), leads to a higher risk for later cardiovascular diseases, an effect that would be mediated by accelerated aging at molecular, structural, and functional levels. FGR remains a leading cause of perinatal morbidity and mortality, affecting ~10% of pregnancies, but ranging from 5 to 25% depending on the population surveyed, with a higher prevalence among pregnant women of low socioeconomic status. In the clinic, FGR is normally defined by a fetal weight below the 10th percentile, however, new evidence shows that impaired intrauterine growth may affect several neonates born over the 10th percentile, especially late in pregnancy, which may be missed from the perinatal survey for preventing adverse outcomes. This points out the need for further studies to improve the understanding and identification of altered fetal growth trajectories and their consequences on vascular function. \r\nStudies in the placenta show that FGR vascular dysfunction is also found at birth in chorionic and umbilical arteries. We have demonstrated the presence of functional and molecular markers (e.g. vasodilator mediators and epigenetic changes) of endothelial dysfunction in human FGR umbilical and chorionic vessels, findings that have been further confirmed by comparing systemic and umbilical arteries in guinea pigs and chicken FGR models. These traits suggest that umbilical artery endothelial cells (HUAEC), in complement with approaches in animal models, can be used as a surrogate to explore the vascular programming within the fetus, however, their translation to clinical preventive applications for promoting healthy aging deserves further studies. It worth noting that fetal reduced oxygen supply (fetal hypoxia) and altered blood flow patterns (e.g. shear stress) are key clinical markers in the FGR, independently of the constraints leading to impaired growth, and both factors exert a tight control of vascular development and function across life. However, how these key stimuli interact and impose an epigenetic program on the endothelial function remains elusive. This proposal will focus on the crosstalk between hypoxia and shear stress that results in the endothelial programming related to impaired fetal growth, and the molecular mechanisms that mediate the vascular responses to these stimuli. Furthermore, we will address if these molecular markers may allow detecting early vascular aging in FGR subjects beyond the 10th centile cutoff. We hypothesize that \u0093Impaired fetal growth conditions are associated with epigenetic programming of aging- and mechanosensing-related miRNAs and transcripts in the endothelium, which can be triggered by the confluence of altered flow patterns and hypoxia resulting in molecular and structural pro-hypertensive biomechanical vascular properties\u0094. \r\nThis hypothesis will be addressed by three General Objectives (GO) involving ex vivo, in vitro, and in vivo observational and mechanistic approaches: GO1 To demonstrate, in HUAEC, whether late FGR results in epigenetic changes related to the regulation of vascular aging and the expression of mechanosensing mechanisms involved in the endothelial-dependent relaxation, and their relationship with general prenatal parameters of vascular health. GO1 will be performed by recruiting HUAEC samples from late FGR and control pregnancies, to assess transcriptomic and DNA methylation analyses that will be crossed with prenatal clinical data. GO2 To study, in vivo, whether hypoxia and shear stress differentially regulate mechanosensing pathways involved in the endothelial-dependent relaxation and their relationship with the in vivo and ex vivo vascular properties (e.g. functional and biomechanical). GO2 will be performed in chicken embryos exposed to hypoxia and treated with agents targeting mechanosensing pathways, in which wall shear stress will be determined by Ultrasound Localization Microscopy, with complementary functional, structural, and molecular analyses. GO 3. To study, in cultured HUAEC, whether stimuli related to impaired fetal growth converge in the regulation of mechanosensing- and aging-related transcripts and miRNA, contributing to the cellular programming of endothelial dysfunction. GO3 will be performed in HUAEC exposed, in vitro, to sustained hypoxia and diverse flow patterns (shear stress), in which target DNA methylation, miRNA, transcripts, and proteins will be assessed. Our expected outcome is to improve the knowledge about the endothelial epigenetic programming after FGR in humans and enhance the characterization of the shear stress patterns and mechanisms associated with chronic fetal hypoxia. These effects will be isolated by studying, in vivo, hypoxic chicken embryos and, in vitro, cultured HUAEC exposed to FGR-like flow patterns. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction but also to open potential approaches for preventing, diagnosing, and treating FGR-pregnancies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2022 - Marzo 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6444\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 2022\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6444\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6444\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, compelling evidence shows how the context in which early life takes place impinges risk or protection for later development of non-communicable chronic diseases. In this regard, impaired fetal growth, as occur in the fetal growth restriction (FGR), leads to a higher risk for later cardiovascular diseases, an effect that would be mediated by accelerated aging at molecular, structural, and functional levels. FGR remains a leading cause of perinatal morbidity and mortality, affecting ~10% of pregnancies, but ranging from 5 to 25% depending on the population surveyed, with a higher prevalence among pregnant women of low socioeconomic status. In the clinic, FGR is normally defined by a fetal weight below the 10th percentile, however, new evidence shows that impaired intrauterine growth may affect several neonates born over the 10th percentile, especially late in pregnancy, which may be missed from the perinatal survey for preventing adverse outcomes. This points out the need for further studies to improve the understanding and identification of altered fetal growth trajectories and their consequences on vascular function. \r\nStudies in the placenta show that FGR vascular dysfunction is also found at birth in chorionic and umbilical arteries. We have demonstrated the presence of functional and molecular markers (e.g. vasodilator mediators and epigenetic changes) of endothelial dysfunction in human FGR umbilical and chorionic vessels, findings that have been further confirmed by comparing systemic and umbilical arteries in guinea pigs and chicken FGR models. These traits suggest that umbilical artery endothelial cells (HUAEC), in complement with approaches in animal models, can be used as a surrogate to explore the vascular programming within the fetus, however, their translation to clinical preventive applications for promoting healthy aging deserves further studies. It worth noting that fetal reduced oxygen supply (fetal hypoxia) and altered blood flow patterns (e.g. shear stress) are key clinical markers in the FGR, independently of the constraints leading to impaired growth, and both factors exert a tight control of vascular development and function across life. However, how these key stimuli interact and impose an epigenetic program on the endothelial function remains elusive. This proposal will focus on the crosstalk between hypoxia and shear stress that results in the endothelial programming related to impaired fetal growth, and the molecular mechanisms that mediate the vascular responses to these stimuli. Furthermore, we will address if these molecular markers may allow detecting early vascular aging in FGR subjects beyond the 10th centile cutoff. We hypothesize that \u0093Impaired fetal growth conditions are associated with epigenetic programming of aging- and mechanosensing-related miRNAs and transcripts in the endothelium, which can be triggered by the confluence of altered flow patterns and hypoxia resulting in molecular and structural pro-hypertensive biomechanical vascular properties\u0094. \r\nThis hypothesis will be addressed by three General Objectives (GO) involving ex vivo, in vitro, and in vivo observational and mechanistic approaches: GO1 To demonstrate, in HUAEC, whether late FGR results in epigenetic changes related to the regulation of vascular aging and the expression of mechanosensing mechanisms involved in the endothelial-dependent relaxation, and their relationship with general prenatal parameters of vascular health. GO1 will be performed by recruiting HUAEC samples from late FGR and control pregnancies, to assess transcriptomic and DNA methylation analyses that will be crossed with prenatal clinical data. GO2 To study, in vivo, whether hypoxia and shear stress differentially regulate mechanosensing pathways involved in the endothelial-dependent relaxation and their relationship with the in vivo and ex vivo vascular properties (e.g. functional and biomechanical). GO2 will be performed in chicken embryos exposed to hypoxia and treated with agents targeting mechanosensing pathways, in which wall shear stress will be determined by Ultrasound Localization Microscopy, with complementary functional, structural, and molecular analyses. GO 3. To study, in cultured HUAEC, whether stimuli related to impaired fetal growth converge in the regulation of mechanosensing- and aging-related transcripts and miRNA, contributing to the cellular programming of endothelial dysfunction. GO3 will be performed in HUAEC exposed, in vitro, to sustained hypoxia and diverse flow patterns (shear stress), in which target DNA methylation, miRNA, transcripts, and proteins will be assessed. Our expected outcome is to improve the knowledge about the endothelial epigenetic programming after FGR in humans and enhance the characterization of the shear stress patterns and mechanisms associated with chronic fetal hypoxia. These effects will be isolated by studying, in vivo, hypoxic chicken embryos and, in vitro, cultured HUAEC exposed to FGR-like flow patterns. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction but also to open potential approaches for preventing, diagnosing, and treating FGR-pregnancies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2022 - Marzo 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6404\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life in patients with rheumatoid arthritis after omega-3 PUFA supplementation and aerobic exercise training\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6404\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6404\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca determinar mecanismos moleculares de como los \u00e1cidos grasos omega-3 y el ejercicio f\u00edsico pueden mejorar la calidad de vida, funcionalidad y par\u00e1metros de inflamaci\u00f3n de pacientes con artritis reumatoide.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2022 - Marzo 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6435\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life in patients with rheumatoid arthritis after omega-3 PUFA supplementation and aerobic exercise training\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6435\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6435\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca determinar mecanismos moleculares de como los \u00e1cidos grasos omega-3 y el ejercicio f\u00edsico pueden mejorar la calidad de vida, funcionalidad y par\u00e1metros de inflamaci\u00f3n de pacientes con artritis reumatoide.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2022 - Febrero 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6398\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Sensing a Disturbance in the Flow: Crosstalk Between Shear Stress and Hypoxia in the Early Origins of Vascular Dysfunction\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6398\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6398\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, compelling evidence shows how the context in which early life takes place impinges risk or protection for later development of non-communicable chronic diseases. In this regard, impaired fetal growth, as occur in the fetal growth restriction (FGR), leads to a higher risk for later cardiovascular diseases, an effect that would be mediated by accelerated aging at molecular, structural, and functional levels. FGR remains a leading cause of perinatal morbidity and mortality, affecting ~10% of pregnancies, but ranging 5 to 25% depending on the nutritional and health conditions of the population surveyed, with a higher prevalence among pregnant women of low socioeconomic status. In the clinic, FGR is normally defined by a fetal weight below the 10th percentile, however, new evidence shows that impaired intrauterine growth may affect several neonates born over the 10th percentile, which may be missed from the perinatal survey for preventing adverse outcomes. This points out the need for further studies to improve the understanding and identification of altered fetal growth trajectories and their consequences on vascular function. Studies in placenta show that FGR vascular dysfunction is also found at birth in chorionic and umbilical arteries. We have demonstrated the presence of functional and molecular markers (e.g. epigenetic changes) of endothelial dysfunction in human umbilical and chorionic vessels, findings that have been further confirmed by comparing systemic (aorta and femoral arteries) and umbilical arteries in animal models of FGR. These traits suggest that umbilical artery endothelial cells (HUAEC) can be used as a surrogate to explore the vascular programming within the fetus, however, their translation to clinical preventive applications for promoting healthy aging deserves further studies. It worth noting that fetal reduced oxygen supply (i.e. fetal hypoxia) and altered blood flow patterns (i.e. shear stress) are key clinical markers in the FGR, independently of the constraints leading to impaired growth, and both factors exert a tight control of vascular development and function across life. However, how these key stimuli interact and impose an epigenetic program on the endothelial function remains elusive. This proposal will focus on the crosstalk between hypoxia and shear stress that results in the endothelial programming related to impaired fetal growth, and the molecular mechanisms that mediate the vascular responses to these stimuli. Furthermore, we will address if these molecular markers may allow detecting early vascular aging in FGR subjects beyond the 10th centile cutoff. We hypothesize that \u0093Impaired fetal growth conditions are associated with epigenetic programming of aging- and mechanosensing-related miRNAs and transcripts in the endothelium, which can be triggered by the confluence of altered flow patterns and hypoxia resulting in molecular and structural pro-hypertensive biomechanical vascular properties\u0094. This hypothesis will be addressed by three General Objectives (GO) involving ex vivo, in vitro, and in vivo observational and mechanistic approaches: GO1 To demonstrate, in HUAEC, whether late FGR results in epigenetic changes related to the regulation of vascular aging and the expression of mechanosensing mechanisms involved in the endothelial-dependent relaxation, and their relationship with general prenatal parameters of vascular health. GO1 will be performed by recruiting HUAEC samples from late FGR and control pregnancies, to assess transcriptomic and DNA methylation analyses that will be crossed with prenatal clinical data. GO2 To study, in vivo, whether stimuli related to FGR (i.e. hypoxia and altered shear stress) differentially regulate mechanosensing pathways involved in the endothelial-dependent relaxation and their relationship with the in vivo and ex vivo vascular properties (e.g. functional and biomechanical). GO2 will be performed in chicken embryos exposed to hypoxia and treated with agents targeting mechanosensing pathways, in which wall shear stress will be determined by Ultrasound Localization Microscopy, with complementary functional, structural, and molecular analyses. GO 3. To study, in cultured HUAEC, whether stimuli related to impaired fetal growth converge in the regulation of mechanosensing-and aging-related transcripts and miRNA, contributing to the cellular programming of endothelial dysfunction. OG3 will be performed in HUAEC exposed, in vitro, to sustained hypoxia and diverse flow patterns (shear stress), in which target DNA methylation, miRNA, transcripts, and proteins will be assessed. Our expected outcome is to improve the knowledge about the endothelial epigenetic programming after FGR and enhance the characterization of in vivo shear stress patterns and mechanisms induced by chronic fetal hypoxia. This project is not only relevant to uncover the developmental approaches for diagnosing and treatments in complicated pregnancies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2022 - Febrero 2026<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6429\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Sensing a Disturbance in the Flow: Crosstalk Between Shear Stress and Hypoxia in the Early Origins of Vascular Dysfunction\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6429\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6429\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, compelling evidence shows how the context in which early life takes place impinges risk or protection for later development of non-communicable chronic diseases. In this regard, impaired fetal growth, as occur in the fetal growth restriction (FGR), leads to a higher risk for later cardiovascular diseases, an effect that would be mediated by accelerated aging at molecular, structural, and functional levels. FGR remains a leading cause of perinatal morbidity and mortality, affecting ~10% of pregnancies, but ranging 5 to 25% depending on the nutritional and health conditions of the population surveyed, with a higher prevalence among pregnant women of low socioeconomic status. In the clinic, FGR is normally defined by a fetal weight below the 10th percentile, however, new evidence shows that impaired intrauterine growth may affect several neonates born over the 10th percentile, which may be missed from the perinatal survey for preventing adverse outcomes. This points out the need for further studies to improve the understanding and identification of altered fetal growth trajectories and their consequences on vascular function. Studies in placenta show that FGR vascular dysfunction is also found at birth in chorionic and umbilical arteries. We have demonstrated the presence of functional and molecular markers (e.g. epigenetic changes) of endothelial dysfunction in human umbilical and chorionic vessels, findings that have been further confirmed by comparing systemic (aorta and femoral arteries) and umbilical arteries in animal models of FGR. These traits suggest that umbilical artery endothelial cells (HUAEC) can be used as a surrogate to explore the vascular programming within the fetus, however, their translation to clinical preventive applications for promoting healthy aging deserves further studies. It worth noting that fetal reduced oxygen supply (i.e. fetal hypoxia) and altered blood flow patterns (i.e. shear stress) are key clinical markers in the FGR, independently of the constraints leading to impaired growth, and both factors exert a tight control of vascular development and function across life. However, how these key stimuli interact and impose an epigenetic program on the endothelial function remains elusive. This proposal will focus on the crosstalk between hypoxia and shear stress that results in the endothelial programming related to impaired fetal growth, and the molecular mechanisms that mediate the vascular responses to these stimuli. Furthermore, we will address if these molecular markers may allow detecting early vascular aging in FGR subjects beyond the 10th centile cutoff. We hypothesize that \u0093Impaired fetal growth conditions are associated with epigenetic programming of aging- and mechanosensing-related miRNAs and transcripts in the endothelium, which can be triggered by the confluence of altered flow patterns and hypoxia resulting in molecular and structural pro-hypertensive biomechanical vascular properties\u0094. This hypothesis will be addressed by three General Objectives (GO) involving ex vivo, in vitro, and in vivo observational and mechanistic approaches: GO1 To demonstrate, in HUAEC, whether late FGR results in epigenetic changes related to the regulation of vascular aging and the expression of mechanosensing mechanisms involved in the endothelial-dependent relaxation, and their relationship with general prenatal parameters of vascular health. GO1 will be performed by recruiting HUAEC samples from late FGR and control pregnancies, to assess transcriptomic and DNA methylation analyses that will be crossed with prenatal clinical data. GO2 To study, in vivo, whether stimuli related to FGR (i.e. hypoxia and altered shear stress) differentially regulate mechanosensing pathways involved in the endothelial-dependent relaxation and their relationship with the in vivo and ex vivo vascular properties (e.g. functional and biomechanical). GO2 will be performed in chicken embryos exposed to hypoxia and treated with agents targeting mechanosensing pathways, in which wall shear stress will be determined by Ultrasound Localization Microscopy, with complementary functional, structural, and molecular analyses. GO 3. To study, in cultured HUAEC, whether stimuli related to impaired fetal growth converge in the regulation of mechanosensing-and aging-related transcripts and miRNA, contributing to the cellular programming of endothelial dysfunction. OG3 will be performed in HUAEC exposed, in vitro, to sustained hypoxia and diverse flow patterns (shear stress), in which target DNA methylation, miRNA, transcripts, and proteins will be assessed. Our expected outcome is to improve the knowledge about the endothelial epigenetic programming after FGR and enhance the characterization of in vivo shear stress patterns and mechanisms induced by chronic fetal hypoxia. This project is not only relevant to uncover the developmental approaches for diagnosing and treatments in complicated pregnancies.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6368\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creacion de imagenes de super-resolucion ultrasonicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6368\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6368\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El desarrollo de herramientas para el an &#769;alisis de funciones vitales a trav &#769;es de im &#769;agenes representa un campo de creciente inter &#769;es, especialmente para el estudio de marcadores tempranos de diversas patolog &#769;&#305;as, as &#769;&#305; como el desarrollo de aplicaciones diagn &#769;osticas a mediano plazo. En este contexto, el an &#769;alisis de la funci &#769;on vascular, a lo largo del ciclo vital, continua siendo un  &#769;area con un alta demanda de nuevas tecnolog &#769;&#305;as, debido a su gran impacto a nivel de salud en la poblaci &#769;on. Esta propuesta busca generar una l &#769;&#305;nea de investigaci &#769;on actualmente casi inexistente en Chile, las im &#769;agenes ultras &#769;onicas m &#769;edicas. En particular, nos gustar &#769;&#305;a introducir en Chile una t &#769;ecnica recientemente propuesta, denominada microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM), tambi &#769;en conocida como im &#769;agenes de su &#769;per- resoluci &#769;on. Esta t &#769;ecnica puede crear im &#769;agenes del sistema circulatoria con una resoluci &#769;on nunca antes vista, lo que permite visualizar vasos sangu &#769;&#305;neos de hasta 5&#956;m. As &#769;&#305;, nuestra propuesta posee dos grandes objetivos. El primero es Optimizar y robusteces los procesos involucrados en el desarrollo de las im &#769;agenes de su &#769;per-resoluci &#769;on ultras &#769;onicas, esto a trav &#769;es de Optimizar los par &#769;ametros de adquisici &#769;on de datos y de procesamiento con el fin de robustecer la generaci &#769;on de este tipo de im &#769;agenes. Nuestro segundo objetivo es generar im &#769;agenes de su &#769;per- resoluci &#769;on de la red vascular interna de placenta humana ex-vivo y a buscar candidatos a marcadores a partir de estas im &#769;agenes.\r\nLa ecograf &#769;&#305;a convencional es ampliamente usada en Chile y el mundo. Es preferida entre otras modalidades de im &#769;agenes (MRI, PET, TC) debido a su portabilidad, bajo costo, naturaleza no invasiva y a que utiliza radiaci &#769;on no ionizante, especialmente en condiciones como el embarazo, o en pacientes con manejo farmacol &#769;ogico complejo, entre otras. Recientemente, se han desarrollado nuevas modalidades de im &#769;agenes ultras &#769;onicas, propiciadas por la mejora en la industria de los semiconductores, lo que ha permitido un incremento en la capacidad de computo de los esc &#769;aneres ultraso &#769;nicos y en el nu &#769;mero de elementos piezoel &#769;ectrico de los transductores ultras &#769;onicos, generando un aumento significativo en la versatilidad y calidad de estas tecnolog &#769;&#305;as. Dentro de estas nuevas t &#769;ecnicas encontramos la microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM) o su &#769;per-resoluci &#769;on ultras &#769;onica. Esta revolucionaria t &#769;ecnica es capaz de superar el l &#769;&#305;mite de difracci &#769;on y producir una resoluci &#769;on diez veces mayor en comparaci &#769;on con la ecograf &#769;&#305;a convencional. Puede ser usada para producir ima &#769;genes vasculares con una resoluci &#769;on sin precedentes de hasta 5 &#956;m permitiendo as &#769;&#305; la visualizaci &#769;on de vasos sangu &#769;&#305;neos microsc &#769;opicos que hasta ahora no pueden ser vistos por ninguna t &#769;ecnica disponible cl &#769;&#305;nicamente. ULM utiliza microburbujas (MBs) de gas (1 &#956;m de di &#769;ametro) que actu &#769;an como fuentes acu &#769;sticas estoc &#769;asticas. Las MBs se inyectan en el torrente sangu &#769;&#305;neo y fluyen dentro del sistema circulatorio, donde aparecen y desaparecen de la regi &#769;on de inter &#769;es, lo que permite su localizaci &#769;on. Luego, la imagen de su &#769;per-resoluci &#769;on se construye a partir de la acumulaci &#769;on de cientos de miles de MBs localizadas.\r\nActualmente, la mayor parte de la investigaci &#769;on en ULM se realiza desde el punto de vista de las ciencias de la ingenier &#769;&#305;a, que deja a veces a la ciencia fundamental como un aspecto secundario. Nuestro equipo, debido al car &#769;acter transdisciplinario de esta propuesta, esta constituido por investigadores de el  &#769;area de la ingenier &#769;&#305;a, f &#769;&#305;sica, biomedicina y matem &#769;aticas. Basados en las fortalezas de este equipo, proponemos estudiar esta tecnolog &#769;&#305;a desde la perspectiva de la ciencia fundamental, buscando limitaciones en ella, y estableciendo los mecanismos fisiol &#769;ogicos que se manifiestan a nivel de las im &#769;agenes de su &#769;per-resoluci &#769;on, permitiendo superar sus actuales limitaciones y potenciando su posible aplicaci &#769;on en el  &#769;area m &#769;edica. En este contexto buscaremos como segundo objetivo el visualizar la microvasculatura de muestras de placenta ex-vivo, las que ser &#769;an donadas voluntariamente por pacientes del hospital regional de Rancagua, y complementar estas observaciones con par &#769;ametros funcionales y moleculares, con el fin de modelar desde distintas perspectivas nuevos marcadores de funci &#769;on vascular.\r\nUsualmente para lograr el avance en le desarrollo de este tipo de t &#769;ecnicas, se requieren condiciones experimentales altamente controlables, las que se logran utilizando sistemas que imitan el tejido en cuesti &#769;on, el que en nuestro caso es el sistema vascular. Para esto, se utilizan mayormente experimentos in-vitro fabricados a partir de microtubos de 50&#8722;150 &#956;m de di &#769;ametro interno. Sin embargo, existe una gran diferencia entre las propiedades de este tipo de sistemas y las propiedades acu &#769;sticas de tejido in-vivo humano. Lo que requiere una gran cantidad de iteraciones experimentales retazando el desarrollo. As &#769;&#305;, al utilizar tejido humano ex-vivo pretendemos aumentar significativamente la velocidad de la curva de aprendizaje y por consiguiente lograr im &#769;agenes de su &#769;per-resoluci &#769;on humano compatibles dentro de la duraci &#769;on de esta propuesta. As &#769;&#305; mismo, el desarrollo de esta propuesta en un modelo vascular como la placenta humana representa un clara oportunidad para aportar en un  &#769;area actualmente limitada en su capacidad diagn &#769;ostica, lo que restringe la aplicaci &#769;on de intervenciones efectivas durante el embarazo, con consecuencias en la salud de la madre y su progenie.\r\nComo proyecciones de este esquema colaborativo esperamos tener acceso a par &#769;ametros biol &#769;ogicos con los cuales generar nuevas formas de diagn &#769;ostico de alta precisi &#769;on, en especial a nivel de las estructuras involucradas, en primera instancia, con el desarrollo de alteraciones vasculares (i.e. vasos de pequen &#771;o calibre). Con ello buscamos desarrollar un tecnolog &#769;&#305;a con base cient &#769;&#305;fica a trav &#769;es de la cual ser &#769;a posible obtener indicadores de mayor sensibilidad y especificidad para variadas condiciones, enfermedades o s &#769;&#305;ndromes, relacionados con la funci &#769;on vascular.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Ciencia, Tecnolog\u00eda, Conocimiento e Innovaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6370\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Divas de la Ciencia\u0094 Mujeres del Pasado Inspirando al Futuro\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6370\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6370\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Cuando pensamos en cient\u00edficos y su aporte a la ciencia, generalmente reconocemos un estereotipo masculino, acompa\u00f1ado de un desconocimiento del rol de la mujer en la ciencia. En nuestro pa\u00eds el n\u00famero de cient\u00edficos va en aumento, en n\u00famero de cient\u00edficas es de aproximadamente un 30% en las diferentes regiones del pa\u00eds. Conjuntamente,  la ciencia es reconocida como un proceso centralizado y debido a la baja difusi\u00f3n y divulgaci\u00f3n, el reconocimiento de referentes nacionales es reducido. La promoci\u00f3n del conocimiento a trav\u00e9s de sus actores en estudiantes de colegio puede incentivar la vocaci\u00f3n cient\u00edfica y promover la equidad de g\u00e9nero en \u00e1reas masculinizadas. El objetivo general de esta propuesta es: Promover el reconocimiento de Grandes Cient\u00edficas hist\u00f3ricas y de Cient\u00edfico(a)s Regionales a trav\u00e9s de la serie \u0093Divas de la Ciencia\u0094 dirigido tanto a estudiantes de colegios como al p\u00fablico general. Los objetivos espec\u00edficos son: 1) Visibilizar a Grandes Cient\u00edficas con el fin de promover su reconocimiento por el p\u00fablico general, 2) Promocionar a Cient\u00edfico(a)s Regionales como nuevos referentes cient\u00edficos por el p\u00fablico general, y 3) Integrar la serie como herramienta de ense\u00f1anza\/aprendizaje a las clases de ciencia en colegios del pa\u00eds. La serie constar\u00e1 de 12 episodios, y cada entrega tendr\u00e1 una presentaci\u00f3n animada de una \u0093Diva\u0094 (3 min) enlazada a la investigaci\u00f3n del Cient\u00edfico(a) Regional (5 min), y divulgada en un canal de YouTube. El dise\u00f1o de los episodios espera generar una experiencia memorable al exponer los problemas que debi\u00f3 enfrentar cada \u0093Diva\u0094 para lograr su investigaci\u00f3n en conjunto con la identificaci\u00f3n con el\/la Cient\u00edfico\/a Regional; adem\u00e1s de utilizar un lenguaje cercano y sencillo, musicalizaci\u00f3n y movimientos de las animaciones digitales. Los cap\u00edtulos estar\u00e1n divididos en tres ciclos de acuerdo a los programas del Mineduc: 7\u00ba-8\u00ba b\u00e1sico (ciclo I), 1\u00ba-2\u00ba Medio (ciclo II), y 3\u00ba-4\u00ba medio (ciclo III). Adem\u00e1s, los profesores interesados ser\u00e1n capacitados para utilizar la serie en sus clases a trav\u00e9s de una gu\u00eda de actividades pr\u00e1cticas. Toda la propuesta no tendr\u00e1 costo alguno para los participantes.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6382\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creacion de imagenes de super-resolucion ultrasonicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6382\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6382\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El desarrollo de herramientas para el an &#769;alisis de funciones vitales a trav &#769;es de im &#769;agenes representa un campo de creciente inter &#769;es, especialmente para el estudio de marcadores tempranos de diversas patolog &#769;&#305;as, as &#769;&#305; como el desarrollo de aplicaciones diagn &#769;osticas a mediano plazo. En este contexto, el an &#769;alisis de la funci &#769;on vascular, a lo largo del ciclo vital, continua siendo un  &#769;area con un alta demanda de nuevas tecnolog &#769;&#305;as, debido a su gran impacto a nivel de salud en la poblaci &#769;on. Esta propuesta busca generar una l &#769;&#305;nea de investigaci &#769;on actualmente casi inexistente en Chile, las im &#769;agenes ultras &#769;onicas m &#769;edicas. En particular, nos gustar &#769;&#305;a introducir en Chile una t &#769;ecnica recientemente propuesta, denominada microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM), tambi &#769;en conocida como im &#769;agenes de su &#769;per- resoluci &#769;on. Esta t &#769;ecnica puede crear im &#769;agenes del sistema circulatoria con una resoluci &#769;on nunca antes vista, lo que permite visualizar vasos sangu &#769;&#305;neos de hasta 5&#956;m. As &#769;&#305;, nuestra propuesta posee dos grandes objetivos. El primero es Optimizar y robusteces los procesos involucrados en el desarrollo de las im &#769;agenes de su &#769;per-resoluci &#769;on ultras &#769;onicas, esto a trav &#769;es de Optimizar los par &#769;ametros de adquisici &#769;on de datos y de procesamiento con el fin de robustecer la generaci &#769;on de este tipo de im &#769;agenes. Nuestro segundo objetivo es generar im &#769;agenes de su &#769;per- resoluci &#769;on de la red vascular interna de placenta humana ex-vivo y a buscar candidatos a marcadores a partir de estas im &#769;agenes.\r\nLa ecograf &#769;&#305;a convencional es ampliamente usada en Chile y el mundo. Es preferida entre otras modalidades de im &#769;agenes (MRI, PET, TC) debido a su portabilidad, bajo costo, naturaleza no invasiva y a que utiliza radiaci &#769;on no ionizante, especialmente en condiciones como el embarazo, o en pacientes con manejo farmacol &#769;ogico complejo, entre otras. Recientemente, se han desarrollado nuevas modalidades de im &#769;agenes ultras &#769;onicas, propiciadas por la mejora en la industria de los semiconductores, lo que ha permitido un incremento en la capacidad de computo de los esc &#769;aneres ultraso &#769;nicos y en el nu &#769;mero de elementos piezoel &#769;ectrico de los transductores ultras &#769;onicos, generando un aumento significativo en la versatilidad y calidad de estas tecnolog &#769;&#305;as. Dentro de estas nuevas t &#769;ecnicas encontramos la microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM) o su &#769;per-resoluci &#769;on ultras &#769;onica. Esta revolucionaria t &#769;ecnica es capaz de superar el l &#769;&#305;mite de difracci &#769;on y producir una resoluci &#769;on diez veces mayor en comparaci &#769;on con la ecograf &#769;&#305;a convencional. Puede ser usada para producir ima &#769;genes vasculares con una resoluci &#769;on sin precedentes de hasta 5 &#956;m permitiendo as &#769;&#305; la visualizaci &#769;on de vasos sangu &#769;&#305;neos microsc &#769;opicos que hasta ahora no pueden ser vistos por ninguna t &#769;ecnica disponible cl &#769;&#305;nicamente. ULM utiliza microburbujas (MBs) de gas (1 &#956;m de di &#769;ametro) que actu &#769;an como fuentes acu &#769;sticas estoc &#769;asticas. Las MBs se inyectan en el torrente sangu &#769;&#305;neo y fluyen dentro del sistema circulatorio, donde aparecen y desaparecen de la regi &#769;on de inter &#769;es, lo que permite su localizaci &#769;on. Luego, la imagen de su &#769;per-resoluci &#769;on se construye a partir de la acumulaci &#769;on de cientos de miles de MBs localizadas.\r\nActualmente, la mayor parte de la investigaci &#769;on en ULM se realiza desde el punto de vista de las ciencias de la ingenier &#769;&#305;a, que deja a veces a la ciencia fundamental como un aspecto secundario. Nuestro equipo, debido al car &#769;acter transdisciplinario de esta propuesta, esta constituido por investigadores de el  &#769;area de la ingenier &#769;&#305;a, f &#769;&#305;sica, biomedicina y matem &#769;aticas. Basados en las fortalezas de este equipo, proponemos estudiar esta tecnolog &#769;&#305;a desde la perspectiva de la ciencia fundamental, buscando limitaciones en ella, y estableciendo los mecanismos fisiol &#769;ogicos que se manifiestan a nivel de las im &#769;agenes de su &#769;per-resoluci &#769;on, permitiendo superar sus actuales limitaciones y potenciando su posible aplicaci &#769;on en el  &#769;area m &#769;edica. En este contexto buscaremos como segundo objetivo el visualizar la microvasculatura de muestras de placenta ex-vivo, las que ser &#769;an donadas voluntariamente por pacientes del hospital regional de Rancagua, y complementar estas observaciones con par &#769;ametros funcionales y moleculares, con el fin de modelar desde distintas perspectivas nuevos marcadores de funci &#769;on vascular.\r\nUsualmente para lograr el avance en le desarrollo de este tipo de t &#769;ecnicas, se requieren condiciones experimentales altamente controlables, las que se logran utilizando sistemas que imitan el tejido en cuesti &#769;on, el que en nuestro caso es el sistema vascular. Para esto, se utilizan mayormente experimentos in-vitro fabricados a partir de microtubos de 50&#8722;150 &#956;m de di &#769;ametro interno. Sin embargo, existe una gran diferencia entre las propiedades de este tipo de sistemas y las propiedades acu &#769;sticas de tejido in-vivo humano. Lo que requiere una gran cantidad de iteraciones experimentales retazando el desarrollo. As &#769;&#305;, al utilizar tejido humano ex-vivo pretendemos aumentar significativamente la velocidad de la curva de aprendizaje y por consiguiente lograr im &#769;agenes de su &#769;per-resoluci &#769;on humano compatibles dentro de la duraci &#769;on de esta propuesta. As &#769;&#305; mismo, el desarrollo de esta propuesta en un modelo vascular como la placenta humana representa un clara oportunidad para aportar en un  &#769;area actualmente limitada en su capacidad diagn &#769;ostica, lo que restringe la aplicaci &#769;on de intervenciones efectivas durante el embarazo, con consecuencias en la salud de la madre y su progenie.\r\nComo proyecciones de este esquema colaborativo esperamos tener acceso a par &#769;ametros biol &#769;ogicos con los cuales generar nuevas formas de diagn &#769;ostico de alta precisi &#769;on, en especial a nivel de las estructuras involucradas, en primera instancia, con el desarrollo de alteraciones vasculares (i.e. vasos de pequen &#771;o calibre). Con ello buscamos desarrollar un tecnolog &#769;&#305;a con base cient &#769;&#305;fica a trav &#769;es de la cual ser &#769;a posible obtener indicadores de mayor sensibilidad y especificidad para variadas condiciones, enfermedades o s &#769;&#305;ndromes, relacionados con la funci &#769;on vascular.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6413\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creacion de imagenes de super-resolucion ultrasonicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6413\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6413\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El desarrollo de herramientas para el an &#769;alisis de funciones vitales a trav &#769;es de im &#769;agenes representa un campo de creciente inter &#769;es, especialmente para el estudio de marcadores tempranos de diversas patolog &#769;&#305;as, as &#769;&#305; como el desarrollo de aplicaciones diagn &#769;osticas a mediano plazo. En este contexto, el an &#769;alisis de la funci &#769;on vascular, a lo largo del ciclo vital, continua siendo un  &#769;area con un alta demanda de nuevas tecnolog &#769;&#305;as, debido a su gran impacto a nivel de salud en la poblaci &#769;on. Esta propuesta busca generar una l &#769;&#305;nea de investigaci &#769;on actualmente casi inexistente en Chile, las im &#769;agenes ultras &#769;onicas m &#769;edicas. En particular, nos gustar &#769;&#305;a introducir en Chile una t &#769;ecnica recientemente propuesta, denominada microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM), tambi &#769;en conocida como im &#769;agenes de su &#769;per- resoluci &#769;on. Esta t &#769;ecnica puede crear im &#769;agenes del sistema circulatoria con una resoluci &#769;on nunca antes vista, lo que permite visualizar vasos sangu &#769;&#305;neos de hasta 5&#956;m. As &#769;&#305;, nuestra propuesta posee dos grandes objetivos. El primero es Optimizar y robusteces los procesos involucrados en el desarrollo de las im &#769;agenes de su &#769;per-resoluci &#769;on ultras &#769;onicas, esto a trav &#769;es de Optimizar los par &#769;ametros de adquisici &#769;on de datos y de procesamiento con el fin de robustecer la generaci &#769;on de este tipo de im &#769;agenes. Nuestro segundo objetivo es generar im &#769;agenes de su &#769;per- resoluci &#769;on de la red vascular interna de placenta humana ex-vivo y a buscar candidatos a marcadores a partir de estas im &#769;agenes.\r\nLa ecograf &#769;&#305;a convencional es ampliamente usada en Chile y el mundo. Es preferida entre otras modalidades de im &#769;agenes (MRI, PET, TC) debido a su portabilidad, bajo costo, naturaleza no invasiva y a que utiliza radiaci &#769;on no ionizante, especialmente en condiciones como el embarazo, o en pacientes con manejo farmacol &#769;ogico complejo, entre otras. Recientemente, se han desarrollado nuevas modalidades de im &#769;agenes ultras &#769;onicas, propiciadas por la mejora en la industria de los semiconductores, lo que ha permitido un incremento en la capacidad de computo de los esc &#769;aneres ultraso &#769;nicos y en el nu &#769;mero de elementos piezoel &#769;ectrico de los transductores ultras &#769;onicos, generando un aumento significativo en la versatilidad y calidad de estas tecnolog &#769;&#305;as. Dentro de estas nuevas t &#769;ecnicas encontramos la microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM) o su &#769;per-resoluci &#769;on ultras &#769;onica. Esta revolucionaria t &#769;ecnica es capaz de superar el l &#769;&#305;mite de difracci &#769;on y producir una resoluci &#769;on diez veces mayor en comparaci &#769;on con la ecograf &#769;&#305;a convencional. Puede ser usada para producir ima &#769;genes vasculares con una resoluci &#769;on sin precedentes de hasta 5 &#956;m permitiendo as &#769;&#305; la visualizaci &#769;on de vasos sangu &#769;&#305;neos microsc &#769;opicos que hasta ahora no pueden ser vistos por ninguna t &#769;ecnica disponible cl &#769;&#305;nicamente. ULM utiliza microburbujas (MBs) de gas (1 &#956;m de di &#769;ametro) que actu &#769;an como fuentes acu &#769;sticas estoc &#769;asticas. Las MBs se inyectan en el torrente sangu &#769;&#305;neo y fluyen dentro del sistema circulatorio, donde aparecen y desaparecen de la regi &#769;on de inter &#769;es, lo que permite su localizaci &#769;on. Luego, la imagen de su &#769;per-resoluci &#769;on se construye a partir de la acumulaci &#769;on de cientos de miles de MBs localizadas.\r\nActualmente, la mayor parte de la investigaci &#769;on en ULM se realiza desde el punto de vista de las ciencias de la ingenier &#769;&#305;a, que deja a veces a la ciencia fundamental como un aspecto secundario. Nuestro equipo, debido al car &#769;acter transdisciplinario de esta propuesta, esta constituido por investigadores de el  &#769;area de la ingenier &#769;&#305;a, f &#769;&#305;sica, biomedicina y matem &#769;aticas. Basados en las fortalezas de este equipo, proponemos estudiar esta tecnolog &#769;&#305;a desde la perspectiva de la ciencia fundamental, buscando limitaciones en ella, y estableciendo los mecanismos fisiol &#769;ogicos que se manifiestan a nivel de las im &#769;agenes de su &#769;per-resoluci &#769;on, permitiendo superar sus actuales limitaciones y potenciando su posible aplicaci &#769;on en el  &#769;area m &#769;edica. En este contexto buscaremos como segundo objetivo el visualizar la microvasculatura de muestras de placenta ex-vivo, las que ser &#769;an donadas voluntariamente por pacientes del hospital regional de Rancagua, y complementar estas observaciones con par &#769;ametros funcionales y moleculares, con el fin de modelar desde distintas perspectivas nuevos marcadores de funci &#769;on vascular.\r\nUsualmente para lograr el avance en le desarrollo de este tipo de t &#769;ecnicas, se requieren condiciones experimentales altamente controlables, las que se logran utilizando sistemas que imitan el tejido en cuesti &#769;on, el que en nuestro caso es el sistema vascular. Para esto, se utilizan mayormente experimentos in-vitro fabricados a partir de microtubos de 50&#8722;150 &#956;m de di &#769;ametro interno. Sin embargo, existe una gran diferencia entre las propiedades de este tipo de sistemas y las propiedades acu &#769;sticas de tejido in-vivo humano. Lo que requiere una gran cantidad de iteraciones experimentales retazando el desarrollo. As &#769;&#305;, al utilizar tejido humano ex-vivo pretendemos aumentar significativamente la velocidad de la curva de aprendizaje y por consiguiente lograr im &#769;agenes de su &#769;per-resoluci &#769;on humano compatibles dentro de la duraci &#769;on de esta propuesta. As &#769;&#305; mismo, el desarrollo de esta propuesta en un modelo vascular como la placenta humana representa un clara oportunidad para aportar en un  &#769;area actualmente limitada en su capacidad diagn &#769;ostica, lo que restringe la aplicaci &#769;on de intervenciones efectivas durante el embarazo, con consecuencias en la salud de la madre y su progenie.\r\nComo proyecciones de este esquema colaborativo esperamos tener acceso a par &#769;ametros biol &#769;ogicos con los cuales generar nuevas formas de diagn &#769;ostico de alta precisi &#769;on, en especial a nivel de las estructuras involucradas, en primera instancia, con el desarrollo de alteraciones vasculares (i.e. vasos de pequen &#771;o calibre). Con ello buscamos desarrollar un tecnolog &#769;&#305;a con base cient &#769;&#305;fica a trav &#769;es de la cual ser &#769;a posible obtener indicadores de mayor sensibilidad y especificidad para variadas condiciones, enfermedades o s &#769;&#305;ndromes, relacionados con la funci &#769;on vascular.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6482\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creacion de imagenes de super-resolucion ultrasonicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6482\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6482\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El desarrollo de herramientas para el an &#769;alisis de funciones vitales a trav &#769;es de im &#769;agenes representa un campo de creciente inter &#769;es, especialmente para el estudio de marcadores tempranos de diversas patolog &#769;&#305;as, as &#769;&#305; como el desarrollo de aplicaciones diagn &#769;osticas a mediano plazo. En este contexto, el an &#769;alisis de la funci &#769;on vascular, a lo largo del ciclo vital, continua siendo un  &#769;area con un alta demanda de nuevas tecnolog &#769;&#305;as, debido a su gran impacto a nivel de salud en la poblaci &#769;on. Esta propuesta busca generar una l &#769;&#305;nea de investigaci &#769;on actualmente casi inexistente en Chile, las im &#769;agenes ultras &#769;onicas m &#769;edicas. En particular, nos gustar &#769;&#305;a introducir en Chile una t &#769;ecnica recientemente propuesta, denominada microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM), tambi &#769;en conocida como im &#769;agenes de su &#769;per- resoluci &#769;on. Esta t &#769;ecnica puede crear im &#769;agenes del sistema circulatoria con una resoluci &#769;on nunca antes vista, lo que permite visualizar vasos sangu &#769;&#305;neos de hasta 5&#956;m. As &#769;&#305;, nuestra propuesta posee dos grandes objetivos. El primero es Optimizar y robusteces los procesos involucrados en el desarrollo de las im &#769;agenes de su &#769;per-resoluci &#769;on ultras &#769;onicas, esto a trav &#769;es de Optimizar los par &#769;ametros de adquisici &#769;on de datos y de procesamiento con el fin de robustecer la generaci &#769;on de este tipo de im &#769;agenes. Nuestro segundo objetivo es generar im &#769;agenes de su &#769;per- resoluci &#769;on de la red vascular interna de placenta humana ex-vivo y a buscar candidatos a marcadores a partir de estas im &#769;agenes.\r\nLa ecograf &#769;&#305;a convencional es ampliamente usada en Chile y el mundo. Es preferida entre otras modalidades de im &#769;agenes (MRI, PET, TC) debido a su portabilidad, bajo costo, naturaleza no invasiva y a que utiliza radiaci &#769;on no ionizante, especialmente en condiciones como el embarazo, o en pacientes con manejo farmacol &#769;ogico complejo, entre otras. Recientemente, se han desarrollado nuevas modalidades de im &#769;agenes ultras &#769;onicas, propiciadas por la mejora en la industria de los semiconductores, lo que ha permitido un incremento en la capacidad de computo de los esc &#769;aneres ultraso &#769;nicos y en el nu &#769;mero de elementos piezoel &#769;ectrico de los transductores ultras &#769;onicos, generando un aumento significativo en la versatilidad y calidad de estas tecnolog &#769;&#305;as. Dentro de estas nuevas t &#769;ecnicas encontramos la microscop &#769;&#305;a de localizaci &#769;on por ultrasonido (ULM) o su &#769;per-resoluci &#769;on ultras &#769;onica. Esta revolucionaria t &#769;ecnica es capaz de superar el l &#769;&#305;mite de difracci &#769;on y producir una resoluci &#769;on diez veces mayor en comparaci &#769;on con la ecograf &#769;&#305;a convencional. Puede ser usada para producir ima &#769;genes vasculares con una resoluci &#769;on sin precedentes de hasta 5 &#956;m permitiendo as &#769;&#305; la visualizaci &#769;on de vasos sangu &#769;&#305;neos microsc &#769;opicos que hasta ahora no pueden ser vistos por ninguna t &#769;ecnica disponible cl &#769;&#305;nicamente. ULM utiliza microburbujas (MBs) de gas (1 &#956;m de di &#769;ametro) que actu &#769;an como fuentes acu &#769;sticas estoc &#769;asticas. Las MBs se inyectan en el torrente sangu &#769;&#305;neo y fluyen dentro del sistema circulatorio, donde aparecen y desaparecen de la regi &#769;on de inter &#769;es, lo que permite su localizaci &#769;on. Luego, la imagen de su &#769;per-resoluci &#769;on se construye a partir de la acumulaci &#769;on de cientos de miles de MBs localizadas.\r\nActualmente, la mayor parte de la investigaci &#769;on en ULM se realiza desde el punto de vista de las ciencias de la ingenier &#769;&#305;a, que deja a veces a la ciencia fundamental como un aspecto secundario. Nuestro equipo, debido al car &#769;acter transdisciplinario de esta propuesta, esta constituido por investigadores de el  &#769;area de la ingenier &#769;&#305;a, f &#769;&#305;sica, biomedicina y matem &#769;aticas. Basados en las fortalezas de este equipo, proponemos estudiar esta tecnolog &#769;&#305;a desde la perspectiva de la ciencia fundamental, buscando limitaciones en ella, y estableciendo los mecanismos fisiol &#769;ogicos que se manifiestan a nivel de las im &#769;agenes de su &#769;per-resoluci &#769;on, permitiendo superar sus actuales limitaciones y potenciando su posible aplicaci &#769;on en el  &#769;area m &#769;edica. En este contexto buscaremos como segundo objetivo el visualizar la microvasculatura de muestras de placenta ex-vivo, las que ser &#769;an donadas voluntariamente por pacientes del hospital regional de Rancagua, y complementar estas observaciones con par &#769;ametros funcionales y moleculares, con el fin de modelar desde distintas perspectivas nuevos marcadores de funci &#769;on vascular.\r\nUsualmente para lograr el avance en le desarrollo de este tipo de t &#769;ecnicas, se requieren condiciones experimentales altamente controlables, las que se logran utilizando sistemas que imitan el tejido en cuesti &#769;on, el que en nuestro caso es el sistema vascular. Para esto, se utilizan mayormente experimentos in-vitro fabricados a partir de microtubos de 50&#8722;150 &#956;m de di &#769;ametro interno. Sin embargo, existe una gran diferencia entre las propiedades de este tipo de sistemas y las propiedades acu &#769;sticas de tejido in-vivo humano. Lo que requiere una gran cantidad de iteraciones experimentales retazando el desarrollo. As &#769;&#305;, al utilizar tejido humano ex-vivo pretendemos aumentar significativamente la velocidad de la curva de aprendizaje y por consiguiente lograr im &#769;agenes de su &#769;per-resoluci &#769;on humano compatibles dentro de la duraci &#769;on de esta propuesta. As &#769;&#305; mismo, el desarrollo de esta propuesta en un modelo vascular como la placenta humana representa un clara oportunidad para aportar en un  &#769;area actualmente limitada en su capacidad diagn &#769;ostica, lo que restringe la aplicaci &#769;on de intervenciones efectivas durante el embarazo, con consecuencias en la salud de la madre y su progenie.\r\nComo proyecciones de este esquema colaborativo esperamos tener acceso a par &#769;ametros biol &#769;ogicos con los cuales generar nuevas formas de diagn &#769;ostico de alta precisi &#769;on, en especial a nivel de las estructuras involucradas, en primera instancia, con el desarrollo de alteraciones vasculares (i.e. vasos de pequen &#771;o calibre). Con ello buscamos desarrollar un tecnolog &#769;&#305;a con base cient &#769;&#305;fica a trav &#769;es de la cual ser &#769;a posible obtener indicadores de mayor sensibilidad y especificidad para variadas condiciones, enfermedades o s &#769;&#305;ndromes, relacionados con la funci &#769;on vascular.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Ciencia, Tecnolog\u00eda, Conocimiento e Innovaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6483\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Divas de la Ciencia\u0094 Mujeres del Pasado Inspirando al Futuro\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6483\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6483\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Cuando pensamos en cient\u00edficos y su aporte a la ciencia, generalmente reconocemos un estereotipo masculino, acompa\u00f1ado de un desconocimiento del rol de la mujer en la ciencia. En nuestro pa\u00eds el n\u00famero de cient\u00edficos va en aumento, en n\u00famero de cient\u00edficas es de aproximadamente un 30% en las diferentes regiones del pa\u00eds. Conjuntamente,  la ciencia es reconocida como un proceso centralizado y debido a la baja difusi\u00f3n y divulgaci\u00f3n, el reconocimiento de referentes nacionales es reducido. La promoci\u00f3n del conocimiento a trav\u00e9s de sus actores en estudiantes de colegio puede incentivar la vocaci\u00f3n cient\u00edfica y promover la equidad de g\u00e9nero en \u00e1reas masculinizadas. El objetivo general de esta propuesta es: Promover el reconocimiento de Grandes Cient\u00edficas hist\u00f3ricas y de Cient\u00edfico(a)s Regionales a trav\u00e9s de la serie \u0093Divas de la Ciencia\u0094 dirigido tanto a estudiantes de colegios como al p\u00fablico general. Los objetivos espec\u00edficos son: 1) Visibilizar a Grandes Cient\u00edficas con el fin de promover su reconocimiento por el p\u00fablico general, 2) Promocionar a Cient\u00edfico(a)s Regionales como nuevos referentes cient\u00edficos por el p\u00fablico general, y 3) Integrar la serie como herramienta de ense\u00f1anza\/aprendizaje a las clases de ciencia en colegios del pa\u00eds. La serie constar\u00e1 de 12 episodios, y cada entrega tendr\u00e1 una presentaci\u00f3n animada de una \u0093Diva\u0094 (3 min) enlazada a la investigaci\u00f3n del Cient\u00edfico(a) Regional (5 min), y divulgada en un canal de YouTube. El dise\u00f1o de los episodios espera generar una experiencia memorable al exponer los problemas que debi\u00f3 enfrentar cada \u0093Diva\u0094 para lograr su investigaci\u00f3n en conjunto con la identificaci\u00f3n con el\/la Cient\u00edfico\/a Regional; adem\u00e1s de utilizar un lenguaje cercano y sencillo, musicalizaci\u00f3n y movimientos de las animaciones digitales. Los cap\u00edtulos estar\u00e1n divididos en tres ciclos de acuerdo a los programas del Mineduc: 7\u00ba-8\u00ba b\u00e1sico (ciclo I), 1\u00ba-2\u00ba Medio (ciclo II), y 3\u00ba-4\u00ba medio (ciclo III). Adem\u00e1s, los profesores interesados ser\u00e1n capacitados para utilizar la serie en sus clases a trav\u00e9s de una gu\u00eda de actividades pr\u00e1cticas. Toda la propuesta no tendr\u00e1 costo alguno para los participantes.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2021 - Junio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6526\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Desarrollo de un sistema digital de evaluaci\u00f3n, seguimiento y recomendaci\u00f3n de estrategias de participaci\u00f3n comunitaria para dispositivos y redes de salud mental\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6526\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6526\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El diagn\u00f3stico de la situaci\u00f3n de salud mental a nivel global y local mantiene resultados\r\npreocupantes, que, sumados al efecto de la pandemia por COVID-19, se traducen en mayor\r\nmagnitud, severidad e inequidad. La participaci\u00f3n comunitaria en salud (PCS) se postula\r\nfrecuentemente como una estrategia transversal que contribuye a abordar estos desaf\u00edos, sostenida\r\ntanto por lineamientos program\u00e1ticos como por la evidencia disponible. Sin embargo, los estudios\r\nsuelen concluir que los componentes espec\u00edficos de las estrategias de participaci\u00f3n son poco claros.\r\nSe sostiene que una falta de claridad conceptual y su traducci\u00f3n operacional dificulta la evaluaci\u00f3n\r\nde su efectividad y eficiencia en los resultados de salud. La presente propuesta sostiene que esta\r\nambig\u00fcedad conceptual y consecuente ausencia de m\u00e9tricas b\u00e1sicas en materia de participaci\u00f3n,\r\nobstaculiza su desarrollo como una dimensi\u00f3n integrada con los sistemas de salud. En virtud de ello,\r\nel proyecto tiene como objetivo central el Desarrollo de un Sistema de Evaluaci\u00f3n, Seguimiento y\r\nRecomendaci\u00f3n de PCS para los dispositivos de salud. Para ello se plantea la (1) Formulaci\u00f3n de un\r\nmodelo conceptual sobre la base de revisi\u00f3n exploratoria de literatura, grupos focales y con el\r\nm\u00e9todo Delphi de consenso de expertos\/as (por experiencia y disciplinares); (2) Dise\u00f1o de un\r\ninstrumento de evaluaci\u00f3n de PCS en los dispositivos de salud, validado sobre una muestra\r\nrepresentativa de centros de salud, estratificada por variables relevantes (rural\/urbano y NSE) en\r\ntres territorios de servicios de salud y 3) Desarrollo de un herramienta digital que aloje al\r\ninstrumento, con funcionalidades para reportar recomendaciones en base a algoritmos. Se espera\r\nque este sistema contribuya a fortalecer la participaci\u00f3n comunitaria en el sistema de salud, as\u00ed\r\ncomo generar m\u00e9tricas para estudios observacionales sobre factores que favorecen la PCS y la\r\nforma en la que esta contribuye a los resultados de salud poblacionales[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021 - Noviembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Colegio M\u00e9dico de Chile<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6530\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            La experiencia de trabajo de cuidados de los trabajadores de la salud en Chile durante la pandemia COVID-19 y su impacto en la salud mental\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6530\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6530\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Se propone la realizaci\u00f3n de un estudio de car\u00e1cter transversal con enfoque anal\u00edtico tem\u00e1tico, que utilizar\u00e1 entrevistas semi-estructuradas, en base al conocimiento emanado del estudio HEROES. Contar\u00e1 con mayoritaria participaci\u00f3n de profesionales m\u00e9dicos y m\u00e9dicas de la Regi\u00f3n Metropolitana. Su objetivo general ser\u00e1 comprender la experiencia subjetiva de m\u00e9dicos y m\u00e9dicas del sector p\u00fablico de salud respecto del trabajo de cuidados durante la pandemia COVID-19.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6383\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de superresoluci\u00f3n ultras\u00f3nicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6383\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6383\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6414\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de superresoluci\u00f3n ultras\u00f3nicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6414\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6414\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6445\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de superresoluci\u00f3n ultras\u00f3nicas en placentas humanas ex vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6445\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6445\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1211962<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021 - Octubre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6374\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Effects of eccentric, concentric and eccentric\/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicenter randomized trial\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6374\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6374\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Es proyecto busca comparar los  efectos de diversos programas de ejercicio f\u00edsico en diversos parametros pronosticos en pacientes con EPOC severo[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1211962<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021 - Octubre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6407\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Effects of eccentric, concentric and eccentric\/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicenter randomized trial\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6407\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6407\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Es proyecto busca comparar los  efectos de diversos programas de ejercicio f\u00edsico en diversos parametros pronosticos en pacientes con EPOC severo[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1211962<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2021 - Octubre 2025<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6438\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Effects of eccentric, concentric and eccentric\/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicenter randomized trial\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6438\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6438\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Es proyecto busca comparar los  efectos de diversos programas de ejercicio f\u00edsico en diversos parametros pronosticos en pacientes con EPOC severo[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2021 - Septiembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio Federal Alem\u00e1n para la Colaboraci\u00f3n Econ\u00f3mica y el Desarrollo (BMZ) a trav\u00e9s de la Alianza Internacional contra los Riesgos Sanitarios en el Comercio de Vida Silvestre y coordinado por la GIZ (Gesellschaft f\u00fcr Internationale Zusammenarbeit)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6490\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6490\" aria-expanded=\"false\" aria-controls=\"collapse-6490\">\n                                            Knowledge, attitudes, and practices towards the risk of zoonotic diseases, wildlife trade and wildlife consumption in Latin America\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6490\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6490\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En el transcurso de este proyecto se recopila informaci\u00f3n que luego se someter\u00e1 a analisis respecto a lo conocimientos, actitudes y pr\u00e1cticas frente al riesgo de enfermedades zoon\u00f3ticas, comercio y consumo de vida silvestre en distintos paises participantes de Latino America.\r\nMinisterio Federal Alem\u00e1n para la Colaboraci\u00f3n Econ\u00f3mica y el Desarrollo (BMZ) a trav\u00e9s de la Alianza Internacional contra los Riesgos Sanitarios en el Comercio de Vida Silvestre y coordinado por la GIZ (Gesellschaft f\u00fcr Internationale Zusammenarbeit) con un importe total de 299.700\u0080.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2021 - Septiembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio Federal Alem\u00e1n para la Colaboraci\u00f3n Econ\u00f3mica y el Desarrollo (BMZ) a trav\u00e9s de la Alianza Internacional contra los Riesgos Sanitarios en el Comercio de Vida Silvestre y coordinado por la GIZ (Gesellschaft f\u00fcr Internationale Zusammenarbeit)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6529\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6529\" aria-expanded=\"false\" aria-controls=\"collapse-6529\">\n                                            Knowledge, attitudes, and practices towards the risk of zoonotic diseases, wildlife trade and wildlife consumption in Latin America\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6529\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6529\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En el transcurso de este proyecto se recopila informaci\u00f3n que luego se someter\u00e1 a analisis respecto a lo conocimientos, actitudes y pr\u00e1cticas frente al riesgo de enfermedades zoon\u00f3ticas, comercio y consumo de vida silvestre en distintos paises participantes de Latino America.\r\nMinisterio Federal Alem\u00e1n para la Colaboraci\u00f3n Econ\u00f3mica y el Desarrollo (BMZ) a trav\u00e9s de la Alianza Internacional contra los Riesgos Sanitarios en el Comercio de Vida Silvestre y coordinado por la GIZ (Gesellschaft f\u00fcr Internationale Zusammenarbeit) con un importe total de 299.700\u0080.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2021 - Agosto 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6384\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Crea y Valida I+D+i Colaborativo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6384\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6384\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca establecer los efectos de un suplemento en base a miel sobre la salud y el bienestar, as\u00ed como la respuesta al tratamiento en personas con \u00falcera g\u00e1stricas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2021 - Agosto 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6405\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Crea y Valida I+D+i Colaborativo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6405\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6405\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca establecer los efectos de un suplemento en base a miel sobre la salud y el bienestar, as\u00ed como la respuesta al tratamiento en personas con \u00falcera g\u00e1stricas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2021 - Agosto 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6415\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Crea y Valida I+D+i Colaborativo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6415\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6415\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca establecer los efectos de un suplemento en base a miel sobre la salud y el bienestar, as\u00ed como la respuesta al tratamiento en personas con \u00falcera g\u00e1stricas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2021 - Agosto 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6436\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Crea y Valida I+D+i Colaborativo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6436\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6436\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca establecer los efectos de un suplemento en base a miel sobre la salud y el bienestar, as\u00ed como la respuesta al tratamiento en personas con \u00falcera g\u00e1stricas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2021 - Agosto 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Corporaci\u00f3n de Fomento de la Producci\u00f3n - CORFO<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6446\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Crea y Valida I+D+i Colaborativo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6446\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6446\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Proyecto que busca establecer los efectos de un suplemento en base a miel sobre la salud y el bienestar, as\u00ed como la respuesta al tratamiento en personas con \u00falcera g\u00e1stricas.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 3220665<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6524\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Cuidados sociocomunitarios de personas con discapacidad en la regi\u00f3n de O&#8217;Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6524\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6524\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]N\u00famero de proyecto: 3220665[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Patrocinante<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 3220665<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6562\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Cuidados sociocomunitarios de personas con discapacidad en la regi\u00f3n de O&#8217;Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6562\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6562\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]N\u00famero de proyecto: 3220665[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>SUSESO \u0096 Proyectos de Investigaci\u00f3n e Innovaci\u00f3n en prevenci\u00f3n de Accidentes del Trabajo y Enfermedades Profesionales<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6528\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Evaluaci\u00f3n de la efectividad de una intervenci\u00f3n multicomponente para mejorar los estilos de vida saludables y reducir el riesgo cardiovascular en trabajadores de empresas de una comuna rural\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6528\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6528\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Nuestro pa\u00eds tiene un gran desaf\u00edo para modificar estilos de vida saludables y reducir el riesgo cardiovascular.\r\nHasta la fecha, la mayor\u00eda de las intervenciones se han focalizado en aspectos o grupos espec\u00edficos, con efectos\r\nmuy limitados. Las experiencias m\u00e1s exitosas han sido aquellas que abordan comunidades completas, tal como lo demostr\u00f3 el proyecto desarrollado en la regi\u00f3n de North Karelia, Finlandia. Por otra parte, los organismos\r\nmultilaterales han se\u00f1alado que el lugar de trabajo juega un rol fundamental para modificar estos estilos de vida e indicadores de salud general, lo que contribuye a reducir accidentes y enfermedades profesionales.\r\nDado que en la comuna de Curaco de V\u00e9lez (Chilo\u00e9) se est\u00e1 iniciando un proyecto integral para mejorar los estilos de vida, esto ofrece una condici\u00f3n \u00f3ptimaa para realizar una prueba piloto en una empresa en ese lugar. Nos proponemos construir una intervenci\u00f3n multicomponente y adaptada culturalmente, que utilice una App nativa (construida ad hoc para este proyecto) como herramienta de apoyo, y evaluar su efectividad para mejorar estilos de vida saludables, reducir riesgo cardiovascular, mejorar la detecci\u00f3n y el control de Hipertensi\u00f3n Arterial y Diabetes Mellitus. Al mismo tiempo evaluaremos su implementaci\u00f3n, para un posible escalamiento futuro.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> MSM2021003<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Julio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6489\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Gesti\u00f3n Inteligente de Recursos H\u00eddricos para la Agricultura\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6489\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6489\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En este proyecto, se busca general nuevas tecnolog\u00edas que permitan mejorar el manejo de recursos h\u00eddricos en la sexta regi\u00f3n.\r\n\r\nDirector de l\u00ednea \"Gesti\u00f3n de Riego Intrapredial con Inteligencia Artificial\"[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Julio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6367\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de super-resoluci\u00f3n ultras\u00f3nicas en placentas humanas ex-vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6367\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6367\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Julio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6381\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de super-resoluci\u00f3n ultras\u00f3nicas en placentas humanas ex-vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6381\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6381\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Julio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6412\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de super-resoluci\u00f3n ultras\u00f3nicas en placentas humanas ex-vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6412\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6412\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Julio 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6481\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Creaci\u00f3n de im\u00e1genes de super-resoluci\u00f3n ultras\u00f3nicas en placentas humanas ex-vivo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6481\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6481\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Octubre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6488\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Dise\u00f1o de una propuesta de educaci\u00f3n sexual integral en ni\u00f1os, ni\u00f1as y ni\u00f1es de 4 y 5 a\u00f1os.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6488\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6488\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La sexualidad seg\u00fan la OMS, (OMS, 2018) es definida como un aspecto central del ser humano, dentro de las dimensiones que abarca se encuentra, la reproducci\u00f3n, placer y\/o erotismo, v\u00ednculos afectivos y g\u00e9nero, a parte del car\u00e1cter inherente al ser humano, se destaca que se encuentra presente durante toda la vida, por esta raz\u00f3n se considera necesario que las estrategias para erradicar brechas de g\u00e9nero deben iniciarse en los primeros a\u00f1os de vida.\r\nHasta aqu\u00ed la mayor parte de los estudios de la tem\u00e1tica se relacionan con poblaci\u00f3n de adolescentes y\/o con la visi\u00f3n de cuidadores\/as poseen del desarrollo sexual afectivo de sus ni\u00f1os, ni\u00f1as y ni\u00f1es, sin embargo, existe incertidumbre en relaci\u00f3n a lo que saben actualmente ni\u00f1os, ni\u00f1as y ni\u00f1es en relaci\u00f3n a sexualidad y cuales han sido sus principales fuentes de informaci\u00f3n. En este contexto, se pretende dise\u00f1ar una propuesta de educaci\u00f3n sexual integral en ni\u00f1os, ni\u00f1as y ni\u00f1es de 4 y 5.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2021 - Octubre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6527\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Dise\u00f1o de una propuesta de educaci\u00f3n sexual integral en ni\u00f1os, ni\u00f1as y ni\u00f1es de 4 y 5 a\u00f1os.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6527\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6527\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La sexualidad seg\u00fan la OMS, (OMS, 2018) es definida como un aspecto central del ser humano, dentro de las dimensiones que abarca se encuentra, la reproducci\u00f3n, placer y\/o erotismo, v\u00ednculos afectivos y g\u00e9nero, a parte del car\u00e1cter inherente al ser humano, se destaca que se encuentra presente durante toda la vida, por esta raz\u00f3n se considera necesario que las estrategias para erradicar brechas de g\u00e9nero deben iniciarse en los primeros a\u00f1os de vida.\r\nHasta aqu\u00ed la mayor parte de los estudios de la tem\u00e1tica se relacionan con poblaci\u00f3n de adolescentes y\/o con la visi\u00f3n de cuidadores\/as poseen del desarrollo sexual afectivo de sus ni\u00f1os, ni\u00f1as y ni\u00f1es, sin embargo, existe incertidumbre en relaci\u00f3n a lo que saben actualmente ni\u00f1os, ni\u00f1as y ni\u00f1es en relaci\u00f3n a sexualidad y cuales han sido sus principales fuentes de informaci\u00f3n. En este contexto, se pretende dise\u00f1ar una propuesta de educaci\u00f3n sexual integral en ni\u00f1os, ni\u00f1as y ni\u00f1es de 4 y 5.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2021 - Octubre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD - Alemania<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6511\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            ECOH: Environment Care with a One Health approach\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6511\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6511\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The environment can be described as indispensable as it houses all life on earth, and evidence suggests that activities in interaction with nature not only provide physical and psychological benefits but also socially and economically.\r\n\r\nNonetheless, we are currently confronted with many environmental challenges, including climate change, loss of biodiversity and degradation of natural habitats, which have adverse health outcomes for animals, humans and our shared environment. Furthermore, regarding the COVID-19 pandemic, additional threats have emerged such as an increase in the use and disposal of plastic products for medical and non-medical applications and the amount of packaging used to deliver food and groceries to residences, leading to significant challenges in handling solid and hazardous medical wastes. This could become a crucial concern in the medium or long term, whilst aggravating the already existing issues, especially in countries with inadequate waste management systems.\r\n\r\nRecognizing this, environmental education has become more relevant than ever in ensuring a sustainable future by promoting responsible decision-making at the individual, institutional and community levels. The strengthening of environmental literacy through formal and informal educational strategies at different stages of the life course, considering day-to-day situations, will eventually allow for the development of capacities in the population, thereby conserving our shared environment.\r\nProject aim:\r\n\r\nThe project's main objective, therefore, is to empower the community for environmental care through educational strategies based on local needs in Guatemala and Bolivia.\r\n\r\nThis is to be achieved using a Participatory Action Research (PAR) approach by forming a multidisciplinary and intersectoral working group that includes professionals from the academy and representatives from diverse sectors like education, work, transportation, legislators and civil society. The project also follows a spiral approach, focusing on a problem and continuing with planning, action, observation and critical reflection, giving rise to a new progressive cycle. To better disseminate the project and population adherence, a digital platform app is to be designed to make available all the education material and specific guides that support this process.\r\n\r\nUltimately, creating awareness and educating, based on evidence, about our actions' impact will allow a better co-existence and promote sustainable development, sustainable use and care of natural resources when considering practices in rural and urban communities[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Mayo 2021 - Octubre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD - Alemania<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6512\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Stingless BEEs as an ecological, Social capital and public health richness\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6512\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6512\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Stingless bees (Apidae: Meliponini) play a substantial role in the ecology, economy, and culture of many communities, especially in South America. They act as the main pollinators for many native florae and cultivated tropical plants. Their products such as honey, pollen, propolis and cerumen have also been used as a source of income for generations while creating an imprint on the culture of native communities.\r\n\r\nNevertheless, in recent decades, stingless bees currently face several environmental threats including the extensive deforestation of native forests, accelerated expansion of urban areas, excessive use of pesticides and fertilizers, agriculture intensification and the introduction\/spread of exotic competing bee species.\r\n\r\nIn this context, meliponiculture \u0096 i.e., keeping stingless bees for their products \u0096 is becoming more important for research not only as an optimal strategy for the conservation of bees and their environment but also for their economic value. In general, meliponiculture also promotes a variety of good environmental practices from different viewpoints in the society, maintains the traditional knowledge of native beekeeping and generates a link with innovation and scientific development. In Bolivia, meliponiculture remains an incipient activity although many indigenous communities have an ancient relationship with stingless bees. In Guatemala, the Maya tribe have also practiced meliponiculture for many years. Nevertheless, traditional knowledge is getting lost over time which must be recovered and supported by new techniques to generate a successful practice of beekeeping.\r\nProject aim:\r\n\r\nConsidering this, the project, therefore, aims to optimize the sustainable development of meliponiculture. This is to be achieved by documenting its traditional use in health while promoting good practices and commercialization to have a positive, direct impact over ecosystems as well as human health in cultural landscapes in indigenous communities in Bolivia and Guatemala.\r\n\r\nFor this, an interdisciplinary methodology is to be designed, which consists of a research component and educational interventions at the various processes of the production chain of meliponiculture: from the producers to consumers. Ultimately, the SBEES project is relevant, taking into account the One Health vision, as it seeks to promote a sustainable interaction between stingless bees, humans and the environment.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2021 - Abril 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6369\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Effects of eccentric, concentric and eccentric\/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicenter randomized trial\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6369\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6369\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2021 - Agosto 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6531\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Riesgo psicosocial y presentismo: un estudio de cohorte en poblaci\u00f3n chilena\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6531\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6531\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2021 - Diciembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Escuela Universitaria de Enfermer\u00eda y Terapia Ocupacional de Terrassa [EUIT]<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6564\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Significados y usos del cuerpo en estudiantes de ciencias de la salud\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6564\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6564\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El present projecte pret\u00e9n descriure la visi\u00f3 que els futurs professionals de la salut tenen del cos i els usos que li donen per tal d\u0092afavorir la reflexi\u00f3 sobre el seu impacte en atenci\u00f3 a l\u0092usuari (l\u0092aproximaci\u00f3 al cos de l\u0092altre).\r\nCon\u00e8ixer els discursos i les pr\u00e0ctiques realitzades amb el cos dels estudiants de primer curs de ci\u00e8ncies de la salut (ter\u00e0pia ocupacional i infermeria) que expliquem la seva relaci\u00f3 amb el \u0093cos\u0094.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1210286<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2021 - Febrero 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6525\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Desarrollo de las habilidades matem\u00e1ticas en ni\u00f1os y ni\u00f1as con trastornos de espectro autista.: un compromiso con la equidad educativa en Chile.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6525\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6525\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Aun cuando no hay una cifra oficial que los cuantifique, los ni\u00f1os y ni\u00f1as con Trastornos del Espectro Autista (TEA) constituyen un grupo importante de personas que requieren y demandan formaci\u00f3n escolar, la cual debe ser, naturalmente, de igual calidad que para el resto de los estudiantes. Esta condici\u00f3n neurol\u00f3gica y de desarrollo es reconocida dentro de algunas pol\u00edticas transversales en educaci\u00f3n, como la LGE (Ley 20.370), que declara asegurar la equidad en el sistema educativo, el Decreto 170 para aquello relacionado con el proceso de identificaci\u00f3n y asignaci\u00f3n de recursos del estado para estudiantes con Necesidades Educativas Especiales, el Decreto 83 referido a las adecuaciones curriculares, y el Dise\u00f1o Universal del Aprendizaje (DUA), que propende al desarrollo curricular atendiendo pr\u00e1cticas inclusivas. Adicionalmente, el Ministerio de Educaci\u00f3n ha implementado una serie de manuales y lineamientos espec\u00edficos sobre TEA, tanto para padres y madres, como para educadores y educadoras. A pesar de todo lo anterior, los testimonios y opiniones de las agrupaciones dan cuenta que, para efectos pr\u00e1cticos, a\u00fan hay escasos avances en esta integraci\u00f3n, la cual se ve complicada adem\u00e1s por una serie de estereotipos sociales propios del desconocimiento sobre este trastorno, que asume una capacidad matem\u00e1tica superior a priori, y otros mitos que afectan la convivencia e integraci\u00f3n de estos ni\u00f1os y ni\u00f1as en las comunidades educativas. Dentro de lo espec\u00edficamente relacionado con la Matem\u00e1tica, dentro de los principales problemas para el trabajo matem\u00e1tico con ni\u00f1os y ni\u00f1as con TEA est\u00e1 el aspecto de la comunicaci\u00f3n verbal, adem\u00e1s del d\u00e9ficit observado en funciones ejecutivas, las que pueden manifestarse a trav\u00e9s de problemas de memoria y\/o planificaci\u00f3n\/organizaci\u00f3n, memoria de trabajo, flexibilidad mental, atenci\u00f3n y autocontrol. As\u00ed, el presente proyecto apunta como objetivo, el fortalecimiento de las habilidades matem\u00e1ticas de ni\u00f1os y ni\u00f1as con TEA. El dise\u00f1o ser\u00e1 realizado bajo un enfoque preferentemente cuantitativo, orientado al nivel preescolar y primer ciclo b\u00e1sico.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2020 - Diciembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6447\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Blood-Brain Barrier  Programming Dysfunction in Intrauterine Hypoxia: Epigenetics, Permeability and Integrity Assessment for Cerebrovascular Protection\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6447\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6447\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Goal: This grant aims to describe the role of epigenetics programming in the progression of BBB injury in growth-restricted neonates. Furthermore, we will identify the molecules and mechanisms of junctional complexes and adhesion molecules of the BBB that are affected by gestational hypoxia.\r\n\r\nThe original contribution of this project is to trace the time course of origins and outcomes of the BBB permeability and integrity impairment related to epigenetic mechanisms, due to gestational chronic hypoxia.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID 757-69-LE20<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Mayo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Salud<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6493\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Estudio sobre acceso a informaci\u00f3n de salud mental en la poblaci\u00f3n general\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6493\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6493\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La presente propuesta tiene como objetivo adaptar y validar un instrumento de evaluaci\u00f3n del grado de conocimiento de la poblaci\u00f3n general sobre salud mental y de sus actitudes en torno a la b\u00fasqueda de ayuda, en el marco del concepto de literacidad en salud mental y aplicar este instrumento a una muestra predeterminada que permita generar una l\u00ednea base sobre la cual planificar acciones y evaluar avances en el tiempo. Esto responde a la licitaci\u00f3n p\u00fablica hecha por el Ministerio de Salud de Chile: Estudio sobre acceso a informaci\u00f3n de salud mental en la poblaci\u00f3n general Licitaci\u00f3n ID 757-69-LE20.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ID 757-69-LE20<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Mayo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Salud<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6535\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Estudio sobre acceso a informaci\u00f3n de salud mental en la poblaci\u00f3n general\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6535\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6535\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La presente propuesta tiene como objetivo adaptar y validar un instrumento de evaluaci\u00f3n del grado de conocimiento de la poblaci\u00f3n general sobre salud mental y de sus actitudes en torno a la b\u00fasqueda de ayuda, en el marco del concepto de literacidad en salud mental y aplicar este instrumento a una muestra predeterminada que permita generar una l\u00ednea base sobre la cual planificar acciones y evaluar avances en el tiempo. Esto responde a la licitaci\u00f3n p\u00fablica hecha por el Ministerio de Salud de Chile: Estudio sobre acceso a informaci\u00f3n de salud mental en la poblaci\u00f3n general Licitaci\u00f3n ID 757-69-LE20.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Noviembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6532\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Dise\u00f1o e implementaci\u00f3n de diagn\u00f3stico de estigma asociado a salud mental en poblaci\u00f3n seleccionada.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6532\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6532\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El estigma asociado a salud mental es uno de los problemas m\u00e1s importantes de la salud mental con perspectiva de salud p\u00fablica hoy, concitando \u0096 en diversos grados de avance - desarrollo acad\u00e9mico, pol\u00edticas\r\np\u00fablicas, acciones locales y participaci\u00f3n de la sociedad civil.\r\nA nivel de pol\u00edticas en salud todav\u00eda hay una importante brecha que completar. En 2010, ya el estigma era parte de los temas definidos en la Estrategia Nacional de Salud, dentro del eje estrat\u00e9gico de \u0093Enfermedades no transmisibles, violencia y discapacidad\u0094, bajo el resultado esperado \u0093Promover la inclusi\u00f3n social de las personas con discapacidad de origen mental\u0094, por ejemplo, se plate\u00f3 el resultado de \u0093Contar con un plan regional para reducir estigma hacia personas con problemas o trastornos mentales\u0094. Si bien esto moviliz\u00f3 algunos desarrollos regionales, esto no alcanz\u00f3 a todo el pa\u00eds. Por esta raz\u00f3n, el Plan Nacional de Salud Mental 2017-2025 volvi\u00f3 a retomar el tema. Esta vez, asign\u00e1ndole mayor prioridad, lo cual queda plasmado en el plan de acci\u00f3n asociado, donde la materia tiene una l\u00ednea espec\u00edfica.\r\nEl objetivo de la l\u00ednea es \u0093reducir el estigma relacionado a problemas de salud mental\u0094 y cuenta entre sus principales iniciativas con:\r\n\u0095 Dise\u00f1ar e implementar un plan para abordar el estigma relacionado con la salud mental\r\n\u0095 Desarrolla un levantamiento sistem\u00e1tico de informaci\u00f3n acerca de buenas pr\u00e1cticas sobre estigma en la salud\r\nmental, en la red de salud, la sociedad civil y el mundo acad\u00e9mico.\r\n\u0095 Realizar un Diagn\u00f3stico de estigma asociado a salud mental en poblaci\u00f3n seleccionada[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> SOCHED 2020-03<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Sociedad Chilena de Endocrinolog\u00eda y Diabetes<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6484\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            COVID-DIAB: CARACTERIZACI\u00d3N GEN\u00c9TICA Y EPIGEN\u00c9TICA DE SUJETOS ADULTOS CON DIAGN\u00d3STICO DE DIABETES DE NUEVA APARICI\u00d3N POSTERIOR A COVID-19\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6484\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6484\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Estudio de casos de Diabetes Mellitus de nueva aparici\u00f3n[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6452\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Chronic exposition to anticholinesterase pesticides\u0092 effects on Hidden Hearing Loss and auditory processing development\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6452\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6452\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El proyecto tiene como objetivo investigar y esclarecer un mecanismo relacionado con la p\u00e9rdida auditiva\r\nvinculada a la exposici\u00f3n a pesticidas. Nos centramos en comprender los efectos cr\u00f3nicos, no agudos, de la\r\nexposici\u00f3n a pesticidas, particularmente en habitantes de zonas rurales cercanas a campos de cultivo. As\u00ed,\r\nnuestro grupo de estudio estuvo constituido por j\u00f3venes residentes o trabajadores de \u00e1reas lim\u00edtrofes a\r\ncampos de cultivo, donde investigamos la posible asociaci\u00f3n entre la disfunci\u00f3n colin\u00e9rgica del sistema\r\nauditivo eferente, inducida por pesticidas anticolinester\u00e1sicos, y su relaci\u00f3n con la p\u00e9rdida auditiva y trastornos\r\nen el procesamiento central.\r\nNuestra hip\u00f3tesis condujo a la creaci\u00f3n de un modelo experimental que sugiere que la exposici\u00f3n a pesticidas\r\norganofosforados est\u00e1 relacionada con el desarrollo temprano de una p\u00e9rdida auditiva oculta mediada por la\r\ndisfunci\u00f3n del sistema eferente auditivo, el cual est\u00e1 estrechamente asociado con sinapsis colin\u00e9rgicas.\r\nNuestros resultados revelaron que la exposici\u00f3n a pesticidas en j\u00f3venes gener\u00f3 problemas relacionados con\r\nla percepci\u00f3n de tonos de alta frecuencia en los registros audiom\u00e9tricos, una disminuci\u00f3n en la amplitud\r\nasociada a la conducci\u00f3n del nervio auditivo y una reducci\u00f3n en la fuerza del reflejo eferente auditivo. Sin\r\nembargo, no se observaron efectos en la percepci\u00f3n auditiva en los voluntarios j\u00f3venes expuestos a\r\npesticidas.\r\nAdicionalmente, este estudio busc\u00f3 establecer una conexi\u00f3n entre los cambios observados en humanos y los\r\nefectos en animales de experimentaci\u00f3n. Para abordar ello, realizamos estudios en ratones, asign\u00e1ndolos a\r\nuno de cuatro grupos experimentales: dos grupos de ratones Wild Type (WT) y dos grupos de ratones\r\ngen\u00e9ticamente modificados (KO) para silenciar funcionalmente el receptor &#945;9\/&#945;10 en la sinapsis olivococlear\r\nmedial. Esta sinapsis, de naturaleza colin\u00e9rgica, es crucial en el eferente auditivo y se comunica directamente\r\ncon las c\u00e9lulas ciliadas externas.\r\nEstos ratones fueron separados seg\u00fan su genotipo y expuestos a Clorpirifos (0,5mg\/kg) mediante inyecciones\r\nintraperitoneales durante 10 d\u00edas, o recibieron solo el veh\u00edculo (aceite de ma\u00edz). Los estudios en animales\r\nrevelaron un aumento significativo en los umbrales auditivos a las 48 horas, aunque este efecto no persisti\u00f3 a\r\nla cuarta semana post-exposici\u00f3n, tanto en ratones WT como KO. Actualmente, estamos analizando\r\nmicrofotograf\u00edas electr\u00f3nicas para establecer un mecanismo asociado a la p\u00e9rdida de sensibilidad y\r\npercepci\u00f3n auditiva inducida por la exposici\u00f3n a organofosforados. Este an\u00e1lisis est\u00e1 pendiente para su\r\npublicaci\u00f3n.\r\nNuestro estudio permiti\u00f3 describir detalladamente el efecto de la exposici\u00f3n a pesticidas en individuos que\r\nresiden cerca de \u00e1reas de cultivo, mostrando un impacto en la sensibilidad y percepci\u00f3n auditiva. Este efecto\r\npodr\u00eda estar asociado, en parte, a la disfunci\u00f3n colin\u00e9rgica inducida por ciertos pesticidas, especialmente los\r\norganofosforados. Este estudio ha sido crucial para formar grupos de trabajo que investiguen el impacto del\r\nuso de pesticidas en la regi\u00f3n, particularmente en la regi\u00f3n de O\u0092Higgins, donde la actividad predominante es\r\nla agricultura y la mayor parte del empleo se concentra en este sector. Sin embargo, todav\u00eda estamos\r\npendientes de llegar a comunidades m\u00e1s distantes, para llevar a cabo un trabajo de divulgaci\u00f3n cient\u00edfica m\u00e1s\r\namplio y tener un mayor impacto en la sociedad.\r\nDesde una perspectiva cient\u00edfica, nuestro estudio es pionero al intentar establecer un mecanismo que vincule\r\nla p\u00e9rdida auditiva con la exposici\u00f3n a pesticidas. Es el primer estudio en describir en detalle los efectos de\r\nestos qu\u00edmicos en j\u00f3venes expuestos cr\u00f3nicamente, y el primero en explorar el impacto de la exposici\u00f3n a\r\npesticidas en el sistema auditivo a trav\u00e9s de un modelo animal.\r\nEn resumen, este estudio sentar\u00e1 las bases para investigaciones m\u00e1s exhaustivas sobre el fuerte impacto de\r\nla exposici\u00f3n a pesticidas en la audici\u00f3n humana, un \u00e1rea a\u00fan poco explorada. Adem\u00e1s, proporcionar\u00e1\r\nevidencia para comprender, desde una perspectiva de las ciencias b\u00e1sicas, los efectos de las sustancias\r\nanticolinester\u00e1sicas en el funcionamiento de la sinapsis olivococlear medial.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Proyecto de investigaci\u00f3n SOCHED No 2020-08<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Mayo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Sociedad Chilena de Endocrinolog\u00eda y Diabetes<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6471\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto del aceite de quinoa (Chenopodium quinoa) en la activaci\u00f3n de NF-&#954;B y Nrf2 y en los niveles de TNF-&#945; y HO-1 inducidos por lipopolisac\u00e1rido en hepatocitos humanos HepG2\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6471\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6471\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]T\u00edtulo: \"Efecto del aceite de quinoa (Chenopodium quinoa) en la activaci\u00f3n de NF-&#954;B y Nrf2 y en los niveles de TNF-&#945; y HO-1 inducidos por lipopolisac\u00e1rido en hepatocitos humanos HepG2\".[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Proyecto de investigaci\u00f3n SOCHED No 2020-08<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Mayo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Sociedad Chilena de Endocrinolog\u00eda y Diabetes<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6476\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto del aceite de quinoa (Chenopodium quinoa) en la activaci\u00f3n de NF-&#954;B y Nrf2 y en los niveles de TNF-&#945; y HO-1 inducidos por lipopolisac\u00e1rido en hepatocitos humanos HepG2\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6476\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6476\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]T\u00edtulo: \"Efecto del aceite de quinoa (Chenopodium quinoa) en la activaci\u00f3n de NF-&#954;B y Nrf2 y en los niveles de TNF-&#945; y HO-1 inducidos por lipopolisac\u00e1rido en hepatocitos humanos HepG2\".[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 11201337<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6485\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Consequences of androgen excess on folate metabolism and epigenetic effects on metabolic phenotype in Chilean women with polycystic ovary syndrome (PCOS).\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6485\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6485\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Polycystic ovary syndrome (PCOS) is a prevalent and multifactorial endocrine disorder in women, which is\r\ncharacterized by reproductive and metabolic alterations that include hyperandrogenism, polycystic ovarian \r\nmorphology, anovulation, insulin resistance, dyslipidemia and obesity with a high risk to develop type 2 \r\ndiabetes and cardiovascular disease. However, the mechanisms that contribute to the development \r\nof metabolic abnormalities are not completely understood. Currently, DNA methylation, an epigenetic \r\nmechanism that regulates gene expression, has been proposed as an attractive possibility that might explain \r\nthe heterogeneity of the syndrome linking the effect of environmental factors on susceptible genes to the \r\npresence of metabolic features. Data from women with PCOS and animal models of hyperandrogenism have \r\nfound differential methylation patterns in several gene promoters related to glucose and lipid metabolism \r\nleading to a dysregulation of the expression of these genes and metabolic disorders. On the other hand, \r\nseveral environmental factors that may contribute with the establishment of these epigenetic modifications \r\nin women with PCOS remain unidentified. In this regard, it is widely accepted that different foods and \r\nnutrients have an impact on the regulation of epigenetic mechanisms, among them it has been \r\nproposed that elevated folic acid (FA) levels could induce an hypermethylation of the DNA which\r\ncould reduce the expression of important regulatory genes including those asociated with \r\nmetabolic function. Interestingly, women with PCOS show changes in folate and homocysteine levels \r\nsuggesting an altered folate metabolism, which could be associated to changes in the methylation patterns \r\nof metabolic genes. In the present research project, we propose that androgen excess disrupts the \r\nfolate cycle leading to folate excess in women with PCOS compared to control women. This \r\nalteration leads to hypermethylation of candidate genes involved in glucose and lipid metabolism \r\n(PPARG, FOXO1, GPAM and APOA2) which may impact the metabolic phenotype of women with \r\nPCOS. To test this hypothesis, 37 women with PCOS and 37 control women will be recruited to assess the \r\neffect of androgen excess in women with PCOS on folate metabolism circulating biomarkers such as folates, \r\nvit B12 and homocysteine (Hcy) (Specific aim 1). These results will be categorized according to quartiles of \r\nfolate consumption according to the dietary pattern, using a validated food frequency questionnaire, and \r\nassociated with circulating androgen levels. In addition, to evaluate whether androgen excess induces \r\nchanges in folate cycle enzymes, gene expression analyses will be performed in peripheral blood mononuclear \r\ncells (PBMC) (Specific aim 2). To establish the causality of our hypothesis, we will evaluate the effect of \r\nandrogen excess on the folate cycle using a cellular model. For this, gene and protein expression of the \r\nenzymes involved on the folate cycle (MAT, SAHH, MS, MTHFR, FOL1R y AHCY) will be analyzed in an \r\nhepatocyte cell line stimulated with testosterone (Specific aim 3). To check the specificity of androgen action\r\nwe will use androgen blockers and aromatase inhibitors. Finally, to determine the effect on genes associated \r\nto glucose and lipid metabolism, DNA methylation in promoter regions and gene expression of candidate \r\ngenes associated to glucose and lipid metabolism (PPARG, FOXO1, GPAM and APOA2) will be analyzed \r\n(Specific aim 4). We expect to find an increase in folate and homocysteine levels, and decreased levels of \r\nvitamin B12 in women with PCOS, asociated with a decreased expression of folate metabolism enzymes. On \r\nthe other hand, in the in vitro model, we expect high levels of folic acid and a decrease in the expression of \r\ngenes involved in folate metabolism in hepatocytes stimulated with androgens. This dysregulation in folate \r\nmetabolism induced by androgen excess may result in hypermethylation of genes involved in lipid and \r\nglucose metabolism such as PPARG, FOXO1, GPAM and APOA2, leading to a lower gene expression which may impact the metabolic parameters of PCOS women. The results obtained from this proposal will help to identify new mechanisms involved in the pathophysiology of metabolic alterations in PCOS leading to the development of more effective strategies of prevention and therapy[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 11201028<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2020 - Noviembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6537\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Socio-labor inclusion and stigma among young adults with autism spectrum disorders\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6537\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6537\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The current study will quantify the level of employment in young adults with ASD and identify barriers to and facilitators of their labor inclusion. In addition, this study will determine if the level of stigma is associated with employment rates in young adults with ASD. The overarching goal is to contribute to improve the quality of life in adults with ASD in Chile by informing the development of public policies and interventions to increase the employment rate in this vulnerable population.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ER190042.<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2020 - Noviembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>PAR EXPLORA O\u0092Higgins 2020<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6456\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6456\" aria-expanded=\"false\" aria-controls=\"collapse-6456\">\n                                            Producto de divulgaci\u00f3n cient\u00edfica ER190042: \u0093Artis y el Laberinto\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6456\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6456\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Desarrollo de libro infantil sobre bienestar.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> ER190042.<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2020 - Noviembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>PAR EXPLORA O\u0092Higgins 2020<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6475\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a class=\"accordion-button bg-transparent p-0 pe-2 collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapse-6475\" aria-expanded=\"false\" aria-controls=\"collapse-6475\">\n                                            Producto de divulgaci\u00f3n cient\u00edfica ER190042: \u0093Artis y el Laberinto\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6475\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6475\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Desarrollo de libro infantil sobre bienestar.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2020 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6492\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            El impacto de la pandemia por COVID-19 sobre las condiciones laborales y el bienestar psicosocial en Chile, desde una perspectiva de g\u00e9nero.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6492\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6492\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo general:\r\nAnalizar la relaci\u00f3n entre las condiciones laborales y de empleo, con el bienestar psicosocial durante la Pandemia por COVID-19 en Chile con perspectiva de g\u00e9nero.\r\nObjetivo(s) espec\u00edfico(s):\r\n- Caracterizar las modificaciones en las condiciones de empleo, trabajo y el bienestar psicosocial, seg\u00fan perspectiva de g\u00e9nero, durante la pandemia por COVID-19, en Chile y en la Regi\u00f3n de O'Higgins\r\n- Relacionar las condiciones de empleo y trabajo, y el bienestar psicosocial seg\u00fan perspectiva de[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2020 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6534\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            El impacto de la pandemia por COVID-19 sobre las condiciones laborales y el bienestar psicosocial en Chile, desde una perspectiva de g\u00e9nero.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6534\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6534\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo general:\r\nAnalizar la relaci\u00f3n entre las condiciones laborales y de empleo, con el bienestar psicosocial durante la Pandemia por COVID-19 en Chile con perspectiva de g\u00e9nero.\r\nObjetivo(s) espec\u00edfico(s):\r\n- Caracterizar las modificaciones en las condiciones de empleo, trabajo y el bienestar psicosocial, seg\u00fan perspectiva de g\u00e9nero, durante la pandemia por COVID-19, en Chile y en la Regi\u00f3n de O'Higgins\r\n- Relacionar las condiciones de empleo y trabajo, y el bienestar psicosocial seg\u00fan perspectiva de[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2020 - Enero 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6453\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Percepci\u00f3n sobre formas de discriminaci\u00f3n hacia personas de la diversidad sexo gen\u00e9rica en la Regi\u00f3n de O&#8217;Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6453\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6453\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]El presente estudio nace de la evidencia que en Am\u00e9rica Latina a\u00fan persiste un conjunto de inequidades que afectan las relaciones de g\u00e9nero y que son sostenidas por las ideolog\u00edas del patriarcado y el heterosexismo (Barrientos, 2015). En particular, tanto el patriarcado como el heterosexismo favorecen un conjunto de condiciones adversas para quienes se definen como lesbianas, gays, bisexuales, transg\u00e9nero e intersexuales (en adelante, LGBTI;Barrientos, 2015;\r\nHerek, 2000) y promueven un modelo binario del g\u00e9nero (masculino o femenino; McCann & Sharek, 2016). Entre todas las condiciones g\u00e9nero-diversas, la poblaci\u00f3n Transg\u00e9nero, entendiendo por tal a aquellas personas cuya identidad de g\u00e9nero o la expresi\u00f3n de \u00e9ste difiere de lo esperado culturalmente una vez que se ha hecho la asignaci\u00f3n de sexo al nacer como hombre o mujer (Davidson, 2007; Valentine, 2007), aparece como la m\u00e1s expuesta a estigma, violencia, prejuicio, social , inequidad y discriminaci\u00f3n en todo \u00e1mbito lo que redunda en un marcado deterioro de sus indicadores de calidad bienestar psicosocial.\r\nDe acuerdo con datos recopilados para la conmemoraci\u00f3n de la Memoria Trans la situaci\u00f3n de transfobia y de violencia hacia la poblaci\u00f3n trans en Sudam\u00e9rica es alarmante, estableci\u00e9ndose como el continente con mayor tasa de mortalidad asociada a cr\u00edmenes de odio. Si bien esta situaci\u00f3n no es exclusiva de nuestro continente, en pa\u00edses donde existen legislaciones que protegen a poblaciones que culturalmente no pueden ser encasilladas como \u0093tradicionales\u0094 muestran tasas de violencia relativamente menores (Transmurder Monitoring, 2018). La soluci\u00f3n a la violencia de g\u00e9nero como un eje, se relaciona fundamentalmente con la capacidad de realizar cambios estructurales en las pol\u00edticas de estado tendientes a propiciar cambios culturales que eviten la segregaci\u00f3n de la poblaci\u00f3n Trans y que \u00e9stas est\u00e9n sustentadas en evidencia constituyendo un discurso s\u00f3lido y un constructo social para la toma de decisiones. Sin embargo, y pese a que en los \u00faltimos a\u00f1os ha aumentado el debate p\u00fablico sobre las personas trans (Halberstam, 2018; Stryker, 2017), lo que ha estimulado el surgimiento de un campo de discusi\u00f3n, investigaci\u00f3n y trabajo para las ciencias sociales y para\r\nla psicolog\u00eda en particular, en Chile la investigaci\u00f3n al respecto es reciente y la informaci\u00f3n\r\n\r\n manejada es incompleta y mayoritariamente no sistem\u00e1tica en especial en regiones, como el caso de Rancagua donde esta es b\u00e1sicamente inexistente.\r\nEl objetivo operacional del estudio es entonces es desarrollar una investigaci\u00f3n exploratoria \/descriptiva, cuanti-cualitativa sistem\u00e1tica en un colectivo Trans organizado (OTR) que abarca la ciudad de Rancagua y alrededores donde podamos recoger informaci\u00f3n extensiva para la caracterizaci\u00f3n sociodemogr\u00e1fica, econ\u00f3mica de los participantes, indicadores de salud f\u00edsica y mental y por otra parte realizar un trabajo cualitativo de tipo narrativo-biogr\u00e1fico con los mismos. De esta manera se pretende acercarnos a \u0093significar\u0094 y \u0093explicar\u0094 la vivencia y las caracter\u00edsticas de comportamiento de las personas transg\u00e9nero de nuestra localidad que las cifras en ocasiones no permiten transparentar. Si bien el aporte en t\u00e9rminos de ampliaci\u00f3n del conocimiento sistem\u00e1tico es uno de los objetivos primarios de la investigaci\u00f3n, tambi\u00e9n consideramos central la posibilidad de contribuir a la sensibilizaci\u00f3n social y de las instancias de gobierno local a trav\u00e9s de informaci\u00f3n objetiva que promueva el mejoramiento de los derechos y calidad de vida de los participantes y poblaci\u00f3n transg\u00e9nero en general.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2020 - Febrero 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Universidad de O'Higgins<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6454\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Personas Transg\u00e9nero en Rancagua: estudio exploratorio cuanti-cualitativo de sus historias de vida y bienestar psico-social\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6454\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6454\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En Chile, la realidad de las personas que se identifican como g\u00e9nero diversas (es decir, no adscriben a la concepci\u00f3n de g\u00e9nero binaria tradicional) ha experimentado cambios en las \u00faltimas d\u00e9cadas con el paulatino reconocimiento de derechos, incremento relativo de la aceptaci\u00f3n social, mayor visibilizaci\u00f3n, etc. Sin embargo, existen estereotipos, prejuicios y creencias arraigadas socialmente que favorecen la permanencia de actitudes y conductas discriminatorias y\/o f\u00f3bicas en distintos \u00e1mbitos sociales. Se ha mostrado que uno de los pilares de las estrategias orientadas a promover, sensibilizar y concientizar en torno al respeto por la diversidad de g\u00e9nero radica en la producci\u00f3n de conocimiento sistem\u00e1tico en torno a la realidad nacional, regional y local que permita la contextualizaci\u00f3n y visibilizaci\u00f3n de las situaciones vitales de las personas y el abordaje desde la acci\u00f3n institucional educativa, de salud, gesti\u00f3n comunitaria, entre otras. Si bien en Chile se han realizado encuestas y se intentan elaborar indicadores para caracterizar el n\u00famero, calidad de vida y tambi\u00e9n actitudes f\u00f3bicas y experiencias de discriminaci\u00f3n en diversos colectivos pertenecientes a la diversidad de g\u00e9nero, por razones de alcance y metodol\u00f3gicas todav\u00eda no son lo suficientemente precisas. En este sentido, en nuestra regi\u00f3n en particular, se verifica un d\u00e9ficit de informaci\u00f3n en torno a la visibilizaci\u00f3n de la diversidad como tambi\u00e9n la presencia de actitudes y pr\u00e1cticas discriminatorias no asumidas ni problematizadas socialmente. Por este motivo, este estudio tiene por finalidad ampliar el conocimiento acerca de las opiniones, valores, comportamientos y actitudes ante la diversidad sexo-gen\u00e9rica en la Regi\u00f3n del Lib.Gral.Bdo. O\u0092Higgins en distintos \u00e1mbitos sociales e institucionales desde una doble perspectiva, cuanti-cualitiva que permitir\u00e1 obtener indicadores objetivos sobre esta realidad y a\r\nsu vez generar un documento audiovisual que permita la socializaci\u00f3n masiva de estos hallazgos, enriquecidos con una exploraci\u00f3n cualitativa de corte biogr\u00e1fico.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> INV 002<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Mayo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6470\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Apoyo a la investigaci\u00f3n en ciencias de la educaci\u00f3n\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6470\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6470\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Predictores socioecon\u00f3micos y psicobiol\u00f3gicos del desempe\u00f1o acad\u00e9mico en estudiantes\r\nde primer a\u00f1o de pedagog\u00eda de la UOH (Programa de Formaci\u00f3n Inicial Docente)\r\n\r\nCl\u00e1sicamente se ha descrito que el rendimiento durante la ense\u00f1anza media de los estudiantes en Chile\r\na trav\u00e9s del NEM y sus resultados en las pruebas de ingreso a la universidad, adem\u00e1s un factor\r\ndeterminando son las condiciones socioecon\u00f3micas, que resultan ser un factor predictivo de\r\nrendimiento acad\u00e9mico durante los primeros a\u00f1os de educaci\u00f3n universitaria. Paralelamente, se ha\r\nconstatado que los estudiantes a lo largo del primer semestre en la universidad sufren un deterioro en\r\nsu calidad del sue\u00f1o y en los h\u00e1bitos alimenticios, todo relacionado con un aumento de sus niveles de\r\nestr\u00e9s. Por otro lado, hipotetizamos una asociaci\u00f3n de estos indicadores con el desempe\u00f1o en pruebas\r\nde memoria de trabajo, y pueden ser elementos predictivos que determinen el desempe\u00f1o acad\u00e9mico.\r\nNuestra investigaci\u00f3n tiene por objetivo estudiar ciertos indicadores de higiene, tales como sue\u00f1o,\r\nestr\u00e9s y alimentaci\u00f3n, con el fin de predecir su importancia en la predicci\u00f3n del desempe\u00f1o\r\nacad\u00e9mico. Contemplamos el uso de datos anonimizados en acuerdo con lo que establezca el comit\u00e9\r\nde \u00e9tica institucional. En el caso espec\u00edfico de estudiantes de educaci\u00f3n b\u00e1sica y educaci\u00f3n especial,\r\ndeterminar los principales factores que afectan el rendimiento acad\u00e9mico, es una herramienta \u00fatil que\r\ncreemos permitir\u00e1 modificar ciertos modelos con el fin de mejorar los procesos de ense\u00f1anza \u0096\r\naprendizaje. Este estudio se enmarca en un proyecto de Fortalecimiento a la formaci\u00f3n Inicial\r\nDocente el cual apoyar\u00e1 con los fondos necesarios para el buen desarrollo de esta investigaci\u00f3n. La\r\ncontribuci\u00f3n institucional de la UOH se limita a autorizar la participaci\u00f3n voluntaria de sus\r\nestudiantes, que se formalizar\u00e1 a trav\u00e9s de la firma del consentimiento informado por cada uno de los\r\nestudiantes de forma voluntaria sin mediar recompensa ni perjuicio fruto de su decisi\u00f3n de colaborar\r\nen el estudio. A los estudiantes de pedagog\u00eda que voluntariamente decidan participar, se les aplicar\u00e1,\r\nal inicio y al final del presente semestre acad\u00e9mico, una encuesta online que evaluar\u00e1 diferentes\r\nmarcadores de estr\u00e9s y mediante el uso de una aplicaci\u00f3n, se recopilar\u00e1 informaci\u00f3n aleatorizada de\r\nsus h\u00e1bitos de alimentaci\u00f3n y de descanso. Estos datos ser\u00e1n analizados considerando elementos de\r\nrendimiento en la educaci\u00f3n media y marcadores socioecon\u00f3micos. Junto con esto, al finalizar el\r\nsemestre, siempre con el consentimiento de cada participante, se solicitar\u00e1 al docente responsable del\r\ncurso las calificaciones y nota final de todos ellos. Estos datos ser\u00e1n analizados cuantitativamente y de\r\nforma anonimizada. Finalmente se evaluar\u00e1n todos los marcadores obtenidos, realizando un an\u00e1lisis\r\ncuantitativo y cualitativo, combinando m\u00e9todos univariados y multivariados para evaluar estos de\r\nmanera exploratoria e inferencial. Posteriormente proponemos dar punto final al estudio realizando un\r\nan\u00e1lisis profundo del efecto de los diferentes componentes a trav\u00e9s de la t\u00e9cnica de PCA.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Junio 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6386\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            II190105 &#8211; Estudio de los mecanismos biomec\u00e1nicos activados por hipoxia a nivel del endotelio vascular\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6386\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6386\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Las enfermedades cardiovasculares (ECV), incluidas la hipertensi\u00f3n, el accidente cerebrovascular y la enfermedad de las arterias coronarias, son las principales patolog\u00edas a nivel mundial con un impacto significativo en la morbilidad y la mortalidad. El riesgo de enfermedades cardiovasculares se explica parcialmente por factores gen\u00e9ticos, pero en mayor medida por est\u00edmulos que tienen lugar durante el desarrollo temprano y el envejecimiento. La funci\u00f3n vascular durante la vida est\u00e1 determinada principalmente por tensiones mec\u00e1nicas resultantes de la presi\u00f3n sangu\u00ednea y el flujo, as\u00ed como por v\u00edas de se\u00f1alizaci\u00f3n activadas por la disponibilidad de ox\u00edgeno. En este contexto, alteraciones en las fuerzas de estiramiento (i.e. tensiones residuales circunferenciales y longitudinales de las arterias), la tensi\u00f3n de corte anormal (shear stress i.e: la fricci\u00f3n del flujo sangu\u00edneo en la superficie arterial luminal) y la hipoxia (i.e. la disminuci\u00f3n relativa de las presiones de ox\u00edgeno) son factores cr\u00edticos en el desarrollo de ECV. \r\nLos miembros de este proyecto se han centrado en \u00e1reas particulares de estos procesos, sin embargo, se requieren esfuerzos adicionales interdisciplinarios para entender de manera integral los mecanismos mec\u00e1nicos y moleculares involucrados en los or\u00edgenes de la disfunci\u00f3n cardiovascular. Recientemente se ha descrito a PIEZO1, un canal de cationes no selectivo, como uno de los principales activadores de la relajaci\u00f3n dependiente de endotelio en respuesta a la tensi\u00f3n de corte. Sin embargo, la regulaci\u00f3n de \u00e9ste, por parte de los est\u00edmulos descritos anteriormente, no ha sido a\u00fan explorada. La presente propuesta busca caracterizar, a trav\u00e9s de un estudio con enfoques en biomec\u00e1nica, fisiolog\u00eda y biolog\u00eda molecular, los cambios en la funci\u00f3n del mecano-sensor PIEZO1, en respuesta a est\u00edmulos f\u00edsicos y biol\u00f3gicos en c\u00e9lulas endoteliales de arteria umbilical humana, con el fin de identificar potenciales blancos de modulaci\u00f3n de la funci\u00f3n vascular en condiciones que promueven las ECV.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Junio 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6417\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            II190105 &#8211; Estudio de los mecanismos biomec\u00e1nicos activados por hipoxia a nivel del endotelio vascular\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6417\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6417\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Las enfermedades cardiovasculares (ECV), incluidas la hipertensi\u00f3n, el accidente cerebrovascular y la enfermedad de las arterias coronarias, son las principales patolog\u00edas a nivel mundial con un impacto significativo en la morbilidad y la mortalidad. El riesgo de enfermedades cardiovasculares se explica parcialmente por factores gen\u00e9ticos, pero en mayor medida por est\u00edmulos que tienen lugar durante el desarrollo temprano y el envejecimiento. La funci\u00f3n vascular durante la vida est\u00e1 determinada principalmente por tensiones mec\u00e1nicas resultantes de la presi\u00f3n sangu\u00ednea y el flujo, as\u00ed como por v\u00edas de se\u00f1alizaci\u00f3n activadas por la disponibilidad de ox\u00edgeno. En este contexto, alteraciones en las fuerzas de estiramiento (i.e. tensiones residuales circunferenciales y longitudinales de las arterias), la tensi\u00f3n de corte anormal (shear stress i.e: la fricci\u00f3n del flujo sangu\u00edneo en la superficie arterial luminal) y la hipoxia (i.e. la disminuci\u00f3n relativa de las presiones de ox\u00edgeno) son factores cr\u00edticos en el desarrollo de ECV. \r\nLos miembros de este proyecto se han centrado en \u00e1reas particulares de estos procesos, sin embargo, se requieren esfuerzos adicionales interdisciplinarios para entender de manera integral los mecanismos mec\u00e1nicos y moleculares involucrados en los or\u00edgenes de la disfunci\u00f3n cardiovascular. Recientemente se ha descrito a PIEZO1, un canal de cationes no selectivo, como uno de los principales activadores de la relajaci\u00f3n dependiente de endotelio en respuesta a la tensi\u00f3n de corte. Sin embargo, la regulaci\u00f3n de \u00e9ste, por parte de los est\u00edmulos descritos anteriormente, no ha sido a\u00fan explorada. La presente propuesta busca caracterizar, a trav\u00e9s de un estudio con enfoques en biomec\u00e1nica, fisiolog\u00eda y biolog\u00eda molecular, los cambios en la funci\u00f3n del mecano-sensor PIEZO1, en respuesta a est\u00edmulos f\u00edsicos y biol\u00f3gicos en c\u00e9lulas endoteliales de arteria umbilical humana, con el fin de identificar potenciales blancos de modulaci\u00f3n de la funci\u00f3n vascular en condiciones que promueven las ECV.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6495\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Identification of Causes, Reasons And Solutions for High COVID-19 mortality rate in AGEd populations (CRASH CAGE)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6495\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6495\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The epidemiology of the coronavirus disease 2019 (COVID-19) have revealed a dramatic\r\nmortality rate in older age groups. Notably, a similar epidemiological pattern was reported with other emerging infections and zoonosis. Further observations have however highlighted substantial differences between countries. By this project, we want to decipher social, epidemiological and biological causes of differences in COVID-19 mortality rates across countries and age groups, convinced that findings may be relevant also for future emerging infection and other zoonosis.\r\nTo this aim, we will first embark in an epidemiological analysis to understand sociodemographic factors associated with higher mortality rates. In parallel, we will characterize potential defects in mounting SARS-CoV-2 specific adaptive cellular responses in most-at-risk population (elderly and frail subjects).\r\nThese two activities will provide important clues to plan preventive strategies. Indeed,\r\npreliminary results suggest that molecules able to normalize lipid metabolism (which is altered in subjects susceptible to COVID-19) may restore T-cell functionality in the elderly. These molecules will be assessed, in vitro, for their capacity boost CD8+ T cell priming against SARS-CoV-2 in elderly and frail individuals. It is important to note that the effectiveness of preventive measures is strictly related to their compliance and, to this aim, proper communication measures are requested. These will be the focus of our IV activity.\r\nElderly and frail subjects constitute a population which should be proactively targeted in\r\npreventive strategies against second waves of COVID-19 but also against outbreaks of future\/new emerging infections and zoonosis.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6496\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Modern Design &#038; Interactive Teaching Methods, MoDITeM for virtual training\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6496\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6496\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]At present the planet is facing a global disease caused by COVID-19, that has been classified as a pandemic by the World Health Organization (WHO). In this exceptional context, WHO recommends quarantine and social distance for reduce spreading, diseases and deaths among the population.1 One of the main effects of these measures is the interruption of classes at schools, colleges and universities, with students at home.1 The impossibility of presential classes interrupted the educational and communication processes, that are very important in this situation of uncertainty, lack of information and fake news.2 For that reason, technology and virtual education are essentials for adaptive learning and also a new way to access from everywhere through mobile devices.3 Nevertheless, it could imply improvisation with a lot of trial and error, increasing inequality between students that could afford a better education and those who not.4 \r\nOn the other hand, implications beyond the healthcare domain - which have placed global sustainable development under threat - highlight the need for the One Health transdisciplinary approach5,6 to tackle the situation7. However, the integration of different disciplines is still a challenge for global health.6 Therefore, capacity building among students in this direction should be promoted.8\r\nWithin this scenario, this pilot course on Modern Design & Interactive Teaching Methods, MoDITeM is designed under the train-the-trainers concept to provide educators in the field of health and other disciplines a methodological framework and didactic teaching methods to develop their own virtual teaching. Teaching methods will promote inter-professional and transdisciplinary learning.  Thus, we will contribute to cope not only with challenges in this abrupt change to virtual education for the isolated student population in Covid's quarantine, but also to promote the search for comprehensive solutions to local problems in the future.\r\nThe pilot project will be implemented in partner universities in three Latin American countries and one African country, strengthening the South-South collaboration network.  Also, it will permit to reach people far away from main cities, improving the socialization of knowledge and equal opportunities for the population. It will allow to improve skills in teaching methods, research communication and sharing knowledge with peers in an LA and African settings, spreading the OH approach and its sustainability.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2020 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6498\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            One Health Knowledge Caf\u00e9\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6498\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6498\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Virtual learning and networking is an effective approach to develop and build on scientific knowledge and professional skills. In 2020, the global community is affected by Coronavirus Disease (COVID-19) limiting people\u0092s ability to travel and meet face to face due to the pandemic problem. Learning from different countries and about various aspects of COVID-19 is even more important and relevant. Countries, professionals and researchers will be able to learn from each other and to contribute in the effort of combating the problem of COVID-19 by establishing better linkages with researchers and professionals from different countries and experts from different fields.\r\nThe Center for International Health of Ludwig Maximilians University has a wide network of institutions and individuals throughout the continents and with different expertise and skill sets. This network and strength of individuals and institutions can be enhanced for a global effort of combating the pandemic by exchanging knowledge, skills and ideas. We propose a simple approach of facilitating the network and knowledge sharing by utilizing the CIH\u0092s 2020 Call for Proposals on One Health Funds.\r\nThrough this project, \u0093OH-Knowledge Cafe\u0094, we will bring together the expertise and network of researchers and professionals from various disciplines, countries and expertise to enable cross learning, sharing and network building. The project will ensure that funding and contribution from the CIHLMU \/DAAD\/BMZ and network partners will be duly acknowledged in all events and products developed.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Junio 2020 - Enero 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6455\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Predictores socioecon\u00f3micos y psicobiol\u00f3gicos del desempe\u00f1o acad\u00e9mico en estudiantes de primer a\u00f1o de pedagog\u00eda\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6455\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6455\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]aaaa[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2020 - Marzo 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6385\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1201283 &#8211; Reprogramming cardiovascular health after intrauterine hypoxia: epigenetics, antioxidants and endogenous gasotransmitters\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6385\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6385\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]There are more than 41 million deaths per year worldwide, 71% of them are due to non-communicable diseases (NCDs), with cardiovascular (CV) causes taking the first place. Adverse intrauterine conditions increase the risk of developing NCDs during the life course, a phenomenon known as Developmental Origins of Health and Disease (DOHaD).\r\nThe most frequent and clinically relevant adverse condition during fetal life is intrauterine hypoxia (IH), which is associated with a high perinatal morbi-mortality. The molecular mechanisms that could be involve in IH causes and consequences are an important aspect in most of the pregnancies at high altitudes (> 2500m), and in 3-4% of the pregnancies with utero-placental complications at lowlands. \r\nNitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are endogenous gasotransmitters with vasodilator properties that can regulate cardiovascular functions. These gasotransmitters may be affected by intrauterine chronic hypoxia- induced oxidative stress, eliciting vascular programming and deriving in cardiovascular dysfunction along life course. \r\nAlthough these gasotransmitters have shown to determine endothelial, smooth muscle and cardiac function, the role of them in the fetal programming CV dysfunction due to developmental hypoxia and their relationship with oxidative stress is still unknown. \r\n\r\nOur hypothesis is that the intrauterine development in chronic hypoxia programms the gasotransmitters pathways (NO, CO and H2S) in the heart and blood vessels through oxidative stress, which impacts in the short, medium and long term cardiovascular function. Therefore, an oral treatment with antenatal melatonin will prevent the hypoxic-induced cardiovascular impairment.\r\n\r\nIn this proposal, we aim to study, in a well-characterized guinea pig model, the origins and outcomes of cardiovascular dysfunction resulting from IH, by characterizing the functional, structural and molecular aspects of vasoactive mechanisms dependent on endogenous gasotransmitters, in the heart and blood vessels. Moreover, as fetal growth restriction and cardiovascular programming are related with hypoxia induced-oxidative stress, we will implement an antenatal treatment with melatonin, a proved antioxidant, to test the prevention of IH-induced cardiovascular risks in the short-, mediate- and long-term. \r\n\r\nTo address these aims, we will study the effects of intrauterine chronic hypoxia and oxidative stress on the NO, CO and H2S related pathways of the cardiovascular system in guinea pigs. We will describe the NO, CO and H2S related pathways, its epigenetic changes and their roles as important regulators of function, structure and biomechanical properties of heart and vessels, under hypoxia induced-oxidative stress.\r\n\r\nThe aforementioned will be done in animals gestated under IH, with or without antenatal melatonin treatment, and follow the cardiovascular function from fetus to adulthood. The methodology is an in vivo non-invasive evaluation of the function and structure of the cardiovascular system (ultrasound); an ex vivo function and biomechanical characterization of heart and arteries (Langendorff, wire myography, biomechanical tests); and in vitro determinations of genetic, protein and epigenetic expression in heart and several vascular beds; at different stages of life.\r\nThese approaches will permit us to correlate and integrate the short-, mediate- and long-term cardiovascular effects related to the gasotransmitters pathways, in the offspring gestated under chronic hypoxia. In addition, we will evaluate a supported treatment with melatonin, to prevent intrauterine growth restriction and cardiovascular impairment after IH exposure, to test the relationship of gasotransmitters pathways with intrauterine oxidative stress.\r\n\r\nWe expect to unravel the mechanisms underlying IH- induced cardiovascular reprogramming focusing on oxidative stress and gasotransmitters, in order to potentiate melatonin treatment as a possible therapy in hypoxia related complicated pregnancies, either at high altitude or lowlands. This grant will effectively provide a valuable resource for the scientific and clinical community to pursue the understanding of cardiovascular NCDs programmed by intrauterine hypoxia, a worldwide burden still without effective therapeutic approach. Furthermore, this will add knowledge to the foundations for the development of novel therapies for intrauterine hypoxia, and the prevention of CV risk in fetuses, neonates and adults.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2020 - Marzo 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6416\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1201283 &#8211; Reprogramming cardiovascular health after intrauterine hypoxia: epigenetics, antioxidants and endogenous gasotransmitters\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6416\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6416\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]There are more than 41 million deaths per year worldwide, 71% of them are due to non-communicable diseases (NCDs), with cardiovascular (CV) causes taking the first place. Adverse intrauterine conditions increase the risk of developing NCDs during the life course, a phenomenon known as Developmental Origins of Health and Disease (DOHaD).\r\nThe most frequent and clinically relevant adverse condition during fetal life is intrauterine hypoxia (IH), which is associated with a high perinatal morbi-mortality. The molecular mechanisms that could be involve in IH causes and consequences are an important aspect in most of the pregnancies at high altitudes (> 2500m), and in 3-4% of the pregnancies with utero-placental complications at lowlands. \r\nNitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are endogenous gasotransmitters with vasodilator properties that can regulate cardiovascular functions. These gasotransmitters may be affected by intrauterine chronic hypoxia- induced oxidative stress, eliciting vascular programming and deriving in cardiovascular dysfunction along life course. \r\nAlthough these gasotransmitters have shown to determine endothelial, smooth muscle and cardiac function, the role of them in the fetal programming CV dysfunction due to developmental hypoxia and their relationship with oxidative stress is still unknown. \r\n\r\nOur hypothesis is that the intrauterine development in chronic hypoxia programms the gasotransmitters pathways (NO, CO and H2S) in the heart and blood vessels through oxidative stress, which impacts in the short, medium and long term cardiovascular function. Therefore, an oral treatment with antenatal melatonin will prevent the hypoxic-induced cardiovascular impairment.\r\n\r\nIn this proposal, we aim to study, in a well-characterized guinea pig model, the origins and outcomes of cardiovascular dysfunction resulting from IH, by characterizing the functional, structural and molecular aspects of vasoactive mechanisms dependent on endogenous gasotransmitters, in the heart and blood vessels. Moreover, as fetal growth restriction and cardiovascular programming are related with hypoxia induced-oxidative stress, we will implement an antenatal treatment with melatonin, a proved antioxidant, to test the prevention of IH-induced cardiovascular risks in the short-, mediate- and long-term. \r\n\r\nTo address these aims, we will study the effects of intrauterine chronic hypoxia and oxidative stress on the NO, CO and H2S related pathways of the cardiovascular system in guinea pigs. We will describe the NO, CO and H2S related pathways, its epigenetic changes and their roles as important regulators of function, structure and biomechanical properties of heart and vessels, under hypoxia induced-oxidative stress.\r\n\r\nThe aforementioned will be done in animals gestated under IH, with or without antenatal melatonin treatment, and follow the cardiovascular function from fetus to adulthood. The methodology is an in vivo non-invasive evaluation of the function and structure of the cardiovascular system (ultrasound); an ex vivo function and biomechanical characterization of heart and arteries (Langendorff, wire myography, biomechanical tests); and in vitro determinations of genetic, protein and epigenetic expression in heart and several vascular beds; at different stages of life.\r\nThese approaches will permit us to correlate and integrate the short-, mediate- and long-term cardiovascular effects related to the gasotransmitters pathways, in the offspring gestated under chronic hypoxia. In addition, we will evaluate a supported treatment with melatonin, to prevent intrauterine growth restriction and cardiovascular impairment after IH exposure, to test the relationship of gasotransmitters pathways with intrauterine oxidative stress.\r\n\r\nWe expect to unravel the mechanisms underlying IH- induced cardiovascular reprogramming focusing on oxidative stress and gasotransmitters, in order to potentiate melatonin treatment as a possible therapy in hypoxia related complicated pregnancies, either at high altitude or lowlands. This grant will effectively provide a valuable resource for the scientific and clinical community to pursue the understanding of cardiovascular NCDs programmed by intrauterine hypoxia, a worldwide burden still without effective therapeutic approach. Furthermore, this will add knowledge to the foundations for the development of novel therapies for intrauterine hypoxia, and the prevention of CV risk in fetuses, neonates and adults.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2020 - Diciembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6491\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            ESTUDIO TIARA: impacto psico-social del Coronavirus (COVID-19) en Argentina, Chile y Bolivia.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6491\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6491\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Este proyecto regional de estudio psicosocial se conforma ante la crisis global por enfermedad de Coronavirus 2019 (COVID-19), la cual fue declarada pandemia global, el 11 de marzo pasado, por la OMS1. El objetivo del Proyecto es evaluar el impacto social y en salud mental que tiene la enfermedad en Argentina, Chile y Bolivia; como as\u00ed tambi\u00e9n generar evidencia para la toma de decisiones en pol\u00edticas de salud y sociales de cada pa\u00eds.\r\nEl estudio TIARA, estudio base del presente proyecto multic\u00e9ntrico, desarrollado e implementado por Silvina Arrossi y Silvina Ramos del CEDES (unidad asociada a CONICET), Argentina y otros investigadores del mismo pa\u00eds, se ampl\u00eda para generar un proyecto multic\u00e9ntrico que re\u00fane el esfuerzo de colaboraci\u00f3n de instituciones e investigadores de tres pa\u00edses, Argentina, Bolivia y Chile.\r\nEn Chile y Bolivia, est\u00e1 dirigido por equipos locales que re\u00fanen una vasta experiencia en estudios sociales, psiquiatr\u00eda, salud mental global y salud p\u00fablica. El estudio cuenta con el apoyo de co-investigadores y cuenta con el apoyo t\u00e9cnico del Departamento de Salud Mental del Ministerio de Salud de Chile, lo que beneficia el efecto traslacional del conocimiento que se genere.\r\n\r\nObjetivos de Investigaci\u00f3n\r\nEste estudio se propone analizar el impacto psico-social y en la vida cotidiana ante las medidas implementadas frente al COVID-19 en Chile y Bolivia, as\u00ed como tambi\u00e9n analizar las estrategias que est\u00e1 implementando la poblaci\u00f3n para sobrellevar estas medidas, tomando como base las recomendaciones de organismos de salud mental nacionales e internacionales. Por otra parte, se recabar\u00e1 informaci\u00f3n acerca de la posible percepci\u00f3n de los aspectos positivos de las medidas de confinamiento, de manera que se pueda hacer un seguimiento en el tiempo de la aceptabilidad e impacto que tienen en las personas y los hogares.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2020 - Diciembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6533\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            ESTUDIO TIARA: impacto psico-social del Coronavirus (COVID-19) en Argentina, Chile y Bolivia.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6533\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6533\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Este proyecto regional de estudio psicosocial se conforma ante la crisis global por enfermedad de Coronavirus 2019 (COVID-19), la cual fue declarada pandemia global, el 11 de marzo pasado, por la OMS1. El objetivo del Proyecto es evaluar el impacto social y en salud mental que tiene la enfermedad en Argentina, Chile y Bolivia; como as\u00ed tambi\u00e9n generar evidencia para la toma de decisiones en pol\u00edticas de salud y sociales de cada pa\u00eds.\r\nEl estudio TIARA, estudio base del presente proyecto multic\u00e9ntrico, desarrollado e implementado por Silvina Arrossi y Silvina Ramos del CEDES (unidad asociada a CONICET), Argentina y otros investigadores del mismo pa\u00eds, se ampl\u00eda para generar un proyecto multic\u00e9ntrico que re\u00fane el esfuerzo de colaboraci\u00f3n de instituciones e investigadores de tres pa\u00edses, Argentina, Bolivia y Chile.\r\nEn Chile y Bolivia, est\u00e1 dirigido por equipos locales que re\u00fanen una vasta experiencia en estudios sociales, psiquiatr\u00eda, salud mental global y salud p\u00fablica. El estudio cuenta con el apoyo de co-investigadores y cuenta con el apoyo t\u00e9cnico del Departamento de Salud Mental del Ministerio de Salud de Chile, lo que beneficia el efecto traslacional del conocimiento que se genere.\r\n\r\nObjetivos de Investigaci\u00f3n\r\nEste estudio se propone analizar el impacto psico-social y en la vida cotidiana ante las medidas implementadas frente al COVID-19 en Chile y Bolivia, as\u00ed como tambi\u00e9n analizar las estrategias que est\u00e1 implementando la poblaci\u00f3n para sobrellevar estas medidas, tomando como base las recomendaciones de organismos de salud mental nacionales e internacionales. Por otra parte, se recabar\u00e1 informaci\u00f3n acerca de la posible percepci\u00f3n de los aspectos positivos de las medidas de confinamiento, de manera que se pueda hacer un seguimiento en el tiempo de la aceptabilidad e impacto que tienen en las personas y los hogares.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2020 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6406\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto de la ingesta de alimentos en la tasa de oxidaci\u00f3n de grasas durante ejercicio en sujetos con exceso de peso: \u00bfqu\u00e9 es mejor ingerir antes\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6406\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6406\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2020 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6437\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Efecto de la ingesta de alimentos en la tasa de oxidaci\u00f3n de grasas durante ejercicio en sujetos con exceso de peso: \u00bfqu\u00e9 es mejor ingerir antes\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6437\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6437\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> SA19I0106<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2020 - Diciembre 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6572\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Validaci\u00f3n del Test del Escal\u00f3n para medir la condici\u00f3n f\u00edsica en ni\u00f1os, ni\u00f1as y adolescentes\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6572\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6572\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"].[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6497\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            OH-TARGET (One Health Training and Research Global Network)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6497\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6497\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Global health cannot be viewed in isolation; it is \"dependent on a person's living environment, on factors such as education, the environment, climate, water and food\" (BMZ Position 02\/2019: Global health, an investment in the future). The One Health approach involves the \"development and implementation of programmes, policies, laws and research in which multiple sectors communicate and collaborate to achieve better public health outcomes\" \/https:\/\/www.who.int\/features\/qa\/one-health\/en\/). The overall objective is to improve global health conditions by understanding the structural health problems caused by the living environment and developing context-specific approaches in a holistic and participatory approach to development cooperation with a focus on education and training. Research serves above all as a means of imparting research competence. The network uses competence-based pedagogy and activating learning methods developed in the past within the framework of the Center for International Health (CIHLMU), expands them, and uses ICT-based learning methods.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Resoluci\u00f3n exenta N\u00b0 2626, 16 de diciembre de 2019<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2019 - Junio 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Desarrollo Social y Familia, Chile<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6494\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Capacitaci\u00f3n Nacional para equipos de trabajo con personas en situaci\u00f3n de calle con discapacidad.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6494\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6494\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]\"Convocatoria Capacitaci\u00f3n Nacional para equipos de trabajo con personas en situaci\u00f3n de\r\ncalle con discapacidad\" del Programa Tr\u00e1nsito a la Vida Independiente, 2019. \r\n\r\nEl presente proyecto fue adjudicado tras proceso de licitaci\u00f3n publica nacional. Resoluci\u00f3n exenta N\u00b0 2626, 16 de diciembre de 2019\r\n\r\nPara la ejecuci\u00f3n de esta propuesta, nuestro equipo propuso una modalidad presencial en las 16 regiones del pa\u00eds con una duraci\u00f3n de 8 horas cronol\u00f3gicas. El enfoque previsto est\u00e1 basado en una metodolog\u00eda de aprendizaje constructivista y dialogante, con el fin de capacitar y fortalecer significativamente a los equipos que trabajan en el Programa de Vida Independiente.\r\n\r\nA trav\u00e9s de este trabajo se capacit\u00f3 desde la Universidad de O\u00b4Higgins a todos los equipos del pa\u00eds de cada una de las regiones. Permitiendo vinculaci\u00f3n activa con el territorio y fortaleciendo redes para el trabajo territorial de mi l\u00ednea de investigaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> Resoluci\u00f3n exenta N\u00b0 2626, 16 de diciembre de 2019<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2019 - Junio 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Desarrollo Social y Familia, Chile<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6536\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Capacitaci\u00f3n Nacional para equipos de trabajo con personas en situaci\u00f3n de calle con discapacidad.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6536\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6536\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]\"Convocatoria Capacitaci\u00f3n Nacional para equipos de trabajo con personas en situaci\u00f3n de\r\ncalle con discapacidad\" del Programa Tr\u00e1nsito a la Vida Independiente, 2019. \r\n\r\nEl presente proyecto fue adjudicado tras proceso de licitaci\u00f3n publica nacional. Resoluci\u00f3n exenta N\u00b0 2626, 16 de diciembre de 2019\r\n\r\nPara la ejecuci\u00f3n de esta propuesta, nuestro equipo propuso una modalidad presencial en las 16 regiones del pa\u00eds con una duraci\u00f3n de 8 horas cronol\u00f3gicas. El enfoque previsto est\u00e1 basado en una metodolog\u00eda de aprendizaje constructivista y dialogante, con el fin de capacitar y fortalecer significativamente a los equipos que trabajan en el Programa de Vida Independiente.\r\n\r\nA trav\u00e9s de este trabajo se capacit\u00f3 desde la Universidad de O\u00b4Higgins a todos los equipos del pa\u00eds de cada una de las regiones. Permitiendo vinculaci\u00f3n activa con el territorio y fortaleciendo redes para el trabajo territorial de mi l\u00ednea de investigaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2019 - Octubre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6371\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Exercise stimulates autophagy by downregulation of NOX2 activity improving young and aged human skeletal muscle function\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6371\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6371\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the past few decades average life expectancy has dramatically increased worldwide; specifically by 2050 the number of older adults will overcome the number of young people in Chile. This leads to a major challenge due to multiple chronic diseases highly prevalent in elderly. Aging process is defined as a series of time-dependent physiological changes that decrease reserve and functional capacity of skeletal muscle. Several studies have proposed that aging is caused by damage of macromolecules by reactive oxygen species (ROS) and decreased autophagy levels, a process that is essential for skeletal muscle regeneration, homeostasis and function. Exercise is a novel strategy used in elderly, which has shown to improve muscle mass, muscle function and decrease chronic diseases in old individuals. However, the molecular mechanisms and signaling pathways involved on the benefits of exercise in aged skeletal muscle are not completely clear. While exercise regulations of oxidative stress and autophagy have been studied separately, a direct interplay between exercise inducing autophagy via a ROS-dependent pathway has not yet been addressed in young or aged human skeletal muscle. Moreover, studies in human skeletal muscle examining the autophagy modulation after endurance exercise are limited and controversial. Although it is known that resting autophagy levels are decreased in aged skeletal muscle, the effects of acute exercise on skeletal muscle autophagy between young and older adults remain to be elucidated and could shed light on regulation of autophagy in humans. Additionally, it is also not known if a controlled exercise-training program can induce similar increases in autophagy levels in older adults. Recently, we have shown that the non-mitochondrial sources of ROS, NADPH oxidases 2 (NOX2), plays a major role in ROS production in skeletal muscle, both at rest and during contracting activity. Furthermore, our preliminary results show that NOX2 expression is increased during the aging process and strongly correlates with decreased autophagy levels detected in aged human skeletal muscle. Moreover, we also show that 12 weeks of endurance exercise training reduced the NOX2 levels in aged human muscle. We speculate that a decrease in NOX2 associated with a decrease in ROS levels in aged skeletal muscle induced by exercise training will improve aged muscle function by re-stablishing autophagy up to young skeletal muscle levels[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2019 - Abril 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6457\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Influencia del cortisol en la memoria de trabajo en estudiantes de preb\u00e1sica de distintos niveles socioecon\u00f3micos\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6457\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6457\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La propuesta tiene como objetivo describir la relaci\u00f3n entre el nivel de estr\u00e9s, medido a trav\u00e9s del nivel de cortisol, con una de las funciones ejecutivas, memoria de trabajo, a trav\u00e9s de distintos niveles socioecon\u00f3micos. Estas interacciones son de inter\u00e9s ya que la capacidad de la memoria de trabajo es predictiva del desempe\u00f1o acad\u00e9mico en contextos educativos formales, y a su vez, hay una relaci\u00f3n entre la capacidad de memoria de trabajo y el nivel socioecon\u00f3mico. Sin embargo, hay evidencia de que no ser\u00eda el nivel socioecon\u00f3mico propiamente tal lo que afecta la capacidad de la memoria de trabajo, sino que el nivel de estr\u00e9s asociado a dicho contexto social. Por tanto, se explorar\u00e1n en las interacciones entre las variables cortisol, capacidad de memoria de trabajo y nivel socioecon\u00f3mico. Esto se har\u00e1 en dos cohortes de estudiantes de\r\npreb\u00e1sica (70 estudiantes de prekinder y 90 de k\u00ednder) de un colegio sin selecci\u00f3n (m\u00e9todo aleatorio), y que por lo tanto tiene estudiantes de distintos niveles socioecon\u00f3micos en los mismos cursos. Es el primer estudio de este tipo realizado en\r\nChile a la fecha, y se espera encontrar evidencia suficiente para dise\u00f1ar programas de intervenci\u00f3n temprana que regulen el nivel de estr\u00e9s en ni\u00f1os con el fin de disminuir los niveles de cortisol, evitando as\u00ed un efecto perjudicial en la memoria de trabajo. Esto, esperando que resulte en un mayor desempe\u00f1o acad\u00e9mico independiente del nivel de estr\u00e9s que pudiese estar asociado a ciertos niveles socioecon\u00f3micos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2019 - Marzo 2023<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6458\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto PAR Explora O&#8217;Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6458\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6458\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> IDI 40008879-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2019 - Marzo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6459\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de \u0093innovaci\u00f3n social en el sector tur\u00edstico\u0094: Modelo de inclusi\u00f3n sociolaboral.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6459\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6459\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Implementar nodos de innovaci\u00f3n social para la inserci\u00f3n de j\u00f3venes con discapacidad por trastornos de salud mental severo, para  que puedan contribuir en el aumento de la competitividad y responsabilidad social en  empresas  del  sector tur\u00edstico  de las comunas de Pichilemu, San Fernando, Rancagua, a trav\u00e9s de un enfoque metodol\u00f3gico  de recuperaci\u00f3n  basado en promoci\u00f3n del desarrollo local, colaborativamente con adultos mayores y mujeres con alto nivel de vulnerabilidad social, durante  los 36 meses de la iniciativa.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> IDI 40008879-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2019 - Marzo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6501\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de \u0093innovaci\u00f3n social en el sector tur\u00edstico\u0094: Modelo de inclusi\u00f3n sociolaboral.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6501\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6501\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Implementar nodos de innovaci\u00f3n social para la inserci\u00f3n de j\u00f3venes con discapacidad por trastornos de salud mental severo, para  que puedan contribuir en el aumento de la competitividad y responsabilidad social en  empresas  del  sector tur\u00edstico  de las comunas de Pichilemu, San Fernando, Rancagua, a trav\u00e9s de un enfoque metodol\u00f3gico  de recuperaci\u00f3n  basado en promoci\u00f3n del desarrollo local, colaborativamente con adultos mayores y mujeres con alto nivel de vulnerabilidad social, durante  los 36 meses de la iniciativa.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> IDI 40008879-0<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2019 - Marzo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Gobierno Regional - GORE<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6538\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Transferencia de \u0093innovaci\u00f3n social en el sector tur\u00edstico\u0094: Modelo de inclusi\u00f3n sociolaboral.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6538\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6538\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Implementar nodos de innovaci\u00f3n social para la inserci\u00f3n de j\u00f3venes con discapacidad por trastornos de salud mental severo, para  que puedan contribuir en el aumento de la competitividad y responsabilidad social en  empresas  del  sector tur\u00edstico  de las comunas de Pichilemu, San Fernando, Rancagua, a trav\u00e9s de un enfoque metodol\u00f3gico  de recuperaci\u00f3n  basado en promoci\u00f3n del desarrollo local, colaborativamente con adultos mayores y mujeres con alto nivel de vulnerabilidad social, durante  los 36 meses de la iniciativa.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2019 - Diciembre 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6499\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Occupational and environmental toxicology assessment for epidemiological studies in developing countries\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6499\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6499\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]The purpose of the workshop was to strength research skills through the exchange of knowledge in Occupational and environmental toxicology in the scientific community. It will help us to identify and reduce physical, chemical and psychosocial risk factors at work and to preserve the health and well-being of workers.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6500\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Proyecto Piloto Cursos Rurales de Salud Ocupacional para Latinoam\u00e9rica\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6500\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6500\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Our aim is to develop an occupational health training program, focusing on professionals and technicians working in rural areas of Latin America, students of health careers conducting their rural internship and related teachers of collaborating universities. The program will be piloted at three sites 2018. The sites were selected to cover a range of typical rural occupational activities and to cover different cultural characteristics (indigenous population, migrant seasonal workers). Each course will be evaluated (e.g., change in knowledge, attitude, and behavior).[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Febrero 2019 - Diciembre 2019<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6502\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Understanding AIDS worldwide studying immunopathogenesis and correlates of protection in HIV infection caused by different subtypes.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6502\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6502\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Through this study, we aimed at establishing an international network to facilitate and initiate the collection of epidemiological and biological evidences aimed at comprehensively assessing the premature aging in children and adolescents infected by HIV, by studying the different phenomena that characterize this status, with particular regards toward CVD, immunosenescence and immunometabolism.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2019 - Marzo 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6387\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Or\u00edgenes epigen\u00e9ticos de la disfunci\u00f3n vascular en el adulto\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6387\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6387\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En la actualidad existe evidencia convincente del limitado impacto que tienen las estrategias destinadas a la prevenci\u00f3n y tratamiento de la hipertensi\u00f3n y otras enfermedades cardiovasculares, una vez que \u00e9stas se manifiestan en el adulto. En este sentido, la identificaci\u00f3n de los mecanismos que determinan a lo largo de la vida, especialmente en etapas tempranas del desarrollo, una mayor susceptibilidad a la aparici\u00f3n de estas enfermedades, representan un desaf\u00edo para implementar estrategias efectivas de prevenci\u00f3n o, alternativas terap\u00e9uticas adecuadas al grado de compromiso de la salud. Considerando la gran influencia que muestra la trayectoria de crecimiento y el estilo de vida sobre el desarrollo de enfermedades vasculares e hipertensi\u00f3n, en los \u00faltimos a\u00f1os ha existido un creciente inter\u00e9s en definir la participaci\u00f3n de mecanismos que modifican la expresi\u00f3n de genes sin alterar la secuencia de estos (i.e. mecanismos epigen\u00e9ticos) sobre el origen y progreso de \u00e9stas. El presente cap\u00edtulo abordar\u00e1 qu\u00e9 es la epigen\u00e9tica, los mecanismos que median dichos efectos y el rol que cumple en definir a nivel molecular la programaci\u00f3n de la(s) respuestas fisiol\u00f3gicas que condicionan el riesgo de desarrollar obesidad en las diferentes etapas del ciclo vital.\r\nLa visi\u00f3n de los factores gen\u00e9ticos como causa de las enfermedades cr\u00f3nicas, incluyendo las cardiovasculares, ha sido el motor de la investigaci\u00f3n biom\u00e9dica en el \u00faltimo siglo. Sin embargo, el padre de la biolog\u00eda moderna, Charles Darwin, plante\u00f3 fuertemente en su obra \u0093El origen de las Especies mediante la Selecci\u00f3n Natural\u0094 que la \u0093ley superior\u0094 del origen de las especies es la adaptaci\u00f3n a \u0093las condiciones de existencia\u0094 (i.e. medioambiente, estilo de vida), la que estar\u00eda por sobre la \u0093selecci\u00f3n natural\u0094 de caracter\u00edsticas heredables (i.e. genes). Posteriormente, ser\u00eda Conrad Waddington en sus estudios de embriolog\u00eda quien propone la importancia de la interacci\u00f3n entre los genes y el ambiente. Lo que se manifiesta en la capacidad que tiene el organismo de generar, a partir un conjunto de genes (genoma) \u00fanico, los distintos tipos y funciones celulares que lo constituyen, mediante respuestas a est\u00edmulos que se suceden en un tiempo y lugar espec\u00edfico. Dicha propiedad del medioambiente de moldear el fenotipo fue definida por Waddington como \u0093epigen\u00e9tica\u0094. \r\nActualmente se denomina como epigen\u00e9tica al conjunto de \u0093mecanismos modificadores del DNA que regulan la plasticidad fenot\u00edpica de una c\u00e9lula u organismo\u0094. A trav\u00e9s de estos mecanismos, nuestros genes pueden expresarse de manera adecuada en respuesta a cambios en el ambiente; pero a la vez definen respuestas fisiol\u00f3gicas a mediano y largo plazo basados en estas se\u00f1ales entregadas por el ambiente. En este contexto, el establecimiento de dichas respuestas limitar\u00eda, a trav\u00e9s del ciclo vital, la plasticidad fenot\u00edpica del individuo. La presente l\u00ednea de investigaci\u00f3n se ha propuesto estudiar los cambios estructurales del sistema vascular y la activaci\u00f3n de mecanismos epigen\u00e9ticos desde etapas tempranas de la vida, que contribuir\u00edan al desarrollo de enfermedades cardiovasculares en el adulto. En este sentido plantemos que \u0093el desarrollo de hipertensi\u00f3n y enfermedades cardiovasculares en el adulto resultar\u00eda de un programaci\u00f3n estructural y epigen\u00e9tica a nivel vascular, mediada por niveles deficitarios de ox\u00edgeno (i.e. hipoxia) y el estr\u00e9s oxidativo intrauterino\u0094. Esta programaci\u00f3n fetal establecer\u00eda una fisiolog\u00eda vascular pro-hipertensiva que devendr\u00eda posteriormente en una disfunci\u00f3n cardiovascular a medida que el individuo envejece.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2019 - Marzo 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6418\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Or\u00edgenes epigen\u00e9ticos de la disfunci\u00f3n vascular en el adulto\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6418\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6418\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]En la actualidad existe evidencia convincente del limitado impacto que tienen las estrategias destinadas a la prevenci\u00f3n y tratamiento de la hipertensi\u00f3n y otras enfermedades cardiovasculares, una vez que \u00e9stas se manifiestan en el adulto. En este sentido, la identificaci\u00f3n de los mecanismos que determinan a lo largo de la vida, especialmente en etapas tempranas del desarrollo, una mayor susceptibilidad a la aparici\u00f3n de estas enfermedades, representan un desaf\u00edo para implementar estrategias efectivas de prevenci\u00f3n o, alternativas terap\u00e9uticas adecuadas al grado de compromiso de la salud. Considerando la gran influencia que muestra la trayectoria de crecimiento y el estilo de vida sobre el desarrollo de enfermedades vasculares e hipertensi\u00f3n, en los \u00faltimos a\u00f1os ha existido un creciente inter\u00e9s en definir la participaci\u00f3n de mecanismos que modifican la expresi\u00f3n de genes sin alterar la secuencia de estos (i.e. mecanismos epigen\u00e9ticos) sobre el origen y progreso de \u00e9stas. El presente cap\u00edtulo abordar\u00e1 qu\u00e9 es la epigen\u00e9tica, los mecanismos que median dichos efectos y el rol que cumple en definir a nivel molecular la programaci\u00f3n de la(s) respuestas fisiol\u00f3gicas que condicionan el riesgo de desarrollar obesidad en las diferentes etapas del ciclo vital.\r\nLa visi\u00f3n de los factores gen\u00e9ticos como causa de las enfermedades cr\u00f3nicas, incluyendo las cardiovasculares, ha sido el motor de la investigaci\u00f3n biom\u00e9dica en el \u00faltimo siglo. Sin embargo, el padre de la biolog\u00eda moderna, Charles Darwin, plante\u00f3 fuertemente en su obra \u0093El origen de las Especies mediante la Selecci\u00f3n Natural\u0094 que la \u0093ley superior\u0094 del origen de las especies es la adaptaci\u00f3n a \u0093las condiciones de existencia\u0094 (i.e. medioambiente, estilo de vida), la que estar\u00eda por sobre la \u0093selecci\u00f3n natural\u0094 de caracter\u00edsticas heredables (i.e. genes). Posteriormente, ser\u00eda Conrad Waddington en sus estudios de embriolog\u00eda quien propone la importancia de la interacci\u00f3n entre los genes y el ambiente. Lo que se manifiesta en la capacidad que tiene el organismo de generar, a partir un conjunto de genes (genoma) \u00fanico, los distintos tipos y funciones celulares que lo constituyen, mediante respuestas a est\u00edmulos que se suceden en un tiempo y lugar espec\u00edfico. Dicha propiedad del medioambiente de moldear el fenotipo fue definida por Waddington como \u0093epigen\u00e9tica\u0094. \r\nActualmente se denomina como epigen\u00e9tica al conjunto de \u0093mecanismos modificadores del DNA que regulan la plasticidad fenot\u00edpica de una c\u00e9lula u organismo\u0094. A trav\u00e9s de estos mecanismos, nuestros genes pueden expresarse de manera adecuada en respuesta a cambios en el ambiente; pero a la vez definen respuestas fisiol\u00f3gicas a mediano y largo plazo basados en estas se\u00f1ales entregadas por el ambiente. En este contexto, el establecimiento de dichas respuestas limitar\u00eda, a trav\u00e9s del ciclo vital, la plasticidad fenot\u00edpica del individuo. La presente l\u00ednea de investigaci\u00f3n se ha propuesto estudiar los cambios estructurales del sistema vascular y la activaci\u00f3n de mecanismos epigen\u00e9ticos desde etapas tempranas de la vida, que contribuir\u00edan al desarrollo de enfermedades cardiovasculares en el adulto. En este sentido plantemos que \u0093el desarrollo de hipertensi\u00f3n y enfermedades cardiovasculares en el adulto resultar\u00eda de un programaci\u00f3n estructural y epigen\u00e9tica a nivel vascular, mediada por niveles deficitarios de ox\u00edgeno (i.e. hipoxia) y el estr\u00e9s oxidativo intrauterino\u0094. Esta programaci\u00f3n fetal establecer\u00eda una fisiolog\u00eda vascular pro-hipertensiva que devendr\u00eda posteriormente en una disfunci\u00f3n cardiovascular a medida que el individuo envejece.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2019 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Superintendencia de Seguridad Social (Concursos SUSESO)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6551\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            La salud mental como factor de riesgo para los accidentes del trabajo y el ausentismo laboral: un estudio de cohorte (Fase 2)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6551\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6551\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Los problemas de salud mental son frecuentes en la poblaci\u00f3n adulta, as\u00ed como en los trabajadores. Las condiciones que generan estr\u00e9s en el ambiente laboral se pueden manifestar como un problema de salud mental entre los trabajadores, y a su vez esto se relaciona con una mayor probabilidad de accidentes y ausentismo laboral. Si se pudiera contar con modelos predictivos que incluyan diferentes variables (del ambiente laboral, sociales, personales, etc.) se podr\u00edan dise\u00f1ar herramientas para la detecci\u00f3n temprana de personas y\/o situaciones con mayor riesgo de accidentabilidad, de igual forma que estrategias de prevenci\u00f3n m\u00e1s efectivas. Para obtener esto se requiere un estudio de cohorte.\r\nEste proyecto corresponde a la segunda etapa de un estudio de cohorte en trabajadores, donde se realizar\u00eda el seguimiento y las evaluaciones del 2do y 3er a\u00f1o. La fase previa tuvo por objetivo la instalaci\u00f3n de la cohorte y la medici\u00f3n de la l\u00ednea basal, que hasta ahora se realiza sin dificultades, en una muestra de alrededor de 390 trabajadores de la Divisi\u00f3n Andina de CODELCO Chile. Esta segunda fase tendr\u00eda como producto un primer modelo predictivo para el riesgo de accidentabilidad y ausentismo laboral.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2018 - Septiembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6460\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Articulando la vinculaci\u00f3n entre la Universidad de O\u0092Higgins y Establecimientos Educacionales Municipales de la VI Regi\u00f3n, a trav\u00e9s de un estudio de salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica, y de trabajo ter\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6460\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6460\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo general:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s de una\r\nexperiencia piloto de vinculaci\u00f3n con el medio escolar, utilizando como medio una investigaci\u00f3n\r\nsobre salud mental y rendimiento acad\u00e9mico en estudiantes de primer ciclo de Ense\u00f1anza\r\nB\u00e1sica, a trav\u00e9s de una estrategia de colaboraci\u00f3n entre actores educacionales, comunitarios y\r\nacad\u00e9micos, bajo una perspectiva de trabajo territorial.\r\nObjetivos espec\u00edficos:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s del desarrollo\r\nde una experiencia piloto que articula el trabajo de actores educacionales, comunitarios y\r\nacad\u00e9micos, en contextos territoriales espec\u00edficos.\r\n2. Desarrollar una investigaci\u00f3n que potencie la estrategia de vinculaci\u00f3n con el medio a trav\u00e9s de\r\nun problema relevante y sentido por la comunidad, cuya finalidad ser\u00e1 identificar la presencia\r\nde un problema de salud mental en estudiantes del primer ciclo de la Ense\u00f1anza B\u00e1sica de\r\nestablecimientos municipales de la Regi\u00f3n de O\u0092Higgins y establecer su asociaci\u00f3n con el\r\nrendimiento acad\u00e9mico de estos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2018 - Septiembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6503\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Articulando la vinculaci\u00f3n entre la Universidad de O\u0092Higgins y Establecimientos Educacionales Municipales de la VI Regi\u00f3n, a trav\u00e9s de un estudio de salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica, y de trabajo ter\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6503\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6503\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo general:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s de una\r\nexperiencia piloto de vinculaci\u00f3n con el medio escolar, utilizando como medio una investigaci\u00f3n\r\nsobre salud mental y rendimiento acad\u00e9mico en estudiantes de primer ciclo de Ense\u00f1anza\r\nB\u00e1sica, a trav\u00e9s de una estrategia de colaboraci\u00f3n entre actores educacionales, comunitarios y\r\nacad\u00e9micos, bajo una perspectiva de trabajo territorial.\r\nObjetivos espec\u00edficos:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s del desarrollo\r\nde una experiencia piloto que articula el trabajo de actores educacionales, comunitarios y\r\nacad\u00e9micos, en contextos territoriales espec\u00edficos.\r\n2. Desarrollar una investigaci\u00f3n que potencie la estrategia de vinculaci\u00f3n con el medio a trav\u00e9s de\r\nun problema relevante y sentido por la comunidad, cuya finalidad ser\u00e1 identificar la presencia\r\nde un problema de salud mental en estudiantes del primer ciclo de la Ense\u00f1anza B\u00e1sica de\r\nestablecimientos municipales de la Regi\u00f3n de O\u0092Higgins y establecer su asociaci\u00f3n con el\r\nrendimiento acad\u00e9mico de estos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2018 - Septiembre 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6539\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Articulando la vinculaci\u00f3n entre la Universidad de O\u0092Higgins y Establecimientos Educacionales Municipales de la VI Regi\u00f3n, a trav\u00e9s de un estudio de salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica, y de trabajo ter\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6539\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6539\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo general:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s de una\r\nexperiencia piloto de vinculaci\u00f3n con el medio escolar, utilizando como medio una investigaci\u00f3n\r\nsobre salud mental y rendimiento acad\u00e9mico en estudiantes de primer ciclo de Ense\u00f1anza\r\nB\u00e1sica, a trav\u00e9s de una estrategia de colaboraci\u00f3n entre actores educacionales, comunitarios y\r\nacad\u00e9micos, bajo una perspectiva de trabajo territorial.\r\nObjetivos espec\u00edficos:\r\n1. Fortalecer la pol\u00edtica institucional de vinculaci\u00f3n con el medio de la UOH, a trav\u00e9s del desarrollo\r\nde una experiencia piloto que articula el trabajo de actores educacionales, comunitarios y\r\nacad\u00e9micos, en contextos territoriales espec\u00edficos.\r\n2. Desarrollar una investigaci\u00f3n que potencie la estrategia de vinculaci\u00f3n con el medio a trav\u00e9s de\r\nun problema relevante y sentido por la comunidad, cuya finalidad ser\u00e1 identificar la presencia\r\nde un problema de salud mental en estudiantes del primer ciclo de la Ense\u00f1anza B\u00e1sica de\r\nestablecimientos municipales de la Regi\u00f3n de O\u0092Higgins y establecer su asociaci\u00f3n con el\r\nrendimiento acad\u00e9mico de estos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2018 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6540\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Atenci\u00f3n Primaria de la Salud: evaluaci\u00f3n de una intervenci\u00f3n comunitaria para la adherencia a tratamiento de pacientes con diagn\u00f3stico de hipertensi\u00f3n arterial y\/o diabetes\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6540\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6540\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2018 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6504\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Los procesos de ense\u00f1anza y evaluaci\u00f3n en el \u00e1rea de salud en grado y posgrado y su vinculaci\u00f3n con el rendicimiento acad\u00e9mico\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6504\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6504\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Este proyecto de investigaci\u00f3n focaliza en la ense\u00f1anza, evaluaci\u00f3n y rendimiento acad\u00e9mico en el \u00e1rea de salud en laFacultad de Ciencias M\u00e9dicas de la UNC y la Escuela de Salud de la Universidad de O\u00b4Higgins-Chile (UOH). El mismoaborda diversos procesos formativos de carreras de grado y posgrado, y se organiza en tres l\u00edneas de investigaci\u00f3n quese articulan entre s\u00ed, una ligada a las trayectorias acad\u00e9micas de los estudiantes de grado y posgrado, otra orientada alsistema de evaluaci\u00f3n en grado y posgrado y una tercera referida a la relaci\u00f3n entre formaci\u00f3n pedag\u00f3gica-disciplinary docente asistencial como as\u00ed tambi\u00e9n su vinculaci\u00f3n con la ense\u00f1anza y evaluaci\u00f3n.Se proponen los siguientesobjetivos: analizar los procesos de ense\u00f1anza y evaluaci\u00f3n en carreras del \u00e1rea de salud en grado y posgrado y surelaci\u00f3n con la trayectoria acad\u00e9mica de los estudiantes por un lado y por otro la relaci\u00f3n entre formaci\u00f3n pedag\u00f3gica- disciplinar -docente?asistencial articulando con los procesos de ense\u00f1anza y evaluaci\u00f3n.Para abordar los objetivos se realizar\u00e1 un an\u00e1lisis longitudinal prospectivo de las cohortes de ingresantes a la Escuela de Tecnolog\u00eda M\u00e9dica, laCarrera de Medicina de la UNC y a la Escuela de Salud (UOH). El registro se efectuar\u00e1 a 1400 estudiantes en la UNCy a 95 en la UOH (2017-2018). Se realizar\u00e1 un estudio de correlaci\u00f3n y comparaci\u00f3n entre la calificaci\u00f3n obtenida enla evaluaci\u00f3n diagn\u00f3stica y los resultados del examen final al t\u00e9rmino de la PFO, incluye 514 estudiantes.Tambi\u00e9nse abordar\u00e1 el sistema de evaluaci\u00f3n de 17 especialidades m\u00e9dicas acreditadas (2018-2020) y la relaci\u00f3n entreformaci\u00f3n pedag\u00f3gica-disciplinar-docente-asistencial en grado y posgrado en ambas universidades. Se implementar\u00e1ncuestionarios abiertos y entrevistas. El an\u00e1lisis de la informaci\u00f3n se llevar\u00e1 a cabo desde un abordaje cuantitativo ycualitativo. Desde lo cuantitativo se propone la combinaci\u00f3n de diferentes m\u00e9todos multivariado, test de comparacionesy datos categorizados, que permitir\u00e1n abordar las variables involucradas tanto exploratoriamente como de manerainferencial. Se utilizar\u00e1 el coeficiente de correlaci\u00f3n lineal de Pearson, el modelo de regresi\u00f3n lineal y se calcular\u00e1el Coeficiente de Cp de Mallows, con un nivel de significaci\u00f3n de 0,05 para todos los casos. Lo cualitativo permitir\u00e1comprender experiencias y perspectivas de los sujetos, la construcci\u00f3n de la teor\u00eda a trav\u00e9s de los hallazgos y lavalidaci\u00f3n mediante el proceso de triangulaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2018 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6543\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Los procesos de ense\u00f1anza y evaluaci\u00f3n en el \u00e1rea de salud en grado y posgrado y su vinculaci\u00f3n con el rendicimiento acad\u00e9mico\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6543\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6543\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Este proyecto de investigaci\u00f3n focaliza en la ense\u00f1anza, evaluaci\u00f3n y rendimiento acad\u00e9mico en el \u00e1rea de salud en laFacultad de Ciencias M\u00e9dicas de la UNC y la Escuela de Salud de la Universidad de O\u00b4Higgins-Chile (UOH). El mismoaborda diversos procesos formativos de carreras de grado y posgrado, y se organiza en tres l\u00edneas de investigaci\u00f3n quese articulan entre s\u00ed, una ligada a las trayectorias acad\u00e9micas de los estudiantes de grado y posgrado, otra orientada alsistema de evaluaci\u00f3n en grado y posgrado y una tercera referida a la relaci\u00f3n entre formaci\u00f3n pedag\u00f3gica-disciplinary docente asistencial como as\u00ed tambi\u00e9n su vinculaci\u00f3n con la ense\u00f1anza y evaluaci\u00f3n.Se proponen los siguientesobjetivos: analizar los procesos de ense\u00f1anza y evaluaci\u00f3n en carreras del \u00e1rea de salud en grado y posgrado y surelaci\u00f3n con la trayectoria acad\u00e9mica de los estudiantes por un lado y por otro la relaci\u00f3n entre formaci\u00f3n pedag\u00f3gica- disciplinar -docente?asistencial articulando con los procesos de ense\u00f1anza y evaluaci\u00f3n.Para abordar los objetivos se realizar\u00e1 un an\u00e1lisis longitudinal prospectivo de las cohortes de ingresantes a la Escuela de Tecnolog\u00eda M\u00e9dica, laCarrera de Medicina de la UNC y a la Escuela de Salud (UOH). El registro se efectuar\u00e1 a 1400 estudiantes en la UNCy a 95 en la UOH (2017-2018). Se realizar\u00e1 un estudio de correlaci\u00f3n y comparaci\u00f3n entre la calificaci\u00f3n obtenida enla evaluaci\u00f3n diagn\u00f3stica y los resultados del examen final al t\u00e9rmino de la PFO, incluye 514 estudiantes.Tambi\u00e9nse abordar\u00e1 el sistema de evaluaci\u00f3n de 17 especialidades m\u00e9dicas acreditadas (2018-2020) y la relaci\u00f3n entreformaci\u00f3n pedag\u00f3gica-disciplinar-docente-asistencial en grado y posgrado en ambas universidades. Se implementar\u00e1ncuestionarios abiertos y entrevistas. El an\u00e1lisis de la informaci\u00f3n se llevar\u00e1 a cabo desde un abordaje cuantitativo ycualitativo. Desde lo cuantitativo se propone la combinaci\u00f3n de diferentes m\u00e9todos multivariado, test de comparacionesy datos categorizados, que permitir\u00e1n abordar las variables involucradas tanto exploratoriamente como de manerainferencial. Se utilizar\u00e1 el coeficiente de correlaci\u00f3n lineal de Pearson, el modelo de regresi\u00f3n lineal y se calcular\u00e1el Coeficiente de Cp de Mallows, con un nivel de significaci\u00f3n de 0,05 para todos los casos. Lo cualitativo permitir\u00e1comprender experiencias y perspectivas de los sujetos, la construcci\u00f3n de la teor\u00eda a trav\u00e9s de los hallazgos y lavalidaci\u00f3n mediante el proceso de triangulaci\u00f3n.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2018 - Diciembre 2024<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>NIMH - NIH<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6544\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            On Track Chile (OTCH) for First Episode Psychosis\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6544\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6544\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Substantial data support early interventions for people experiencing FEP to ameliorate symptoms and minimize disability. FEP programs have been widely and successfully implemented in high-income countries (HIC). With the partial exception of Chile, however, there is not a single low-and-middle income country (LMIC) that offers universal access to FEP services. Chile is unique among LMICs in having created a platform for the implementation of FEP services, including 1) a FEP policy that mandates identification of FEP individuals at primary care and delivery of community-based FEP treatments at outpatient clinics, and 2) a public health care system within which this mandate can be fulfilled. Nonetheless, our team has documented that FEP services provided at outpatient clinics do not conform to recently established evidence-based approaches. Therefore, the overarching goal of this project is to address the shortfall in evidence-based practices for FEP in Chile by first adapting OnTrackChile (OTCH) from OnTrackNY (OTNY), a coordinated specialty care program for FEP currently being implemented across New York State and the US, and then implementing OTCH on a wide scale. Like most FEP programs, OTNY is clinically effective, but unlike most others, it also has a wellestablished training and technical assistance infrastructure and a proven track record of being scaled up in large urban areas. To achieve our main goal, we will use the Dynamic Adaptation Process model to first inform the adaptation and implementation of OTCH in the Chilean context. We will then use a Hybrid Trial Type 1 design to evaluate the implementation of OTCH, as well as its effectiveness and cost, in a cluster randomized controlled trial (RCT) (N = 300 from 21 outpatient clinics). The cluster-RCT will include the following: blinded interviews with participants (baseline, 12, 24 months); detailed information about service use (every 3 months, needed for cost estimates); assessments of mental health providers (6,12, and 24 months, needed for service and implementation outcomes); and ongoing mixed methods evaluation of the implementation process.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Junio 2018 - Diciembre 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>DAAD - Alemania<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6514\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Labor insertion, working conditions, and health in recently graduated health professionals: A cohort study\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6514\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6514\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]During the last decades, employment conditions has changed in an important way. Although these changes have included more flexible employment relations, it has also included higher levels of job insecurity and lack of social security. This situation has affected all groups of workers, including those in stable jobs(2) and people working in the health sector. Those changes in the labour market have particularly affected young professionals, in this sense, the current rate of youth unemployment is one of the highest reported in recent year, or the conditions in which they work are poor or informal, often working in jobs below their professional training, generating a major concern for the professional future. This situation could generate also additional stress at this stage of life, as well as frustration and demotivation.\r\n\r\nLittle information is available about working conditions and labour insertion process in young health professionals and the association with health conditions. For this, Maria Teresa Solis Soto (Alumna, Bolivia) in coordination with Leonardo Brice\u00f1o (Universidad del Rosario, Colombia), and Ricardo Oyarzun (Universidad Austral de Chile) carried out a study (baseline) to evaluate the relationship between work experiences, expectations and individual characteristics with physical and mental health in newly graduated young professionals.\r\n\r\nThis study, also has the support of Universidade Federal do Paran\u00e1-Brazil, Universidad San Francisco Xavier de Chuquisaca- Bolivia, CIH Alumni Network, and Master in International Occupational Safety and Health. In the universities included, all students in the last year were invited to participate. For baseline study, we collected information about socioeconomic information and, lifestyle, Job expectations, History of previous working conditions, psychosocial factors (pre-employment), academic Information, health conditions.\r\n\r\nThe study ask for ethical approval in each country. International ethical research guidelines were considered at all research steps. A written informed consent form as well as a letter explaining the importance of the study were to the questionnaire. Confidentiality and voluntary participation was respected.\\ Preliminary results were disseminated to inform the local universities. This information will be useful for universities and labour organizations in order to implement strategies that fit with the current and future labour market conditions taking care of the human resource for health.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2018 - Marzo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6388\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1181341.Time-course modeling of the vascular epigenetic programming by fetal growth restriction: role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6388\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6388\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Adverse intrauterine conditions, such as fetal growth restriction (FGR), increase the risk to develop cardiometabolic diseases in the adulthood. This concept has been called \u0091Developmental Origins of Health and Disease\u0092 (DOHaD) and relies on the activation of mechanisms sensing and signaling a diversity of stimuli during early development that later leads to higher risk of disease. The mechanisms that have been broadly suggested to be involved in these processes are epigenetic modifications in key gene promoters that could \u0091record\u0092 normal and abnormal perinatal stimuli. Intrauterine oxidative stress and chronic hypoxia are common features in FGR. Several cellular processes require the participation of pro-oxidant molecules which are normally neutralized by antioxidant defenses. However, under determined conditions, such as chronic hypoxia, the pro-oxidants overcome these defenses inducing oxidative stress. The latter is an important stimulus that regulates vascular function and cardiovascular physiology, playing a key role in the development of cardiovascular diseases, regulating negatively the bioavailability of the main vasodilator nitric oxide (NO). In addition, the vascular system presents a high phenotypic plasticity during life, which is modulated and restricted by epigenetic mechanisms (including DNA methylation, histone post-translational modifications, and micro RNAs). \r\nThe higher cardiovascular risk in adults born with FGR can be traced back to a reduced arterial compliance in pre-pubertal subjects and a decreased peripheral endothelial-dependent vascular relaxation at birth. This endothelial dysfunction (ED) is also observed in FGR placental vessels, suggesting an early onset of ED that could be evidenced in systemic and placental arteries. Our studies in human placentae have demonstrated that ED in FGR can be modulated by oxidative stress and is associated with changes in proteome profile as well as an epigenetic-mediated regulation of eNOS expression. Similarly, in guinea pigs, we have found that ED in FGR is also occurring in the fetal arteries and is prevented by maternal treatment with antioxidants. Analysis of eNOS expression and Nos3 promoter DNA methylation profile in endothelial cells from the aorta and umbilical arteries of FGR guinea pigs shows common molecular markers of ED in FGR systemic and umbilical vessels which are reverted by a maternal antioxidant treatment. Altogether, these data support the role of oxidative stress in the epigenetic programming of ED in FGR and the potential predictive value of studying human umbilical arteries endothelial cells (HUAEC). However, there are no studies addressing the time course and origins of the ED in FGR and the participation of additional epigenetic mechanisms, such as miRNAs, in this process.    \r\nHere, we put forward two inter-related hypotheses. First, that arterial endothelium from babies with FGR show a genomic DNA methylation signature along with an altered expression of miRNAs miR-21, miR-126 & miR-155, which contributes to changes in the expression of enzymes related to NO synthesis, endothelial dysfunction, and vascular remodeling. Second, that FGR has, during gestation, dynamic changes in the expression of miRNAs miR-21, miR-126 & miR-155 as an early response to hypoxia and oxidative stress in the fetus leading, in the long term, to endothelial dysfunction and vascular remodeling. These hypothesis will be tested in primary cultures of HUAEC from FGR neonates and validated using guinea pig and chick embryo models of FGR according to the following general aims (GA): GA-1 To demonstrate, in human umbilical artery endothelial cells, whether FGR is associated with an altered epigenetic regulation (i.e. increased levels of miR-21, miR-126 & miR-155 and a differential genomic DNA methylation) of NO-related enzymes (i.e. eNOS, DDAH1, Nrf2, Arg2, and HO-1), which modifies the response to hypoxia and impairs angiogenic capacity.GA-2 To demonstrate, in FGR guinea pigs, whether circulating levels of miR-21, miR-126 & miR-155 are dynamically regulated during the development of fetal vascular dysfunction and if the prevention of oxidative stress by an antioxidant administration to mothers, contributes to this regulation. GA-3 To demonstrate, in FGR chicken embryos, whether the silencing of miR-21, miR-126 and miR-155 expression modifies the endothelial and vascular dysfunction induced by chronic hypoxia and oxidative stress. Our expected outcome is to demonstrate that miRNAs miR-21, miR-126 & miR-155 participates in the early defense to hypoxia and oxidative stress in the FGR, but leading at long-term to ED. Further, we propose that regulation of these miRNAs during gestation could prevent these effects. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction, but also to open potential approaches for treatments in complicated pregnancies in humans. Combined, our program of work offers insights into mechanisms underlying the association between intrauterine hypoxia, oxidative stress and the increased risk of developing cardiovascular disease in later life, and possible interventions considering administration of therapeutic agents at critical stages of intrauterine development.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2018 - Marzo 2022<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6419\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1181341.Time-course modeling of the vascular epigenetic programming by fetal growth restriction: role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6419\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6419\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Adverse intrauterine conditions, such as fetal growth restriction (FGR), increase the risk to develop cardiometabolic diseases in the adulthood. This concept has been called \u0091Developmental Origins of Health and Disease\u0092 (DOHaD) and relies on the activation of mechanisms sensing and signaling a diversity of stimuli during early development that later leads to higher risk of disease. The mechanisms that have been broadly suggested to be involved in these processes are epigenetic modifications in key gene promoters that could \u0091record\u0092 normal and abnormal perinatal stimuli. Intrauterine oxidative stress and chronic hypoxia are common features in FGR. Several cellular processes require the participation of pro-oxidant molecules which are normally neutralized by antioxidant defenses. However, under determined conditions, such as chronic hypoxia, the pro-oxidants overcome these defenses inducing oxidative stress. The latter is an important stimulus that regulates vascular function and cardiovascular physiology, playing a key role in the development of cardiovascular diseases, regulating negatively the bioavailability of the main vasodilator nitric oxide (NO). In addition, the vascular system presents a high phenotypic plasticity during life, which is modulated and restricted by epigenetic mechanisms (including DNA methylation, histone post-translational modifications, and micro RNAs). \r\nThe higher cardiovascular risk in adults born with FGR can be traced back to a reduced arterial compliance in pre-pubertal subjects and a decreased peripheral endothelial-dependent vascular relaxation at birth. This endothelial dysfunction (ED) is also observed in FGR placental vessels, suggesting an early onset of ED that could be evidenced in systemic and placental arteries. Our studies in human placentae have demonstrated that ED in FGR can be modulated by oxidative stress and is associated with changes in proteome profile as well as an epigenetic-mediated regulation of eNOS expression. Similarly, in guinea pigs, we have found that ED in FGR is also occurring in the fetal arteries and is prevented by maternal treatment with antioxidants. Analysis of eNOS expression and Nos3 promoter DNA methylation profile in endothelial cells from the aorta and umbilical arteries of FGR guinea pigs shows common molecular markers of ED in FGR systemic and umbilical vessels which are reverted by a maternal antioxidant treatment. Altogether, these data support the role of oxidative stress in the epigenetic programming of ED in FGR and the potential predictive value of studying human umbilical arteries endothelial cells (HUAEC). However, there are no studies addressing the time course and origins of the ED in FGR and the participation of additional epigenetic mechanisms, such as miRNAs, in this process.    \r\nHere, we put forward two inter-related hypotheses. First, that arterial endothelium from babies with FGR show a genomic DNA methylation signature along with an altered expression of miRNAs miR-21, miR-126 & miR-155, which contributes to changes in the expression of enzymes related to NO synthesis, endothelial dysfunction, and vascular remodeling. Second, that FGR has, during gestation, dynamic changes in the expression of miRNAs miR-21, miR-126 & miR-155 as an early response to hypoxia and oxidative stress in the fetus leading, in the long term, to endothelial dysfunction and vascular remodeling. These hypothesis will be tested in primary cultures of HUAEC from FGR neonates and validated using guinea pig and chick embryo models of FGR according to the following general aims (GA): GA-1 To demonstrate, in human umbilical artery endothelial cells, whether FGR is associated with an altered epigenetic regulation (i.e. increased levels of miR-21, miR-126 & miR-155 and a differential genomic DNA methylation) of NO-related enzymes (i.e. eNOS, DDAH1, Nrf2, Arg2, and HO-1), which modifies the response to hypoxia and impairs angiogenic capacity.GA-2 To demonstrate, in FGR guinea pigs, whether circulating levels of miR-21, miR-126 & miR-155 are dynamically regulated during the development of fetal vascular dysfunction and if the prevention of oxidative stress by an antioxidant administration to mothers, contributes to this regulation. GA-3 To demonstrate, in FGR chicken embryos, whether the silencing of miR-21, miR-126 and miR-155 expression modifies the endothelial and vascular dysfunction induced by chronic hypoxia and oxidative stress. Our expected outcome is to demonstrate that miRNAs miR-21, miR-126 & miR-155 participates in the early defense to hypoxia and oxidative stress in the FGR, but leading at long-term to ED. Further, we propose that regulation of these miRNAs during gestation could prevent these effects. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction, but also to open potential approaches for treatments in complicated pregnancies in humans. Combined, our program of work offers insights into mechanisms underlying the association between intrauterine hypoxia, oxidative stress and the increased risk of developing cardiovascular disease in later life, and possible interventions considering administration of therapeutic agents at critical stages of intrauterine development.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1895<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2018 - Abril 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6462\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica de la regi\u00f3n de O\u0092Higgins: mejorando logros educacionales en establecimientos municipales\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6462\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6462\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La construcci\u00f3n de un modelo predictivo, que podr\u00eda dar origen a una herramienta de screening para ayudar al profesor a identificar un problema de salud mental en el aula y solicitar ayuda a los equipos de apoyo psico-pedag\u00f3gico dentro del establecimiento. De igual forma, este proyecto podr\u00eda dar origen a una cohorte de estudiantes que permita profundizar en el estudio de la relaci\u00f3n salud mental \u0096 resultados acad\u00e9micos, con productos cient\u00edficos (conocimiento) y tecnol\u00f3gicos de innovaci\u00f3n, que apoyen el trabajo de los docentes y sus establecimientos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1895<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2018 - Abril 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6505\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica de la regi\u00f3n de O\u0092Higgins: mejorando logros educacionales en establecimientos municipales\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6505\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6505\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La construcci\u00f3n de un modelo predictivo, que podr\u00eda dar origen a una herramienta de screening para ayudar al profesor a identificar un problema de salud mental en el aula y solicitar ayuda a los equipos de apoyo psico-pedag\u00f3gico dentro del establecimiento. De igual forma, este proyecto podr\u00eda dar origen a una cohorte de estudiantes que permita profundizar en el estudio de la relaci\u00f3n salud mental \u0096 resultados acad\u00e9micos, con productos cient\u00edficos (conocimiento) y tecnol\u00f3gicos de innovaci\u00f3n, que apoyen el trabajo de los docentes y sus establecimientos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1895<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2018 - Abril 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Ministerio de Educaci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6545\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Salud mental y resultados acad\u00e9micos en ni\u00f1os del primer ciclo de Ense\u00f1anza B\u00e1sica de la regi\u00f3n de O\u0092Higgins: mejorando logros educacionales en establecimientos municipales\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6545\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6545\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La construcci\u00f3n de un modelo predictivo, que podr\u00eda dar origen a una herramienta de screening para ayudar al profesor a identificar un problema de salud mental en el aula y solicitar ayuda a los equipos de apoyo psico-pedag\u00f3gico dentro del establecimiento. De igual forma, este proyecto podr\u00eda dar origen a una cohorte de estudiantes que permita profundizar en el estudio de la relaci\u00f3n salud mental \u0096 resultados acad\u00e9micos, con productos cient\u00edficos (conocimiento) y tecnol\u00f3gicos de innovaci\u00f3n, que apoyen el trabajo de los docentes y sus establecimientos.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2018 - Mayo 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6541\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Evaluaci\u00f3n Pre &#8211; Piloto Programa de Formaci\u00f3n de Cuidadores en ni\u00f1os con trastornos del desarrollo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6541\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6541\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La Organizaci\u00f3n Mundial de la Salud en conjunto con Autism Speaks ha desarrollado el Programa de Formaci\u00f3n a Cuidadores (CST) para ni\u00f1os y ni\u00f1as con TD (OMS, 2018). Dicho proyecto se enmarca en las recomendaciones de la \u0093Gu\u00eda de Intervenci\u00f3n mhGAP para los trastornos mentales, neurol\u00f3gicos y por uso de sustancias de OMS, la cual se implementa desde el a\u00f1o 2016 en la red de Atenci\u00f3n Primaria de Salud de Chile, con un m\u00f3dulo espec\u00edfico de trastornos del desarrollo (OMS, 2010; MINSAL 2018).\r\n\r\nObjetivo general\r\nEvaluar aceptabilidad y factibilidad del pre-piloto CST implementado en la Comuna de Santiago Centro.\r\n\r\nObjetivos espec\u00edficos\r\n1. Analizar las medidas de evaluaci\u00f3n aplicadas a trav\u00e9s de la realizaci\u00f3n del programa.\r\n2. Realizar entrevista a facilitadores y grupo focal a padres, una vez finalizado el programa.\r\n\r\nEstudio cuali-cuantitativo.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2018 - Marzo 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6461\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de la Unidad de An\u00e1lisis Biol\u00f3gicos y Qu\u00edmicos de la Universidad de O\u0092Higgins: Cuantificaci\u00f3n de pesticidas en muestras vegetales y humanas de la regi\u00f3n de O\u00b4Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6461\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6461\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2018 - Marzo 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6542\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fortalecimiento de la Unidad de An\u00e1lisis Biol\u00f3gicos y Qu\u00edmicos de la Universidad de O\u0092Higgins: Cuantificaci\u00f3n de pesticidas en muestras vegetales y humanas de la regi\u00f3n de O\u00b4Higgins\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6542\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6542\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Enero 2018 - Diciembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Intramural Research Award Program (IRAP). Touro University California College of Education and Health Sciences.<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6513\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Conocimientos, actitudes y pr\u00e1cticas relacionadas con el c\u00e1ncer cervical en Monteagudo rural, Bolivia.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6513\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6513\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Conocimientos, actitudes y pr\u00e1cticas relacionadas con el c\u00e1ncer cervical en Monteagudo rural, Bolivia.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Responsable Alterno<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2017 - Octubre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6506\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Building a Consortium: Planning Research to Improve Accessibility to Mental Health Services for Vulnerable Populations in Latin America.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6506\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6506\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Latin America is home to an estimated 600 million people, the majority of whom live in severe economic deprivation and political instability. While mental illness and substance use problems (MISUP) in Latin America account for approximately a tenth of the world's total burden of the disease, very few individuals receive adequate treatment. 18 million Latin Americans are reported to be facing unemployment, eviction, and homelessness as a result of mental disorders. Untreated MISUP are a major public health issue as they can lead to long-term disability, impaired functioning, caregiver burden, and ultimately premature death. Given the prevalence of such issues in Latin America, an effort to address health equity and accessibility to mental health services is warranted. Research regarding mental health service use in Latin America is scarce, with even fewer studies focusing on barriers to accessibility such as stigma and discrimination. The goal for this project is to share key insights among Latin American countries to better understand factors that inhibit access to mental health services. Funding for a 3-day meeting bringing together key stakeholders from Chile, Canada, Peru, Bolivia and Argentina who are actively addressing these issues will serve three objectives: 1. Dissemination of Research - Disseminating findings from anti-stigma projects in Chile, Peru and Canada detailing challenges within their health systems, impact of interventions and opportunities to further research in this area. 2. Information Gathering - Exploring research studies concerning factors that prevent access to mental health care in Bolivia and Argentina to extract key insights from each approach. 3. Collaboration - Developing new, relevant and collaborative regional projects, research and interventions addressing accessibility to mental health services.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Noviembre 2017 - Octubre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6547\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Building a Consortium: Planning Research to Improve Accessibility to Mental Health Services for Vulnerable Populations in Latin America.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6547\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6547\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Latin America is home to an estimated 600 million people, the majority of whom live in severe economic deprivation and political instability. While mental illness and substance use problems (MISUP) in Latin America account for approximately a tenth of the world's total burden of the disease, very few individuals receive adequate treatment. 18 million Latin Americans are reported to be facing unemployment, eviction, and homelessness as a result of mental disorders. Untreated MISUP are a major public health issue as they can lead to long-term disability, impaired functioning, caregiver burden, and ultimately premature death. Given the prevalence of such issues in Latin America, an effort to address health equity and accessibility to mental health services is warranted. Research regarding mental health service use in Latin America is scarce, with even fewer studies focusing on barriers to accessibility such as stigma and discrimination. The goal for this project is to share key insights among Latin American countries to better understand factors that inhibit access to mental health services. Funding for a 3-day meeting bringing together key stakeholders from Chile, Canada, Peru, Bolivia and Argentina who are actively addressing these issues will serve three objectives: 1. Dissemination of Research - Disseminating findings from anti-stigma projects in Chile, Peru and Canada detailing challenges within their health systems, impact of interventions and opportunities to further research in this area. 2. Information Gathering - Exploring research studies concerning factors that prevent access to mental health care in Bolivia and Argentina to extract key insights from each approach. 3. Collaboration - Developing new, relevant and collaborative regional projects, research and interventions addressing accessibility to mental health services.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2017 - Septiembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6389\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Development of in ovo model for treating the hypoxia-induced fetal growth restriction in the chicken embryo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6389\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6389\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]As a scientist in Chile, I have been focused on understanding the mechanisms underlying fetal vascular dysfunction associated with altered fetal growth with a special interest in impaired fetal growth and epigenetic regulation.   Fetal growth restriction (FGR), commonly defined by a weight below the 10th percentile is associated with increased perinatal morbidity and mortality with an incidence of 3 to 10% of all live births1, 2. Therefore, FGR remains at the forefront of basic science and clinical investigation, as it poses a significant problem on every nation\u0092s wealth and health.  Adverse conditions in complicated pregnancy known to induce FGR include reductions in fetal oxygenation or chronic fetal hypoxia3.  Several studies in humans have established that high altitude pregnancy reduces fetal growth 4-6.  Further, several studies in mammalian animal models of hypoxic pregnancy have also reported a significant effect in slowing fetal growth7. However, since most high altitude populations are also impoverished with a high prevalence of maternal undernutrition and since hypoxic exposure of mammalian animals during pregnancy can reduce maternal food intake7, the partial contributions of fetal under-nutrition versus fetal under-oxygenation in promoting FGR remain uncertain.  \r\nThe Giussani group at the University of Cambridge have combined the chick embryo model with hypoxic incubation to isolate the direct effects of chronic fetal hypoxia in promoting FGR.  This group has shown that incubation at high altitude of fertilized eggs laid by sea level hens leads to FGR.  Conversely, incubation at sea level of fertilized eggs laid by high altitude hens that normally show FGR completely recovered fetal growth.  Importantly, incubation at high altitude of fertilized eggs laid by sea level with oxygen supplementation also prevented FGR8.  Recent studies by the Cambridge group have also reported that isobaric rather than hypobaric chronic fetal hypoxia also leads to FGR in the chick embryo9.  Further, they have reported that FGR as a result of isolated chronic fetal hypoxia is associated with significant oxidative stress and endothelial dysfunction in fetal peripheral circulations. Treatment of chick embryos during hypoxic incubation with the antioxidant melatonin rescued the endothelial dysfunction in peripheral circulations by the end of the incubation period. The mechanisms involved included reduced oxidative stress, enhanced antioxidant capacity, restored vascular endothelial growth factor expression and increased NO bioavailability9.  Combined, therefore, studies by the Cambridge group have isolated a direct effect of hypoxia in promoting FGR and fetal endothelial dysfunction independent of effects at the level of the placenta or the mother and suggest that antioxidant therapy may also have a direct protective effect on the fetus.\r\nThese findings are of particular interest to me because my research group in Chile has recently established a guinea pig experimental model of FGR.  This is by progressive bilateral occlusion of the uterine arteries during the second half of gestation that gradually increases placental vascular resistance10, 11. Using this guinea pig model, we have recently shown that FGR induces epigenetic programming of eNOS expression in the fetal endothelium, which is prevented by a maternal treatment with N-acetylcysteine11. However, whether the effects of increased placental vascular resistance on the fetal epigenetic programming of eNOS expression is due to fetal under-nutrition versus fetal under-oxygenation in this model of FGR again remains uncertain.  Therefore, the aim of my research proposal is to use the Cambridge chick embryo model of FGR as a result of hypoxic incubation to isolate the direct effects of chronic fetal hypoxia on epigenetic regulation promoting fetal vascular dysfunction.  This would be the first step to enable better identification of potential targets for clinical intervention designed to protect the developing fetal circulation in pregnancy complicated by FGR and chronic fetal hypoxia.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2017 - Septiembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6420\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Development of in ovo model for treating the hypoxia-induced fetal growth restriction in the chicken embryo\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6420\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6420\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]As a scientist in Chile, I have been focused on understanding the mechanisms underlying fetal vascular dysfunction associated with altered fetal growth with a special interest in impaired fetal growth and epigenetic regulation.   Fetal growth restriction (FGR), commonly defined by a weight below the 10th percentile is associated with increased perinatal morbidity and mortality with an incidence of 3 to 10% of all live births1, 2. Therefore, FGR remains at the forefront of basic science and clinical investigation, as it poses a significant problem on every nation\u0092s wealth and health.  Adverse conditions in complicated pregnancy known to induce FGR include reductions in fetal oxygenation or chronic fetal hypoxia3.  Several studies in humans have established that high altitude pregnancy reduces fetal growth 4-6.  Further, several studies in mammalian animal models of hypoxic pregnancy have also reported a significant effect in slowing fetal growth7. However, since most high altitude populations are also impoverished with a high prevalence of maternal undernutrition and since hypoxic exposure of mammalian animals during pregnancy can reduce maternal food intake7, the partial contributions of fetal under-nutrition versus fetal under-oxygenation in promoting FGR remain uncertain.  \r\nThe Giussani group at the University of Cambridge have combined the chick embryo model with hypoxic incubation to isolate the direct effects of chronic fetal hypoxia in promoting FGR.  This group has shown that incubation at high altitude of fertilized eggs laid by sea level hens leads to FGR.  Conversely, incubation at sea level of fertilized eggs laid by high altitude hens that normally show FGR completely recovered fetal growth.  Importantly, incubation at high altitude of fertilized eggs laid by sea level with oxygen supplementation also prevented FGR8.  Recent studies by the Cambridge group have also reported that isobaric rather than hypobaric chronic fetal hypoxia also leads to FGR in the chick embryo9.  Further, they have reported that FGR as a result of isolated chronic fetal hypoxia is associated with significant oxidative stress and endothelial dysfunction in fetal peripheral circulations. Treatment of chick embryos during hypoxic incubation with the antioxidant melatonin rescued the endothelial dysfunction in peripheral circulations by the end of the incubation period. The mechanisms involved included reduced oxidative stress, enhanced antioxidant capacity, restored vascular endothelial growth factor expression and increased NO bioavailability9.  Combined, therefore, studies by the Cambridge group have isolated a direct effect of hypoxia in promoting FGR and fetal endothelial dysfunction independent of effects at the level of the placenta or the mother and suggest that antioxidant therapy may also have a direct protective effect on the fetus.\r\nThese findings are of particular interest to me because my research group in Chile has recently established a guinea pig experimental model of FGR.  This is by progressive bilateral occlusion of the uterine arteries during the second half of gestation that gradually increases placental vascular resistance10, 11. Using this guinea pig model, we have recently shown that FGR induces epigenetic programming of eNOS expression in the fetal endothelium, which is prevented by a maternal treatment with N-acetylcysteine11. However, whether the effects of increased placental vascular resistance on the fetal epigenetic programming of eNOS expression is due to fetal under-nutrition versus fetal under-oxygenation in this model of FGR again remains uncertain.  Therefore, the aim of my research proposal is to use the Cambridge chick embryo model of FGR as a result of hypoxic incubation to isolate the direct effects of chronic fetal hypoxia on epigenetic regulation promoting fetal vascular dysfunction.  This would be the first step to enable better identification of potential targets for clinical intervention designed to protect the developing fetal circulation in pregnancy complicated by FGR and chronic fetal hypoxia.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #48A2F9\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Septiembre 2017 - Diciembre 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#48A2F9 !important; color:#FFF\">En Ejecuci\u00f3n<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6548\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Desarrollo de instrumentos culturalmente espec\u00edficos sobre estigma hacia la enfermedad mental y su relaci\u00f3n con funcionalidad global en Am\u00e9rica Latina (Development of Specific Cultural Elements to Evaluate Stigmas towards Mental Health and its Relationshi\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6548\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6548\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]*Research Question(s)\/Hypothesis (es)\r\nAim 1: To examine the degree to which 'what matters most' differs in Chile and Argentina from other cultures in which this has been studied by qualitatively assessing key culture-specific domains of stigma. We propose that thematic analyses will reveal differences in how \u0091what matters most\u0092 shapes stigma in these contexts.\r\nAim 2: To operationalize items to create \u0091culture-specific\u0092 stigma modules for two widely used stigma measures. We will operationalize culture-specific variation in stigma via a pool of initial survey items and use pilot testing with local experts and respondents to create final \u0091culture specific\u0092 stigma modules for each scale.\r\nAim 3: To validate 2 new measures of \u0091culture-specific\u0092 and \u0091universal\u0092 aspects of stigma by administering these measures to 150 participants in Chile. We propose that our \u0091culture-specific\u0092 modules will aid prediction of construct validity scales, with different domains of global functioning as key outcomes.\r\n*Study Implementation\r\nWe are carrying out our fieldwork to develop culturally specific assessments of stigma in two sites: the city of Cordoba in Argentina and in the Santiago Metropolitan area and the adjacent Region of O\u0092Higgins in Chile.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Agosto 2017 - Diciembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6546\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Atenci\u00f3n Primaria y Salud Mental: Estudio multic\u00e9ntrico de Redes de Servicios de Salud Mental en Per\u00fa, Argentina, Bolivia, Ecuador y Chile  (EVAREDCOM)\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6546\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6546\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]La Becas Iberoamericana, J\u00f3venes Profesores e Investigadores de Santander Universidades permiti\u00f3 iniciar y desarrollar una l\u00ednea de investigaci\u00f3n que aun mantengo vinculada a la evaluaci\u00f3n de servicios de salud mental comunitaria.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2017 - Junio 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6392\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Time-course modeling of the endothelial epigenetic programming by fetal growth restriction: role of miRNAs miR-21 &#038; miR-126.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6392\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6392\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2017 - Junio 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6423\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Time-course modeling of the endothelial epigenetic programming by fetal growth restriction: role of miRNAs miR-21 &#038; miR-126.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6423\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6423\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2017 - Enero 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6549\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Desarrollo y evaluaci\u00f3n de un modelo de intervenci\u00f3n basado en tecnolog\u00edas de la informaci\u00f3n y de la comunicaci\u00f3n (TICs) para reducir el riesgo de suicidio adolescente en establecimientos educacionales de la RM y la VI Regi\u00f3n.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6549\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6549\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Objetivo General del proyecto fue desarrollar y evaluar un modelo de intervenci\u00f3n basado en tecnolog\u00edas de la informaci\u00f3n y comunicaci\u00f3n para reducir riesgo suicida y fortalecer factores protectores de la salud mental en adolescentes de establecimientos educacionales de la RM y VI Regi\u00f3n.\r\nEl producto central es una plataforma web, con aplicaciones m\u00f3viles asociadas, que incluye un componente psicoeducativo y uno interactivo que estar\u00e1 constituido por recursos que fomentan el apoyo entre pares (adolescentes) y la generaci\u00f3n de estrategias para afrontar problemas afectivos y sociales.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2017 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6390\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1170608. Biomechanical behavior of arteries from chronic hypoxic animals: experiments, modelling, numerical simulation and validation\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6390\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6390\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Appropriate arterial function and structure are vital for a proper cardiovascular performance and therefore fundamental for a healthy life. Arterial function depends on cellular and molecular mechanisms but as well on the structural features. In fact, it has been shown that structural and biomechanical properties of vessels are very much related to several cardiovascular pathologies, such as systemic and pulmonary hypertension. Chronic lack of oxygen (hypoxia), may determine an impairment of the cardiovascular function, potentially deriving in pulmonary\/systemic hypertension and cardiac failure. This is particularly relevant in human populations exposed to high altitude (above 2500m), either in chronic continuous (permanent inhabitants) or chronic intermittent (shifts of high altitude workers, such as miners, custom agents astronomers; and mountaineers) fashions. Most of the studies about vascular effects of chronic hypoxia have focused on function and molecular mechanisms involved in the pathophysiological responses. However, few is known about the biomechanical responses of systemic, pulmonary and cerebral arteries in these conditions, particularly in the chronic exposure to hypoxia as it happens in high-altitude population and in several diseases in lowlanders. The main goal of this project is to determine the vascular biomechanical characteristics of a representative rat paradigm of living under hypoxia and, in addition, establish the modelling, numerical simulation and experimental validation of the biomechanical responses of arterial vessels.\r\nSpecifically, three different types of vessels (aorta, carotid and femoral), at different age (neonates, juveniles and adults)\r\nwill be analyzed, either under normoxic, chronic permanent hypoxic or chronic intermittent hypoxic conditions.\r\nSmall rodents have been extensively used as a paradigm of cardiovascular and vascular function, allowing massive\r\nsteps in the knowledge of mechanisms involved in cardiovascular pathologies. Using a rat model, we will deeply analyze\r\nthe biomechanical properties of the vasculature of animals exposed to chronic hypoxia (permanent or intermittent) in a\r\nhypobaric chamber, adding substantial data for the comprehension of the vascular biomechanical behaviour under these\r\nconditions.\r\nThe need for a better understanding of the biomechanical response of arteries leads to the development of constitutive\r\nmodels that may define realistic and reliable stress-strain relationships. In this project, several constitutive models aimed\r\nat describing the biomechanical behaviour of soft tissues will be assessed. The specific aspects to be taken into account\r\nof the vessels biomechanical characterisation are: incompressibility of the tissue, presence of large deformations, isotropic and anisotropic material behaviours, residual stresses, rate dependent (i.e., viscous) effects, damage and active response. The material characterisation of the biomechanical behaviour of rat arteries will be performed via in-vitro biaxial and myograph tensile tests and ring opening test, considering standard, cyclic and relaxation loading conditions. From these experiments, the material characterisation will also involve the derivation of the material parameters. Specifically, we will address the development of algorithms for the treatment of non-linearities in the fitting procedure and sensitivity analysis to determine the consistency of the parameters found with this methodology. The analysis will also include comparison between the numerical predictions of the different constitutive models in their application to experimental data to be measured in this project.\r\nThe analysis of the response of pressurised straight arterial vessels will be additionally carried out. Importantly, this\r\ntest mimics the in-vivo physiological conditions of the arterial vessel. Aside from the internal pressure, axial stretching is\r\nusually considered. As a non-uniform biaxial stress state is commonly developed in this test, this fact extends the validity of the material characterisation. The material response will be described via the constitutive models previously characterised. Due to the complex stress and strain patterns developed in this problem, numerical simulations defined in the context of the finite element method will be performed. The obtained numerical results will be validated with the corresponding experimental measurements. Moreover, we expect to characterise the biomechanical properties of different vascular beds, representatives of systemic, pulmonary and cerebral circulations. We shall also describe the effects of chronic hypoxia on these properties. Furthermore, we will perform histological analyses to assess the ultrastructure and the wall components of the intima, media and adventitia layers and relate them with the biomechanical findings.\r\nThe outcomes of this project will enhance the knowledge necessary to integrate the functional, structural and\r\nbiomechanical properties of vascular tissues. Clearly, our data will provide useful information not only for vascular pathophysiology understanding, but also for optimization of medical diagnosis, prognosis and potential therapeutic approaches to the related pathologies[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2017 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6391\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1171406. Fetal programming of inflammatory responses and body fat by maternal obesity: Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6391\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6391\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Overweight and Obesity are worldwide epidemic conditions defined as a body mass index (BMI) &#8805; 25 and &#8805;30, respectively, characterized by an excessive accumulation of adipose tissue in the body that impairs both physical and psychosocial health and well-being [1]. Notably, according to the Chilean National Health Survey (ENS 2009-2010), 60% of woman in reproductive age (i.e. 15 and 44 years) are overweight or obese [2] with detrimental consequences on women as well as offspring health at long term. Epidemiological evidences have recognized pre-gestational obesity and, in a lesser degree, excessive gestational weight gain (GWG) as independent risk factors in the development of maternal complications and adverse perinatal outcomes [3]. This includes congenital malformations, perinatal death, large for gestational age babies (LGA, >p 90th), macrosomia (> 4 Kg at birth), birth dystocia, neonatal hypoglycemia, and others [4]. This evidences leaded the Institute of Medicine of the National Academy of Sciences of the United States (IOM) to provide guidelines for maternal weight gain in 1990, updated in 2009 [5] in order to improve maternal and perinatal outcomes. Conversely, a large number of evidence has shown that a deficient maternal nutrition during pregnancy affects the early in utero development, inducing adaptations\/responses in the fetus and neonate which have been associated to increased risk of diseases in adulthood [6]. This concept, known as \"Developmental Origins of Health and Disease\u0094 (DOHaD, referred also as intrauterine programming in this proposal) which was coined by Professor David Barker, who reported the association of low birth weight and the risk of T2DM and cardiovascular disease. Notably not only in utero under-nutrition (e.g. intrauterine growth restriction) but also over-nutrition (e.g. macrosomia, LGA) increase the cardiometabolic risk in the offspring [7-9]. Whilst the effect of maternal undernutrition on the risk of disease in the offspring has been extensively addressed, new efforts are required to clarify how increased maternal obesity and body fat previous and during pregnancy impinge an increased cardiometabolic risk in the progeny.\r\n   In this context, in addition to perinatal complications associated with maternal obesity (MO), there is evidence of persistent adverse effects in the offspring throughout their lifespan. In fact, excessive maternal gestational weight gain is associated with a 2-fold increase in cardiometabolic risk in the offspring, which is evidenced since early infancy [10]. Notably, this effect is substantially higher (~5-fold increase) in offspring from women that initiate their pregnancy with obesity [11, 12]. This is relevant due to the high rate of childhood overweight\/obesity in Chile (32.2% of the children &#8804; 6 yo are overweight\/obese, according to the ENS 2010), which is a strong predictor of later cardiometabolic complications in adulthood [13]. The effect of MO on susceptibility to obesity in the offspring appears to be independent of the presence of gestational diabetes (GDM) [14, 15]. This could have its origin during fetal development since it has been described that newborn whose mothers are obese, with normal glycaemia during gestation, present an increased adiposity versus lean mass compared to control pregnancies [16]. In this respect, it is noteworthy that the size of abdominal adipose tissue and hepatocellular lipid content in neonates strongly correlates with maternal BMI [17-19]. This has been also observed in offspring from pregnant obese non-human primates and mice, which exhibit increased accumulation of hepatic triglycerides and ceramides even before birth [17-19]. Furthermore, MO also relates with metabolic disturbances in the newborn, such as a reduced insulin sensitivity and altered inflammatory markers [20]. Altogether these data suggest that postnatal obesity could be programmed by MO during fetal development, however the mechanisms underlying the intrauterine programming of obesity are currently unknown. In this context inflammation, a mechanism exacerbated in pregnancies with MO, represents a potential pathway participating in this process.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2017 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6421\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1170608. Biomechanical behavior of arteries from chronic hypoxic animals: experiments, modelling, numerical simulation and validation\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6421\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6421\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Appropriate arterial function and structure are vital for a proper cardiovascular performance and therefore fundamental for a healthy life. Arterial function depends on cellular and molecular mechanisms but as well on the structural features. In fact, it has been shown that structural and biomechanical properties of vessels are very much related to several cardiovascular pathologies, such as systemic and pulmonary hypertension. Chronic lack of oxygen (hypoxia), may determine an impairment of the cardiovascular function, potentially deriving in pulmonary\/systemic hypertension and cardiac failure. This is particularly relevant in human populations exposed to high altitude (above 2500m), either in chronic continuous (permanent inhabitants) or chronic intermittent (shifts of high altitude workers, such as miners, custom agents astronomers; and mountaineers) fashions. Most of the studies about vascular effects of chronic hypoxia have focused on function and molecular mechanisms involved in the pathophysiological responses. However, few is known about the biomechanical responses of systemic, pulmonary and cerebral arteries in these conditions, particularly in the chronic exposure to hypoxia as it happens in high-altitude population and in several diseases in lowlanders. The main goal of this project is to determine the vascular biomechanical characteristics of a representative rat paradigm of living under hypoxia and, in addition, establish the modelling, numerical simulation and experimental validation of the biomechanical responses of arterial vessels.\r\nSpecifically, three different types of vessels (aorta, carotid and femoral), at different age (neonates, juveniles and adults)\r\nwill be analyzed, either under normoxic, chronic permanent hypoxic or chronic intermittent hypoxic conditions.\r\nSmall rodents have been extensively used as a paradigm of cardiovascular and vascular function, allowing massive\r\nsteps in the knowledge of mechanisms involved in cardiovascular pathologies. Using a rat model, we will deeply analyze\r\nthe biomechanical properties of the vasculature of animals exposed to chronic hypoxia (permanent or intermittent) in a\r\nhypobaric chamber, adding substantial data for the comprehension of the vascular biomechanical behaviour under these\r\nconditions.\r\nThe need for a better understanding of the biomechanical response of arteries leads to the development of constitutive\r\nmodels that may define realistic and reliable stress-strain relationships. In this project, several constitutive models aimed\r\nat describing the biomechanical behaviour of soft tissues will be assessed. The specific aspects to be taken into account\r\nof the vessels biomechanical characterisation are: incompressibility of the tissue, presence of large deformations, isotropic and anisotropic material behaviours, residual stresses, rate dependent (i.e., viscous) effects, damage and active response. The material characterisation of the biomechanical behaviour of rat arteries will be performed via in-vitro biaxial and myograph tensile tests and ring opening test, considering standard, cyclic and relaxation loading conditions. From these experiments, the material characterisation will also involve the derivation of the material parameters. Specifically, we will address the development of algorithms for the treatment of non-linearities in the fitting procedure and sensitivity analysis to determine the consistency of the parameters found with this methodology. The analysis will also include comparison between the numerical predictions of the different constitutive models in their application to experimental data to be measured in this project.\r\nThe analysis of the response of pressurised straight arterial vessels will be additionally carried out. Importantly, this\r\ntest mimics the in-vivo physiological conditions of the arterial vessel. Aside from the internal pressure, axial stretching is\r\nusually considered. As a non-uniform biaxial stress state is commonly developed in this test, this fact extends the validity of the material characterisation. The material response will be described via the constitutive models previously characterised. Due to the complex stress and strain patterns developed in this problem, numerical simulations defined in the context of the finite element method will be performed. The obtained numerical results will be validated with the corresponding experimental measurements. Moreover, we expect to characterise the biomechanical properties of different vascular beds, representatives of systemic, pulmonary and cerebral circulations. We shall also describe the effects of chronic hypoxia on these properties. Furthermore, we will perform histological analyses to assess the ultrastructure and the wall components of the intima, media and adventitia layers and relate them with the biomechanical findings.\r\nThe outcomes of this project will enhance the knowledge necessary to integrate the functional, structural and\r\nbiomechanical properties of vascular tissues. Clearly, our data will provide useful information not only for vascular pathophysiology understanding, but also for optimization of medical diagnosis, prognosis and potential therapeutic approaches to the related pathologies[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2017 - Marzo 2021<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6422\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1171406. Fetal programming of inflammatory responses and body fat by maternal obesity: Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6422\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6422\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Overweight and Obesity are worldwide epidemic conditions defined as a body mass index (BMI) &#8805; 25 and &#8805;30, respectively, characterized by an excessive accumulation of adipose tissue in the body that impairs both physical and psychosocial health and well-being [1]. Notably, according to the Chilean National Health Survey (ENS 2009-2010), 60% of woman in reproductive age (i.e. 15 and 44 years) are overweight or obese [2] with detrimental consequences on women as well as offspring health at long term. Epidemiological evidences have recognized pre-gestational obesity and, in a lesser degree, excessive gestational weight gain (GWG) as independent risk factors in the development of maternal complications and adverse perinatal outcomes [3]. This includes congenital malformations, perinatal death, large for gestational age babies (LGA, >p 90th), macrosomia (> 4 Kg at birth), birth dystocia, neonatal hypoglycemia, and others [4]. This evidences leaded the Institute of Medicine of the National Academy of Sciences of the United States (IOM) to provide guidelines for maternal weight gain in 1990, updated in 2009 [5] in order to improve maternal and perinatal outcomes. Conversely, a large number of evidence has shown that a deficient maternal nutrition during pregnancy affects the early in utero development, inducing adaptations\/responses in the fetus and neonate which have been associated to increased risk of diseases in adulthood [6]. This concept, known as \"Developmental Origins of Health and Disease\u0094 (DOHaD, referred also as intrauterine programming in this proposal) which was coined by Professor David Barker, who reported the association of low birth weight and the risk of T2DM and cardiovascular disease. Notably not only in utero under-nutrition (e.g. intrauterine growth restriction) but also over-nutrition (e.g. macrosomia, LGA) increase the cardiometabolic risk in the offspring [7-9]. Whilst the effect of maternal undernutrition on the risk of disease in the offspring has been extensively addressed, new efforts are required to clarify how increased maternal obesity and body fat previous and during pregnancy impinge an increased cardiometabolic risk in the progeny.\r\n   In this context, in addition to perinatal complications associated with maternal obesity (MO), there is evidence of persistent adverse effects in the offspring throughout their lifespan. In fact, excessive maternal gestational weight gain is associated with a 2-fold increase in cardiometabolic risk in the offspring, which is evidenced since early infancy [10]. Notably, this effect is substantially higher (~5-fold increase) in offspring from women that initiate their pregnancy with obesity [11, 12]. This is relevant due to the high rate of childhood overweight\/obesity in Chile (32.2% of the children &#8804; 6 yo are overweight\/obese, according to the ENS 2010), which is a strong predictor of later cardiometabolic complications in adulthood [13]. The effect of MO on susceptibility to obesity in the offspring appears to be independent of the presence of gestational diabetes (GDM) [14, 15]. This could have its origin during fetal development since it has been described that newborn whose mothers are obese, with normal glycaemia during gestation, present an increased adiposity versus lean mass compared to control pregnancies [16]. In this respect, it is noteworthy that the size of abdominal adipose tissue and hepatocellular lipid content in neonates strongly correlates with maternal BMI [17-19]. This has been also observed in offspring from pregnant obese non-human primates and mice, which exhibit increased accumulation of hepatic triglycerides and ceramides even before birth [17-19]. Furthermore, MO also relates with metabolic disturbances in the newborn, such as a reduced insulin sensitivity and altered inflammatory markers [20]. Altogether these data suggest that postnatal obesity could be programmed by MO during fetal development, however the mechanisms underlying the intrauterine programming of obesity are currently unknown. In this context inflammation, a mechanism exacerbated in pregnancies with MO, represents a potential pathway participating in this process.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2017 - Diciembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Superintendencia de Seguridad Social (Concursos SUSESO)<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6552\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            La salud mental como factor de riesgo para los accidentes del trabajo y el ausentismo laboral: un estudio de cohorte\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6552\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6552\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Nuestro proyecto, espera dos grandes aportes.\r\nUn primer resultado de este proyecto corresponde al mejor conocimiento acerca de la interrelaci\u00f3n que existe entre los problemas de salud mental y otras condiciones que afectan la salud de los trabajadores, como es el caso de los accidentes. Y lo mismo se puede se\u00f1alar respecto del mejor conocimiento de los factores que inciden en el ausentismo, y por tanto en las consecuencias que este puede tener para los trabajadores y para las empresas.\r\nUn segundo resultado se refiere al desarrollo de instrumentos para la identificaci\u00f3n de este tipo de problemas en los trabajadores. Uno de los primeros pasos para el desarrollo de intervenciones es contar con encuestas y\/o escalas (instrumentos psicom\u00e9tricos) que sean eficientes en la identificaci\u00f3n de estos s\u00edntomas mentales, lo m\u00e1s breve posibles, focalizada en aquellos s\u00edntomas m\u00e1s relevantes y adaptada para la realidad de nuestro pa\u00eds, y en especial para ser aplicada a trabajadores dentro de nuestras ambientes laborales.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Abril 2016 - Abril 2020<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6463\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Din\u00e1mica neuronal eferente desde la corteza auditiva al receptor coclear durante paradigmas de atenci\u00f3n selectiva en pacientes con tinnitus y chinchillas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6463\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6463\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Diciembre 2015 - Junio 2017<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6465\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            International Network for Auditory and Cognition Center\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6465\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6465\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2015 - Octubre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6464\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            De la Presbiacusia a la demencia: Un enfoque B\u00e1sico-Cl\u00ednico\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6464\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6464\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2014 - Febrero 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6393\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1141195 &#8211; Early risk of asthma in children exposed to in-utero maternal obesity. An epigenetic-mediated programming of immune function\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6393\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6393\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Asthma is a chronic disease that affects young children starting mostly in the first years of life; with a high prevalence across countries globally. In Santiago, Chile, the prevalence of asthma among children 6-7 and 13-14 years of age is 11% and 15%, respectively; and for recurrent wheezing during the first year of life is as high as 22%. Asthma is the fourth most common cause of disability-adjusted life years for children aged 10\u009614 yrs and an important cause of reduced quality of life and exercise tolerance, higher rates of school absenteeism and hospitalization. A recent study done in Santiago reports that 30.4% of all infants visits to the emergency department presented with wheezing and wheezing exacerbations accounted for 8.4% hospital admission. Treatment of asthma currently focuses in reducing symptoms; however the morbidity remains high due to limited curative options and the unresolved etiology of asthma. There are no well-established methods or diagnostic tools to indentify the risk to develop asthma, and the current accepted practice base the diagnosis on parental or self-reported symptoms. One of the most accepted tools to predict asthma early in the infancy was developed by our team (the Asthma Predictive Index); and has been incorporated in most asthma early diagnosis guidelines globally. However, there is growing evidence supporting that beside genetic inheritance, maternal health during gestation represents an important factor conditioning the risk of asthma in the offspring. Thus a better understanding of pathogenesis of asthma in the neonatal period throughout uncovering the mechanisms that explain the associations between fetal life cues with asthma would contribute to an early prevention and treatment. \r\nImmune function plays a central role in the development of asthma, but the relative contribution of different immune cell types (i.e. mast cells, eosinophils, lymphocytes, neutrophils and monocytes\/macrophages) to this disease is still under examination. Nonetheless, it is clear that asthma presents an altered expression of pro-inflammatory molecules (IL-12, TNF-&#945;) and anti-inflammatory mediators (IL-10, IL-4). Notably, modulation of M1-M2 polarization of monocytes and macrophages seems to be crucial for the development of altered immune response in asthma, and this process would be tightly regulated by epigenetic mechanisms (i.e. DNA methylation, histone modifications). Numerous clinical and epidemiological studies have underlined the detrimental or beneficial role of nutritional factors in complex inflammation-related disorders such as allergy and asthma. It is now progressively better established that most of this risk is influenced in the very early stages of development, by a process of \u0093early life programming\u0094 in which epigenetic mechanisms  will actively participates. Remarkably, maternal obesity during gestation associates with increased plasma levels of TNF-&#945; at birth, and a 4-fold increased risk of asthma in the offspring. Also growing data show that epigenetic mechanisms exert an important control on the altered immune function observed in autoimmune and inflammatory controlling the expression of key genes. However, whether maternal obesity during pregnancy influences the immune function and the risk of asthma in the offspring throughout epigenetic mechanisms has not been addressed.\r\nIn this context we propose that \u0093Maternal obesity during pregnancy increases the risk of developing asthma in the offspring by an epigenetic-mediated programming of the inflammatory response in monocytes. This programmed inflammatory response is characterized by a higher expression of pro-inflammatory molecules (IL-12, TNF-&#945;) along with a lower expression of anti-inflammatory mediators (IL-10, IL-4R&#945;) which occurs due to changes in the methylation status of the promoter regions of these immune response- key genes\u0094. Studying a cohort of 400 children (0\u00963 years old) born from mother with or without obesity during pregnancy this proposal will address whether: a) the increased risk of asthma in children born from obese mother can be observed at 3 years of life; b) the increased asthma risk in these children associates with an altered immune reactivity in monocytes at birth; and c) the altered immune reactivity in monocytes occurs along with changes in the DNA methylation status at the promoter regions of asthma-related genes. \r\nThis study would reveal new molecular markers contributing to early diagnosis of asthma during childhood, as well as establish the real effects of epigenetic mechanisms modeling the immune function and responses at long term.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2014 - Febrero 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6424\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1141195 &#8211; Early risk of asthma in children exposed to in-utero maternal obesity. An epigenetic-mediated programming of immune function\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6424\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6424\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Asthma is a chronic disease that affects young children starting mostly in the first years of life; with a high prevalence across countries globally. In Santiago, Chile, the prevalence of asthma among children 6-7 and 13-14 years of age is 11% and 15%, respectively; and for recurrent wheezing during the first year of life is as high as 22%. Asthma is the fourth most common cause of disability-adjusted life years for children aged 10\u009614 yrs and an important cause of reduced quality of life and exercise tolerance, higher rates of school absenteeism and hospitalization. A recent study done in Santiago reports that 30.4% of all infants visits to the emergency department presented with wheezing and wheezing exacerbations accounted for 8.4% hospital admission. Treatment of asthma currently focuses in reducing symptoms; however the morbidity remains high due to limited curative options and the unresolved etiology of asthma. There are no well-established methods or diagnostic tools to indentify the risk to develop asthma, and the current accepted practice base the diagnosis on parental or self-reported symptoms. One of the most accepted tools to predict asthma early in the infancy was developed by our team (the Asthma Predictive Index); and has been incorporated in most asthma early diagnosis guidelines globally. However, there is growing evidence supporting that beside genetic inheritance, maternal health during gestation represents an important factor conditioning the risk of asthma in the offspring. Thus a better understanding of pathogenesis of asthma in the neonatal period throughout uncovering the mechanisms that explain the associations between fetal life cues with asthma would contribute to an early prevention and treatment. \r\nImmune function plays a central role in the development of asthma, but the relative contribution of different immune cell types (i.e. mast cells, eosinophils, lymphocytes, neutrophils and monocytes\/macrophages) to this disease is still under examination. Nonetheless, it is clear that asthma presents an altered expression of pro-inflammatory molecules (IL-12, TNF-&#945;) and anti-inflammatory mediators (IL-10, IL-4). Notably, modulation of M1-M2 polarization of monocytes and macrophages seems to be crucial for the development of altered immune response in asthma, and this process would be tightly regulated by epigenetic mechanisms (i.e. DNA methylation, histone modifications). Numerous clinical and epidemiological studies have underlined the detrimental or beneficial role of nutritional factors in complex inflammation-related disorders such as allergy and asthma. It is now progressively better established that most of this risk is influenced in the very early stages of development, by a process of \u0093early life programming\u0094 in which epigenetic mechanisms  will actively participates. Remarkably, maternal obesity during gestation associates with increased plasma levels of TNF-&#945; at birth, and a 4-fold increased risk of asthma in the offspring. Also growing data show that epigenetic mechanisms exert an important control on the altered immune function observed in autoimmune and inflammatory controlling the expression of key genes. However, whether maternal obesity during pregnancy influences the immune function and the risk of asthma in the offspring throughout epigenetic mechanisms has not been addressed.\r\nIn this context we propose that \u0093Maternal obesity during pregnancy increases the risk of developing asthma in the offspring by an epigenetic-mediated programming of the inflammatory response in monocytes. This programmed inflammatory response is characterized by a higher expression of pro-inflammatory molecules (IL-12, TNF-&#945;) along with a lower expression of anti-inflammatory mediators (IL-10, IL-4R&#945;) which occurs due to changes in the methylation status of the promoter regions of these immune response- key genes\u0094. Studying a cohort of 400 children (0\u00963 years old) born from mother with or without obesity during pregnancy this proposal will address whether: a) the increased risk of asthma in children born from obese mother can be observed at 3 years of life; b) the increased asthma risk in these children associates with an altered immune reactivity in monocytes at birth; and c) the altered immune reactivity in monocytes occurs along with changes in the DNA methylation status at the promoter regions of asthma-related genes. \r\nThis study would reveal new molecular markers contributing to early diagnosis of asthma during childhood, as well as establish the real effects of epigenetic mechanisms modeling the immune function and responses at long term.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #03286B\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2013 - Octubre 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#03286B !important; color:#FFF\">Ejecutado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6372\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Modulaci\u00f3n de la autofagia por el receptor de inositol trifosfato (IP3R) en distrofia muscular de Duchenne\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6372\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6372\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2013 - Febrero 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6394\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            FONDEF D11I1098 &#8211; Nueva formulaci\u00f3n farmacol\u00f3gica para el tratamiento y la prevenci\u00f3n de la hipertensi\u00f3n arterial y disfunci\u00f3n vascular: Respuesta integrada a una patolog\u00eda multifactorial.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6394\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6394\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]1.\tLa hipertensi\u00f3n arterial esencial es el principal factor de riesgo cardiovascular, con una prevalencia del 30-40 % en la poblaci\u00f3n adulta, que llega al 75% en mayores de 65 a\u00f1os. A pesar del desarrollo de f\u00e1rmacos, la efectividad de los tratamientos actuales es limitada. En cerca de 50% de los pacientes, el tratamiento farmacol\u00f3gico no logra controlar la presi\u00f3n arterial elevada. La hipertensi\u00f3n es de origen multifactorial, pero existe consenso que la disfunci\u00f3n endotelial juega un papel primordial en su desarrollo. La bio-disponibilidad del \u00f3xido n\u00edtrico (NO), que es el principal vasodilatador, est\u00e1 reducida en la mayor\u00eda de las enfermedades vasculares debido al estr\u00e9s oxidativo y al aumento de la expresi\u00f3n y actividad de arginasa, una enzima que compite por el sustrato del NO. Este proyecto desarrollamos una nueva combinaci\u00f3n farmacol\u00f3gica dirigida a proteger el NO, combinando las propiedades vasodilatadoras y anti-remodeladoras del inhibidor de la arginasa \u00e1cido 2(s)-Amino-6-Boronohexanoico (ABH) y de del antioxidante N-Acetilciste\u00edna (NAC). Buscamos introducir una nueva forma de enfocar el tratamiento para la hipertensi\u00f3n arterial, atacando con esta formulaci\u00f3n farmacol\u00f3gica los mecanismos moleculares que subyacen a la disfunci\u00f3n endotelial: baja bio-disponibilidad de NO y aumento del estr\u00e9s oxidativo. En un modelo de hipertensi\u00f3n en ratas inducido por hipoxia intermitente cr\u00f3nica, cuya presi\u00f3n fue monitorizada por telemetr\u00eda, evaluamos el efecto de la combinaci\u00f3n sobre la hipertensi\u00f3n arterial y la disfunci\u00f3n vascular. La combinaci\u00f3n ABH+NAC reduce la presi\u00f3n arterial elevada, revierte la reducci\u00f3n del di\u00e1metro interno de las arterias, regulariza la funci\u00f3n endotelial y contr\u00e1ctil en arterias y disminuye el estr\u00e9s oxidativo. No encontramos efectos adversos sobre la funci\u00f3n renal y hep\u00e1tica. Estos resultados dieron origen a la presentaci\u00f3n de dos solicitudes de patentes en Chile y de protecci\u00f3n CTP en el extranjero para un nuevo m\u00e9todo de s\u00edntesis de ABH y de los efectos ben\u00e9ficos de la combinaci\u00f3n sobre la hipertensi\u00f3n y disfunci\u00f3n endotelial. En conjunto con el Laboratorio Andr\u00f3maco se estableci\u00f3 una estrategia de propiedad industrial ex post, as\u00ed como las acciones cient\u00edfico-tecnol\u00f3gicas conducentes a las siguientes fases de desarrollo del medicamento: pruebas precl\u00ednicas en otros modelos de hipertensi\u00f3n, desarrollo gal\u00e9nico y\/o fase cl\u00ednica I. Dado que el resultado de producci\u00f3n de la formulaci\u00f3n  deber\u00e1 pasar a\u00fan por pruebas cl\u00ednicas antes de ser dispuesto a los beneficiarios, la patente de este nuevo f\u00e1rmaco podr\u00e1 ser utilizada como activo principal para capturar capital de inversi\u00f3n que permita continuar con este proceso, o bien para licenciar a empresas con inter\u00e9s en el rubro. Junto a la Fundaci\u00f3n del Adulto Mayor, desarrollamos actividades de extensi\u00f3n con la finalidad de informar a la comunidad y con ello contribuir a prevenir los efectos delet\u00e9reos de la hipertensi\u00f3n en la poblaci\u00f3n de mayor riesgo cardiovascular. En esta propuesta se espera validar una nueva terapia antihipertensiva que ataque los mecanismos fisiopatol\u00f3gicos principales de la disfunci\u00f3n vascular que conduce a la hipertensi\u00f3n arterial esencial.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2013 - Febrero 2017<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6395\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1130801. Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the Intrauterine Growth Restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6395\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6395\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Compelling evidence shows that adverse intrauterine conditions increase the risk to develop cardiometabolic diseases in the adulthood. This concept has been called \u0091Developmental Origins of Health and Disease\u0092 (DOHaD) and relies on the activation of mechanisms sensing and signaling a diversity of stimuli during early development that later lead to higher risk of disease. The mechanisms that have been broadly suggested to be involved in these processes are epigenetic modifications in key gene promoters that could \u0091record\u0092 normal and abnormal perinatal stimuli. \r\n   Intrauterine oxidative stress is a common feature in conditions with altered fetal growth (i.e. intrauterine growth restriction \u0096IUGR-, or macrosomia). Several cellular processes require the participation of pro-oxidant molecules which are normally neutralized by antioxidant defenses. However, under determined conditions the pro-oxidants overcome these defenses inducing oxidative stress. The latter is an important stimulus that regulates vascular function and cardiovascular physiology, playing a key role in the development of cardiovascular diseases, regulating negatively the bioavailability of the main vasodilator nitric oxide (NO). In addition, the vascular system presents a high phenotypic plasticity during life, which is modulated and restricted by epigenetic mechanisms (including DNA methylation, histone post-translational modifications and micro RNAs). \r\n   Interestingly, cultured placental endothelium derived from complicated pregnancies presents persistent abnormal phenotypes, characterized by altered expression of proteins involved in NO-dependent vasodilation (i.e. eNOS and arginase), suggesting an early onset of endothelial dysfunction. Preliminary data from in vitro experiments, show that this altered expression of eNOS in IUGR placenta-derived endothelial cells is accompanied by epigenetic alterations in the promoter of its gene. Moreover, these cells can be reprogrammed to a \u0093normal type\u0094, interfering with the molecular machinery that preserves the DNA methylation pattern. However, there are no studies addressing the role of the pro-oxidant status associated to IUGR on the epigenetic programming of placental vascular dysfunction, and whether these epigenetic changes reflect those present in other fetal vascular beds or in the adult cardiovascular system.\r\n   Therefore, we hypothesized that the in utero oxidative stress, that characterizes IUGR, induces an epigenetic programming of the endothelial function, which is linked to abnormal umbilical and fetal vascular reactivity and higher risk of adult cardiovascular disease. These epigenetic changes lead to an altered expression of endothelial function-related proteins and to their response to superimposed oxidative stress in umbilical and systemic arteries in the fetus and adult guinea pig. \r\n   If true, the development of IUGR in the presence of antioxidant treatment should prevent the vascular impairment in the fetus and the adult guinea pig. This hypothesis will be tested in an IUGR guinea pig model according to the following general aims (GA): GA-1. To determine whether the IUGR-associated oxidative stress induces endothelial dysfunction in umbilical and systemic arteries, altering the basal expression of proteins implicated in the NO-dependent vasodilation (NO-DV) pathway and their response to oxidative stress; GA-2. To determine in umbilical artery (UAEC) and aortic (AEC) endothelial cells whether endothelial dysfunction induced by fetal oxidative stress associates with epigenetic changes in the promoter of genes implicated in the NO-DV pathway, altering their response to oxidative stress in vitro; GA-3. To determine in adult life whether the IUGR-associated oxidative stress results in increased markers of endothelial dysfunction, oxidative stress and cardiovascular disease. GA-4. To determine in AEC of adults born with IUGR whether endothelial dysfunction induced by fetal oxidative stress is associated with epigenetic changes in the promoter of genes implicated in the NO-DV pathway and their response to oxidative stress in vitro, correlating them with those found at term of gestation. \r\n   IUGR will be induced by uterine artery ligation in a pregnant sow, and the role of oxidative stress in the vascular programming will be analyzed treating IUGR pregnancies with the antioxidant N-acetylcysteine. The acute effect of pro- and anti-oxidants on vascular reactivity and NO-dependent vasodilation will be determined by wire-myography in IUGR near-term fetuses and adults guinea pig arteries. Further, the presence of proteins related with NO-dependent vasodilation (eNOS, arginase, HO-1, NQO1 and DHFR) in these vessels will be determined by immunohistochemistry. Endothelial epigenetic programming will be analyzed in primary cell cultures from UAEC and AEC in near-term fetuses and AEC in adult guinea pigs. \r\n   Our expected outcome is to demonstrate that oxidative stress is one of the main sources of the IUGR-induced dysfunction in fetal and adult vascular beds. Further, we expect that the NAC treatment should be able to prevent partially or totally the programmed vascular impairment. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction, but also to propose eventual treatments in complicated pregnancies, that unfortunately present a very high rate in humans.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2013 - Febrero 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6425\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            FONDEF D11I1098 &#8211; Nueva formulaci\u00f3n farmacol\u00f3gica para el tratamiento y la prevenci\u00f3n de la hipertensi\u00f3n arterial y disfunci\u00f3n vascular: Respuesta integrada a una patolog\u00eda multifactorial.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6425\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6425\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]1.\tLa hipertensi\u00f3n arterial esencial es el principal factor de riesgo cardiovascular, con una prevalencia del 30-40 % en la poblaci\u00f3n adulta, que llega al 75% en mayores de 65 a\u00f1os. A pesar del desarrollo de f\u00e1rmacos, la efectividad de los tratamientos actuales es limitada. En cerca de 50% de los pacientes, el tratamiento farmacol\u00f3gico no logra controlar la presi\u00f3n arterial elevada. La hipertensi\u00f3n es de origen multifactorial, pero existe consenso que la disfunci\u00f3n endotelial juega un papel primordial en su desarrollo. La bio-disponibilidad del \u00f3xido n\u00edtrico (NO), que es el principal vasodilatador, est\u00e1 reducida en la mayor\u00eda de las enfermedades vasculares debido al estr\u00e9s oxidativo y al aumento de la expresi\u00f3n y actividad de arginasa, una enzima que compite por el sustrato del NO. Este proyecto desarrollamos una nueva combinaci\u00f3n farmacol\u00f3gica dirigida a proteger el NO, combinando las propiedades vasodilatadoras y anti-remodeladoras del inhibidor de la arginasa \u00e1cido 2(s)-Amino-6-Boronohexanoico (ABH) y de del antioxidante N-Acetilciste\u00edna (NAC). Buscamos introducir una nueva forma de enfocar el tratamiento para la hipertensi\u00f3n arterial, atacando con esta formulaci\u00f3n farmacol\u00f3gica los mecanismos moleculares que subyacen a la disfunci\u00f3n endotelial: baja bio-disponibilidad de NO y aumento del estr\u00e9s oxidativo. En un modelo de hipertensi\u00f3n en ratas inducido por hipoxia intermitente cr\u00f3nica, cuya presi\u00f3n fue monitorizada por telemetr\u00eda, evaluamos el efecto de la combinaci\u00f3n sobre la hipertensi\u00f3n arterial y la disfunci\u00f3n vascular. La combinaci\u00f3n ABH+NAC reduce la presi\u00f3n arterial elevada, revierte la reducci\u00f3n del di\u00e1metro interno de las arterias, regulariza la funci\u00f3n endotelial y contr\u00e1ctil en arterias y disminuye el estr\u00e9s oxidativo. No encontramos efectos adversos sobre la funci\u00f3n renal y hep\u00e1tica. Estos resultados dieron origen a la presentaci\u00f3n de dos solicitudes de patentes en Chile y de protecci\u00f3n CTP en el extranjero para un nuevo m\u00e9todo de s\u00edntesis de ABH y de los efectos ben\u00e9ficos de la combinaci\u00f3n sobre la hipertensi\u00f3n y disfunci\u00f3n endotelial. En conjunto con el Laboratorio Andr\u00f3maco se estableci\u00f3 una estrategia de propiedad industrial ex post, as\u00ed como las acciones cient\u00edfico-tecnol\u00f3gicas conducentes a las siguientes fases de desarrollo del medicamento: pruebas precl\u00ednicas en otros modelos de hipertensi\u00f3n, desarrollo gal\u00e9nico y\/o fase cl\u00ednica I. Dado que el resultado de producci\u00f3n de la formulaci\u00f3n  deber\u00e1 pasar a\u00fan por pruebas cl\u00ednicas antes de ser dispuesto a los beneficiarios, la patente de este nuevo f\u00e1rmaco podr\u00e1 ser utilizada como activo principal para capturar capital de inversi\u00f3n que permita continuar con este proceso, o bien para licenciar a empresas con inter\u00e9s en el rubro. Junto a la Fundaci\u00f3n del Adulto Mayor, desarrollamos actividades de extensi\u00f3n con la finalidad de informar a la comunidad y con ello contribuir a prevenir los efectos delet\u00e9reos de la hipertensi\u00f3n en la poblaci\u00f3n de mayor riesgo cardiovascular. En esta propuesta se espera validar una nueva terapia antihipertensiva que ataque los mecanismos fisiopatol\u00f3gicos principales de la disfunci\u00f3n vascular que conduce a la hipertensi\u00f3n arterial esencial.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2013 - Febrero 2017<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6426\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1130801. Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the Intrauterine Growth Restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction.\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6426\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6426\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Compelling evidence shows that adverse intrauterine conditions increase the risk to develop cardiometabolic diseases in the adulthood. This concept has been called \u0091Developmental Origins of Health and Disease\u0092 (DOHaD) and relies on the activation of mechanisms sensing and signaling a diversity of stimuli during early development that later lead to higher risk of disease. The mechanisms that have been broadly suggested to be involved in these processes are epigenetic modifications in key gene promoters that could \u0091record\u0092 normal and abnormal perinatal stimuli. \r\n   Intrauterine oxidative stress is a common feature in conditions with altered fetal growth (i.e. intrauterine growth restriction \u0096IUGR-, or macrosomia). Several cellular processes require the participation of pro-oxidant molecules which are normally neutralized by antioxidant defenses. However, under determined conditions the pro-oxidants overcome these defenses inducing oxidative stress. The latter is an important stimulus that regulates vascular function and cardiovascular physiology, playing a key role in the development of cardiovascular diseases, regulating negatively the bioavailability of the main vasodilator nitric oxide (NO). In addition, the vascular system presents a high phenotypic plasticity during life, which is modulated and restricted by epigenetic mechanisms (including DNA methylation, histone post-translational modifications and micro RNAs). \r\n   Interestingly, cultured placental endothelium derived from complicated pregnancies presents persistent abnormal phenotypes, characterized by altered expression of proteins involved in NO-dependent vasodilation (i.e. eNOS and arginase), suggesting an early onset of endothelial dysfunction. Preliminary data from in vitro experiments, show that this altered expression of eNOS in IUGR placenta-derived endothelial cells is accompanied by epigenetic alterations in the promoter of its gene. Moreover, these cells can be reprogrammed to a \u0093normal type\u0094, interfering with the molecular machinery that preserves the DNA methylation pattern. However, there are no studies addressing the role of the pro-oxidant status associated to IUGR on the epigenetic programming of placental vascular dysfunction, and whether these epigenetic changes reflect those present in other fetal vascular beds or in the adult cardiovascular system.\r\n   Therefore, we hypothesized that the in utero oxidative stress, that characterizes IUGR, induces an epigenetic programming of the endothelial function, which is linked to abnormal umbilical and fetal vascular reactivity and higher risk of adult cardiovascular disease. These epigenetic changes lead to an altered expression of endothelial function-related proteins and to their response to superimposed oxidative stress in umbilical and systemic arteries in the fetus and adult guinea pig. \r\n   If true, the development of IUGR in the presence of antioxidant treatment should prevent the vascular impairment in the fetus and the adult guinea pig. This hypothesis will be tested in an IUGR guinea pig model according to the following general aims (GA): GA-1. To determine whether the IUGR-associated oxidative stress induces endothelial dysfunction in umbilical and systemic arteries, altering the basal expression of proteins implicated in the NO-dependent vasodilation (NO-DV) pathway and their response to oxidative stress; GA-2. To determine in umbilical artery (UAEC) and aortic (AEC) endothelial cells whether endothelial dysfunction induced by fetal oxidative stress associates with epigenetic changes in the promoter of genes implicated in the NO-DV pathway, altering their response to oxidative stress in vitro; GA-3. To determine in adult life whether the IUGR-associated oxidative stress results in increased markers of endothelial dysfunction, oxidative stress and cardiovascular disease. GA-4. To determine in AEC of adults born with IUGR whether endothelial dysfunction induced by fetal oxidative stress is associated with epigenetic changes in the promoter of genes implicated in the NO-DV pathway and their response to oxidative stress in vitro, correlating them with those found at term of gestation. \r\n   IUGR will be induced by uterine artery ligation in a pregnant sow, and the role of oxidative stress in the vascular programming will be analyzed treating IUGR pregnancies with the antioxidant N-acetylcysteine. The acute effect of pro- and anti-oxidants on vascular reactivity and NO-dependent vasodilation will be determined by wire-myography in IUGR near-term fetuses and adults guinea pig arteries. Further, the presence of proteins related with NO-dependent vasodilation (eNOS, arginase, HO-1, NQO1 and DHFR) in these vessels will be determined by immunohistochemistry. Endothelial epigenetic programming will be analyzed in primary cell cultures from UAEC and AEC in near-term fetuses and AEC in adult guinea pigs. \r\n   Our expected outcome is to demonstrate that oxidative stress is one of the main sources of the IUGR-induced dysfunction in fetal and adult vascular beds. Further, we expect that the NAC treatment should be able to prevent partially or totally the programmed vascular impairment. This project is not only relevant to uncover the developmental mechanisms that determine short- and long-term vascular dysfunction, but also to propose eventual treatments in complicated pregnancies, that unfortunately present a very high rate in humans.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2012 - Diciembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6397\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondequip EQM-120205 Plataforma para el estudio de Metilaci\u00f3n de DNA,PyromarkQ96\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6397\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6397\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Julio 2012 - Diciembre 2018<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6428\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondequip EQM-120205 Plataforma para el estudio de Metilaci\u00f3n de DNA,PyromarkQ96\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6428\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6428\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"][\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2012 - Febrero 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6396\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1120928 &#8211; INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES: EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6396\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6396\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Hay pruebas s\u00f3lidas de que tanto la restricci\u00f3n del crecimiento intrauterino (RCIU) y la macrosom\u00eda fetal (peso\r\nal nacer > 4000 g) est\u00e1n fuertemente asociados con el aumento del riesgo de enfermedades cr\u00f3nicas en la vida\r\nadulta (i.e. hipertensi\u00f3n arterial y diabetes tipo 2). La asociaci\u00f3n entre el desarrollo peri-concepcional y fetal con\r\nla salud en la vida adulta, llamada \u0093Programaci\u00f3n Fetal\u0094 se basa en la activaci\u00f3n de mecanismos de detecci\u00f3n\r\ny se\u00f1alizaci\u00f3n de una diversidad de est\u00edmulos durante el desarrollo temprano. Los mecanismos que han sido\r\nampliamente sugerido que participan en estos procesos son las modificaciones epigen\u00e9ticas que podr\u00edan\r\nregistrar los est\u00edmulos perinatales. Como testigo de los cambios perinatales a los que se ve expuesto el\r\nembri\u00f3n y luego el feto en su desarrollo y crecimiento est\u00e1 la placenta, que junto con estar constituida por tejido\r\nque regula el intercambio de nutrientes y la modulaci\u00f3n inmune est\u00e1 formada por una importante red vascular\r\nque permite obtener desde la sangre materna los nutrientes, el ox\u00edgeno, las se\u00f1ales hormonales y del sistema\r\ninmune. El sistema vascular de la placenta se proyecta igualmente en la circulaci\u00f3n sist\u00e9mica del feto, donde se\r\nsugiere que ocurren adaptaciones en las condiciones patol\u00f3gicas antes mencionadas (RCIU y macrosom\u00eda fetal\r\nsecundaria a obesidad materna), condicionando as\u00ed a estos ni\u00f1os a presentar un elevado riesgo de\r\nenfermedades cardiometab\u00f3licas en la vida adulta.\r\nEste proyecto propuso estudiar la presencia de marcas epigen\u00e9ticas (cambios en el patr\u00f3n de metilaci\u00f3n de\r\ncitosinas en la regi\u00f3n promotora de genes y cambios en la modificaci\u00f3n de histonas que participan en el estado\r\nde compactaci\u00f3n\/relajaci\u00f3n de la cromatina) en las c\u00e9lulas vasculares de la arteria umbilical (HUAEC), cambios\r\nen la funci\u00f3n vascular y expresi\u00f3n de genes, prote\u00ednas y actividad de enzimas claves en la funci\u00f3n vascular en\r\ntres grupos de gestantes: 1) gestantes normopeso con fetos de crecimiento normal denominados \u0093Adecuados\r\npara la Edad Gestacional\u0094 (AEG); 2) gestantes normopeso con fetos que presentaron Restricci\u00f3n del\r\nCrecimiento IntraUterino (RCIU) y 3) gestantes con obesidad pregestacional que tuvieron hijos que fueron\r\nGrandes para la Edad Gestacional (FMOM).\r\nLos objetivos y los resultados principales de este proyecto fueron:\r\n1) Estudiar el tono vascular de las arterias umbilicales y cori\u00f3nicas de la placenta en estas tres condiciones\r\ncl\u00ednicas con acento en la participaci\u00f3n de las v\u00edas dependiente de \u00f3xido n\u00edtrico, un vasodilatador dependiente\r\ndel endotelio, clave en el tono vascular placentario. Se determin\u00f3 que las arterias cori\u00f3nicas y placentarias de\r\nlos fetos RCIU y FMOM presentan disfunci\u00f3n vascular dependiente de \u00f3xido n\u00edtrico y que existe un desbalance\r\nentre la actividad de arginasa-2\/eNOS que favorece esta disfunci\u00f3n. (ver Krause et al. Placenta 2012; 2013;\r\nSchneider et al., Placenta 2015).\r\n2) Determinar si estos cambios en el tono vascular placentario y umbilical se correlacionan a cambios en la\r\nexpresi\u00f3n de genes y prote\u00ednas claves en la funci\u00f3n vascular (eNOS, Arg2, CAT-1) y de respuesta estr\u00e9s\r\noxidativo (NOX4, GPx-1, SOD-1 y HO-1) en los cultivos primarios de HUAEC de las tres condiciones cl\u00ednicas,\r\nas\u00ed como en los tejidos (cordones umbilicales y arterias cori\u00f3nicas) (ver Schneider et al., Placenta 2015). Se\r\ndetermin\u00f3 que estos vasos est\u00e1n marcados por una respuesta cr\u00f3nica a estr\u00e9s oxidativo, presentando una\r\nlimitada reserva vascular al estr\u00e9s oxidativo, comparado con los tejidos provenientes de embarazos AEG (ver\r\nSchneider et al., Placenta 2015).\r\n3) Estudiar la presencia de modificaciones epigen\u00e9ticas presentes en la regi\u00f3n promotora de los genes\r\nrelacionados con la v\u00eda de s\u00edntesis del \u00f3xido n\u00edtrico (NO) y determinar si la respuesta al estr\u00e9s oxidativo y\/o\r\nhipoxia est\u00e1n programadas epigeneticamente. Se determin\u00f3 que de todos los genes estudiados s\u00f3lo eNOS y\r\nArg2 presentan cambios en el patr\u00f3n de metilaci\u00f3n en la regi\u00f3n promotora (ver Krause et al., Epigenetics\r\n2013) que se correlacionan con las modificaciones de histonas encargadas de regular el estado de\r\ncompactaci\u00f3n de la cromatina (Caniuguir et al., en preparaci\u00f3n).\r\n4) Ahondar en la participaci\u00f3n de los mecanismos epigen\u00e9ticos (HDAC y DNMT) en la expresi\u00f3n basal de estos\r\ngenes en las tres condiciones cl\u00ednicas. Se determin\u00f3 muy elegantemente como NO es quien regula a nivel\r\nepigen\u00e9tico la apertura de la cromatina de arginasa 2 y su actividad transcripcional (ver Krause et al., Biochem\r\nPharmacol 2016).\r\nEl desarrollo de este proyecto tuvo como fruto 18 art\u00edculos en revistas indexadas, la mitad de ellos\r\ndirectamente relacionados con resultados de este proyecto y los otros de colaboraciones nacidas durante estos\r\na\u00f1os, que apuntan directamente a comprender los mecanismos que subyacen la programaci\u00f3n fetal de\r\nenfermedades cardiometab\u00f3licas en tejido placentario, en ni\u00f1os pre-adolescentes, modelos animales de RCIU y\r\nobesidad materna, proyectos cl\u00ednicos de seguimiento de ni\u00f1os, etc.\r\nEste proyecto aport\u00f3 en forma sustantiva a la generaci\u00f3n de nuevo conocimiento en relaci\u00f3n a los\r\nmecanismos moleculares que subyacen a la programaci\u00f3n vascular alterada en fetos con RCIU y FMOM,\r\nque est\u00e1n en mayor riesgo de desarrollar enfermedades vasculares en la vida postnatal, con la relevancia\r\ncl\u00ednica de la potencial aplicaci\u00f3n en la detecci\u00f3n temprana de factores de riesgo cardiovascular en el\r\nnacimiento.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #EFB956\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2012 - Febrero 2016<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#EFB956 !important; color:#FFF\">Adjudicado<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6427\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Fondecyt Regular 1120928 &#8211; INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES: EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6427\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6427\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Hay pruebas s\u00f3lidas de que tanto la restricci\u00f3n del crecimiento intrauterino (RCIU) y la macrosom\u00eda fetal (peso\r\nal nacer > 4000 g) est\u00e1n fuertemente asociados con el aumento del riesgo de enfermedades cr\u00f3nicas en la vida\r\nadulta (i.e. hipertensi\u00f3n arterial y diabetes tipo 2). La asociaci\u00f3n entre el desarrollo peri-concepcional y fetal con\r\nla salud en la vida adulta, llamada \u0093Programaci\u00f3n Fetal\u0094 se basa en la activaci\u00f3n de mecanismos de detecci\u00f3n\r\ny se\u00f1alizaci\u00f3n de una diversidad de est\u00edmulos durante el desarrollo temprano. Los mecanismos que han sido\r\nampliamente sugerido que participan en estos procesos son las modificaciones epigen\u00e9ticas que podr\u00edan\r\nregistrar los est\u00edmulos perinatales. Como testigo de los cambios perinatales a los que se ve expuesto el\r\nembri\u00f3n y luego el feto en su desarrollo y crecimiento est\u00e1 la placenta, que junto con estar constituida por tejido\r\nque regula el intercambio de nutrientes y la modulaci\u00f3n inmune est\u00e1 formada por una importante red vascular\r\nque permite obtener desde la sangre materna los nutrientes, el ox\u00edgeno, las se\u00f1ales hormonales y del sistema\r\ninmune. El sistema vascular de la placenta se proyecta igualmente en la circulaci\u00f3n sist\u00e9mica del feto, donde se\r\nsugiere que ocurren adaptaciones en las condiciones patol\u00f3gicas antes mencionadas (RCIU y macrosom\u00eda fetal\r\nsecundaria a obesidad materna), condicionando as\u00ed a estos ni\u00f1os a presentar un elevado riesgo de\r\nenfermedades cardiometab\u00f3licas en la vida adulta.\r\nEste proyecto propuso estudiar la presencia de marcas epigen\u00e9ticas (cambios en el patr\u00f3n de metilaci\u00f3n de\r\ncitosinas en la regi\u00f3n promotora de genes y cambios en la modificaci\u00f3n de histonas que participan en el estado\r\nde compactaci\u00f3n\/relajaci\u00f3n de la cromatina) en las c\u00e9lulas vasculares de la arteria umbilical (HUAEC), cambios\r\nen la funci\u00f3n vascular y expresi\u00f3n de genes, prote\u00ednas y actividad de enzimas claves en la funci\u00f3n vascular en\r\ntres grupos de gestantes: 1) gestantes normopeso con fetos de crecimiento normal denominados \u0093Adecuados\r\npara la Edad Gestacional\u0094 (AEG); 2) gestantes normopeso con fetos que presentaron Restricci\u00f3n del\r\nCrecimiento IntraUterino (RCIU) y 3) gestantes con obesidad pregestacional que tuvieron hijos que fueron\r\nGrandes para la Edad Gestacional (FMOM).\r\nLos objetivos y los resultados principales de este proyecto fueron:\r\n1) Estudiar el tono vascular de las arterias umbilicales y cori\u00f3nicas de la placenta en estas tres condiciones\r\ncl\u00ednicas con acento en la participaci\u00f3n de las v\u00edas dependiente de \u00f3xido n\u00edtrico, un vasodilatador dependiente\r\ndel endotelio, clave en el tono vascular placentario. Se determin\u00f3 que las arterias cori\u00f3nicas y placentarias de\r\nlos fetos RCIU y FMOM presentan disfunci\u00f3n vascular dependiente de \u00f3xido n\u00edtrico y que existe un desbalance\r\nentre la actividad de arginasa-2\/eNOS que favorece esta disfunci\u00f3n. (ver Krause et al. Placenta 2012; 2013;\r\nSchneider et al., Placenta 2015).\r\n2) Determinar si estos cambios en el tono vascular placentario y umbilical se correlacionan a cambios en la\r\nexpresi\u00f3n de genes y prote\u00ednas claves en la funci\u00f3n vascular (eNOS, Arg2, CAT-1) y de respuesta estr\u00e9s\r\noxidativo (NOX4, GPx-1, SOD-1 y HO-1) en los cultivos primarios de HUAEC de las tres condiciones cl\u00ednicas,\r\nas\u00ed como en los tejidos (cordones umbilicales y arterias cori\u00f3nicas) (ver Schneider et al., Placenta 2015). Se\r\ndetermin\u00f3 que estos vasos est\u00e1n marcados por una respuesta cr\u00f3nica a estr\u00e9s oxidativo, presentando una\r\nlimitada reserva vascular al estr\u00e9s oxidativo, comparado con los tejidos provenientes de embarazos AEG (ver\r\nSchneider et al., Placenta 2015).\r\n3) Estudiar la presencia de modificaciones epigen\u00e9ticas presentes en la regi\u00f3n promotora de los genes\r\nrelacionados con la v\u00eda de s\u00edntesis del \u00f3xido n\u00edtrico (NO) y determinar si la respuesta al estr\u00e9s oxidativo y\/o\r\nhipoxia est\u00e1n programadas epigeneticamente. Se determin\u00f3 que de todos los genes estudiados s\u00f3lo eNOS y\r\nArg2 presentan cambios en el patr\u00f3n de metilaci\u00f3n en la regi\u00f3n promotora (ver Krause et al., Epigenetics\r\n2013) que se correlacionan con las modificaciones de histonas encargadas de regular el estado de\r\ncompactaci\u00f3n de la cromatina (Caniuguir et al., en preparaci\u00f3n).\r\n4) Ahondar en la participaci\u00f3n de los mecanismos epigen\u00e9ticos (HDAC y DNMT) en la expresi\u00f3n basal de estos\r\ngenes en las tres condiciones cl\u00ednicas. Se determin\u00f3 muy elegantemente como NO es quien regula a nivel\r\nepigen\u00e9tico la apertura de la cromatina de arginasa 2 y su actividad transcripcional (ver Krause et al., Biochem\r\nPharmacol 2016).\r\nEl desarrollo de este proyecto tuvo como fruto 18 art\u00edculos en revistas indexadas, la mitad de ellos\r\ndirectamente relacionados con resultados de este proyecto y los otros de colaboraciones nacidas durante estos\r\na\u00f1os, que apuntan directamente a comprender los mecanismos que subyacen la programaci\u00f3n fetal de\r\nenfermedades cardiometab\u00f3licas en tejido placentario, en ni\u00f1os pre-adolescentes, modelos animales de RCIU y\r\nobesidad materna, proyectos cl\u00ednicos de seguimiento de ni\u00f1os, etc.\r\nEste proyecto aport\u00f3 en forma sustantiva a la generaci\u00f3n de nuevo conocimiento en relaci\u00f3n a los\r\nmecanismos moleculares que subyacen a la programaci\u00f3n vascular alterada en fetos con RCIU y FMOM,\r\nque est\u00e1n en mayor riesgo de desarrollar enfermedades vasculares en la vida postnatal, con la relevancia\r\ncl\u00ednica de la potencial aplicaci\u00f3n en la detecci\u00f3n temprana de factores de riesgo cardiovascular en el\r\nnacimiento.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 3130635<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Octubre 2011 - Septiembre 2015<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6468\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            Mecanismos de modulaci\u00f3n eferente auditiva en un modelo de atenci\u00f3n selectiva en ratones gen\u00e9ticamente modificados y en chinchillas\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6468\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6468\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Mecanismos de modulaci\u00f3n eferente auditiva en un modelo de atenci\u00f3n selectiva en ratones gen\u00e9ticamente modificados y en chinchillas: Se realizo medici\u00f3n de funcionamiento eferente auditivo en modelos modificados gen\u00e9ticamente y bajo inhibici\u00f3n farmacol\u00f3gica. Se evalu\u00f3 en una prueba conductual los resultados.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Investigador\/a Responsable<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"  circle--pattern-bottom-large col-sm-12 col-md-12 img-article\"><div class=\"holder-publish col-md-12\" style=\"border-bottom: 1px solid #35DB54\"><div class=\"content-holder h-100 component-border overflow-hidden row m-0 p-4 aling-items-center\"><ul class=\"p-0 list-style-none\"><li class=\"p-0 ms-1 me-2\"><i class=\"fa fa-solid fa-id-card-clip fa-fw\"><\/i> 1100975<\/li><li class=\"p-0 ms-1\"><i class=\"fa fa-regular fa-calendar fa-fw ms-1\"><\/i>Marzo 2010 - Marzo 2013<\/li><\/ul><div class=\"caption col-12 p-0 col-md-12 row m-0 align-items-center\"><div class=\"px-md-1\"><small class=\"badge rounded-pill fw-semibold\" style=\"background-color:#35DB54 !important; color:#FFF\">Finalizado<\/small><small class=\"ms-2 badge rounded-pill fw-semibold\" style=\"background-color:#F0F1F3 !important; color:#797979\"><i class=\"fa fa-solid fa-lg fa-money-check-dollar fa-fw me-1\"><\/i>Agencia Nacional de Investigaci\u00f3n y Desarrollo - ANID<\/small>\n                            <div class=\"accordion accordion-flush\" id=\"6569\">\n                                <div class=\"accordion-item\">\n                                    <h3 class=\"my-0 small-space pt-2 title-ss text-decoration-none accordion-header\">\n                                        <a role=\"button\" class=\"bg-transparent p-0\" href=\"\">\n                                            <i class=\"fas fa-solid fa-link fa-fw me-2\"><\/i>\n                                            VALIDATION OF NEUROPSYCHOLOGICAL TESTS AND BIOMARKERS FOR THE DIAGNOSIS OF MILD ALZHEIMER DISEASE\n                                        <\/a><\/h3>\n                                    <div id=\"collapse-6569\" class=\"accordion-collapse collapse\" data-bs-parent=\"#6569\">\n                                        <div class=\"accordion-body p-0 pt-4 pb-4\">\n                                            [vc_section el_class=\"container mx-auto align-items-center circle--pattern\" css=\".vc_custom_1648956589196{padding-top: 3rem !important;}\"][vc_row el_class=\"pb-5\"][vc_column][vc_wp_custommenu nav_menu=\"6\"][uoh_breadcrumb_component automatic_breadcrumb=\"true\"][uoh_title_component title_dropdown=\"big\" title_decorator=\"true\"]{{title}}[\/uoh_title_component][vc_column_text css=\"\"]Research project aimed at identifying neuropsychological and biological markers for the early detection of Alzheimer's disease.[\/vc_column_text][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649209804184{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5\"][vc_row el_class=\"container mx-auto align-items-center p-md-0 pt-5\"][vc_column el_class=\"p-0\"][\/vc_column][\/vc_row][\/vc_section][vc_section css=\".vc_custom_1649210787516{background-color: #f6faff !important;}\" el_class=\"p-md-0 pt-md-5 pb-md-5\"][vc_row el_class=\"container mx-auto align-items-center\"][vc_column][\/vc_column][\/vc_row][\/vc_section]\n                                        <\/div>\n                                    <\/div>\n                                <\/div>\n                            <\/div><div class=\"mt-3\"><i class=\"fas fa-solid fa-user-tag fa-fw me-2\"><\/i><small class=\"text-muted\">Co-Investigador\/a<\/small><\/div><span class=\"caption-field-publish\"><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Cap\u00edtulos de Libros&#8221; tab_id=&#8221;cap-libros&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Otros escritos e informes&#8221; tab_id=&#8221;otros&#8221;]<link rel=\"stylesheet\" id=\"font-awesome-css\" href=\"https:\/\/cdnjs.cloudflare.com\/ajax\/libs\/font-awesome\/6.5.1\/css\/all.min.css\" type=\"text\/css\" media=\"all\"><div class=\"row m-0 p-0\"><div class=\"col-12 col-md-9 pt-5 pt-md-0 px-md-0 \"><\/div><\/div>[\/vc_tta_section][vc_tta_section title=&#8221;Contacto&#8221; tab_id=&#8221;contacto&#8221;][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row][\/vc_section]<\/p>\n<\/div>","protected":false},"featured_media":1282,"template":"","institute_academics":[3],"profile_academics":[7],"class_list":["post-1281","academics","type-academics","status-publish","has-post-thumbnail","hentry","institute_academics-instituto-de-ciencias-de-la-salud","profile_academics-academico"],"rut_academico":"15109479-1","mail_academico":"juan.pino@uoh.cl","n_proyectos":"8","n_publicaciones":"24","n_libros":"0","n_cap_libros":"6","n_otros_libros":"1","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - 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